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Mar 2025
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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

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The compound... : Neural Regeneration Research

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Treadmill exercise in combination with acousto-optic and... : Neural Regeneration Research

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Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid

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Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

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1-s2.0-S2589004225003700-main-html.html

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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis

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Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds

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Cannabinoid Receptor Type 2 Agonist, GW405833, Reduced the Impacts of MDA-MB-231 Breast Cancer Cells on Bone Cells

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  DOI: 10.1002/cam4.70709
  
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onlinelibrary.wiley.com/doi/10.1002/cam4.70709
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The TSH receptor antibody reactome contributes to retro-orbital inflammation

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  DOI: 10.1210/jendso/bvae182
  
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BPS Publications

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  DOI: 10.1111/bph.17475
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17475
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HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

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Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling

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  DOI: 10.3389/fmolb.2025.1537523
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11821485/
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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

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  DOI: 10.7554/eLife.97268
  
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Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling

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  DOI: 10.1158/1535-7163.MCT-21-0848
  
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aacrjournals.org/mct/article/21/7/1160/705294/Peptide-PDHPS1-Inhibits-Ovarian-Cancer-Growth
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Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer

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  DOI: 10.1158/0008-5472.CAN-23-3987
  
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aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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mTORC2 Regulates Actin Polymerization in Auditory Cells

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hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways

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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice

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The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin

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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons

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1-s2.0-S2589004225002160-main-html.html

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Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation

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Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling

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Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization

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Jan 2025
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Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial

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Lactate homeostasis is maintained through regulation of glycolysis and lipolysis

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  DOI: 10.1016/j.cmet.2024.12.009
  
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Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction

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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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  DOI: 10.1016/j.molcel.2024.12.025
  
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Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity

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  DOI: 10.1158/0008-5472.CAN-24-1509
  
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Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients

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  DOI: 10.1016/j.cell.2024.12.010
  
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Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring

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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

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Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

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Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

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Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches

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Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding

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The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies

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Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

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Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1

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FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology

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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

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Porphyromonas gingivalis-Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis

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Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer

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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery

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Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing

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Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism

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MOTS-c modulates skeletal muscle function by directly binding and activating CK2

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Reprogramming of fibroblasts into cancer-associated fibroblasts via IGF2-mediated autophagy promotes metastasis of lung cancer cells

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Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy

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Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice

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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981

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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia

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Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1

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Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

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Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

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Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development

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Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females

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Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis

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Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death

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NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs

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Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases

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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction

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  DOI: 10.1038/s41467-024-52587-w
  
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Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus

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TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus

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A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis

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mTOR activity paces human blastocyst stage developmental progression

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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

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FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation

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mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes

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IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion

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Impact of WIN site inhibitor on the WDR5 interactome

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  RRID:AB_2797780
  
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Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice

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Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers

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Novel Miniaturized Drug Conjugate Leverages HSP90 Driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors

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Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels

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PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes

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  RRID:AB_329825
  
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Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis

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Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

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  RRID:AB_2224726
  
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Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis

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Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation

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Endothelial metabolic control of insulin sensitivity through resident macrophages

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Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial

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Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma

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Activating mTOR mutations are detrimental in nutrient-poor conditions

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  DOI: 10.1158/0008-5472.CAN-22-0121
  
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aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming

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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response

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Aldehydes alter TGF-β signaling and induce obesity and cancer

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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo

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Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

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Acetate enables metabolic fitness and cognitive performance during sleep disruption

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Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients

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Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation

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Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model

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Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway

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Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons

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mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology

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Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway

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Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

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Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

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E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network

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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice

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Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling

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Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization

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Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway

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A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model

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Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

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RHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance

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PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1

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BPS Publications

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Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling

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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

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Notch2 signaling governs activated B cells to form memory B cells

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Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors

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Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell

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Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor

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Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits

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Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies

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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer

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Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice

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Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model

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Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer

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eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

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mct-23-0285-html.html

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Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway

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Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation

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Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma

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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder

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Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance

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Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction

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Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis

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Contrasting consequences of podocyte IGF1R inhibition

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor

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Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

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Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis

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Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas

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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption

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Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells

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Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer

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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect

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Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system

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Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis

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BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

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A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

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Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy

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Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1

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Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

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ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis

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CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo

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12958_2024_1204_MOESM1_ESM-html.html

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Oct4 controls basement membrane development during human embryogenesis

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AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer

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The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells

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Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome

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The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan

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Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina

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Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor

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Nanodrug-bacteria conjugates-mediated oncogenic collagen depletion enhances immune checkpoint blockade therapy against pancreatic cancer

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Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy

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