3,402 Matching Annotations
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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12395558/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PCV2 Infection Upregulates SOCS3 Expression to Facilitate Viral Replication in PK-15 Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390612/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Introducing CAR-T Therapy in Kazakhstan: Establishing Academic-Scale Lentiviral Vector and CAR-T Cell Production
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    pmc.ncbi.nlm.nih.gov/articles/PMC12385160/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12408614/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protein arginine methyltransferase 5 sustains Tip60-EP400 complex via SRSF1 in Merkel cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373721/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407461/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12372299/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Atypical cadherin FAT1 promotes tumorigenesis by suppressing autophagic cell death in glioblastoma under hypoxia or nutrient stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12409952/
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    Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406714/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12404763/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393524/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393442/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During Ligand-Mediated Transcriptional Burst Events
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393356/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting FSP1 triggers ferroptosis in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12363832/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407096/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Maspin/SerpinB5 is a cytoskeleton-binding protein that regulates epithelial cell shape
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373898/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373798/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398332/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear pore complex dysfunction drives TDP-43 pathology in ALS
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390953/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SALSA: a novel flow cytometry assay to detect ascorbate at the single-cell level
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398858/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Syncytial death mediated by oncolytic rVSV-NDV dynamically activates immunogenic apoptosis and necroptosis in human lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390950/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolomics analysis of SNAT2-deficient cells: Implications for the discovery of selective small-molecule inhibitors of an amino acid transporter
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390925/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through in vivo expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410412/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12401778/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer Cell‐Secreted miR‐33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12408367/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407345/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC12376557/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7
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    pmc.ncbi.nlm.nih.gov/articles/PMC12376547/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12400060/
  32. www.biorxiv.org www.biorxiv.org
    Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics
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    biorxiv.org/content/10.1101/2025.08.27.672586v1
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Cas13d-Mediated Targeting of a Context-Specific Essential Gene Enables Selective Elimination of Uveal Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393512/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pooled CRISPR screens identifies key regulators of bovine stem cell expansion for cultured meat
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  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target
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    pmc.ncbi.nlm.nih.gov/articles/PMC12370961/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12392329/
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    Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming
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    sciencedirect.com/science/article/pii/S2211124725009970
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    Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity
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    A Polyomavirus-Positive Merkel Cell Carcinoma Mouse Model Supports a Unified Origin for Somatic and Germ Cell Cancers
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    mdpi.com/2072-6694/17/17/2800
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    Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinoma
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    biorxiv.org/content/10.1101/2025.08.24.671070v1
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    SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124725009106
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    Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems
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    nature.com/articles/s41467-025-63570-4
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    Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets
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    sciencedirect.com/science/article/pii/S2211124725009829
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    K29-Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202509817
  45. Aug 2025
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    Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy
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    sciencedirect.com/science/article/pii/S2666379125003908
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    Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1074761325003358
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    L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma
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    biorxiv.org/content/10.1101/2025.08.22.671773v1
  49. www.biorxiv.org www.biorxiv.org
    DFFB suppresses interferon to enable cancer persister cell regrowth
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    biorxiv.org/content/10.1101/2025.08.15.670603v1
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    Evolution of the SARS-CoV-2 spike protein in utilizing host transmembrane serine proteases
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    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
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    sciencedirect.com/science/article/pii/S2666979X25002356
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    Generation of human embryonic stem cell line expressing dCas9-TET1 fusion protein for epigenetic editing
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    sciencedirect.com/science/article/pii/S1873506125001618
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROS-dependent localization of glycolytic enzymes to mitochondria
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    pmc.ncbi.nlm.nih.gov/articles/PMC12359183/
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    Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202502074
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    ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis
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    sciencedirect.com/science/article/pii/S1534580725004733
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12350263/
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    Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
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    sciencedirect.com/science/article/pii/S0969212625002667
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    Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
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    sciencedirect.com/science/article/pii/S1097276525006148
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glucose transporter 1 is essential to maintain brain endothelial cell homeostasis under hyperglycemia condition | American Journal of Physiology-Cell Physiology | American Physiological Society
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    pmc.ncbi.nlm.nih.gov/articles/PMC12341840/
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    Chemogenetic detection and quantitation of H2O2 in living cells
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    nature.com/articles/s41596-025-01226-9
  62. 52.53.155.43 52.53.155.43
    bneo_neo-2024-000538-main-html.html
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    HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
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    cell.com/cell-metabolism/fulltext/S1550-4131(25)00334-1
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    Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation
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    cell.com/cell-systems/abstract/S2405-4712(25)00179-6
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unlocking ESCC Progression: CCL15-CCR1 Axis Activates AKT/ERK1/2/c-Jun/CDK2 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305565/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Zinc finger protein 695 facilitates the proliferation of colorectal cancer cells through activation of the NEK2 and PI3K/Akt/mTOR signaling pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12308799/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM5α/Cyclophilin A-Modified MDBK Cells for Lentiviral-Based Gene Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12298503/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DIRAS1 Drives Oxaliplatin Resistance in Colorectal Cancer via PHB1-Mediated Mitochondrial Homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12292402/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The tandem CD33-CLL1 CAR-T as an approach to treat acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12274197/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    As a New Tumor Suppressor Gene, PID1 Activates the AMPK-mTOR Signal to Inhibit the Progression of Bladder Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302987/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Live Imaging and Interactome Analysis of Zika and Chikungunya Viral RNAs Via Dual-Action Aptamer Tag
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265164/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced lipid metabolism serves as a metabolic vulnerability to a polyunsaturated fatty acid (PUFA)-rich diet in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270246/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Influenza A virus induces PI4P production at the endoplasmic reticulum in an ATG16L1-dependent manner to promote the egress of viral ribonucleoproteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286409/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HAX1 inhibits apoptosis and promotes maturation of neutrophils
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282001/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278530/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288892/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GPC2-targeted CAR T cells engineered with NFAT-inducible membrane-tethered IL-15/IL-21 exhibit enhanced activity against neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278764/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282088/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification and characterization of functional and trans-dominant negative HERV-K (HML-2) Rec proteins encoded in the human genome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265724/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Analysis of astrocyte progenitors derived from human induced pluripotent stem cells in vitro and following transplantation into the intact spinal cord
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262438/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PUM2 binds SARS-CoV-2 RNA and PUM1 mildly reduces viral RNA levels, but neither protein affects progeny virus production
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262702/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZNF865 (BLST) Regulates Human Cell Senescence and DNA Damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262657/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis effector protein PE5 hijacks the host CRL2 ubiquitin ligase complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259106/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259098/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311787/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
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