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  1. Mar 2023
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    Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke
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    sciencedirect.com/science/article/pii/S2211124723002449
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    Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9975292/
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    DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network
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    sciencedirect.com/science/article/pii/S1097276523001077
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    RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation
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    sciencedirect.com/science/article/pii/S1097276523001065
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    Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity
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    1. scibot 02 Mar 2023
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    sciencedirect.com/science/article/pii/S2211124723002164
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  8. Feb 2023
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    RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex
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    sciencedirect.com/science/article/pii/S2211124723001080
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    Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation
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    1. scibot 16 Feb 2023
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    sciencedirect.com/science/article/pii/S1074761323000250
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    Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
    1
    1. scibot 03 Feb 2023
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    sciencedirect.com/science/article/pii/S0092867422015811
  12. Jan 2023
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    Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
    1
    1. scibot 26 Jan 2023
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    Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation
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    1. scibot 26 Jan 2023
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    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
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    sciencedirect.com/science/article/pii/S009286742201529X
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    Resurrection of endogenous retroviruses during aging reinforces senescence
    1
    1. scibot 07 Jan 2023
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    Combined control of the fibroblast contractile program by YAP and TAZ
    1
    1. scibot 06 Jan 2023
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      DOI: 10.1152/ajplung.00210.2021

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    Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation
    1
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    sciencedirect.com/science/article/pii/S2211124722017612
  19. Dec 2022
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    The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
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    1. scibot 18 Dec 2022
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    Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease
    1
    1. scibot 11 Dec 2022
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    Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis
    1
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    sciencedirect.com/science/article/pii/S2211124722016205
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
    1
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    sciencedirect.com/science/article/pii/S2211124722016424
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    CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9682343/
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    Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages
    1
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      DOI: 10.1016/j.celrep.2022.111738

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  26. Nov 2022
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    Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry
    1
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    sciencedirect.com/science/article/pii/S2211124722015686
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB
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    1. scibot 22 Nov 2022
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      DOI: 10.1111/jnc.15707

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15707
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
    1
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    sciencedirect.com/science/article/pii/S2589004222014560
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    sciencedirect.com/science/article/pii/S2211124722014656
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    LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly
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  33. Oct 2022
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    Steroidogenic factor 1 regulates transcription of the inhibin B co-receptor in pituitary gonadotrope cells
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      DOI: 10.1210/endocr/bqac131

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    academic.oup.com/endo/article/163/11/bqac131/6661776
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    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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    Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
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    sciencedirect.com/science/article/pii/S2211124722012840
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    A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)
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  39. Sep 2022
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    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
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  41. Aug 2022
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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  43. Jul 2022
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    Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
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    sciencedirect.com/science/article/pii/S2211124722008646
  45. yc.mlpla.mil.cn yc.mlpla.mil.cn
    Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
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      DOI: 10.1016/j.chembiol.2022.06.007

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    yc.mlpla.mil.cn/s/com/sciencedirect/www/G.https/science/article/pii/S2451945622002392
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    Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish
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  47. Jun 2022
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells
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    NRF2 Serves A Critical Role In Regulation Of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation
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    TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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    YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
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    SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine
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    Allele-specific aberration of imprinted domain chromosome architecture associates with large offspring syndrome
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    Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex
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    CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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    The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
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    FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas
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  65. Mar 2022
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    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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    MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes
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    HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
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    Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
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    TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
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    A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h
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    Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
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  99. Sep 2021
  100. www.science.org www.science.org
    Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
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    ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance
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    RORα is critical for mTORC1 activity in T cell-mediated colitis
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    Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination
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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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    Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation
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    Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB
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    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
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    METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
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    Acetylation of Cytidine in mRNA Promotes Translation Efficiency
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  119. Jul 2021
  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cystatin C Improves Blood‐Brain Barrier Integrity After Ischemic Brain Injury in Mice
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      anti-normal rabbit IgG

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    Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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    Thyroid Hormone Receptor β Suppression of RUNX2 is Mediated by Brahma Related Gene 1 Dependent Chromatin Remodeling
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    PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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    An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
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  135. Jun 2021
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    Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
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    ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia
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  141. May 2021
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    FSHB Transcription is Regulated by a Novel 5’ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism
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  144. www.sciencedirect.com www.sciencedirect.com
    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
    1
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    An Activity-Mediated Transition in Transcription in Early Postnatal Neurons
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  146. www.sciencedirect.com www.sciencedirect.com
    Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism
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  147. www.sciencedirect.com www.sciencedirect.com
    Folding Keratin Gene Clusters during Skin Regional Specification
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    Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment
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    Glutamine Metabolism Controls Chondrocyte Identity and Function
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    Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health
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  151. Apr 2021
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    Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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      Polyclonal Normal Rabbit IgG

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    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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    Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
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    N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles
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    Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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  160. Mar 2021
  161. www.embopress.org www.embopress.org
    Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation and expression of endogenous CREB‐regulated transcription coactivators (CRTC) 1, 2 and 3 in the rat adrenal gland
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  163. Feb 2021
  164. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serotonin signaling by maternal neurons upon stress ensures progeny survival
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function
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  169. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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  170. academic.oup.com academic.oup.com
    Levonorgestrel inhibits embryo attachment by eliminating uterine induction of leukemia inhibitory factor
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    BET inhibition by JQ1 produces divergent transcriptional regulation of SOCS genes in adipocytes
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  172. www.cell.com www.cell.com
    TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  174. Jan 2021
  175. www.sciencedirect.com www.sciencedirect.com
    Impact of WIN site inhibitor on the WDR5 interactome
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  176. elifesciences.org elifesciences.org
    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
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  177. Dec 2020
  178. www.mdpi.com www.mdpi.com
    Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
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  179. link.springer.com link.springer.com
    Vagal afferent fibers contribute to the anti-inflammatory reactions by vagus nerve stimulation in concanavalin A model of hepatitis in rats
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  180. Nov 2020
  181. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors
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  182. www.sciencedirect.com www.sciencedirect.com
    TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction
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  183. www.jneurosci.org www.jneurosci.org
    The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death
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  184. Oct 2020
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TMEM41B is a pan-flavivirus host factor
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  187. www.sciencedirect.com www.sciencedirect.com
    Tristetraprolin promotes hepatic inflammation and tumor initiation but restrains cancer progression to malignancy.
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      Normal rabbit immunoglobulin G

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  188. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    cell.com/developmental-cell/abstract/S1534-5807(20)30420-2
  189. www.sciencedirect.com www.sciencedirect.com
    Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia
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  190. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Pharmacological Modulation of Blood–Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions
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      normal rabbit IgG

      DOI: 10.3390/ph13100279

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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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    Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies
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      AB_1031062

      DOI: 10.1080/20013078.2020.1812261

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    The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression
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      DOI: 10.1016/j.celrep.2020.107724

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    Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
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      DOI: 10.1016/j.celrep.2020.107695

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    Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
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    Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits
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    Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
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    The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
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    Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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    Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP
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    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
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    Termination of acute stress response by the endocannabinoid system is regulated through LSD1‐mediated transcriptional repression of 2‐AG hydrolases ABHD6 and MAGL
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      DOI: 10.1111/jnc.15000

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    Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival
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      DOI: 10.1016/j.devcel.2020.04.003

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    FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression
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    Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
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      RRID:AB_1031062

      DOI: 10.1016/j.immuni.2020.01.003

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    Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
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      RRID:AB_1031062

      DOI: 10.1016/j.cell.2020.03.052

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    An Optimized Protocol for ChIP-Seq from Human Embryonic Stem Cell Cultures
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      RRID:AB_1031062

      DOI: 10.1016/j.xpro.2020.100062

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    Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
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      RRID:AB_1031062

      DOI: 10.1016/j.stem.2020.03.002

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    Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription
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      RRID:AB_1031062

      DOI: 10.1016/j.cmet.2020.05.007

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    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties
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      RRID:AB_1031062

      DOI: 10.7554/eLife.33947

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    Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
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      RRID:AB_1031062

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    MYC Controls the Epstein-Barr Virus Lytic Switch
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    Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice
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      RRID:AB_1031062

      DOI: 10.3389/fnins.2020.00766

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    PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
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      DOI: 10.1016/j.nbd.2020.105026

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    Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells
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      anti‐IgG antibody

      DOI: 10.15252/embj.2019104319

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  219. Jan 2020
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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      DOI: 10.1016/j.ccell.2018.05.002

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    Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription
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    Exon-Mediated Activation of Transcription Starts
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    Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR
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    Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus
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    Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis
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    A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
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    cell.com/cell-metabolism/fulltext/S1550-4131(19)30664-3
  231. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
    1
    1. scibot 13 Jan 2020
      RRID:AB_1031062

      DOI: 10.1016/j.ccell.2019.08.003

      Resource: (Cell Signaling Technology Cat# 2729, RRID:AB_1031062)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_1031062

      What is this?

      RRID:AB_1031062 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC6853173/