2,784 Matching Annotations
  1. Dec 2025
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    Mitochondrial VHL rewires cell metabolism in hypoxia
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    Hepatic adaptation to chronic metabolic stress primes tumorigenesis
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    sciencedirect.com/science/article/pii/S0092867425013662
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    Testosterone-induced metabolic changes in seminal vesicle epithelium modify seminal plasma components with potential to improve sperm motility
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    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    Structure of the TXNL1-bound proteasome
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    Immune‐Related Protein and Non‐Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection
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    Different effects of 3-week disuse on the phenotype and gene expression of the calf and thigh muscles
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    Extracellular Vesicles Favor Early Peripheral Immunosenescence Through Modulation of the Senescence-Associated Secretory Phenotype in HIV Infection
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    CDK4/6 inhibition reprograms the breast cancer immunopeptidome via Rb-dependent chromatin and transcriptomic remodeling
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    The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis
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    Purmorphamine exerts anti-obesity effects by enhancing secretin-activated brown fat thermogenesis
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    Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface
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    IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy
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    APLP1 Interacts with SARM1 and Regulates Axonal Maintenance and Post-Injury Degeneration
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    IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy
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    NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
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    Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors
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  31. Nov 2025
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    A triple-action PROTAC for wild-type p53 cancer therapy
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    Spring-like mechanics enable rapid inactivation and stochastic single-channel gating of the mechanically activated PIEZO channel
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    Harnessing the E3 ligase SPOP for targeted degradation of the NUP98::KDM5A fusion oncoprotein
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    Identification of a common ketohexokinase-dependent link driving alcohol intake and alcohol-associated liver disease in mice
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    RhoA allosterically activates phospholipase Cε via its EF hands
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    System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses
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    Control of aging-associated neurodegeneration via hypothalamic extracellular vesicles containing parathymosin
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    Biallelic variants in the UTRN gene cause a novel form of multiple congenital arthrogryposis
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    Monitoring the complexity and dynamics of mitochondrial translation
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    An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels
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    ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation
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    Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
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    Shining a Light on Skeletal Muscle Regeneration: Red Photobiomodulation Boosts Myoblast Differentiation In Vitro
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  65. Oct 2025
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    L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas
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    Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
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    SMARCA1 regulates PARP1-dependent ABC transporters expression and mediates doxorubicin resistance in triple-negative breast cancer
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    Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
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    Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
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    Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
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    RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition
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    Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherin
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    Modeling response to the KRAS-G12C inhibitor AZD4625 in KRASG12C NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms
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    Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity
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    ATG4B is required for mTORC1-mediated anabolic activity and is associated with clinical outcomes in non-small cell lung cancer
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    A non-canonical immunometabolic function of BRD3 during sepsis
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    Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus[image]
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    pmc.ncbi.nlm.nih.gov/articles/PMC12528902/
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    Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
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    Cryo-EM structure of phospholipase Cε defines N-terminal domains and their roles in activity
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    Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice
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    Auranofin synergizes with cisplatin in reducing tumor burden of Notch-dependent ovarian cancer
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    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
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    CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression
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    Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity
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    Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
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