515 Matching Annotations
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    Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity
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    elifesciences.org/articles/105978
  3. Aug 2025
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    A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
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    sciencedirect.com/science/article/pii/S1097276525006513
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    Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo
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    Multiomics Profiling of Extracellular Vesicles Supports Their Involvement in Endothelial Senescence‐Associated Vascular Dysfunction
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  7. Jul 2025
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    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
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    Matrix Stiffness Regulates TGFβ1‐Induced αSMA Expression via a G9a‐LATS‐YAP Signaling Cascade
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    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    Rapamycin Reduces Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification
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    Integrative Analysis of DNA Methylation and Gene Expression Reveals Key Molecular Signatures in Spatial Memory Impairment of Sepsis-Associated Encephalopathy
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    The matricellular protein ADAMTS-like 2 regulates differentiation of skeletal muscle-resident fibro-adipogenic progenitor cells
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    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease
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    Synaptic activity causes minute-scale changes in BAF complex composition and function
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  21. May 2025
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    Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
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    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing
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    MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples
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    Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia
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    High-confidence glycosomal membrane protein inventory unveils trypanosomal peroxin PEX15
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    Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice
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    Identification of a growth-promoting gene cluster in the region 2q24 as a driver of tumorigenesis in childhood hepatoblastoma
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  29. Apr 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    Fibril fuzzy coat is important for α-synuclein pathological transmission activity
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    A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance
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    CaV2.1 mediates presynaptic dysfunction induced by amyloid β oligomers
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  34. Mar 2025
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    Heroin Regulates the Voltage-Gated Sodium Channel Auxiliary Subunit, SCN1b, to Modulate Nucleus Accumbens Medium Spiny Neuron Intrinsic Excitability and Cue-Induced Heroin Seeking
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  39. Feb 2025
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    TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms
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    AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack
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    Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
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    Dynamic regulation of RNA Polymerase III transcription in mouse embryonic stem cells during heat shock stress
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    Novel Pannexin 1 isoform is increased in cancer
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  46. Jan 2025
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    Structural and functional analysis of the Nipah virus polymerase complex
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    Lysosomal activity in response to the incubation of pristine and functionalized carbon nanodots
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    Claudin-4 stabilizes the genome via nuclear and cell cycle remodeling to support ovarian cancer cell survival
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    mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
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    Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs
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    The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling
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    Co-essentiality analysis identifies PRR12 as a cohesin interacting protein and contributor to genomic integrity
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  56. Dec 2024
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    Intron retention of an adhesion GPCR generates 1TM isoforms required for 7TM-GPCR function
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    Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation
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    Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes
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    Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles
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    Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
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    Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
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    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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  70. Nov 2024
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
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    A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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  76. Oct 2024
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1
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    Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
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  80. Sep 2024
  81. www.biorxiv.org www.biorxiv.org
    Zika virus NS3 drives the assembly of a viroplasm-like structure
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    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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    Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity
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    Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
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    Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
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    Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis
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    Identification of a Master Regulator of Differentiation in Toxoplasma
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    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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    Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    Pooled endogenous protein tagging and recruitment for systematic profiling of protein function
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    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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    Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells
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  96. Aug 2024
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  200. Jun 2023
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  209. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
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    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
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  217. Apr 2023
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    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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