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Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

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1. scibot 22 May 2026
  
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  DOI: 10.7554/eLife.104778
  
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2026.05.11.724407.full-html.html

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1. scibot 21 May 2026
  
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54.241.53.176/bfcffe42e71061fda5786106304e0751d5cf2645/2026.05.11.724407.full-html.html
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ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

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1. scibot 20 May 2026
  
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sciencedirect.com/science/article/pii/S0896627326003302
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A CRISPR activation screen identifies SPART as a pan-orthoflavivirus restriction factor

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1. scibot 20 May 2026
  
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sciencedirect.com/science/article/pii/S1931312826001745
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DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer

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1. scibot 19 May 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179828/
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CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

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1. scibot 19 May 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179391/
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A regulatory circuitry driving a noradrenergic to mesenchymal transition highlights YAP/TAZ as critical players in neuroblastoma plasticity

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1. scibot 19 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117351
  
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sciencedirect.com/science/article/pii/S2211124726004298
May 2026
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Presentation of identical tumor antigen peptides by canine and human MHC class I

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1. scibot 16 May 2026
  
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sciencedirect.com/science/article/pii/S2589004226013507
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miR-93-mediated PTEN suppression and CNS-specific T cell exhaustion shape the leukemia niche in infant KMT2A::AFF1+ B-ALL

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1. scibot 16 May 2026
  
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sciencedirect.com/science/article/pii/S2211124726004316
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Cooperative response loops enhanced by histamine signaling during tumor-neutrophil crosstalk in pleural mesothelioma

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1. scibot 16 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117361
  
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sciencedirect.com/science/article/pii/S2211124726004390
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Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer

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1. scibot 15 May 2026
  
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nature.com/articles/s41467-026-72116-1
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Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response

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1. scibot 15 May 2026
  
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nature.com/articles/s41388-026-03814-9
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Human Sperm-Induced Cell-Cell Fusion Requiring JUNO (hSPICER): A paradigm shift to test sperm fertilizing potential

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1. scibot 15 May 2026
  
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  DOI: 10.64898/2026.05.07.723220
  
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biorxiv.org/content/10.64898/2026.05.07.723220v1
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Autophagy-lysosomal dependency defines a vulnerable physiological state in drug-tolerant persister cells of triple-negative breast cancer

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1. scibot 14 May 2026
  
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  DOI: 10.1007/s10495-026-02310-5
  
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link.springer.com/article/10.1007/s10495-026-02310-5
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Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential

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1. scibot 14 May 2026
  
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  DOI: 10.1016/j.chom.2026.04.015
  
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Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.019
  
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sciencedirect.com/science/article/pii/S109727652600273X
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Galvanin (TMEM154) is an electric-field sensor for directed cell migration

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1. scibot 13 May 2026
  
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  Plasmid_12260
  
  DOI: 10.1016/j.cell.2026.04.026
  
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sciencedirect.com/science/article/pii/S0092867426004617
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Protocol for lentiviral generation and transduction of human-derived endometrial epithelial organoids to study uterine function and pathologies

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1. scibot 12 May 2026
  
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  DOI: 10.1016/j.xpro.2026.104558
  
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Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

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1. scibot 09 May 2026
  
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  DOI: 10.7554/eLife.106587
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13143275/
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CIAPIN1 functions as a redox-sensitive transcriptional repressor of Tp53 during vascular remodeling

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1. scibot 09 May 2026
  
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  RRID:Addgene_12260
  
  DOI: 10.7150/thno.124965
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13142666/
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Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity

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1. scibot 09 May 2026
  
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sciencedirect.com/science/article/pii/S2666379126002181
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Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

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1. scibot 08 May 2026
  
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sciencedirect.com/science/article/pii/S1535610826002163
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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion

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  DOI: 10.1016/j.xcrm.2026.102788
  
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TENT5A Maintains MYC mRNA Stability to Enhance Osteosarcoma Stemness

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1. scibot 06 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-4635
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13136882/
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Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer

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1. scibot 06 May 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
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TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma

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1. scibot 06 May 2026
  
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  DOI: 10.1038/s41388-026-03767-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13136027/
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Intra-tumoral tertiary lymphoid structures characterized by a B cell-related signature elicit antitumor effect through HAPLN3 in hepatocellular carcinoma

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1. scibot 05 May 2026
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/2326-6066.CIR-25-0758
  
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aacrjournals.org/cancerimmunolres/article/14/5/771/784463/Intratumoral-Tertiary-Lymphoid-Structures
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Protocol for identifying cellular reprogramming minimal networks using combinatorial transcription factor screening

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  DOI: 10.1016/j.xpro.2026.104527
  
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Structure of zebrafish NLRP3 reveals a novel mode of inflammasome activation

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1. scibot 01 May 2026
  
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  DOI: 10.64898/2026.04.17.719140
  
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biorxiv.org/content/10.64898/2026.04.17.719140v1
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Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states

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nature.com/articles/s41588-026-02550-w
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The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK

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sciencedirect.com/science/article/pii/S2451945626001121
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BAG6 and RNF126 promote the degradation of cytosolic misfolded proteins that contain buried degron motifs

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biorxiv.org/content/10.64898/2026.04.24.720685v1
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An RNA-centric interactomics screen identifies novel proviral and antiviral genome binding interactors for tick-borne encephalitis virus

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  DOI: 10.64898/2026.04.23.720161
  
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biorxiv.org/content/10.64898/2026.04.23.720161v1
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The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

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  DOI: 10.1093/nar/gkag334
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13128273/
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The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion

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  DOI: 10.1016/j.devcel.2026.04.001
  
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sciencedirect.com/science/article/pii/S1534580726001243
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Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection

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1. scibot 01 May 2026
  
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  plasmid_12260
  
  DOI: 10.1016/j.celrep.2026.117090
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13124994/
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Time-resolved proteomics reveals five modules of stress granule disassembly and identifies SYNCRIP as a late-phase clearance factor

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  DOI: 10.1016/j.biocel.2026.106961
  
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sciencedirect.com/science/article/pii/S1357272526000658
Apr 2026
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MYC-bound enhancer RNAs in cis regulate gene transcription and tumorigenesis

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  DOI: 10.1126/sciadv.aeb5147
  
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A supracellular actin network transmits forces over long distances at the apical surface of squamous carcinoma cells

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HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication

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Unbiased niche labeling maps immune-excluded niche in bone metastasis

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Interaction of NDRG1 and TGM2 modulates DNA replication and repair

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pmc.ncbi.nlm.nih.gov/articles/PMC13112271/
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Distinct malignant cell states and myeloid glutamate signaling associated with aggressive pancreatic neuroendocrine tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC13118131/
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Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity

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USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma

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GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma

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Integrated Multi-omic Profiling Identifies BRD8/EP400 as a Pivotal Chromatin Module Mediating Anti-HER2 Response in HR+/HER2+ Breast Cancer

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Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

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Actomyosin contractility is a potent suppressor of mesoderm induction by human pluripotent stem cells

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CCDC80 suppresses high-grade serous ovarian cancer migration via negative regulation of B7-H3

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febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70235
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PALINCODE: Recording cell lineage with ternary palindromic CRISPR bits

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Dual Specificity Phosphatase 4 Enhances Immunotherapy Response by Inhibiting TGF-β1 Secretion in Hepatocellular Carcinoma

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Tuning the sensitivity of mechanosensory receptors through histidine scanning

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cell.com/cell/fulltext/S0092-8674(25)01499-0
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Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention

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Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery

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Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis

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aacrjournals.org/cancerimmunolres/article/14/3/478/774853/Immunotherapy-Inhibits-Tumor-Cholesterol-Synthesis
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Bone Metastatic Progression of Prostate Cancer is Regulated by TRIM28-LDHA Mediated Metabolism

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aacrjournals.org/mcr/article/24/2/93/772003/Bone-Metastatic-Progression-of-Prostate-Cancer-Is
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Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells

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ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3

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aacrjournals.org/bloodcancerdiscov/article/7/1/129/771360/ID2-Suppresses-Multiple-Myeloma-Cell-Proliferation
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Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages

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aacrjournals.org/cancerimmunolres/article/13/12/2054/768330/Functional-Genetic-Screens-Reveal-Key-Pathways
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Chronic ISG15 Exposure Accelerates CD8+ T-cell Dysfunction while Increasing PD-1 Blockade Sensitivity in Oral Squamous Cell Carcinoma

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aacrjournals.org/cancerimmunolres/article/13/11/1829/766805/Chronic-ISG15-Exposure-Accelerates-CD8-T-cell
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MTHFD2-mediated ubiquitination and degradation of FOXO1 promote tongue squamous cell carcinoma progression

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aacrjournals.org/mcr/article/24/4/270/775482/MTHFD2-Mediated-Ubiquitination-and-Degradation-of
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Table 2 Overview of plasmids used.

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nature.com/articles/s41598-026-48584-2/tables/2
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RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

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Mechanisms of gene regulation by SRCAP and H2A.Z

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The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling

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An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection

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Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodeling

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Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation

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pmc.ncbi.nlm.nih.gov/articles/PMC13082235/
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mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway

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The Erlin1/2 complex is a dynamic scaffold for membrane microdomain assembly on the endoplasmic reticulum

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cell.com/molecular-cell/abstract/S1097-2765(26)00157-7
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Adapting Upright Light Sheet Fluorescence Microscopy for Imaging at Air-Liquid Interface

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Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

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2026.04.04.716465.full-html.html

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54.241.53.176/0229c40ca310a236905d7351f876d02676bfa53f/2026.04.04.716465.full-html.html
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eIF4G2-dependent translation restrains pancreatic cancer progression

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A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential

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pmc.ncbi.nlm.nih.gov/articles/PMC13077004/
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Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence

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AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma

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A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

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1. scibot 15 Apr 2026
  
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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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sciencedirect.com/science/article/pii/S2451945626000747
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Activation of neurogenesis improves amyloid-β pathology and cognitive function through AMP kinase signaling in Alzheimer’s disease model mice

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1. scibot 11 Apr 2026
  
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Identification of STMN1 as a lactylation-related driver of lung cancer progression using Mendelian randomization

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1. scibot 10 Apr 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13051255/
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Laptm4a mediates renal ischemia-reperfusion injury by regulating the UNC5B-AKT/mTOR signaling pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC13053316/
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Cholecystokinin A Receptor Knockdown Diminishes Colon Cancer Cell Invasive Potential via Modulation of Integrin/FAK, EMT, and uPA/uPAR/MMP2 Axis

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1. scibot 10 Apr 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13040287/
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ONX-0914 Suppresses Hormone-Sensitive Prostate Cancer by Promoting O-GlcNAcylation-Mediated Stabilization of TCF7L1

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pmc.ncbi.nlm.nih.gov/articles/PMC13040289/
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APOBEC3B regulates HPV replication by inducing R-loop formation and DNA damage

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1. scibot 10 Apr 2026
  
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  packaging
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13035229/
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CD4 T-cell platform for delivering interferons as an antiviral countermeasure with a focus on SARS-CoV-2

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pmc.ncbi.nlm.nih.gov/articles/PMC13032555/
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Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center

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pmc.ncbi.nlm.nih.gov/articles/PMC13025127/
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SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

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pmc.ncbi.nlm.nih.gov/articles/PMC13060607/
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Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12849445/
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Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips

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pmc.ncbi.nlm.nih.gov/articles/PMC13039962/
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Protocol to identify SINE-VNTR-Alu regulators using genome-wide screening in human K562 cells

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PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

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pmc.ncbi.nlm.nih.gov/articles/PMC13056290/
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X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer

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nature.com/articles/s41388-026-03740-w
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Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation

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Identification of the mitochondria-related gene IRF7 shared by physical exercise and Parkinson’s disease and exploration of its potential molecular mechanisms

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pmc.ncbi.nlm.nih.gov/articles/PMC13033288/
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An epigenetic bifunctional that toggles between transactivation and repression

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pmc.ncbi.nlm.nih.gov/articles/PMC13015318/
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Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC13015432/
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Reprogramming mRNA localization by targeted RNA-protein interference

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pmc.ncbi.nlm.nih.gov/articles/PMC12991119/
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Depleting HIF-1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF-independent pathways

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pmc.ncbi.nlm.nih.gov/articles/PMC13007490/
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circOMA1 delivered by exosomes regulates DRD2-mediated prolactinoma resistance

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  DOI: 10.3892/ijmm.2026.5812
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13042270/
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Microbial sensing through the non-canonical inflammasome modulates airway type 2 immunity

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pmc.ncbi.nlm.nih.gov/articles/PMC13033652/
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CENPF Overexpression Induced by HBV Infection Facilitates the G1/S Cell Cycle Transition of Hepatocellular Carcinoma Cells via MYC Pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC13051194/
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COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function

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pmc.ncbi.nlm.nih.gov/articles/PMC12987470/
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Allele-selective disruption of pathogenic VWF variants in type 2 von Willebrand disease using CRISPR/Cas9

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  DOI: 10.1182/bloodadvances.2025018760
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12952769/
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Serotonin modulates lineage plasticity in neuroendocrine prostate cancer via epigenetic reprogramming

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aacrjournals.org/cancerdiscovery/article/16/4/760/775565/Serotonin-Modulates-Lineage-Plasticity-in
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Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer

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  DOI: 10.1158/0008-5472.CAN-25-1532
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12758111/
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Targeted inhibition of Nrf2 potentiates antitumor immunity and enhances the efficacy of immunotherapy in hepatocellular carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13034291/
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Microtubules guide Aurora B substrate geometries for accurate chromosome segregation

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  DOI: 10.1126/sciadv.aea2112
  
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  DOI: 10.1126/sciadv.aea2112
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13015866/
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KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival

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  DOI: 10.1126/sciadv.aea2106
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12998525/
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CLOCK-catalyzed histone H3K37 glutarylation suppresses H3K36 trimethylation pathways in glioblastoma

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  DOI: 10.1126/sciadv.aea1127
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13015892/
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Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure

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pmc.ncbi.nlm.nih.gov/articles/PMC13004020/
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Multiomic analysis of clonal development reveals new regulators of leukemic cell growth

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pmc.ncbi.nlm.nih.gov/articles/PMC13041715/
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EP4 influences bortezomib resistance in multiple myeloma by modulating endoplasmic reticulum stress via the phosphatidylinositol 3-kinase/protein kinase B pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12955957/
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ZXDB Drives Macrophage Inflammatory Programming in Sepsis‐Induced Acute Kidney Injury by Recruiting EIF4A3 to Enhance ACACA Translation

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pmc.ncbi.nlm.nih.gov/articles/PMC13011163/
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A targeting lentiviral vector for generation of CAR-T cells in vivo

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pmc.ncbi.nlm.nih.gov/articles/PMC13009191/
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CHK1 is an integral regulator of DNA replication in human cells

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pmc.ncbi.nlm.nih.gov/articles/PMC13039271/
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MOV10 Promotes the Proliferation of Goat Mammary Epithelial Cells by Regulating the miR-21-5p-Mediated TGFβ/Smad7 Signaling Pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC13000603/
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CRISPR/Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function and recovery after myocardial infarction

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pmc.ncbi.nlm.nih.gov/articles/PMC13045639/
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CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13050104/
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The HIF-2 Transcription Factor Mediates Resistance to Ferroptosis in Pancreatic Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13052133/
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SDF2L1 modulates oxLDL-induced endoplasmic reticulum stress, protein aggregation, and O-mannosylation in myocardial infarction and lung cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13003032/
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Development of a Live‐Cell Imaging Assay to Elucidate Spatiotemporal Dynamics of Extracellular Vesicle Fusion with Target Cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12949999/
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Engineered subtilisin protease degrades active KRAS in cancer cells, leading to differential cell targeting

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pmc.ncbi.nlm.nih.gov/articles/PMC12991091/
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Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus

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pmc.ncbi.nlm.nih.gov/articles/PMC13001379/
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Pharmacologic and Oncohistone Inhibition of SETD2 Converge on Genomic Instability

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  plasmid_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12984950/
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HIV-1 Vpr is targeted for degradation by autophagy

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  plasmid_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12970978/
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Defining the functional role and potential as an immunotherapeutic target of ALCAM in neuroblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12729689/
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HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression

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pmc.ncbi.nlm.nih.gov/articles/PMC12974484/
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Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia

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pmc.ncbi.nlm.nih.gov/articles/PMC13039848/
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Discovery of synthetic G-quadruplex DNA as SARS-CoV-2 helicase inhibitor with antiviral, anti-inflammatory and antioxidative properties

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pmc.ncbi.nlm.nih.gov/articles/PMC13039202/
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The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage

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pmc.ncbi.nlm.nih.gov/articles/PMC13039405/
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Androgen receptor-dependent DRAM1 activation drives autophagic resistance to BRAF inhibitors in BRAFV600-mutant melanoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13004951/
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PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78

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pmc.ncbi.nlm.nih.gov/articles/PMC13020080/
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Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics

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Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer

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science.org/doi/10.1126/sciimmunol.adt7832
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AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13039981/
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Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma

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nature.com/articles/s41388-026-03744-6
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Phosphorylation-driven Targeted Protein Degradation of Oncogenic β-catenin

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biorxiv.org/content/10.64898/2026.03.16.712096v1
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Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer’s disease

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biorxiv.org/content/10.64898/2026.03.14.711835v1
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Catabolism of extracellular glutathione supplies cysteine to support tumours

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  12260
  
  DOI: 10.1038/s41586-026-10268-2
  
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nature.com/articles/s41586-026-10268-2
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Vesicle trafficking 1 in breast cancer tissue and serum orchestrates metastatic progression and an immunosuppressive microenvironment

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sciencedirect.com/science/article/pii/S1567576926004091
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The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma

1
1. scibot 01 Apr 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13032475/
Mar 2026
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IFIT3 Associates with m⁶A-Modified RNA to Restrict Hepatitis C Virus Infection

1
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  DOI: 10.64898/2026.03.25.714224
  
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biorxiv.org/content/10.64898/2026.03.25.714224v1
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Pre-existing cell states predict resistance to multiple treatments

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sciencedirect.com/science/article/pii/S2666979X26000534
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ER-localized ceramide accumulation contributes to replicative senescence

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  Addgene Plasmid Cat#12260
  
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sciencedirect.com/science/article/pii/S2451945626000735
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A senescent tumor cell-derived nanovesicle directly primes splenic T cells to potentiate cancer radiotherapy

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The Disruption of the HIV-1 Gag Start Codon via Editing Using MmCas12m-Dual Base Editor-Loaded Virus-like Particles

1
1. scibot 29 Mar 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13025988/
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Three-dimensional reconstruction of a biliary system in a bioengineered liver using decellularized scaffold

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Mechanically-induced Septin Networks Protect Nuclear Integrity

1
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Establishment of a 3D Multicellular HCC Tumor Spheroid Model to Unravel Nrf2’s Influence on the Tumor Immune Microenvironment

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  RRID:Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13023928/
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Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor

1
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pmc.ncbi.nlm.nih.gov/articles/PMC13018213/
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Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy

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  RRID:Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13018473/
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Integrating traditional omics and AI-driven approaches for discovery and validation of novel MicroRNA biomarkers and therapeutic targets in thyroid cancer

1
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pmc.ncbi.nlm.nih.gov/articles/PMC12891075/
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CELF2 Promotes Tau Exon 10 Inclusion via Hinge Domain-Mediated Nuclear Condensation, Driving Cognitive Dysfunction in Tauopathy Models

1
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  psPAX2
  
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Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways

1
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Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia

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pmc.ncbi.nlm.nih.gov/articles/PMC12875880/
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Protocol for stable cell line production to express muscle-type nicotinic receptor

1
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pmc.ncbi.nlm.nih.gov/articles/PMC12997218/
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Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network

1
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  psPAX2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12917913/
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Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

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Dual receptor engagement by mannose-capped lipoarabinomannan reprograms macrophage lipid metabolism in tuberculosis

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pmc.ncbi.nlm.nih.gov/articles/PMC12934963/
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CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13014710/
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Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity

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Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication

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  Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12867696/
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Protocol to generate immunocompetent human heart-macrophage assembloids for the study of immune-cardiac interactions

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  DOI: 10.1016/j.xpro.2026.104411
  
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Intensity modulation of trichromatic split fluorescent proteins for live cell mapping

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  plasmid_12260
  
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A cytomegalovirus-encoded lncRNA blocks cell-cycle progression

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1-s2.0-S2352345X26000494-main-html.html

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  Addgene_12260
  
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Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma

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TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway

1
1. scibot 26 Mar 2026
  
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  plasmid_12
  
  DOI: 10.1186/s12967-026-07831-w
  
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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis

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Development and validation of a PSMA-positive triple-negative breast cancer mouse model for preclinical targeted radionuclide therapies

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pmc.ncbi.nlm.nih.gov/articles/PMC13003023/
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New selective and allosteric FLT3 inhibitors show efficacy against resistant acute myeloid leukemia cells

1
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  Plasmid_12260
  
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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Functional chromatin signatures premark future lineage-specific enhancers

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  AddgeneCat#12260
  
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HE4 drives PD-L1 expression in myeloid cells via IFN-γR-JAK-STAT3 signaling to promote tumor immune evasion

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  Addgene_12260
  
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A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer

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  addgeneCat#12260
  
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Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia

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Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

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  DOI: 10.1016/j.stem.2026.02.009
  
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1-s2.0-S2589004226007479-main-html.html

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  Addgene Cat# 12260
  
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

1
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ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

1
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  Addgene_12260
  
  DOI: 10.1016/j.molcel.2026.02.012
  
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A single-cell CRISPR screen defines a gene regulatory network governing human pluripotency in primed and naive cells

1
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  plasmid_12260
  
  DOI: 10.1016/j.celrep.2026.117124
  
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Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects

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  RRID:Addgene_12260
  
  DOI: 10.64898/2026.03.06.710116
  
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biorxiv.org/content/10.64898/2026.03.06.710116v1
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NIPAL1 Drives a Metabolic-Epigenetic Feedback Loop to Promote Lactate-Mediated Immune Evasion in Esophageal Cancer

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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520055
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FEBS Press

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febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70226
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Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC12934820/
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A developmentally regulated long-range enhancer-promoter contact mediates human neural development

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  DOI: 10.64898/2025.12.01.691702
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12822576/
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aGPCR-HEK: A Stable High-Expression Inducible Mammalian Cell Expression System for Adhesion GPCR Structural Biology Applications

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  DOI: 10.21769/BioProtoc.5621
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12971277/
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Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects

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pmc.ncbi.nlm.nih.gov/articles/PMC12924462/
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ATP release mediated by TRPM3 enhances invasion in glioblastoma

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  DOI: 10.1080/19768354.2026.2629066
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12912218/
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Development and characterization of immortalized mouse intestinal epithelial cell lines

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  DOI: 10.1038/s41598-026-38295-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12966478/
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CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer

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  DOI: 10.1038/s41523-025-00888-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12891518/
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Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR

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  DOI: 10.1038/s41392-026-02593-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12953643/
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Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

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  DOI: 10.1016/j.stem.2025.12.019
  
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1-s2.0-S2589004226004827-main-html.html

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  DOI: 10.1016/j.isci.2026.115107
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12972699/
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MRCKα represses GEF-H1 mediated RhoA activation to promote ovarian cancer spheroid growth and invasion

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  DOI: 10.64898/2026.02.06.704384
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12918926/

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