2,847 Matching Annotations
  1. May 2022
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
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    Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
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    KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4
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    Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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    Redox profiles of Amyotrophic Lateral Sclerosis lymphoblasts with or without known SOD1 mutations
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    Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration
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    CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte
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  12. Apr 2022
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    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
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    Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice
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    GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease
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    Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine
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  38. Mar 2022
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    Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development
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    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors
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    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer
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    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
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    Canonical thyroid hormone receptor β action stimulates hepatocyte proliferation in male mice
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    A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
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    Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
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    Generation of a MSX1 knockout human embryonic stem cell line using CRISPR/Cas9 technology
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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  71. Feb 2022
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    Systematic illumination of druggable genes in cancer genomes
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    HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: Strategy to combat COVID-19
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    Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
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    Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors
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    Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins
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    Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy
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    Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway regulates intestinal mucosal barrier in Crohn's disease
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    Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells
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    Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex
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    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
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    Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
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  84. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
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    Identification of a dihydropyridine scaffold that blocks ryanodine receptors
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    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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    Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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