3,489 Matching Annotations
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    CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
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    biorxiv.org/content/10.1101/2025.10.14.681840v1
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    The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
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    CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma
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    nature.com/articles/s41598-025-20183-7
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    Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc
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    WNK1 promotes head and neck squamous cell carcinoma progression through activation of NF-κB signaling pathway
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    Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
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    The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
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    A novel Frizzled 7 antibody disrupts the Wnt pathway and inhibits Wilms tumor growth
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    Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis
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    Tuning insulin receptor signaling using de novo-designed agonists
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    Vitamin C conveys geroprotection on primate ovaries
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  13. Oct 2025
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    CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    The upregulation of GDF15 is controlled epigenetically by oncogenic TCF19 signaling in human hepatocellular carcinoma
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    The role of MRGPRX1 in the melanogenesis of human primary epidermal melanocytes
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    Mechanochemical waves in focal adhesions during cell migration
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    Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer
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    Development of a Porcine Cell Line Stably Expressing Ephrin-B2 for Nipah Virus Research and Diagnostic Testing
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    DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
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    Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy
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    Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiation Therapy
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    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
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  31. Sep 2025
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    KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer
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    IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation
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    Direct Activity Measurement of Heterotrimeric Gi Proteins and Gq Protein By Effector Pulldown
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    Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics
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    Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding
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    Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding
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    SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages
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    JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein
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    TKTL1: a new candidate gene in non-obstructive azoospermia
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    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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    The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism
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    Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma
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    Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer
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    Cooperativity between Ras pathway mutations in colonic tumorigenesis
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    Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis: Cx58 promotes the metastasis of NSCLC
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    2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
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    PIBF1 expression and survival outcome in TNBC and Non-TNBC breast cancer patients with lymph node metastasis who undertaken chemotherapy
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    AVJ16 inhibits lung carcinoma by targeting IGF2BP1
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    MED12 mutation induces RTK inhibitor resistance in NSCLC via MEK/ERK pathway activation by inflammatory cytokines
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    <em>Clinical & Translational Immunology</em> | ASI Journal | Wiley Online Library
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    CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade
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    MicroRNA-885-5p regulates cell cycle progression in liver cancer cells
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    Inorganic Polyphosphate Triggers NLRP3 Inflammasome and Promotes the Epithelial-to-Mesenchymal Transition and Migration of Colorectal Cancer Cells Through TRPM8 Receptor
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    Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma
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    Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
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    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    Sympathetic Neurons Promote Small Cell Lung Cancer Through the Beta-2 Adrenergic Receptor
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    Resilience and vulnerabilities of tumor cells under purine shortage stress
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    Development of Degraders and 2-pyridinecarboxyaldehyde (2-PCA) as a recruitment Ligand for FBXO22
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    The p400 complex promotes HIV-1 latency by suppressing viral transcription and altering the host cell state
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  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  100. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  101. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  103. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  116. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  117. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  118. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  119. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  121. www.biorxiv.org www.biorxiv.org
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  123. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  124. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  146. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  149. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  151. 52.53.155.43 52.53.155.43
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  154. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  155. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  156. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  157. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  158. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  159. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  160. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  161. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  162. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  163. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  164. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  165. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  166. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  167. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  168. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  169. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  170. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  171. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  172. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  173. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  174. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks
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  175. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
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  176. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATR promotes mTORC1 activity via de novo cholesterol synthesis
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  177. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse
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  178. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307719/
  179. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE1 insertion into the NACC2 locus disrupts the HDM2 axis and activates lung oncogenic signaling
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  180. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer
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  181. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity
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  182. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    METTL9 sustains vertebrate neural development primarily via non-catalytic functions
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  183. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
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  184. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation
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  185. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
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  186. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform
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    Transdifferentiation of tongue muscle cells into cancer-associated fibroblasts in response to tongue squamous cell carcinoma
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  188. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12274581/
  189. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections
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  190. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
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  191. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8
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  192. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1
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  193. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression
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    Functional mitochondrial respiration is essential for glioblastoma tumour growth
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  195. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic Transition
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  196. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Select early growth response (Egr) isoforms augment hypoxia inducible factor 2 (HIF-2) regulation of erythropoietin (Epo) gene expression in mammals[image]
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    DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint
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    p62/SQSTM1 impairs immunotherapy in lung adenocarcinoma by suppressing immune infiltration and peripheral immune response
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    UBD‐mediated glycolytic reprogramming promotes M2 macrophage polarization in ovarian cancer immune evasion
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    A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
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    Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma
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    Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk
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    Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis
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    Precision targeting of C3+ reactive astrocyte subpopulations with endogenous ADAR in an iPSC-derived model
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