295 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2024.115101

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    sciencedirect.com/science/article/pii/S2211124724014529
  3. www.science.org www.science.org
    Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells
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      DOI: 10.1126/scisignal.adi8753

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    science.org/doi/10.1126/scisignal.adi8753
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    The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
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      DOI: 10.1016/j.immuni.2024.11.017

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    sciencedirect.com/science/article/pii/S1074761324005326
  5. Dec 2024
  6. www.sciencedirect.com www.sciencedirect.com
    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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      DOI: 10.1016/j.cell.2024.11.009

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    sciencedirect.com/science/article/pii/S0092867424013266
  7. Nov 2024
  8. www.biorxiv.org www.biorxiv.org
    Structure of the TXNL1-bound proteasome
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      DOI: 10.1101/2024.11.08.622741

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    biorxiv.org/content/10.1101/2024.11.08.622741v1
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
    1
    1. scibot 10 Nov 2024
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      DOI: 10.7554/eLife.97854

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    pmc.ncbi.nlm.nih.gov/articles/PMC11542922/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β2-integrins control HIF1α activation in human neutrophils
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      DOI: 10.3389/fimmu.2024.1406967

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    pmc.ncbi.nlm.nih.gov/articles/PMC11513320/
  11. Oct 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
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      DOI: 10.1101/2024.09.09.612106

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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      DOI: 10.4103/NRR.NRR-D-23-01299

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    ncbi.nlm.nih.gov/pmc/articles/PMC11438333/
  14. Sep 2024
  15. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    1. scibot 27 Sep 2024
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      DOI: 10.1093/hmg/ddae135

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    dx.doi.org/10.1093/hmg/ddae135
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1097276524007032
  17. aacrjournals.org aacrjournals.org
    Activating mTOR mutations are detrimental in nutrient-poor conditions
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      DOI: 10.1158/0008-5472.CAN-22-0121

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    aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
  18. Aug 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    sciencedirect.com/science/article/pii/S1097276524006191
  20. www.sciencedirect.com www.sciencedirect.com
    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.mce.2024.112341

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    sciencedirect.com/science/article/pii/S0303720724001977
  21. www.sciencedirect.com www.sciencedirect.com
    Sestrin2 drives ER-phagy in response to protein misfolding
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      DOI: 10.1016/j.devcel.2024.07.004

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    sciencedirect.com/science/article/pii/S1534580724004416
  22. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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      AB_2105622

      DOI: 10.1152/ajpcell.00385.2020

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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  23. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
    1
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      2983

      DOI: 10.1186/s13578-021-00640-2

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    cellandbioscience.biomedcentral.com/article/10.1186/s13578-021-00640-2
  24. www.embopress.org www.embopress.org
    NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes
    1
    1. scibot 02 Aug 2024
      Rabbit monoclonal mTOR

      DOI: 10.15252/embj.2020105990

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    embopress.org/doi/full/10.15252/embj.2020105990
  25. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
    1
    1. scibot 02 Aug 2024
      mTOR

      DOI: 10.1016/j.molcel.2020.11.008

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  26. Jul 2024
  27. www.sciencedirect.com www.sciencedirect.com
    Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice
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      AB_2105622

      DOI: 10.1016/j.jare.2024.07.024

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    sciencedirect.com/science/article/pii/S2090123224003096
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    Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms
    1
    1. scibot 19 Jul 2024
      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2024.114414

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    sciencedirect.com/science/article/pii/S2211124724007435
  29. www.sciencedirect.com www.sciencedirect.com
    Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway
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      AB_2105622

      DOI: 10.1016/j.isci.2024.110429

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    sciencedirect.com/science/article/pii/S2589004224016547
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    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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      DOI: 10.1016/j.isci.2024.110467

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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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      DOI: 10.1016/j.xcrm.2024.101645

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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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      RRID: AB_2105622

      DOI: 10.3892/or.2024.8760

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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  33. Jun 2024
  34. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
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    Cardioprotective effect of Cinnamamide derivative compound 10 against myocardial ischemia-reperfusion through regulating cardiac autophagy via Sirt1
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      DOI: 10.1016/j.biopha.2024.116819

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    sciencedirect.com/science/article/pii/S0753332224007030
  36. May 2024
  37. academic.oup.com academic.oup.com
    Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy
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      RRID:AB_2105622

      DOI: 10.1210/endocr/bqae030

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    academic.oup.com/endo/article-abstract/165/5/bqae030/7630457
  38. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
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      DOI: 10.1038/nature05972

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    52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
  39. www.sciencedirect.com www.sciencedirect.com
    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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      RRID:AB_2105622

      DOI: 10.1016/j.xcrm.2024.101552

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    sciencedirect.com/science/article/pii/S2666379124002441
  40. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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      RRID:AB_2105622

      DOI: 10.1016/j.celrep.2024.114173

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      DOI: 10.1016/j.celrep.2024.114173

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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  41. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      RRID:AB_2105622

      DOI: 10.1111/bph.16391

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
  42. www.cell.com www.cell.com
    Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
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      RRID:AB_2105622

      DOI: 10.1016/j.xcrm.2024.101519

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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00188-5
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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      RRID:AB_2105622

      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  44. Apr 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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    1. scibot 24 Apr 2024
      RRID:AB_2105622

      DOI: 10.7554/eLife.92243

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034944/
  46. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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      Cell Signaling, 2983S

      DOI: 10.1016/j.antiviral.2024.105891

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      Cell Signaling, 2983S

      DOI: 10.1016/j.antiviral.2024.105891

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    sciencedirect.com/science/article/pii/S0166354224001001
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    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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      RRID:AB_2105622

      DOI: 10.1016/j.immuni.2024.03.021

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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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  75. Oct 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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  90. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
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  96. Jun 2023
  97. www.sciencedirect.com www.sciencedirect.com
    ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation
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    The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC
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    Acetate controls endothelial-to-mesenchymal transition
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    Restored autophagy is protective against PAK3-induced cardiac dysfunction
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  101. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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  102. May 2023
  103. 52.53.155.43 52.53.155.43
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    ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL
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    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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    A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation
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  107. www.embopress.org www.embopress.org
    eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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  109. Apr 2023
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
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  112. Mar 2023
  113. www.sciencedirect.com www.sciencedirect.com
    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  114. Feb 2023
  115. academic.oup.com academic.oup.com
    STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
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    Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix
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  117. Jan 2023
  118. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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  120. Dec 2022
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    Ring domains are essential for GATOR2-dependent mTORC1 activation
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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  123. 52.53.155.43 52.53.155.43
    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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  124. www.sciencedirect.com www.sciencedirect.com
    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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  126. Nov 2022
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    Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies
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  128. Oct 2022
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1
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  130. Sep 2022
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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  132. www.sciencedirect.com www.sciencedirect.com
    Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiplexed protein profiling reveals spatial subcellular signaling networks
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  134. www.tandfonline.com www.tandfonline.com
    Determination of mTOR signal pathway in MMTV-TGFα mice ovary at different ages
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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  136. Aug 2022
  137. www.sciencedirect.com www.sciencedirect.com
    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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  138. 52.53.155.43 52.53.155.43
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    Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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  141. Jul 2022
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  143. Jun 2022
  144. 52.53.155.43 52.53.155.43
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates Neuroinflammation via PI3K/Akt/mTOR Signaling Pathway in Alzheimer’s-Like Disease Model
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    Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation
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    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  150. Apr 2022
  151. www.sciencedirect.com www.sciencedirect.com
    L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy
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    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  155. Mar 2022
  156. www.sciencedirect.com www.sciencedirect.com
    Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat
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    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    The mTOR chromatin-bound interactome in prostate cancer
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    Nicotinamide Breaks Effector CD8 T cell Responses by Targeting mTOR Signaling
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    Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin
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  161. Feb 2022
  162. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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  163. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  165. Jan 2022
  166. www.nature.com www.nature.com
    Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  169. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis
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    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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  171. Dec 2021
  172. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
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  173. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
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  178. www.nature.com www.nature.com
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  179. Nov 2021
  180. 52.53.155.43 52.53.155.43
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  181. Oct 2021
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
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  184. Sep 2021
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  186. Aug 2021
  187. www.sciencedirect.com www.sciencedirect.com
    Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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  189. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice
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