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Jan 2020
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  DOI: 10.7554/eLife.43333
  
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TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency

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Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion

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sciencedirect.com/science/article/pii/S2211124719303390
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FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development

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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

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CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

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sciencedirect.com/science/article/pii/S2211124719305017
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  DOI: 10.7554/eLife.40396
  
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METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

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sciencedirect.com/science/article/pii/S1097276519302692
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The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

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Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State

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Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

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sciencedirect.com/science/article/pii/S1097276519301443
Nov 2018
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Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing

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Molecular Interface of Neuronal Innate Immunity, Synaptic Vesicle Stabilization, and Presynaptic Homeostatic Plasticity

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Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

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The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death

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Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response

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Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

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MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

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A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression

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ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer

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The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

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LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling

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A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication

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A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission

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A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation

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Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase

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Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase

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Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination

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Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila

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Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency

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SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

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Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

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An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

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Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death

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Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109

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NonA and CPX Link the Circadian Clockwork to Locomotor Activity in Drosophila

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BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor

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Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex

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Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

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SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

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HDAC3-selective inhibition activates brown and beige fat through PRDM16

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Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

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Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

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Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain

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Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

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Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency

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The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

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USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels

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Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis

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Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses

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Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

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Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis

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A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells

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EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

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ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals

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Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

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A Metabolic Basis for Endothelial-to-Mesenchymal Transition

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Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages

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Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase

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The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

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Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer

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Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression

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Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

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Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation

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A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans

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Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

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Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

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GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion

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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms

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The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity

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KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

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Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

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A compartmentalized signaling network mediates crossover control in meiosis

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Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation

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ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

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Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

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Dissection of affinity captured LINE-1 macromolecular complexes

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Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

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SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

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Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms

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NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

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FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells

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Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

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DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

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Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition

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A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination

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ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition

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Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

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Untitled document

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A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

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“Epigenetic control of early neurodegenerative events in Diabetic Retinopathy by the histone deacetylase SIRT6”

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Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER

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Untitled document

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A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

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Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery

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Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice

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Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress

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The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding

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The Glycolytic Pyruvate Kinase Is Recruited Directly into the Viral Replicase Complex to Generate ATP for RNA Synthesis

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A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

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Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis

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11β-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation

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An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.

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NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

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Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer

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Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation

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Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

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Life-Long Neurogenic Activity of Individual Neural Stem Cells and Continuous Growth Establish an Outside-In Architecture in the Teleost Pallium

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Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion

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Ribosome Collision Is Critical for Quality Control during No-Go Decay

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation

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Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration

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A Split-Abl Kinase for Direct Activation in Cells

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Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation

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SAGA Is a General Cofactor for RNA Polymerase II Transcription

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Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication

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The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

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Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase

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Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

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In Situ Capture of Chromatin Interactions by Biotinylated dCas9

1
1. scibot 08 Nov 2017
  
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  RRID:AB_262044
  
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Characterisation of a stably integrated expression system for exogenous protein expression in DT40

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1. scibot 08 Nov 2017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5482329/
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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport

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Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @Jmenke
  
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

1
1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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Xenopus laevis M18BP1 Directly Binds Existing CENP-A Nucleosomes to Promote Centromeric Chromatin Assembly

1
1. scibot 08 Nov 2017
  
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A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
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elifesciences.org elifesciences.org

Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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elifesciences.org/articles/24998
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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
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Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

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1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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Opening a New Time Window for Treatment of Stroke by Targeting HDAC2

1
1. scibot 08 Nov 2017
  
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  Curator: @Zeljana_Babic
  
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jneurosci.org/content/37/28/6712
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Untitled document

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1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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jneurosci.org/content/37/27/6575
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Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

1
1. scibot 08 Nov 2017
  
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  Mouse anti-FLAG
  
  Curator: @chewbeccax
  
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Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase)

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jneurosci.org/content/37/10/2709
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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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elifesciences.org/articles/25237
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Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1931312817302457
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MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

1
1. scibot 08 Nov 2017
  
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  AB_262044
  
  Curator: @chewbeccax
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5462538/

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