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Feb 2023
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Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells

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1. scibot 23 Feb 2023
  
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  DOI: 10.1002/advs.202207499
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202207499
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PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma

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1. scibot 17 Feb 2023
  
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  DOI: 10.1158/0008-5472.CAN-21-4313
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9388591/
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Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer

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1. scibot 17 Feb 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-2245
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9929516/
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Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

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1. scibot 16 Feb 2023
  
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  DOI: 10.1016/j.immuni.2023.01.026
  
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sciencedirect.com/science/article/pii/S1074761323000389
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Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

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1. scibot 15 Feb 2023
  
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  DOI: 10.1371/journal.pbio.3001967
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
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CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer

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1. scibot 15 Feb 2023
  
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  DOI: 10.1016/j.xpro.2023.102097
  
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sciencedirect.com/science/article/pii/S2666166723000552
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ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions

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1. scibot 11 Feb 2023
  
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  DOI: 10.1038/s12276-023-00945-x
  
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nature.com/articles/s12276-023-00945-x
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A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

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1. scibot 11 Feb 2023
  
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  DOI: 10.1371/journal.ppat.1011101
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9907829/
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PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells

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1. scibot 10 Feb 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-2370
  
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2. scibot 10 Feb 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/0008-5472.CAN-22-2370
  
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aacrjournals.org/cancerres/article/83/3/398/716188/PINK1-Mediated-Mitophagy-Promotes-Oxidative
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Monitoring cell fate in 3D organotypic human squamous epithelial cultures

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1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.xpro.2023.102101
  
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sciencedirect.com/science/article/pii/S266616672300059X
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Piperlongumine conjugates induce targeted protein degradation

1
1. scibot 09 Feb 2023
  
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  plasmid_12259
  
  DOI: 10.1016/j.chembiol.2023.01.004
  
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sciencedirect.com/science/article/pii/S2451945623000272
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Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

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1. scibot 09 Feb 2023
  
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  DOI: 10.1158/2159-8290.CD-21-1672
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
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CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

1
1. scibot 08 Feb 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2023.112076
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
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Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

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1. scibot 03 Feb 2023
  
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  plasmid_12259
  
  DOI: 10.1016/j.molcel.2023.01.015
  
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sciencedirect.com/science/article/pii/S1097276523000382
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A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands

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1. scibot 01 Feb 2023
  
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  DOI: 10.1016/j.crmeth.2023.100394
  
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sciencedirect.com/science/article/pii/S2667237523000012
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Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity

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1. scibot 01 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.105962
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
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The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

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1. scibot 01 Feb 2023
  
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  DOI: 10.1007/s00395-023-00978-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9879848/
Jan 2023
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation

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1. scibot 28 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111897
  
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sciencedirect.com/science/article/pii/S221112472201796X
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Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

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1. scibot 28 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1371/journal.ppat.1011080
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9876383/
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Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins

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1. scibot 26 Jan 2023
  
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  DOI: 10.3390/v15020262
  
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mdpi.com/1999-4915/15/2/262
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CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression

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1. scibot 25 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.3390/antiox12010014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9854525/
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Attenuating iPSC reprogramming stress with dominant-negative BET peptides

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1. scibot 25 Jan 2023
  
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  DOI: 10.1016/j.isci.2022.105889
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9860338/
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Optimized protocols for chromatin immunoprecipitation of exogenously expressed epitope-tagged proteins

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1. scibot 24 Jan 2023
  
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  Plasmid_12259
  
  DOI: 10.1016/j.xpro.2023.102050
  
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sciencedirect.com/science/article/pii/S2666166723000084
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Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling

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1. scibot 24 Jan 2023
  
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  plasmid_12259
  
  DOI: 10.1016/j.celrep.2023.112031
  
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sciencedirect.com/science/article/pii/S2211124723000426
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TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

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1. scibot 21 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112012
  
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sciencedirect.com/science/article/pii/S2211124723000232
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Protocol to study presynaptic protein synthesis in ex vivo mouse hippocampal slices using HaloTag technology

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1. scibot 21 Jan 2023
  
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  DOI: 10.1016/j.xpro.2022.101986
  
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sciencedirect.com/science/article/pii/S2666166722008668
www.biorxiv.org www.biorxiv.org

Actin nucleators safeguard replication forks by limiting nascent strand degradation

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1. scibot 20 Jan 2023
  
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  DOI: 10.1101/2023.01.12.523639
  
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biorxiv.org/content/10.1101/2023.01.12.523639v1
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Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.stem.2022.12.010
  
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sciencedirect.com/science/article/pii/S1934590922004945
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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

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1. scibot 19 Jan 2023
  
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  Plasmid_12259
  
  DOI: 10.1016/j.cell.2022.12.025
  
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sciencedirect.com/science/article/pii/S0092867422015380
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Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.cell.2022.12.043
  
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sciencedirect.com/science/article/pii/S0092867422015860
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

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1. scibot 18 Jan 2023
  
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  plasmid_12259
  
  DOI: 10.1038/s41467-022-35757-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9839780/
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Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

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1. scibot 15 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-22-0427
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9827116/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

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1. scibot 15 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-22-0489
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9827110/
journals.lww.com journals.lww.com

Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research

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1. scibot 14 Jan 2023
  
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  DOI: 10.4103/1673-5374.361516
  
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journals.lww.com/nrronline/Fulltext/2023/07000/Oncogenic_BRAFV600E_induces_microglial.38.aspx
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Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles

1
1. scibot 14 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1111/tra.12876
  
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onlinelibrary.wiley.com/doi/10.1111/tra.12876
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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

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1. scibot 14 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1007/s00125-022-05856-6
  
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link.springer.com/article/10.1007/s00125-022-05856-6
rupress.org rupress.org

Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion

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1. scibot 12 Jan 2023
  
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  plasmid_12259
  
  DOI: 10.1083/jcb.202204100
  
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rupress.org/jcb/article/222/2/e202204100/213712/Fibroblasts-secrete-fibronectin-under-lamellipodia
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DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling

1
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111986
  
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A whole genome CRISPR screen identifies AHR loss as a mechanism of PARP7 inhibitor resistancePARP7 inhibitor CRISPR screen

1
1. scibot 12 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/1535-7163.MCT-21-0841
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9769698/
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Nonstructural protein 1 widespread RNA decay phenotype varies among coronaviruses

1
1. scibot 11 Jan 2023
  
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  Plasmid #12259 (Addgene)
  
  DOI: 10.1016/j.isci.2022.105887
  
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Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells

1
1. scibot 11 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.xpro.2022.101992
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9826815/
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Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin

1
1. scibot 11 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.cell.2022.12.016
  
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Resurrection of endogenous retroviruses during aging reinforces senescence

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1. scibot 07 Jan 2023
  
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  plasmid_12259
  
  DOI: 10.1016/j.cell.2022.12.017
  
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MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

1
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  Addgene_12259
  
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Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis

1
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  DOI: 10.1016/j.joca.2022.12.010
  
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METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

1
1. scibot 06 Jan 2023
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.stem.2022.12.006
  
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Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

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  RRID:Addgene_12259
  
  DOI: 10.1016/j.ccell.2022.12.003
  
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cell.com/cancer-cell/fulltext/S1535-6108(22)00589-X
Dec 2022
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Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection

1
1. scibot 31 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1128/mbio.02446-22
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9765453/
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IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis

1
1. scibot 31 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/2767-9764.crc-22-0262
  
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Virus-like particle – mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection

1
1. scibot 30 Dec 2022
  
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  plasmid_12259
  
  DOI: 10.3389/fcimb.2022.1079926
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9795031/
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The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities

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1. scibot 29 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1007/s12035-022-03153-2
  
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link.springer.com/article/10.1007/s12035-022-03153-2
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IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis

1
1. scibot 24 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/2767-9764.CRC-22-0262
  
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aacrjournals.org/cancerrescommun/article/2/12/1545/711358/IL1-Expression-Driven-by-Androgen-Receptor-Absence
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Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing

1
1. scibot 24 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/0008-5472.CAN-21-2519
  
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aacrjournals.org/cancerres/article/82/17/3002/708290/Efficient-Correction-of-Oncogenic-KRAS-and-TP53
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IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury

1
1. scibot 24 Dec 2022
  
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  Addgene_12259
  
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sciencedirect.com/science/article/pii/S2211124722017405
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ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

1
1. scibot 20 Dec 2022
  
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  Addgene_12259
  
  DOI: 10.1016/j.devcel.2022.11.015
  
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AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer

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1. scibot 20 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1007/s00018-022-04638-y
  
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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

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1. scibot 18 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111819
  
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Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection

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1. scibot 18 Dec 2022
  
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  Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111817
  
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Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines

2
1. scibot 17 Dec 2022
  
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  plasmid_12259
  
  DOI: 10.1007/978-1-0716-2639-9_22
  
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  RRID:Addgene_12
  
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Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System

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1. scibot 17 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1007/978-1-0716-2639-9_23
  
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link.springer.com/protocol/10.1007/978-1-0716-2639-9_23
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Engineered cell entry links receptor biology with single-cell genomics

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.cell.2022.11.016
  
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A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

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1. scibot 11 Dec 2022
  
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  DOI: 10.1016/j.cell.2022.11.005
  
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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

2
1. scibot 08 Dec 2022
  
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  12259
  
  DOI: 10.1016/j.celrep.2022.111653
  
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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

1
1. scibot 08 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.molcel.2022.11.010
  
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sciencedirect.com/science/article/pii/S1097276522010991
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Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma

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1. scibot 03 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/2159-8290.CD-22-0287
  
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aacrjournals.org/cancerdiscovery/article/12/12/2800/711177/Serial-Profiling-of-Circulating-Tumor-DNA
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IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

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1. scibot 02 Dec 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.15252/emmm.202115631
  
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embopress.org/doi/10.15252/emmm.202115631
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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

1
1. scibot 01 Dec 2022
  
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  Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111727
  
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sciencedirect.com/science/article/pii/S2211124722016059
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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis

1
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  Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111728
  
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sciencedirect.com/science/article/pii/S2211124722016060
Nov 2022
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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins

1
1. scibot 24 Nov 2022
  
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  Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111675
  
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sciencedirect.com/science/article/pii/S2211124722015492
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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

1
1. scibot 24 Nov 2022
  
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  Addgene_12259
  
  DOI: 10.1016/j.celrep.2022.111678
  
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sciencedirect.com/science/article/pii/S2211124722015522
52.53.155.43 52.53.155.43

Nuclear envelope protein LBR protects the genome from chromosomal instability and tumorigenesis

1
1. scibot 22 Nov 2022
  
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  plasmid_12259
  
  DOI: 10.1093/hmg/ddac235
  
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52.53.155.43/cc79e40c92dade70c5729b9199717becabfd0bfe/ddac235-html.html
aacrjournals.org aacrjournals.org

p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness

1
1. scibot 22 Nov 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/1078-0432.CCR-22-1357
  
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aacrjournals.org/clincancerres/article/28/21/4757/709842/p53-Inhibits-Bmi-1-driven-Self-Renewal-and-Defines
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GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry

1
1. scibot 19 Nov 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.isci.2022.105481
  
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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation

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The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool

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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci

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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

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MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation

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Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway

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The phenotypic landscape of essential human genes

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Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice

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Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

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Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent in situ hybridization and a dual reporter system

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Multiphase coalescence mediates Hippo pathway activation

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Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector

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Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964

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HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

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HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev

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Oct 2022
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ccr-22-1357-html.html

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Lentiviral vector mediated gene therapy for type I Dent disease effectively ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice

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Imaging Inflammasome Activation in Microglia

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m6A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress

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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments

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Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection

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The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies

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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

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Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis

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CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

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Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector

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HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

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POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

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Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

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The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

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Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

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Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfments

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Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

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Opto-katanin, an optogenetic tool for localized, microtubule disassembly

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A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity

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Determining glioma cell invasion and proliferation in ex vivo organotypic mouse brain slices using whole-mount immunostaining and tissue clearing

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TGFBR3 supports anoikis through suppressing ATF4 signaling

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GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer

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Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization

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Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation

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Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin

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CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation

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Scalable CRISPR-Cas9 chemical genetic screens in non-transformed human cells

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SerpinB3 drives cancer stem cell survival in glioblastoma

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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

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Human coronaviruses disassemble processing bodies

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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy

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Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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can-21-2908-html.html

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Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions

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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

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Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains

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Identifying cell receptors for the nanoparticle protein corona using genome screens

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Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine

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Spatial multi-omic map of human myocardial infarction

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CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer

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Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype

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Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity

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METTL14-dependent m6A modification controls iNKT cell development and function

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Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope

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A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus

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EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity

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FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations

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Protocol for genome-wide CRISPR knockout screens of bacterial cytotoxins in HeLa cells

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The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors

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HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance

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Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

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Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

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Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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Self-assembly of pericentriolar material in interphase cells lacking centrioles

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BPS Publications

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A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions

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Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery

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http://medrxiv.org/cgi/content/short/2020.12.07.20245167

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Mislocalization of protein kinase A drives pathology in Cushing’s syndrome

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Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer

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Targeting the transcriptional activity of STAT3 by a novel fusion protein

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EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks

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52.53.155.43 52.53.155.43

cd-21-0680-html.html

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mct-21-0841-html.html

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Transcriptional reprogramming differentiates active from inactive ESR1 fusions in endocrine therapy-refractory metastatic breast cancer

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi

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Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma

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Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached

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Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

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Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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Granger-causal inference of the lamellipodial actin regulator hierarchy by live cell imaging without perturbation

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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions

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Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes

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Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

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YAP1 activation is associated with the progression and response to immunotherapy of non-muscle invasive bladder cancer

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A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs

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Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation

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DDX41 is required for cGAS-STING activation against DNA virus infection

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HIV-1 exploits the Fanconi anemia pathway for viral DNA integration

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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

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sciencedirect.com/science/article/pii/S1934590922001709
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Interpretation of cancer mutations using a multi-scale map of protein systems

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1. scibot 25 May 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1126/science.abf3067
  
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c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.isci.2022.104325
  
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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  AddgeneCat. #12259
  
  DOI: 10.1016/j.devcel.2022.04.018
  
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Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

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1. scibot 19 May 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.isci.2022.104349
  
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Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway

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  RRID:Addgene_12259
  
  DOI: 10.1016/j.ebiom.2022.104060
  
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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

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1. scibot 18 May 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.7554/eLife.76541
  
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Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

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1. scibot 14 May 2022
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/1535-7163.MCT-21-0142
  
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MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

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A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

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  DOI: 10.1016/j.cmet.2022.04.009
  
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Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway

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  DOI: 10.1016/j.celrep.2022.110790
  
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sciencedirect.com/science/article/pii/S2211124722005575

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