432 Matching Annotations
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    Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma
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    sciencedirect.com/science/article/pii/S2589004224018297
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    Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC6551610/
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    Dual effect of N-terminal deletion of cardiac myosin essential light chain in mitigating cardiomyopathy
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    Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions
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  7. Aug 2024
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    The cullin Rtt101 promotes ubiquitin-dependent DNA−protein crosslink repair across the cell cycle
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    Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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    sciencedirect.com/science/article/pii/S1097276524005793
  11. Jul 2024
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    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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    Observing isolated synaptic vesicle association and fusion ex vivo
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    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    cell.com/molecular-cell/fulltext/S1097-2765(24)00511-2
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    Polymerization of ZBTB transcription factors regulates chromatin occupancy
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    Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons
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  17. Jun 2024
  18. www.cell.com www.cell.com
    Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss.
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    cell.com/iscience/abstract/S2589-0042(24)01346-4
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    Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
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    HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
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    The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres
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    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    Truncated protein isoforms generate diversity of protein localization and function in yeast
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    elife-92755-v2-html.html
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      D. Secondary antibodies

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  28. May 2024
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
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    Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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    ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
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    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
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    Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins
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    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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      DOI: 10.1158/1078-0432.CCR-22-2854

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  38. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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      DOI: 10.1016/j.celrep.2024.114152

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    sciencedirect.com/science/article/pii/S2211124724004807
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    Revealing the grammar of small RNA secretion using interpretable machine learning
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  42. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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      DOI: 10.7554/elife.92755

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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins
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    Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
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  47. Mar 2024
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    Molecular determinants and signaling effects of PKA RIα phase separation
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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    Identification of an H-Ras nanocluster disrupting peptide
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  56. link.springer.com link.springer.com
    UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
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  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pyruvate dehydrogenase kinase 2 knockdown restores the ability of amyotrophic lateral sclerosis-linked SOD1G93A rat astrocytes to support motor neuron survival by increasing mitochondrial respiration
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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  59. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  64. Dec 2023
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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  66. Nov 2023
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    Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates
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    Manipulating the 3D organization of the largest synthetic yeast chromosome
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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  77. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  78. Oct 2023
  79. www.sciencedirect.com www.sciencedirect.com
    Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice
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    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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  87. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR
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  91. Aug 2023
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    Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
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    Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease
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    The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes
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    RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
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    Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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    Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4+ T cells
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  100. Jul 2023
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    CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement
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    Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  105. Jun 2023
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    Sex-Dependent Effects of Chronic Restraint Stress on Mood-Related Behaviours and Neurochemistry in Mice
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    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization
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    Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7
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  114. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
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  117. www.embopress.org www.embopress.org
    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Ubx5-Cdc48 assists the protease Wss1 at DNA-protein crosslink sites in yeast
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    Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19
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  122. Apr 2023
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    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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    Vascular cells improve functionality of human cardiac organoids
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    Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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  130. Mar 2023
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    The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability
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    S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signaling
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    Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
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    Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner
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    Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
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    Increased alcohol dehydrogenase 1 activity promotes longevity
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    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
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    Regulation of DNA damage response by trimeric G-proteins
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    Fibroblast growth factor-21 improves insulin action in nonlactating ewes
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    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Carbonic anhydrases in development: morphological observations and gene expression profiling in sea urchin embryos exposed to acetazolamide
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    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  151. Dec 2022
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    Bidirectional promoter activity from expression cassettes can drive off-target repression of neighboring gene translation
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    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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    A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
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    Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals
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    R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization
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    DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro
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  162. Oct 2022
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    Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice
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    Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease
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    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
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  168. Sep 2022
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    Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation
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    Exploring the target scope of KEAP1 E3 ligase-based PROTACs
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  171. Aug 2022
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    Dual control of formin-nucleated actin assembly by the chromatin and ER in mouse oocytes
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
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    Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance
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  176. Jul 2022
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    EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes
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  178. www.sciencedirect.com www.sciencedirect.com
    Filter trapping protocol to detect aggregated proteins in human cell lines
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    Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma
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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells
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  181. Jun 2022
  182. www.nature.com www.nature.com
    MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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  184. elifesciences.org elifesciences.org
    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance
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    Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy
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    How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  188. May 2022
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    Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents
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    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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    Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
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  192. Apr 2022
  193. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Copper bis(thiosemicarbazone) complexes modulate P-glycoprotein expression and function in human brain microvascular endothelial cells
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    The lipophilic cyclic peptide cyclosporin A induces aggregation of gel-forming mucins
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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  196. Mar 2022
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Local hyperthermia therapy induces browning of white fat and treats obesity
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    Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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  203. Feb 2022
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    Poly(ADP-ribose) drives condensation of FUS via a transient interaction
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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  209. Jan 2022
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    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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    GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors
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    YAP1 and PRDM14 converge to promote cell survival and tumorigenesis
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  215. Dec 2021
  216. jasn.asnjournals.org jasn.asnjournals.org
    Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
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  217. cancerimmunolres.aacrjournals.org cancerimmunolres.aacrjournals.org
    The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
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  218. www.nature.com www.nature.com
    Evolution of a histone variant involved in compartmental regulation of NAD metabolism
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  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
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  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts
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  221. Nov 2021
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    Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
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    A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy
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    Merkel cell polyomavirus T-antigens regulate DICER1 mRNA stability and translation through HSC70
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    sciencedirect.com/science/article/pii/S2589004221012335
  225. www.sciencedirect.com www.sciencedirect.com
    Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice
    1
    1. scibot 03 Nov 2021
      926–32210

      DOI: 10.1016/j.ejphar.2021.174614

      Resource: (LI-COR Biosciences Cat# 926-32210, RRID:AB_621842)

      Curator: @Naa003

      SciCrunch record: RRID:AB_621842

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      RRID:AB_621842 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0014299921007706
  226. Oct 2021
  227. www.sciencedirect.com www.sciencedirect.com
    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
    1
    1. scibot 27 Oct 2021
      RRID:AB_621842

      DOI: 10.1016/j.celrep.2021.109899

      Resource: (LI-COR Biosciences Cat# 926-32210, RRID:AB_621842)

      Curator: @scibot

      SciCrunch record: RRID:AB_621842

      What is this?
      RRID:AB_621842
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    sciencedirect.com/science/article/pii/S2211124721013693