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PKN2 is a dependency of the mesenchymal-like cancer cell state

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Conversion of natural cytokine receptors into orthogonal synthetic biosensors

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Target RNA recognition drives PIWI∗ complex assembly for transposon silencing

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Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP

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ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation

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Mask protein keeps NF-κB precursor inactive by inducing a closed conformation and isolating it in biomolecular condensates

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FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

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  DOI: 10.1002/advs.202503082
  
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A Commander-independent function of COMMD3 in endosomal trafficking

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  DOI: 10.7554/eLife.105264
  
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2025.08.28.672006v1.full-html.html

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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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Aug 2025
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Uncovering phenotypic inheritance from single cells with Microcolony-seq

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  DOI: 10.1016/j.cell.2025.08.001
  
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cell.com/cell/fulltext/S0092-8674(25)00915-8
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Electrochemical coupling at the plasma membrane by mouse voltage-sensitive phosphatase requires association with basigin

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1-s2.0-S2589004225016967-main-html.html

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Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation

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lanz-et-al-hdac6-dependent-deacetylation-of-sae2-enhances-sumo1-conjugation-for-mitotic-integrity-html.html

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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

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1-s2.0-S2589004225016529-main-html.html

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The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth

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DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps

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  DOI: 10.1016/j.ccell.2025.07.014
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00320-4
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Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks

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Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation

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RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart

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  DOI: 10.1038/s44319-025-00497-3
  
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Interaction between W41 of the hepatitis B virus preS1 surface peptide and Y146/F274 of the cellular receptor molecule NTCP is essential for virus entry

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NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy

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  DOI: 10.1016/j.devcel.2019.03.013
  
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NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants

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Microglia mediated by LAG3 regulate astrocyte morphogenesis in the brain white matter

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Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor–associated bullous pemphigoid

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  DOI: 10.1126/sciadv.adv9423
  
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Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor–associated bullous pemphigoid

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  DOI: 10.1126/sciadv.adv9423
  
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2025.07.28.667286v1.full-html.html

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Structural basis of pseudoGTPase-mediated protein-protein interactions

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ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

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  DOI: 10.1002/advs.202509477
  
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Jul 2025
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Temperature-responsive N4-acetylcytidine mRNA modification controls thermosensory flowering in Arabidopsis

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bilinovich-et-al-2025-methyl-cpg-binding-domain-as-a-protein-interaction-partner-in-promoter-regulation-and-html.html

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  DOI: 10.6084/m9.figshare.29361725.v1
  
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52.53.155.43/71efcdc483a88b8314a69385c8ba7fc2816578e0/bilinovich-et-al-2025-methyl-cpg-binding-domain-as-a-protein-interaction-partner-in-promoter-regulation-and-html.html
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Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis

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The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

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Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

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CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors

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β-catenin functions as a molecular adapter for disordered cBAF interactions

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CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

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Mechanism of cotranslational protein N-myristoylation in human cells

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Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid

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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC

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Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness

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Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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BPS Publications

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JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24

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In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque

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OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression

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A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses

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A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics

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Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer

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TAS-seq enables subcellular single-stranded adenosine profiling by signal peptide-assisted adenosine deamination

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EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC

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PDF-html.html

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Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences

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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

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The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

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SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes

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Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation

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Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease

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CRAMP1 drives linker histone expression to enable Polycomb repression

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The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible

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A Commander-independent function of COMMD3 in endosomal trafficking

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A novel loss-of-function variant in STAT1 causes Mendelian susceptibility to mycobacterial disease

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Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

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GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake

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Methionine-triggered growth arrest reveals activation of Gcn2 by methionine transporter endocytosis

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Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling

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Synaptic activity causes minute-scale changes in BAF complex composition and function

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Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51

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Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

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Rifampin mediated decapsulation and enhanced bacterial clearance: a new mechanism of rifamycins

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PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity

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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

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A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment

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GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration

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β-synuclein blocks α-synuclein condensate fusion to disrupt the maturation of phase separation

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Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes

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A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment

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CapdevilaCastillo_columbia_0054D_18600-html.html

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ATP-release pannexin channels are gated by lysophospholipids

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SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

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Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

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Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis

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A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation

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Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle

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eIF5A controls mitoprotein import by relieving ribosome stalling at TIM50 translocase mRNA

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Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

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ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression

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Engineering ARMMs for improved intracellular delivery of CRISPR-Cas9

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DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation

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Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

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OsHYPK/NatA-mediated N-terminal acetylation regulates the homeostasis of NLR immune protein to fine-tune rice immune responses and growth

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Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation

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NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis

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Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

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EFA6A, a Guanine Nucleotide Exchange Factor for Arf6, Regulates Developmental Stage-Dependent Spine Morphogenesis, Synaptic Plasticity, and Long-Term Memory in the Hippocampus

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1-s2.0-S2589004225008983-main-html.html

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Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing

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Dynamic control of H2A.Zub and H3K27me3 by ambient temperature during cell fate determination in Arabidopsis

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Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction

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The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome

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MIA40 suppresses cell death induced by apoptosis-inducing factor 1

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Distinct roles of spindle checkpoint proteins in meiosis

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ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

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ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

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Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement

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Proton perception and activation of a proton-sensing GPCR

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DUX-mediated configuration of p300/CBP drives minor zygotic genome activation independent of its catalytic activity

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Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue

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A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

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RAF1 kinase contributes to autophagic lysosome reformation

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The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis

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Identification of the core regulatory program driving NEUROD1-induced neuronal reprogramming

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Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription

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Complementary Ribo-seq approaches map the translatome and provide a small protein census in the foodborne pathogen Campylobacter jejuni

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The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibition

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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity

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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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The HAVCR1-centric host factor network drives Zika virus vertical transmission

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An in vivo screen identifies NAT10 as a master regulator of brain metastasis

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ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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Binding domain mutations provide insight into CTCF’s relationship with chromatin and its contribution to gene regulation

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Small-molecule RNA therapeutics to target prostate cancer

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Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs

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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

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Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1

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Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity

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A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

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Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

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PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD

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The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti-Tumor Effector Cytotoxic T Cells

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Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy

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Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality

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Florigen-producing cells express FPF1-LIKE PROTEIN 1 to accelerate flowering and stem growth in Arabidopsis

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TFEB/3 govern repair Schwann cell generation and function following peripheral nerve injury

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RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis

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Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations

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A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin

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Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation

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The deubiquitylating enzyme Fat facets promotes Fat signalling and restricts tissue growth

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KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC

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Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators

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E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages

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Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor

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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

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HnRNPAB promotes pancreatic ductal adenocarcinoma extravasation and liver metastasis by stablizing MYC mRNA

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KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31

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Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma

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Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development

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Heterotypic interactions among members of the death domain superfamily with implications for p75NTR-mediated co-signaling

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Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

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Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety

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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

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RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori

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Structures and mRNP remodeling mechanism of the TREX-2 complex

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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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Ligand interaction landscape of transcription factors and essential enzymes in E. coli

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An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer

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Dynamic molecular architecture of the synaptonemal complex

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  DOI: 10.1126/sciadv.adq9374
  
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A Commander-independent function of COMMD3 in endosomal trafficking

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  DOI: 10.1101/2024.12.12.628173
  
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A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia

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  DOI: 10.1016/j.cell.2024.12.024
  
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NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism

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  DOI: 10.1186/s10020-024-01062-9
  
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RBBP6 anchors pre-mRNA 3′ end processing to nuclear speckles for efficient gene expression

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  DOI: 10.1016/j.molcel.2024.12.016
  
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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

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  DOI: 10.1016/j.celrep.2024.115205
  
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C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity

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A conserved acetylation switch enables pharmacological control of tubby-like protein stability

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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

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CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability

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Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

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Protocol for in vitro observation of HDAC4 condensation during induced cardiac reprogramming

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Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation

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Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4

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A famsin-glucagon axis mediates glucose homeostasis

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HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis

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A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

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  DOI: 10.1016/j.celrep.2024.115143
  
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IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth

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The human zinc-binding cysteine proteome

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  DOI: 10.1016/j.cell.2024.11.025
  
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Formyl-methionine-mediated eukaryotic ribosome quality control pathway for cold adaptation

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cell.com/molecular-cell/abstract/S1097-2765(24)00990-0
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Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

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pmc.ncbi.nlm.nih.gov/articles/PMC11567002/

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