341 Matching Annotations
  1. Apr 2024
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    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    1. scibot 20 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824001193
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    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
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    aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    sciencedirect.com/science/article/pii/S2211124724004479
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
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    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements
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    Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions
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    Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice
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  12. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle
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    1. scibot 26 Mar 2024
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    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
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    TLR2 regulates hair follicle cycle and regeneration via BMP signaling
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    Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPKα lactylation in intervertebral disc degeneration
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    1. scibot 15 Mar 2024
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    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    Mechanisms of HIV-Mediated Blood-Brain Barrier Compromise and Leukocyte Transmigration under the Current Antiretroviral Era.
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    1. scibot 07 Mar 2024
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    sciencedirect.com/science/article/pii/S2589004224004577
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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  23. Feb 2024
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    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    An iron rheostat controls hematopoietic stem cell fate
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    Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
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    Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo
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      DOI: 10.1126/sciadv.adk1835

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    Stromal-derived MAOB promotes prostate cancer growth and progression
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    Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma
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    Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling
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  31. Jan 2024
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    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    cell.com/cell-reports/abstract/S2211-1247(23)01438-9
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    A Novel Macrolide–Del-1 Axis to Regenerate Bone in Old Age
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    ncbi.nlm.nih.gov/pmc/articles/PMC10797555/
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    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
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    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
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    miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.
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    FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10772350/
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    Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors
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    sciencedirect.com/science/article/pii/S2211124723016406
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer
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  42. Dec 2023
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    SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis
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    Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron
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    FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression
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    Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
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    IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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    Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer
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    Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis
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    A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
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    GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4+ T cells
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    Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
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  86. May 2023
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    Site-specific R-loops induce CGG repeat contraction and fragile X gene reactivation
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    Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
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    Hypoxia-induced loss of SRSF2-dependent DNA methylation promotes CTCF-mediated alternative splicing of VEGFA in breast cancer
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    LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation
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    ATR protects centromere identity by promoting DAXX association with PML nuclear bodies
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    eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
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    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
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    A hyper-quiescent chromatin state formed during aging is reversed by regeneration
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    UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer
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    Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia
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    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy
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    TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated Regions
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes.
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    Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
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    Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke
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    DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network
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    RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation
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    Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex
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    Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation
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    Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
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    Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
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    Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation
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    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
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    Resurrection of endogenous retroviruses during aging reinforces senescence
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    Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation
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    The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
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    Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease
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    Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness
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    Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages
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    Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry
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    Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly
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    Steroidogenic factor 1 regulates transcription of the inhibin B co-receptor in pituitary gonadotrope cells
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    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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    A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)
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    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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    Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
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    Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
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    Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells
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    NRF2 Serves A Critical Role In Regulation Of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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    YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4
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    SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine
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    Allele-specific aberration of imprinted domain chromosome architecture associates with large offspring syndrome
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    CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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    The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
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    FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas
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  175. Mar 2022
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    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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