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Feb 2023
www.embopress.org www.embopress.org

Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer

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1. scibot 23 Feb 2023
  
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  DOI: 10.15252/embr.202256524
  
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embopress.org/doi/10.15252/embr.202256524
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy

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1. scibot 27 Jan 2023
  
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  DOI: 10.3389/fimmu.2022.1011943
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9872099/
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S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas

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1. scibot 25 Jan 2023
  
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  DOI: 10.1016/j.neo.2022.100874
  
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sciencedirect.com/science/article/pii/S1476558622000999
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MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.ccell.2022.12.007
  
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sciencedirect.com/science/article/pii/S1535610822005931
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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1. scibot 07 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-21-0003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
Dec 2022
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 23 Dec 2022
  
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  DOI: 10.1111/bph.15984
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15984
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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.ccell.2022.11.014
  
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Cancer cell-derived type I interferons instruct tumor monocyte polarization

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1. scibot 08 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111769
  
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sciencedirect.com/science/article/pii/S2211124722016527
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The CIt protocol: a blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells.

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1. scibot 02 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105537
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9682353/
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Original research: Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity

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1. scibot 01 Dec 2022
  
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  DOI: 10.1136/jitc-2022-004806
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9703354/
Nov 2022
aacrjournals.org aacrjournals.org

A novel selective inhibitor JBI-589 targets PAD4-mediated neutrophil migration to suppress tumor progression

1
1. scibot 22 Nov 2022
  
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  DOI: 10.1158/0008-5472.CAN-21-4045
  
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aacrjournals.org/cancerres/article/82/19/3561/709408/A-Novel-Selective-Inhibitor-JBI-589-Targets-PAD4
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Phototherapy with cancer-specific nanoporphyrin potentiates immunotherapy in bladder cancer

1
1. scibot 22 Nov 2022
  
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  DOI: 10.1158/1078-0432.CCR-22-1362
  
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aacrjournals.org/clincancerres/article/28/21/4820/709840/Phototherapy-with-Cancer-Specific-Nanoporphyrin
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Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis

1
1. scibot 10 Nov 2022
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.celrep.2022.111611
  
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sciencedirect.com/science/article/pii/S2211124722014802
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Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

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1. scibot 05 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111478
  
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sciencedirect.com/science/article/pii/S2211124722013286
jitc.bmj.com jitc.bmj.com

Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

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1. scibot 03 Nov 2022
  
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  DOI: 10.1136/jitc-2022-004874
  
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jitc.bmj.com/content/10/10/e004874
Oct 2022
52.53.155.43 52.53.155.43

ccr-22-1362 (1)-html.html

1
1. scibot 27 Oct 2022
  
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  RRID:AB_10949053
  
  DOI: 10.1158/1078-0432.ccr-22-1362
  
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52.53.155.43/8399c7b6c65b0ab27684aece59896da930ab4034/ccr-22-1362 (1)-html.html
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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

1
1. scibot 20 Oct 2022
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.immuni.2022.09.014
  
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sciencedirect.com/science/article/pii/S1074761322005088
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Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

1
1. scibot 20 Oct 2022
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.cmet.2022.09.021
  
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sciencedirect.com/science/article/pii/S1550413122004119
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The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

1
1. scibot 09 Oct 2022
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.cell.2022.09.020
  
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sciencedirect.com/science/article/pii/S0092867422011928
Sep 2022
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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.016
  
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Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1

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1. scibot 15 Sep 2022
  
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  DOI: 10.1016/j.cmet.2022.08.016
  
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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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1. scibot 13 Sep 2022
  
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  DOI: 10.1016/j.xcrm.2022.100744
  
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sciencedirect.com/science/article/pii/S2666379122002932
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PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

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1. scibot 02 Sep 2022
  
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  DOI: 10.1158/2159-8290.CD-21-0694
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904293/
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

1
1. scibot 02 Sep 2022
  
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  DOI: 10.1158/2159-8290.CD-21-1077
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
Aug 2022
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Tumor targeted 4-1BB agonist antibody-albumin fusions with high-affinity to FcRn induce anti-tumor immunity without toxicity

1
1. scibot 30 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104958
  
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sciencedirect.com/science/article/pii/S2589004222012305
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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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1. scibot 25 Aug 2022
  
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  DOI: 10.1016/j.cmet.2022.08.002
  
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Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111201
  
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Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

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1. scibot 02 Aug 2022
  
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  DOI: 10.1016/j.immuni.2022.07.001
  
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sciencedirect.com/science/article/pii/S107476132200334X
Jul 2022
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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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1. scibot 27 Jul 2022
  
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  DOI: 10.1016/j.ccell.2022.06.011
  
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sciencedirect.com/science/article/pii/S1535610822002756
Jun 2022
52.53.155.43 52.53.155.43

cd-21-1022-html.html

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1. scibot 30 Jun 2022
  
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  AB_10949053
  
  DOI: 10.1158/2159-8290.CD-21-1022
  
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2. scibot 25 Jun 2022
  
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  DOI: 10.1158/2159-8290.cd-21-1022
  
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  DOI: 10.1158/2159-8290.cd-21-1022
  
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52.53.155.43/dae3a722cb0f412060233d3b16799226aa47507e/cd-21-1022-html.html
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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling

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1. scibot 22 Jun 2022
  
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  DOI: 10.1016/j.chembiol.2022.05.012
  
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sciencedirect.com/science/article/pii/S2451945622002045
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Flow cytometry analysis of endothelial cells and subsets of exhausted CD8+ T cells in murine tumor models

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1. scibot 09 Jun 2022
  
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  DOI: 10.1016/j.xpro.2022.101444
  
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sciencedirect.com/science/article/pii/S2666166722003240
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PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

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1. scibot 09 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110914
  
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sciencedirect.com/science/article/pii/S221112472200691X
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Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.ccell.2022.05.006
  
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Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

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  DOI: 10.1016/j.ccell.2022.04.004
  
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Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer

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  DOI: 10.1016/j.cmet.2022.04.003
  
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Apr 2022
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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  DOI: 10.1016/j.immuni.2022.03.007
  
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PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

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  DOI: 10.1016/j.celrep.2022.110582
  
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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

1
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  DOI: 10.1016/j.xcrm.2022.100554
  
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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

1
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  DOI: 10.1016/j.cmet.2022.02.010
  
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Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells

1
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  RRID:AB_2894808
  
  DOI: 10.7150/thno.69198
  
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Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity

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  DOI: 10.1016/j.xcrm.2022.100534
  
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Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

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Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

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  DOI: 10.1016/j.cell.2021.12.039
  
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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  DOI: 10.1016/j.ccell.2021.12.009
  
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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

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  DOI: 10.1038/s41467-021-27349-7
  
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The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota

1
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Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor

1
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  DOI: 10.1016/j.isci.2021.103392
  
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Nov 2021
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Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

1
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  DOI: 10.1016/j.ccell.2021.10.008
  
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LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

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  DOI: 10.1016/j.medj.2021.10.002
  
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Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

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  DOI: 10.1016/j.cell.2021.09.019
  
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Sep 2021
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Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell

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  RRID:AB_10949053
  
  DOI: 10.1136/jitc-2021-003100
  
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Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

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  RRID:AB_10949053
  
  DOI: 10.1016/j.xcrm.2021.100399
  
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Effects of exercise and anti-PD-1 on the tumour microenvironment

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  RRID:AB_10
  
  DOI: 10.1016/j.imlet.2021.08.005
  
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Aug 2021
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Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

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  RRID:AB_10949053
  
  DOI: 10.1016/j.cell.2021.07.029
  
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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

1
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  RRID:AB_10949053
  
  DOI: 10.1016/j.celrep.2021.109516
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.047
  
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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

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  RRID:AB_10949053
  
  DOI: 10.1016/j.cell.2018.10.028
  
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Untitled document

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  DOI: 10.1016/j.cell.2018.10.014
  
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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

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  DOI: 10.1016/j.immuni.2018.11.014
  
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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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  RRID:AB_10949053
  
  DOI: 10.1016/j.cell.2018.10.038
  
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Oncolytic Newcastle disease virus expressing a checkpoint inhibitor as a radioenhancing agent for murine melanoma

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  DOI: 10.1016/j.ebiom.2019.10.032
  
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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

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  DOI: 10.1016/j.ccell.2021.06.018
  
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Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma

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1. scibot 21 Jul 2021
  
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  DOI: 10.1016/j.isci.2021.102759
  
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Lipopolysaccharide-mediated chronic inflammation promotes tobacco carcinogen-induced lung cancer and determines the efficacy of immunotherapy

1
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  DOI: 10.1158/0008-5472.CAN-20-1994
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7878420/
Jun 2021
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

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  DOI: 10.1016/j.cell.2021.05.038
  
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Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer

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  DOI: 10.1016/j.celrep.2021.109285
  
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Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

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  DOI: 10.7554/eLife.58688
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8203293/
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Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response

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1. scibot 15 Jun 2021
  
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  DOI: 10.1016/j.xpro.2021.100595
  
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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

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1. scibot 03 Jun 2021
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.cell.2021.05.021
  
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May 2021
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A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustains their immunosuppressive function in melanoma

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  DOI: 10.1158/0008-5472.CAN-20-3510
  
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BPS Publications

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  DOI: 10.1111/bph.15457
  
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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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  DOI: 10.1016/j.stem.2020.06.022
  
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Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

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  DOI: 10.1016/j.molcel.2021.01.010
  
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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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  DOI: 10.1016/j.celrep.2021.109076
  
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Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy

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  DOI: 10.1016/j.celrep.2021.109071
  
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Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets

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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

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CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

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  DOI: 10.1016/j.cmet.2021.02.015
  
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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

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  InVivoPlus anti-mouse PD-1 (CD279)
  
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PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor

1
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  DOI: 10.1126/scisignal.aau4518
  
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Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

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Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

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  DOI: 10.1172/jci.insight.134386
  
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Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

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1. scibot 21 Jan 2021
  
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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.02.008
  
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FOXD3 Regulates VISTA Expression in Melanoma

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  DOI: 10.1016/j.celrep.2019.12.036
  
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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

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Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

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  DOI: 10.1172/jci.insight.134386
  
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Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

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  DOI: 10.1016/j.ccell.2020.02.006
  
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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

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  DOI: 10.1016/j.ccell.2020.03.016
  
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

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sciencedirect.com/science/article/pii/S107476132030042X
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Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors

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  DOI: 10.1016/j.ccell.2019.10.008
  
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B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

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  DOI: 10.1016/j.cell.2019.10.028
  
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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

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  DOI: 10.1016/j.cell.2019.07.019
  
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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

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  DOI: 10.1016/j.cell.2019.10.029
  
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Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

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  DOI: 10.1016/j.ccell.2019.10.001
  
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Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

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  DOI: 10.1016/j.celrep.2019.05.020
  
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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

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  DOI: 10.1016/j.celrep.2019.04.091
  
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Untitled document

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  DOI: 10.1016/j.immuni.2018.12.021
  
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Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

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  DOI: 10.1016/j.ccell.2019.04.003
  
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Nov 2018
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

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IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy

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Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

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Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity

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Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

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Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization

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TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment

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Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

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Nov 2017
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Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade

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Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

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1. scibot 08 Nov 2017
  
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  Anti-PD-1 (clone RMP1-14)BioXcellCat# BE0146
  
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Systemic Immunity Is Required for Effective Cancer Immunotherapy

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