259 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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    1. scibot 01 May 2024
      RRID:AB_2105622

      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  3. Apr 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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    1. scibot 24 Apr 2024
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      DOI: 10.7554/eLife.92243

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034944/
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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    1. scibot 23 Apr 2024
      Cell Signaling, 2983S

      DOI: 10.1016/j.antiviral.2024.105891

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      Cell Signaling, 2983S

      DOI: 10.1016/j.antiviral.2024.105891

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    sciencedirect.com/science/article/pii/S0166354224001001
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    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
    2
    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114094

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    sciencedirect.com/science/article/pii/S2211124724004224
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.ebiom.2024.105099

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    sciencedirect.com/science/article/pii/S2352396424001348
  9. Mar 2024
  10. www.biorxiv.org www.biorxiv.org
    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    1. scibot 21 Mar 2024
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      DOI: 10.1101/2024.02.29.582877

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    biorxiv.org/content/10.1101/2024.02.29.582877v1
  11. Feb 2024
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    Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase
    2
    1. scibot 16 Feb 2024
      RRID:AB_2105622

      DOI: 10.1016/j.isci.2024.109102

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      DOI: 10.1016/j.isci.2024.109102

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    sciencedirect.com/science/article/pii/S2589004224003237
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    BPS Publications
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    1. scibot 16 Feb 2024
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      DOI: 10.1111/bph.16283

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16283
  14. content.iospress.com content.iospress.com
    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    1. scibot 16 Feb 2024
      RRID:AB_2105622

      DOI: 10.3233/JAD-221058

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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113714

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    sciencedirect.com/science/article/pii/S2211124724000421
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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    1. scibot 06 Feb 2024
      RRID:AB_3075347

      DOI: 10.1016/j.cmet.2024.01.005

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    sciencedirect.com/science/article/pii/S1550413124000068
  17. Jan 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
    2
    1. scibot 25 Jan 2024
      RRID:AB_2105622

      DOI: 10.1126/sciadv.adi2012

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      DOI: 10.1126/sciadv.adi2012

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers
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      DOI: 10.1158/2767-9764.CRC-23-0275

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    ncbi.nlm.nih.gov/pmc/articles/PMC10793200/
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    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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      DOI: 10.1016/j.cmet.2023.12.016

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    sciencedirect.com/science/article/pii/S1550413123004679
  21. Dec 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.devcel.2023.11.021

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    sciencedirect.com/science/article/pii/S1534580723006196
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    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
    1
    1. scibot 02 Dec 2023
      RRID:AB_2105622

      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
    1
    1. scibot 02 Dec 2023
      RRID:AB_2105622

      DOI: 10.1152/japplphysiol.00246.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678411/
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  27. Nov 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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      DOI: 10.1016/j.isci.2023.108399

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    sciencedirect.com/science/article/pii/S2589004223024768
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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      DOI: 10.1016/j.cmet.2023.10.016

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    sciencedirect.com/science/article/abs/pii/S1550413123003856
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    Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway
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      DOI: 10.1016/j.heliyon.2023.e22800

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    sciencedirect.com/science/article/pii/S2405844023100089
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    PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
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      DOI: 10.1016/j.cmet.2023.11.001

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    sciencedirect.com/science/article/abs/pii/S1550413123004114
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    2
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      RRID:AB_2105622

      DOI: 10.1126/science.adh5021

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      RRID:AB_2105622

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    ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
  33. 52.53.155.43 52.53.155.43
    s11684-022-0959-5 (1)-html.html
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      RRID:AB_2105622

      DOI: 10.3389/fncel.2020.552213

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      DOI: 10.3389/fncel.2020.552213

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    52.53.155.43/248247a6c473b6538a75d1aee7982a849ed2ea8a/s11684-022-0959-5 (2)-html.html
  34. Oct 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
    1
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      RRID:AB_2105622

      DOI: 10.3390/cancers15205082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
  36. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  37. www.science.org www.science.org
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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      RRID:AB_2105622

      DOI: 10.1126/science.adh5021

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    science.org/doi/10.1126/science.adh5021
  38. www.science.org www.science.org
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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      DOI: 10.1126/sciadv.abo3610

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    science.org/doi/10.1126/sciadv.abo3610
  39. www.sciencedirect.com www.sciencedirect.com
    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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      DOI: 10.1016/j.isci.2023.108022

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    sciencedirect.com/science/article/pii/S2589004223020990
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    Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice
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      DOI: 10.1016/j.biopha.2023.115639

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    sciencedirect.com/science/article/pii/S0753332223014373
  41. Sep 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
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      DOI: 10.1016/j.molcel.2023.08.022

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    sciencedirect.com/science/article/pii/S1097276523006585
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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      DOI: 10.1016/j.molcel.2023.08.032

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    sciencedirect.com/science/article/pii/S1097276523006950
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    WNK1 is required during male pachynema to sustain fertility.
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      DOI: 10.1016/j.isci.2023.107616

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    sciencedirect.com/science/article/pii/S2589004223016930
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation
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  46. Aug 2023
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    O-GlcNAcylation of Raptor transduces glucose signals to mTORC1
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    52.53.155.43/d8c850c315bd1ef9a1794152cac296a4123affe5/British J Pharmacology - 2023 - Wang - Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3-html.html
  49. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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  55. Jun 2023
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    ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation
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    The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC
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    Acetate controls endothelial-to-mesenchymal transition
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    Restored autophagy is protective against PAK3-induced cardiac dysfunction
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    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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  61. May 2023
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    ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL
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    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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    A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation
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    eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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  68. Apr 2023
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
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  71. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  73. Feb 2023
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    STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
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    Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix
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  76. Jan 2023
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    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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  79. Dec 2022
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    Ring domains are essential for GATOR2-dependent mTORC1 activation
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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  85. Nov 2022
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    Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies
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  87. Oct 2022
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    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1
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  89. Sep 2022
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    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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    Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
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    Multiplexed protein profiling reveals spatial subcellular signaling networks
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    Determination of mTOR signal pathway in MMTV-TGFα mice ovary at different ages
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    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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  95. Aug 2022
  96. www.sciencedirect.com www.sciencedirect.com
    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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  97. 52.53.155.43 52.53.155.43
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  98. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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  100. Jul 2022
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  102. Jun 2022
  103. 52.53.155.43 52.53.155.43
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation
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    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  109. Apr 2022
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    L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy
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    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  114. Mar 2022
  115. www.sciencedirect.com www.sciencedirect.com
    Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat
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    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    The mTOR chromatin-bound interactome in prostate cancer
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nicotinamide Breaks Effector CD8 T cell Responses by Targeting mTOR Signaling
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    Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin
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  120. Feb 2022
  121. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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  122. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  124. Jan 2022
  125. www.nature.com www.nature.com
    Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  128. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis
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    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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  130. Dec 2021
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    Translational and post-translational control of human naïve versus primed pluripotency
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  132. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  134. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
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  137. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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  138. Nov 2021
  139. 52.53.155.43 52.53.155.43
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  140. Oct 2021
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
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  143. Sep 2021
  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of human mTOR complexes by DEPTOR
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  145. Aug 2021
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    Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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  159. Jul 2021
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    Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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    A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex
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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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    Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock
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  171. Jun 2021
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    TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
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    Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
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  175. May 2021
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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      DOI: 10.1210/endocr/bqaa133

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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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  185. Apr 2021
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    Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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  188. Feb 2021
  189. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    cell.com/molecular-cell/abstract/S1097-2765(20)30836-4
  190. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
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      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.01.012

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  191. www.sciencedirect.com www.sciencedirect.com
    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
    1
    1. scibot 24 Feb 2021
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2021.108744

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    sciencedirect.com/science/article/pii/S2211124721000577
  192. Jan 2021
  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    1
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      RRID:AB_2105622

      DOI: 10.1016/j.cell.2020.12.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  194. Nov 2020
  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
    1
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      RRID:AB_2105622

      DOI: 10.7554/eLife.55994

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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  196. Oct 2020
  197. www.sciencedirect.com www.sciencedirect.com
    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
    1
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    sciencedirect.com/science/article/pii/S2211124720312195
  198. Sep 2020
  199. www.sciencedirect.com www.sciencedirect.com
    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
    1
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      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2020.107753

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    sciencedirect.com/science/article/pii/S2211124720307336
  200. www.sciencedirect.com www.sciencedirect.com
    JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding
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      DOI: 10.1016/j.celrep.2020.107668

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  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
    1
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      DOI: 10.1111/jnc.14979

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14979
  202. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
    1
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      DOI: 10.1016/j.cell.2020.05.053

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    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
    1
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      DOI: 10.1016/j.cmet.2020.04.011

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  204. academic.oup.com academic.oup.com
    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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      DOI: 10.1210/endocr/bqaa037

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    Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex
    1
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    Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
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  207. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  208. www.sciencedirect.com www.sciencedirect.com
    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
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      DOI: 10.1016/j.devcel.2020.02.015

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  209. www.cell.com www.cell.com
    Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
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      RRID:AB_2105622

      DOI: 10.1016/j.cell.2018.11.030

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  210. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.15131

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15131
  211. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
    1
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      DOI: 10.15252/embr.201949898

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    embopress.org/doi/abs/10.15252/embr.201949898
  212. www.sciencedirect.com www.sciencedirect.com
    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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      DOI: 10.1016/j.stem.2019.12.006

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    sciencedirect.com/science/article/pii/S1934590919305247
  213. www.sciencedirect.com www.sciencedirect.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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      DOI: 10.1016/j.cell.2020.02.019

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    sciencedirect.com/science/article/pii/S009286742030163X
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    The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy
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      RRID: AB_2105622

      DOI: 10.1016/j.ebiom.2020.102813

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    sciencedirect.com/science/article/pii/S2352396420301882
  215. academic.oup.com academic.oup.com
    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
    1
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      mTOR

      DOI: 10.1093/jb/mvaa076

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    academic.oup.com/jb/article/doi/10.1093/jb/mvaa076/5870373
  216. Aug 2020
  217. academic.oup.com academic.oup.com
    Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling
    1
    1. scibot 30 Aug 2020
      RRID:AB_10693786

      DOI: 10.1093/cercor/bhz306

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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhz306/5673286
  218. Jan 2020
  219. www.sciencedirect.com www.sciencedirect.com
    The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo
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      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2019.07.037

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    sciencedirect.com/science/article/pii/S2211124719309349
  220. www.mdpi.com www.mdpi.com
    Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
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      RRID:AB_2105622

      DOI: 10.3390/cancers11070910

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    Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice
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      RRID:AB_2105622

      DOI: 10.1016/j.neuropharm.2019.107710

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    Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation
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      DOI: 10.1016/j.neuron.2019.07.011

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  223. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR
    1
    1. scibot 13 Jan 2020
      RRID:AB_2105622

      DOI: 10.1002/glia.23682

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    onlinelibrary.wiley.com/doi/abs/10.1002/glia.23682
  224. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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      DOI: 10.1038/s41467-019-13086-5

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    nature.com/articles/s41467-019-13086-5
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    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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      RRID:AB_2105622

      DOI: 10.1016/j.cmet.2019.07.010

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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2019.06.085

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  227. dev.biologists.org dev.biologists.org
    Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors
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      RRID:AB_2105622

      DOI: 10.1242/dev.178871

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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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      RRID:AB_2105622

      DOI: 10.1016/j.immuni.2019.06.007

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  229. academic.oup.com academic.oup.com
    Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome
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      RRID:AB_2105622

      DOI: 10.1093/cercor/bhz141

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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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      DOI: 10.1016/j.stem.2019.05.001

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  231. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial–Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis
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      RRID:AB_2105622

      DOI: 10.1158/0008-5472.CAN-18-0620

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