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    Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
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    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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    BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
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  8. Apr 2024
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
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    Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
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    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    12958_2024_1204_MOESM1_ESM-html.html
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    Oct4 controls basement membrane development during human embryogenesis
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    AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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    The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan
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    Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina
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    Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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    Nanodrug-bacteria conjugates-mediated oncogenic collagen depletion enhances immune checkpoint blockade therapy against pancreatic cancer
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    Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy
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    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
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    TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice
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    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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    CircTBC1D22A inhibits the progression of colorectal cancer through autophagy regulated via miR-1825/ATG14 axis
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells
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  38. Feb 2024
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    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
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    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2
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    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology
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    Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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    AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing
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  175. www.nature.com www.nature.com
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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    Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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    Identification of XAF1 as an endogenous AKT inhibitor
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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