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Sumoylation profiles and mitochondrial dynamics in in vivo and in vitro models of Parkinson’s disease

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Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death

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Resolving the subcellular redox landscape of Coenzyme Q

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Intermembrane coupling between Bcl-xL and the IP3 receptor supports local Ca2+ transfer at ER-mitochondrial contacts

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Enhanced dopamine transporter binding is associated with species-specific 2C-B-induced reinforcement in marmosets, but not in mice

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An antibody-PROTAC conjugate targets BRD4/c-Myc/PD-L1 to enhance immunotherapy efficacy in triple-negative breast cancer

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Seipin modulates Alzheimer’s disease pathogenesis by regulating ferroptosis through a glycine-mediated metabolic pathway

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Microbial metabolite hyodeoxycholic acid induces macrophage immunometabolic reprogramming and alleviates ulcerative colitis

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GBP6 maintains mitochondrial bioenergetics to promote immune evasion from NK cells in cervical cancer

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Asprosin expression and its role in regulating proliferation, cell cycle, and apoptosis in mouse hippocampal HT-22 cells

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The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate

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Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation

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A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

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The requirement of MALT1 activity for the growth of adult T cell leukemia/lymphoma

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Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study

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Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis

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  DOI: 10.1126/sciadv.adz8681
  
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Temporal control of macrophage pro-inflammatory phenotype by a biphasic HIF-1α regulatory program

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ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment

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Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis

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Bcl11a orchestrates multilineage integrity in aging hematopoiesis by regulating multipotent progenitor fate decisions

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A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns

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Skipjack tuna bone-derived biocalcium ameliorates osteoblast and osteoclast differentiation through microRNA21 regulation

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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance

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Localized mRNAs and protein synthesis in cortical layer 1

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TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration

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Targeted antibody-drug conjugates for rhabdomyosarcoma and other FGFR4-expressing cancers

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TMEM97 regulates cholesterol biosynthesis and mitochondrial metabolism in gastric carcinoma

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TRF2 enriched cytoplasmic chromatin drives cGAS-STAT1-mediated inflammation in senescence

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Regulation of protein abundance in neurons by selective translation of 3′UTR isoforms

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  DOI: 10.64898/2026.07.08.737200
  
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TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancer

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LAMA5 links extracellular matrix organization to a candidate WNT-associated endothelial signaling niche during human chondrogenesis

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Engineering T Cells with a Tumor-Reactive Chimeric T Cell Receptor Reduces Exhaustion and Promotes Persistence to Elicit Enhanced Antitumor Responses

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  DOI: 10.1158/0008-5472.CAN-25-0777
  
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aacrjournals.org/cancerres/article/86/11/2688/785304/Engineering-T-Cells-with-a-Tumor-Reactive-Chimeric
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Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T Cell Expansion in Hepatocellular Carcinoma

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  DOI: 10.1158/0008-5472.CAN-25-0346
  
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aacrjournals.org/cancerres/article/86/8/1939/782621/Intratumoral-Lactobacillus-johnsonii-Enhances
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HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma

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  DOI: 10.1158/0008-5472.CAN-24-3989
  
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aacrjournals.org/cancerres/article/85/20/3875/766093/HPV-E5-Mediates-Resistance-to-Chemotherapy-and
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Combining PD-L1 blockade with a second-generation HSP110 inhibitor enhances antitumor immunity in colorectal cancer

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TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake

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PRDM16 modulates aspects of cell cycle dynamics and maturation in human iPSC-derived cardiomyocytes

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HDAC-driven autophagy repression aids macrophage immune evasion by K. pneumoniae strains displaying classical, MDR, and hypervirulent phenotypes

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PUMILIO proteins maintain lineage balance via post-transcriptional repression of germline fate and promotion of somatic differentiation

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Kir2.1 channels drive macrophage migration through enhancing store-operated Ca2+ entry. | American Journal of Physiology-Cell Physiology | American Physiological Society

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Exploring the molecular cargos associated with extracellular vesicles extracted from bone tissue to identify novel players in osteoblast function

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Exploring the molecular cargos associated with extracellular vesicles extracted from bone tissue to identify novel players in osteoblast function | American Journal of Physiology-Cell Physiology | American Physiological Society

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A druggable ATP13A3–antizyme switch controls adaptive polyamine uptake in cancer

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Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C–mutant non-small cell lung cancer

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Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin

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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience

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Supra-additive neuroprotective effects of berberine–metformin combination in diabetic encephalopathy: Chou–Talalay synergy quantification, AMPK–Nrf2 axis modulation, and pharmacokinetic verification

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RelB drives integrin-mediated stress tolerance and relapse in high-grade serous ovarian cancer

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An IGF2BP3-dependent metabolic circuit governs macrophage recruitment and immunosuppression in glioblastoma

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Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis

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Neural stem cells as potential mediators of prenatal dietary stress through epigenetic mechanisms

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Chronic glucocorticoid exposure disrupts lactate homeostasis and hippocampal neurogenesis by reducing cerebrovascular monocarboxylate transporter 1, leading to behavioral abnormalities in mice

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Epigenetic activation of NK-cell effector programs and caspase-8-dependent apoptosis mediates the antitumor activity of LGP in NSCLC

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TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging

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Otopetrin 1 protects against adipose tissue wasting during cancer cachexia progression

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Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome

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Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs

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BPS Publications

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koe-et-al-2026-n-linked-glycosylation-regulates-snat2-trafficking-and-stability-in-pancreatic-ductal-adenocarcinoma-html.html

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Thyroid Hormone Receptor Beta Suppresses Cancer Cell Activity by Differential Regulation of Glycogen Metabolism

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Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Non-Hormonal Endometriosis Therapy

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Aberrant histone methylation profile in patients with sporadic primary hyperparathyroidism

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Keratinocytes and PDGF-B/PDGFRβ signaling modulate peripheral opioid tolerance

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Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

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PBK as a potential biomarker and therapeutic target for metastatic pheochromocytomas and paragangliomas

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Identification of FXYD5 as an oncogene in pediatric papillary thyroid cancer

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IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC

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Elevated mitochondrial Ca2+ impairs satellite cell pool expansion in response to skeletal muscle injury

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Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation

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The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair

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Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA

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A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapy

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Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke

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Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor

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Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity

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UBE2B Drives NF-κB Signaling and Gastric Cancer Progression through BIRC2-Mediated K63-Linked Ubiquitination of TRAF1

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Ibrutinib and PD-1 blockade potentiate mesothelin-targeting CAR-T cell therapy in preclinical models of pancreatic cancer

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Administration of Pgk1 missense mutation leads to more effective mitigation of neurodegenerative effects observed in ALS mice and transgenic zebrafish

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HMGA2 regulates fear and growth: Canine GWAS and functional evidence

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The novel immunocompetent Eµ-SOX11CCND1 mouse model phenotypically and molecularly resembles human mantle cell lymphoma

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A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability

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Lactylation Converts ABHD6 into a Mitochondrial Regulator That Drives Lenvatinib Resistance in Hepatocellular Carcinoma

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Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity

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Hypoxia-activated PROTAC for dual inhibition of FAK and EGFR enables synergistic mechano-chemical cancer therapy

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FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity

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Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation

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A Wireless 3D Magneto-Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

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Metformin dual-targets metabolism and survival pathways in BPDCN

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RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

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SNF1/AMPK controls its own localization by phosphorylating its activating kinase Sak1

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Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling

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Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

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Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans

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Mycobacterium tuberculosis subverts macrophage-mediated defense through exploitation of the Zn transporter ZIP8

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Collective cell migration plasticity in patient-derived digestive cancer organoids is dictated by environment sensing and contractility

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The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction

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RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages

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Uric acid promotes dietary lipid absorption through microbiome and metabolomic remodeling via a liver-gut endocrine axis

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Targeting arginine metabolism overcomes chemotherapy resistance in aggressive-variant prostate cancers

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IL-4/IL-13 signaling suppresses ABT-263-induced apoptosis in senescent human fibroblasts

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Importin-β1 functions as a chromatin sensor to position the contractile ring for cytokinesis

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An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma

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Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids

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FusionTarget: Computational framework for drug repurposing against modeled fusion protein structures from genomic breakpoints

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FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions

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BPS Publications

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FEBS Press

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A Zinc Finger Protein-Based Prognostic Model in Lung Adenocarcinoma Identifies FGD3 as a Marker Associated with Lorlatinib Resistance

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Bmal1 regulates thermogenic function by modulation of lipolytic and OXPHOS gene expression in male mice brown adipocytes

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Triptolide enhances anti-cancer activities of irinotecan in human colon cancer HT-29 cells in vitro and HT-29 cell xenograft tumor model in nude mice

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Placental Pathology and HTRA4-Mediated Autophagic Flux Disruption in Selective Fetal Growth Restriction Types I and III: A Morphological and Transcriptomic Study

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YY1 Binding Motif at Upstream of Rep/Cap Increases AAV Yield and Full Capsids

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MicroRNA-200s attenuate demyelination caused by Angiostrongylus cantonensis in a mouse model by targeting phosphatase and tensin homolog

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Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging

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Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma

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Lipid Nanoparticle-Delivered Circ_0017866 Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing Endothelial-Mesenchymal Transition via the miR-124-3p/CLDND1 Axis

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Delivery of ATSP-7041 by Minimally Invasive Nasal Depot (MIND) to Target Diffuse Intrinsic Pontine Glioma

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Genomic Subtype Influences BH3 Mimetic Drug Sensitivity and Synergy with Cytotoxic Chemotherapeutics in T-cell Acute Lymphoblastic Leukemia

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CTSZ-dependent anoikis resistance enhances malignant characters of glioblastoma via NF-κB signaling

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Mitochondrial dysfunction activates ADAMTS-5 expression via mt-dsRNA-PKR-Spi-1 axis in osteoarthritic chondrocytes

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ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling

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TLR4-paxillin-Rac1 signaling mediates LPS-induced dysregulation of keratinocyte function

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NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition

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The impact of cannabidiol (CBD) in hyperglycemic zebrafish (Danio rerio)

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Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

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Identification of the regulatory elements and protein substrates of lysine acetoacetylation

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Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential

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Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia

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The key regulator circ_0003295 promotes arsenic-induced lung carcinogenesis and progression by enhancing mitochondrial function

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Galvanin (TMEM154) is an electric-field sensor for directed cell migration

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Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids

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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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Proximity labeling proteomics maps radial glial ciliary proteins across the developing telencephalon

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A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma

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Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

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Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer

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Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP/NLRP3 after intracerebral hemorrhage

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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion

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A ZNF-nanobody fusion reveals SUMOylation-dependent changes in p53 protein localization

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Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia

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CLDN6 Expression Plasticity in Ovarian Cancer: Insights into Therapeutic Optimization for CLDN6-Targeted Immunotherapy

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ZSTK3744, a novel aryl hydrocarbon receptor agonist, exhibits efficacy against chemotherapy-resistant triple-negative breast cancer

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mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures

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Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR

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Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity

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NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis

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The long isoform of ZAP coordinates multiple enzymes to mediate complete decay of target transcripts

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A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatid Angomonas deanei

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LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation

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QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp–overexpressing cancer models

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Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control

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SFPQ prevents MDA5-mediated activation of innate immunity and preserves cell viability

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Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer

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AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models

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Tuning the sensitivity of mechanosensory receptors through histidine scanning

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Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis

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Protocol to identify covalent inhibitors targeting RhoA Cys16

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ISGylation is disrupted by UBA7 gene variants identified in individuals with neurodevelopmental disorder phenotypes

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1-s2.0-S2589004226011764-main-html.html

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Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis

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Generalizable, high-throughput image analysis of subcellular structures using dispersion indices

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B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

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Sex-Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu-erh Tea

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ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing

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2026.03.16.711738.full-html.html

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Preclinical Combination Targeting VEGF and PI3K in a Rare, Aggressive Mixed Endometrial Carcinoma: An Applied Case Report

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Optineurin modulates mTORC2/AKT/STAT3 signaling to control MHC class II expression and adaptive immunity against HSV-1

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Tolerance to extracellular acidic pH facilitates tumor plasticity

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Chemotherapy-Induced Oral Mucosal Injury Is Defined by p53 Activation, Cell Cycle Arrest and Diverse Epithelial Progenitor Dynamics

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Faecalibacterium prausnitzii, depleted in the Parkinson’s disease microbiome, improves motor deficits in α-synuclein overexpressing mice

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PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy

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SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma

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SNAT1 (SLC38A1) Is Not the Main Glutamine Transporter in Melanoma, but Controls Metabolism via Glutamine-Dependent Activation of P62 (SQSTM1)/cMYC-Axis

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Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner

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Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

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A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer

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1-s2.0-S2589004226010862-main-html.html

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A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs

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Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes

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Macrophage-Targeted Nanocarriers Based on Tetrahedral DNA Nanostructure Alleviate Sepsis-Induced Acute Lung Injury by Triple-Pathway Suppression of Pyroptosis

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The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity

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Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neurons

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Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF

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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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1-s2.0-S2589004226009247-main-html.html

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Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome

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The AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations

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Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression

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Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation

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Postnatal plasticity in the paralaminar nucleus of the pallial amygdala in juvenile swine brain

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Directed evolution of APOX for proximity labeling using phenols with high redox potentials

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Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics

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