4,071 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905269/
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    BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
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    sciencedirect.com/science/article/pii/S1097276526000328
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    A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity
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    sciencedirect.com/science/article/pii/S266723752600007X
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    ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124726000884
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    sciencedirect.com/science/article/pii/S0092867425015028
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    TRPV1 Downregulation Impairs Prostate Cancer Growth: Functional and Translational Insights from Cellular and In Vivo Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905635/
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    HP1α depletion and TGFβ activation exert antagonistic effects on 3D genome organization
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    biorxiv.org/content/10.64898/2026.02.12.705282v1
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    Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12911328/
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    Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer
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    sciencedirect.com/science/article/pii/S2666379126000388
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    Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000303
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    Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice
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    sciencedirect.com/science/article/pii/S1550413126000124
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    Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney
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    sciencedirect.com/science/article/pii/S2211124726000847
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    Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
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    sciencedirect.com/science/article/pii/S009286742600111X
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    Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12896819/
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    The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12895852/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12893420/
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    Genome-wide screens identify core regulators of cell surface prion protein expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12894898/
  20. Feb 2026
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    Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis
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    sciencedirect.com/science/article/pii/S2451945626000267
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    SNAP25 undergoes phase separation to facilitate the assembly of the synaptic vesicle fusion machinery
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    sciencedirect.com/science/article/pii/S2211124726000616
  23. 54.241.53.176 54.241.53.176
    2026.01.31.703051.full-html.html
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    54.241.53.176/817d1ae27212347f382894a7416c0a21d3d8e9f2/2026.01.31.703051.full-html.html
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IGF2BP3/m6A-mediated intron retention isoform of DUSP6 promotes cisplatin resistance in nasopharyngeal carcinoma by inhibiting pyroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12888195/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adgrg6/Gpr126 is required for compact wall integrity and establishing trabecular identity during cardiac trabeculation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12886893/
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    Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death
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    sciencedirect.com/science/article/pii/S2211124726000422
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    Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo
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    pmc.ncbi.nlm.nih.gov/articles/PMC12885239/
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    HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress
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    sciencedirect.com/science/article/pii/S1097276526000353
  29. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202507238
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12876832/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12864753/
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    Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors
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    sciencedirect.com/science/article/pii/S2666379125006184
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    The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer
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    sciencedirect.com/science/article/pii/S1097276525005507
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    Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
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    C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes
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    sciencedirect.com/science/article/pii/S0896627325009328
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    Integrating natural and engineered genetic variations to decode regulatory influence on blood traits
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Lysine Demethylase KDM4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12856980/
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    SF3B1K700E neoantigen is a CD8+ T-cell target shared across human myeloid neoplasms
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    pmc.ncbi.nlm.nih.gov/articles/PMC12858050/
  39. www.science.org www.science.org
    α-Synuclein expression is required for somatodendritic dopamine release and immediate early gene induction
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    science.org/doi/10.1126/sciadv.ady6978
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    Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors
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    sciencedirect.com/science/article/pii/S1074761326000361
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    Pharmacological Targeting of NR4A1 Restrains Lipid Metabolism–Ferroptosis Axis in UVR-Induced Skin Aging
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    sciencedirect.com/science/article/pii/S0944711326001480
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    A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2
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    sciencedirect.com/science/article/pii/S2211124726000094
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    NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis
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    sciencedirect.com/science/article/pii/S2211124726000070
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    Interferon dependent immune memory during HSV-1 neuronal latency via increased H3K9me3 and restriction by ATRX
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    nature.com/articles/s41467-025-66477-2
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12665105/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4
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    pmc.ncbi.nlm.nih.gov/articles/PMC12837743/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pancreatic Cancer Stem Cells Co-Expressing SOX2, OCT4, and TERThigh Represent an Aggressive Subpopulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12839176/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms
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    pmc.ncbi.nlm.nih.gov/articles/PMC12832721/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Menin-driven mTOR signaling sustains taxane resistance in CRPC and reveals a targetable vulnerability for combination therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12853843/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12777463/
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    Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12757029/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12637489/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR screen identifies host factors associated with bovine parainfluenza virus 3 infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12674325/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811383/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12706054/
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    Mapping cis- and trans-regulatory target genes of human-specific deletions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12727812/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12783633/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SNORA49 negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing SOX9 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12824223/
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    Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710741/
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    Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12744402/
  61. Jan 2026
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATAD2 drives melanoma growth and progression and inhibits ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12852765/
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
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    CRISPR activation screens map the genomic landscape of cancer glycome remodeling
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    sciencedirect.com/science/article/pii/S2666979X26000017
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    1-s2.0-S2589004226001665-main-html.html
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    Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo
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    pmc.ncbi.nlm.nih.gov/articles/PMC12885239/
  67. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Cholesterol-DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/admi.202500806
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11770945/
  69. 54.241.53.176 54.241.53.176
    2026.01.19.700398v1.full-html.html
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    54.241.53.176/920dac77fb602c31bea028e2a56d4a986d400748/2026.01.19.700398v1.full-html.html
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    Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression
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    sciencedirect.com/science/article/pii/S1550413125005844
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    54.241.53.176/ca60c4c2a1e906c1762fed2c822dc77ccf0438f0/e013832.full-html.html
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    Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
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    sciencedirect.com/science/article/pii/S2666379125006512
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    SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
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    sciencedirect.com/science/article/pii/S2211124725016687
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual targeting of AMRC12 and Malassezia globosa disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12775802/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12690534/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12813672/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-canonical EGFR signaling promotes MAPK-dependent extrusion of epithelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12752489/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ribosome-binding protein 1 maintains peroxisome biogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12752496/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12721884/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12642484/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710652/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12822632/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Discovering the complete enhancer map of human herpesviruses using a natural language processing model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12780183/
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    Myomaker and ether lipids cooperate to promote fusion-competent membrane states
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    sciencedirect.com/science/article/pii/S2211124725016729
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    Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018–2020 epidemic
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    sciencedirect.com/science/article/pii/S0092867425014357
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The hemopexin domain of matrix metalloproteinase-9 attenuates lipopolysaccharide-induced interleukin-6 secretion in liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC12820117/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12822389/
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    Context-specific Angiogenin-mediated tRNA fragments (tDRs) biogenesis shapes the mitochondrial stress response.
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  174. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    New mechanistic insights into macrophage extracellular trap formation induced by a parasitic nematode, Strongyloides stercoralis
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  175. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C1orf50 Accelerates Epithelial-Mesenchymal Transition and the Cell Cycle of Hepatocellular Carcinoma
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  176. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role and mechanism of ubiquitin-specific protease 35 in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12549345/
  177. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520364/
  178. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat
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  179. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12492746/
  180. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stable production of immortalized hPC-MSC-derived extracellular vesicles: integrated cargo analysis and functional validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12590667/
  181. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic discovery of subcellular RNA patterns in the gut epithelium
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  182. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancer
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  183. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARFGAP1 serves as a critical host factor during E30 infection: QS11 inhibits viral pathogenesis in hFcRn-IFNAR−/− mice
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  184. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α
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  185. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Effect of heme oxygenase-1 on the expression of interferon-stimulated genes
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  186. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lung endothelial PEAR1 induces tumor cell dormancy
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  187. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer
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  188. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Notch signal pathway related gene signature predicts overall survival in colorectal cancer
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  189. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors
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  190. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    P3H4 Enhances the Proliferation, Invasion, and Glycolysis of Hepatocellular Carcinoma Cells
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  191. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
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  192. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EP300 compromises antitumor immunity by increasing SOCS1 expression
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  193. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DKK3-LRP1 complex and a chemical inhibitor regulate Aβ clearance in models of Alzheimer’s disease
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    ASPL couples the assembly of stress granules with their VCP-mediated disassembly
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    Resistance to radiation enhances metastasis by altering RNA metabolism
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  196. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanochemical waves in focal adhesions during cell migration
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    3D-bioprinted liver cancer models derived from primary hepatocytes for simulating cancer initiation and drug screening
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  198. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes
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