295 Matching Annotations
  1. Feb 2021
  2. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
    1. scibot 24 Feb 2021
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.01.012

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  3. www.sciencedirect.com www.sciencedirect.com
    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
    1
    1. scibot 24 Feb 2021
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2021.108744

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    sciencedirect.com/science/article/pii/S2211124721000577
  4. Jan 2021
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    1
    1. scibot 26 Jan 2021
      RRID:AB_2105622

      DOI: 10.1016/j.cell.2020.12.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  6. Nov 2020
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
    1
    1. scibot 21 Nov 2020
      RRID:AB_2105622

      DOI: 10.7554/eLife.55994

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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  8. Oct 2020
  9. www.sciencedirect.com www.sciencedirect.com
    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
    1
    1. scibot 07 Oct 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.108230

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    sciencedirect.com/science/article/pii/S2211124720312195
  10. Sep 2020
  11. www.sciencedirect.com www.sciencedirect.com
    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
    1
    1. scibot 23 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.107753

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    sciencedirect.com/science/article/pii/S2211124720307336
  12. www.sciencedirect.com www.sciencedirect.com
    JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding
    1
    1. scibot 17 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.107668

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    sciencedirect.com/science/article/pii/S2211124720306215
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
    1
    1. scibot 17 Sep 2020
      RRID:AB_2105622

      DOI: 10.1111/jnc.14979

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14979
  14. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
    1
    1. scibot 17 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
  15. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
    1
    1. scibot 15 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.cmet.2020.04.011

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    sciencedirect.com/science/article/pii/S1550413120301935
  16. academic.oup.com academic.oup.com
    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
    1
    1. scibot 14 Sep 2020
      RRID:AB_2105622

      DOI: 10.1210/endocr/bqaa037

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    academic.oup.com/endo/article/161/4/bqaa037/5788411
  17. www.sciencedirect.com www.sciencedirect.com
    Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex
    1
    1. scibot 13 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.107664

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    sciencedirect.com/science/article/pii/S2211124720306173
  18. www.sciencedirect.com www.sciencedirect.com
    Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
    1
    1. scibot 09 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.stem.2020.01.013

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    sciencedirect.com/science/article/pii/S1934590920300138
  19. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
    1. scibot 09 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.01.012

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  20. www.sciencedirect.com www.sciencedirect.com
    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
    1
    1. scibot 07 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.devcel.2020.02.015

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    sciencedirect.com/science/article/pii/S1534580720301428
  21. www.cell.com www.cell.com
    Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
    1
    1. scibot 06 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.cell.2018.11.030

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    cell.com/cell/abstract/S0092-8674(18)31555-1
  22. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 06 Sep 2020
      RRID:AB_2105622

      DOI: 10.1111/bph.15131

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15131
  23. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
    1
    1. scibot 04 Sep 2020
      mTOR

      DOI: 10.15252/embr.201949898

      Resource: (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2105622

      Curator comments: mTOR (7C10) Rabbit mAb antibody Cell Signaling Technology Cat# 2983

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      RRID:AB_2105622 RRIDCUR:Missing
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    embopress.org/doi/abs/10.15252/embr.201949898
  24. www.sciencedirect.com www.sciencedirect.com
    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
    1
    1. scibot 04 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.stem.2019.12.006

      Resource: (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

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      RRIDCUR:Validated RRID:AB_2105622
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    sciencedirect.com/science/article/pii/S1934590919305247
  25. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
    1
    1. scibot 03 Sep 2020
      RRID:AB_2105622

      DOI: 10.1016/j.cell.2020.02.019

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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  26. www.sciencedirect.com www.sciencedirect.com
    The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy
    1
    1. scibot 03 Sep 2020
      RRID: AB_2105622

      DOI: 10.1016/j.ebiom.2020.102813

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    sciencedirect.com/science/article/pii/S2352396420301882
  27. academic.oup.com academic.oup.com
    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
    1
    1. scibot 03 Sep 2020
      mTOR

      DOI: 10.1093/jb/mvaa076

      Resource: (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

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      Curator comments: mTOR (7C10) Rabbit mAb antibody Cell Signaling Technology Cat# 2983

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      RRID:AB_2105622 RRIDCUR:Missing
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    academic.oup.com/jb/article/doi/10.1093/jb/mvaa076/5870373
  28. Aug 2020
  29. academic.oup.com academic.oup.com
    Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling
    1
    1. scibot 30 Aug 2020
      RRID:AB_10693786

      DOI: 10.1093/cercor/bhz306

      Resource: (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2105622

      Curator comments: mTOR (7C10) Rabbit mAb antibody Cell Signaling Technology Cat# 2983

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      RRIDCUR:Incorrect RRID:AB_2105622 RRIDCUR:Unresolved
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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhz306/5673286
  30. Jan 2020
  31. www.sciencedirect.com www.sciencedirect.com
    The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2019.07.037

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      RRID:AB_2105622 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719309349
  32. www.mdpi.com www.mdpi.com
    Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.3390/cancers11070910

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    mdpi.com/2072-6694/11/7/910/htm
  33. www.sciencedirect.com www.sciencedirect.com
    Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.neuropharm.2019.107710

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    sciencedirect.com/science/article/pii/S0028390819302680
  34. www.sciencedirect.com www.sciencedirect.com
    Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.neuron.2019.07.011

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    sciencedirect.com/science/article/pii/S0896627319306373
  35. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1002/glia.23682

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    onlinelibrary.wiley.com/doi/abs/10.1002/glia.23682
  36. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1038/s41467-019-13086-5

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    nature.com/articles/s41467-019-13086-5
  37. www.sciencedirect.com www.sciencedirect.com
    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.cmet.2019.07.010

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    sciencedirect.com/science/article/pii/S1550413119303833
  38. www.sciencedirect.com www.sciencedirect.com
    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2019.06.085

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    sciencedirect.com/science/article/pii/S2211124719308654
  39. dev.biologists.org dev.biologists.org
    Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1242/dev.178871

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    dev.biologists.org/content/146/20/dev178871
  40. www.sciencedirect.com www.sciencedirect.com
    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.immuni.2019.06.007

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    sciencedirect.com/science/article/pii/S1074761319302778
  41. academic.oup.com academic.oup.com
    Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1093/cercor/bhz141

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    academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhz141/5540232
  42. www.sciencedirect.com www.sciencedirect.com
    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.stem.2019.05.001

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    sciencedirect.com/science/article/pii/S193459091930205X
  43. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial–Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1158/0008-5472.CAN-18-0620

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      RRID:AB_2105622 RRIDCUR:Validated
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    cancerres.aacrjournals.org/content/79/4/735
  44. www.sciencedirect.com www.sciencedirect.com
    Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.cmet.2019.05.018

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      RRID:AB_2105622 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S155041311930258X
  45. www.sciencedirect.com www.sciencedirect.com
    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2019.07.084

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      RRID:AB_2105622 RRIDCUR:Validated
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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    Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity
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    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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    A Method for the Acute and Rapid Degradation of Endogenous Proteins
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    2. scibot 05 Nov 2018
      RRID:AB_2105622

      Curator: @evieth

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
  88. academic.oup.com academic.oup.com
    Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice
    1
    1. scibot 05 Nov 2018
      AB_2105622

      Curator: @evieth

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Validated
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    academic.oup.com/endo/article/159/1/519/4562294
  89. academic.oup.com academic.oup.com
    IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase
    1
    1. scibot 05 Nov 2018
      AB_2105622

      Curator: @evieth

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Validated
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    academic.oup.com/endo/article/158/12/4270/4117214
  90. Nov 2017
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
    1
    1. scibot 08 Nov 2017
      RRID:AB_2105622

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      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  92. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
    1
    1. scibot 08 Nov 2017
      RRID:AB_2105622

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517304914
  93. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      CSTCat#2983

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622
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    sciencedirect.com/science/article/pii/S1074761317302339
  94. elifesciences.org elifesciences.org
    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
    1
    1. scibot 08 Nov 2017
      AB_2105622

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Validated
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    elifesciences.org/articles/25237
  95. academic.oup.com academic.oup.com
    Maternal Low Protein Isocaloric Diet Suppresses Pancreatic β-Cell Proliferation in Mouse Offspring via miR-15b
    1
    1. scibot 08 Nov 2017
      Cell Signalling Technology; number 2983 

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622
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    academic.oup.com/endo/article/157/12/4782/2758433/Maternal-Low-Protein-Isocaloric-Diet-Suppresses
  96. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
    1
    1. scibot 08 Nov 2017
      AB_2105622

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622
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    sciencedirect.com/science/article/pii/S2405471216304082
  97. elifesciences.org elifesciences.org
    Dynamics of mTORC1 activation in response to amino acids
    2
    1. scibot 08 Nov 2017
      AB_2105622

      Curator: @Zeljana_Babic

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2105622 RRIDCUR:Validated
    2. scibot 08 Nov 2017
      AB_2105622

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622
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    elifesciences.org/articles/19960
  98. www.sciencedirect.com www.sciencedirect.com
    An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
    1
    1. scibot 08 Nov 2017
      Rabbit monoclonal anti-mTOR (7C10)

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867416316671
  99. www.sciencedirect.com www.sciencedirect.com
    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
    1
    1. scibot 08 Nov 2017
      AB_2105622

      Curator: @kaitlinsung

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276516308991
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of mTORC1 by lysosomal calcium and calmodulin
    1
    1. scibot 08 Nov 2017
      AB_2105622

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2105622 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5106211/
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Autophagy inhibition in endogenous and nutrient‐deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro
    1
    1. scibot 08 Nov 2017
      Cell Signaling Technology, rabbit monoclonal, 2983, AB_2105622

      Curator: @bandrow

      Curator note: Cell Signaling Technology Cat# 2983, RRID:AB_2105622

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

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      RRID:AB_2105622
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23733/full
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model
    1
    1. scibot 08 Nov 2017
      AB_2105622

      Curator: @gabimpine

      Resource used:

      (Cell Signaling Technology Cat# 2983, RRID:AB_2105622)

      SciCrunch record: RRID:AB_2105622

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2105622 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC4107404/