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Dec 2022
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Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation

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1. scibot 02 Dec 2022
  
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  Plasmid_12260
  
  DOI: 10.1016/j.celrep.2022.111630
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9687083/
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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis

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1. scibot 01 Dec 2022
  
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  Addgene #12260
  
  DOI: 10.1016/j.celrep.2022.111728
  
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sciencedirect.com/science/article/pii/S2211124722016060
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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

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1. scibot 01 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111727
  
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sciencedirect.com/science/article/pii/S2211124722016059
Nov 2022
www.nature.com www.nature.com

Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature

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1. scibot 24 Nov 2022
  
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  addgene_12260
  
  DOI: 10.1038/s41467-022-34790-9
  
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nature.com/articles/s41467-022-34790-9
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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins

1
1. scibot 24 Nov 2022
  
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  Addgene_12260
  
  DOI: 10.1016/j.celrep.2022.111675
  
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sciencedirect.com/science/article/pii/S2211124722015492
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Autophagy promotes cell survival by maintaining NAD levels

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1. scibot 22 Nov 2022
  
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  DOI: 10.1016/j.devcel.2022.10.008
  
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sciencedirect.com/science/article/pii/S1534580722007602
52.53.155.43 52.53.155.43

Nuclear envelope protein LBR protects the genome from chromosomal instability and tumorigenesis

1
1. scibot 22 Nov 2022
  
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  plasmid_12260
  
  DOI: 10.1093/hmg/ddac235
  
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52.53.155.43/cc79e40c92dade70c5729b9199717becabfd0bfe/ddac235-html.html
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Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

1
1. scibot 22 Nov 2022
  
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  DOI: 10.7554/eLife.82006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9674345/
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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

1
1. scibot 19 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/2767-9764.crc-22-0024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
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Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells

1
1. scibot 19 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/2767-9764.crc-22-0270
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648415/
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GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry

1
1. scibot 19 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.isci.2022.105481
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9668739/
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

1
1. scibot 18 Nov 2022
  
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  Plasmid_12260
  
  DOI: 10.1016/j.celrep.2022.111716
  
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sciencedirect.com/science/article/pii/S2211124722015947
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

1
1. scibot 18 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.isci.2022.105458
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
www.pnas.org www.pnas.org

Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation

1
1. scibot 17 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1073/pnas.2122188119
  
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pnas.org/doi/abs/10.1073/pnas.2122188119
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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

1
1. scibot 16 Nov 2022
  
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  12260
  
  DOI: 10.1016/j.xcrm.2022.100821
  
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sciencedirect.com/science/article/pii/S2666379122003809
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The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool

1
1. scibot 16 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.celrep.2022.111645
  
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sciencedirect.com/science/article/pii/S2211124722015169
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Genome-scale CRISPR screening in a single mouse liver

1
1. scibot 16 Nov 2022
  
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  plasmid_12260
  
  DOI: 10.1016/j.xgen.2022.100217
  
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sciencedirect.com/science/article/pii/S2666979X22001707
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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

1
1. scibot 11 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.ccell.2022.10.009
  
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sciencedirect.com/science/article/pii/S1535610822005001
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MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation

1
1. scibot 10 Nov 2022
  
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  12260
  
  DOI: 10.1016/j.celrep.2022.111598
  
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sciencedirect.com/science/article/pii/S2211124722014632
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Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

1
1. scibot 10 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.celrep.2022.111612
  
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sciencedirect.com/science/article/pii/S2211124722014814
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Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway

1
1. scibot 09 Nov 2022
  
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  Plasmid_12260
  
  DOI: 10.1016/j.chembiol.2022.10.003
  
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sciencedirect.com/science/article/pii/S2451945622003579
rupress.org rupress.org

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

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1. scibot 08 Nov 2022
  
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  plasmid_12260
  
  DOI: 10.1084/jem.20220484
  
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rupress.org/jem/article/220/1/e20220484/213662/Inherited-human-ITK-deficiency-impairs-IFN
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Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice

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1. scibot 05 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.celrep.2022.111482
  
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sciencedirect.com/science/article/pii/S2211124722013328
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron

2
1. scibot 04 Nov 2022
  
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  Addgene #12260
  
  DOI: 10.1016/j.isci.2022.105316
  
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  Addgene_12260
  
  DOI: 10.1016/j.isci.2022.105316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9549715/
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Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

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1. scibot 04 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.ccell.2022.10.002
  
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sciencedirect.com/science/article/pii/S1535610822004937
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Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis

1
1. scibot 04 Nov 2022
  
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  plasmid_12
  
  DOI: 10.1016/j.stem.2022.10.005
  
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  RRID:Addgene_12260 RRIDCUR:Unresolved
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sciencedirect.com/science/article/pii/S1934590922004234
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Multiphase coalescence mediates Hippo pathway activation

1
1. scibot 03 Nov 2022
  
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  12260
  
  DOI: 10.1016/j.cell.2022.09.036
  
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sciencedirect.com/science/article/pii/S0092867422012557
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Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964

1
1. scibot 03 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.str.2022.10.003
  
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sciencedirect.com/science/article/pii/S0969212622003926
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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

1
1. scibot 03 Nov 2022
  
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  plasmid_12260
  
  DOI: 10.1016/j.molcel.2022.10.005
  
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sciencedirect.com/science/article/pii/S1097276522009625
www.nature.com www.nature.com

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

1
1. scibot 03 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1038/s41467-022-34252-2
  
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nature.com/articles/s41467-022-34252-2
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HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev

1
1. scibot 02 Nov 2022
  
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  plasmid_12260
  
  DOI: 10.1038/s41598-022-21714-2
  
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nature.com/articles/s41598-022-21714-2
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS

1
1. scibot 02 Nov 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1083/jcb.202201024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9617480/
Oct 2022
aacrjournals.org aacrjournals.org

CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization

1
1. scibot 27 Oct 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/1078-0432.CCR-22-0991
  
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aacrjournals.org/clincancerres/article/28/20/4521/709577/CircIPO7-Promotes-Nasopharyngeal-Carcinoma
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m6A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress

1
1. scibot 26 Oct 2022
  
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  12260
  
  DOI: 10.1016/j.celrep.2022.111546
  
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sciencedirect.com/science/article/pii/S2211124722014024
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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

1
1. scibot 26 Oct 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.celrep.2022.111561
  
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sciencedirect.com/science/article/pii/S221112472201422X
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Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis

1
1. scibot 20 Oct 2022
  
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  plasmid_12260
  
  DOI: 10.1016/j.celrep.2022.111514
  
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sciencedirect.com/science/article/pii/S221112472201364X
link.springer.com link.springer.com

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

1
1. scibot 15 Oct 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1007/s00018-022-04586-7
  
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link.springer.com/article/10.1007/s00018-022-04586-7
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BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes

1
1. scibot 12 Oct 2022
  
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  Addgene_12260
  
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Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors

1
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POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

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Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

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  DOI: 10.1038/s41587-022-01494-w
  
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The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

1
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  RRID:Addgene_1226
  
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Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression

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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

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Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells

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  RRID:Addgene_12260
  
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Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

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  RRID:Addgene_12260
  
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Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

1
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  AddGene#12260
  
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Opto-katanin, an optogenetic tool for localized, microtubule disassembly

1
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A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

1
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  plasmid_12260
  
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The lncRNA ALPHA specifically targets chikungunya virus to control infection

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A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity

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Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study

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  Addgene_12260
  
  DOI: 10.4274/jtgga.galenos.2022.2022-1-14
  
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TGFBR3 supports anoikis through suppressing ATF4 signaling

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  Addgene_12260
  
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journals.biologists.com/jcs/article/135/17/jcs258396/276460/TGFBR3-supports-anoikis-through-suppressing-ATF4
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GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer

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Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization

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Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

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Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation

1
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  RRID:Addgene_12260
  
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Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin

1
1. scibot 21 Sep 2022
  
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  Plasmid - psPAX2
  
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ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection

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  plasmid_12260
  
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CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation

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  Addgene plasmid #12260
  
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Scalable CRISPR-Cas9 chemical genetic screens in non-transformed human cells

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SerpinB3 drives cancer stem cell survival in glioblastoma

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Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer

1
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  RRID:Addgene_12
  
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Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer

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  RRID:Addgene_12260
  
  DOI: 10.3390/cancers14174219
  
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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

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  Plasmid_12260
  
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Human coronaviruses disassemble processing bodies

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  Addgene_12260
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9439236/
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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  RRID:Addgene_12260
  
  DOI: 10.1158/2159-8290.CD-21-1077
  
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Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells

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  DOI: 10.1158/2767-9764.CRC-22-0270
  
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aacrjournals.org/cancerrescommun/article/2/8/842/708157/Na-H-exchanger-1-Enhances-Antitumor-Activity-of
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TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages

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  RRID:Addgene_12260
  
  DOI: 10.1128/mbio.01456-22
  
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Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

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  RRID:Addgene_12260
  
  DOI: 10.1128/mbio.01055-22
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9426523/
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Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy

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  plasmid_12260
  
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Aug 2022
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Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers

1
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  Addgene_12260
  
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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

1
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SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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S146L in MYC is a context-dependent activating substitution in cancer development

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Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites

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cd-21-1671-html.html

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can-21-2908-html.html

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Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions

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Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency

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RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation

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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

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Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4+ T cell responses restricted by single HLA class II allotype in an individual

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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

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Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases

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Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

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Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification

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Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells

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Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains

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Identifying cell receptors for the nanoparticle protein corona using genome screens

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Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine

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Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo

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BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL

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Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity

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METTL14-dependent m6A modification controls iNKT cell development and function

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Protocol for genome-wide CRISPR knockout screens of bacterial cytotoxins in HeLa cells

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The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors

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HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance

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Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

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cir-22-0088-html.html

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can-21-4313-html.html

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52.53.155.43/cccf0ba471fe636f8ee073caf3b8f7a0d9b2bd8e/can-21-4313-html.html
aacrjournals.org aacrjournals.org

Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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can-21-3713-html.html

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Self-assembly of pericentriolar material in interphase cells lacking centrioles

1
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BPS Publications

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  DOI: 10.1111/bph.15896
  
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A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions

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  DOI: 10.1016/j.xcrm.2022.100686
  
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Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery

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Mislocalization of protein kinase A drives pathology in Cushing’s syndrome

1
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Targeting the transcriptional activity of STAT3 by a novel fusion protein

2
1. scibot 12 Jul 2022
  
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EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks

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Transcriptional reprogramming differentiates active from inactive ESR1 fusions in endocrine therapy-refractory metastatic breast cancer

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52.53.155.43 52.53.155.43

cd-21-0680-html.html

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mcr-22-0111-html.html

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Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells

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  RRID:Addgene_12260
  
  DOI: 10.15252/embr.202154133
  
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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance

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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling

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Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma

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Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi

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Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

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Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression

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Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

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Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

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RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

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  DOI: 10.1038/s41467-022-30794-7
  
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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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Granger-causal inference of the lamellipodial actin regulator hierarchy by live cell imaging without perturbation

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Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD

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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model

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HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions

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The SETDB1–TRIM28 complex suppresses antitumor immunity

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  RRID:Addgene_12260
  
  DOI: 10.1158/2326-6066.CIR-21-0754
  
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YAP1 activation is associated with the progression and response to immunotherapy of non-muscle invasive bladder cancer

1
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  DOI: 10.1016/j.ebiom.2022.104092
  
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A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs

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Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation

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  DOI: 10.1007/s00018-022-04312-3
  
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DDX41 is required for cGAS-STING activation against DNA virus infection

1
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Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies

1
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Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

1
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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2

1
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.biocel.2022.106228
  
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Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma

1
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  DOI: 10.1158/0008-5472.CAN-21-0810
  
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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

1
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  RRID:Addgene_12260
  
  DOI: 10.7554/eLife.75594
  
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Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway

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  RRID: Addgene_12260
  
  DOI: 10.1016/j.ebiom.2022.104060
  
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c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

1
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Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

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  RRID:Addgene_12260
  
  DOI: 10.7554/eLife.76541
  
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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

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MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

1
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A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway

1
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

2
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

1
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  plasmid_12260
  
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Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection

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  DOI: 10.1038/s41596-022-00695-6
  
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Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

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SETD4-mediated KU70 methylation suppresses apoptosis

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The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62

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The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

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Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer

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Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure

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The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells

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  DOI: 10.1038/s41420-022-01044-y
  
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Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation

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Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

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Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

1
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Identifying a confused cell identity for esophageal squamous cell carcinoma

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CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses

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Establishing transgenic murine esophageal organoids

1
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BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors

1
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  plasmid_12260
  
  DOI: 10.3389/fonc.2022.766794
  
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In vitro and in vivo assay of the ER lipid scramblase TMEM41B

1
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Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity

1
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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

1
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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

1
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Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis

1
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  Plasmid_12260
  
  DOI: 10.1016/j.cell.2022.03.030
  
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A presynaptic phosphosignaling hub for lasting homeostatic plasticity

1
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Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli

1
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Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model

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Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

2
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.ccell.2022.03.008
  
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Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

1
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Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex

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Rapid establishment of human colonic organoid knockout lines

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  Addgene_12260
  
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sciencedirect.com/science/article/pii/S2666166722001885
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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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1. scibot 14 Apr 2022
  
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  Addgene_12260
  
  DOI: 10.1016/j.celrep.2022.110575
  
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sciencedirect.com/science/article/pii/S2211124722003199
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Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs

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1. scibot 14 Apr 2022
  
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  RRID:Addgene_12
  
  DOI: 10.1016/j.biomaterials.2022.121509
  
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  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8999341/
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Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function

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1. scibot 13 Apr 2022
  
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  Plasmid_12260
  
  DOI: 10.1016/j.ccell.2022.03.006
  
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sciencedirect.com/science/article/pii/S1535610822001210
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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1. scibot 13 Apr 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.immuni.2022.03.007
  
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sciencedirect.com/science/article/pii/S1074761322001303
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Single Transcript Knockdown-Replacement Strategy Employing 5’ UTR Secondary Structures to Precisely Titrate Rescue Protein Translation

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1. scibot 13 Apr 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.3389/fgeed.2022.803375
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8995503/
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Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

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1. scibot 07 Apr 2022
  
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  AddgeneCat# 12260
  
  DOI: 10.1016/j.celrep.2022.110637
  
  Resource: RRID:Addgene_12260
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S2211124722003898
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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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1. scibot 07 Apr 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.molcel.2022.03.016
  
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sciencedirect.com/science/article/pii/S1097276522002544
aacrjournals.org aacrjournals.org

GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia

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1. scibot 05 Apr 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/1541-7786.MCR-21-0352
  
  Resource: RRID:Addgene_12260
  
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aacrjournals.org/mcr/article/20/4/501/682307/GFI1-Cooperates-with-IKZF1-IKAROS-to-Activate-Gene
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 05 Apr 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.1111/bph.15763
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15763
Mar 2022
elifesciences.org elifesciences.org

Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

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1. scibot 31 Mar 2022
  
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  RRID:Addgene_12260
  
  DOI: 10.7554/eLife.69229
  
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elifesciences.org/articles/69229

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