1,123 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
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    1. scibot 21 Dec 2024
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      DOI: 10.1101/2024.07.17.603931

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    pmc.ncbi.nlm.nih.gov/articles/PMC11275733/
  3. pubs.acs.org pubs.acs.org
    Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1
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    1. scibot 20 Dec 2024
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    FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
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    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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  6. Dec 2024
  7. 52.53.155.43 52.53.155.43
    can-24-0456-html.html
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    Porphyromonas gingivalis-Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis
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    onlinelibrary.wiley.com/doi/10.1111/jre.13372
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
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  10. 52.53.155.43 52.53.155.43
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
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    Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
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    sciencedirect.com/science/article/pii/S1934590924003771
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    Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
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    Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
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    1. scibot 02 Dec 2024
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  18. Nov 2024
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MOTS-c modulates skeletal muscle function by directly binding and activating CK2
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    Reprogramming of fibroblasts into cancer-associated fibroblasts via IGF2-mediated autophagy promotes metastasis of lung cancer cells
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    sciencedirect.com/science/article/pii/S2589004224024945
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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      DOI: 10.7554/eLife.101652

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    Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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    pmc.ncbi.nlm.nih.gov/articles/PMC11544388/
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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    1. scibot 14 Nov 2024
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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      DOI: 10.2147/JIR.S481101

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  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1
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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis
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  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation
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  29. www.jneurosci.org www.jneurosci.org
    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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  32. Oct 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    ncbi.nlm.nih.gov/pmc/articles/PMC11456883/
  34. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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      DOI: 10.1158/2326-6066.CIR-24-0061

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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
  35. aacrjournals.org aacrjournals.org
    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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      DOI: 10.1158/1535-7163.MCT-20-0590

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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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      DOI: 10.4103/NRR.NRR-D-23-01299

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  38. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  39. Sep 2024
  40. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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  41. link.springer.com link.springer.com
    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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  42. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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      DOI: 10.1111/bph.17306

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  43. www.sciencedirect.com www.sciencedirect.com
    mTOR activity paces human blastocyst stage developmental progression
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    Novel Miniaturized Drug Conjugate Leverages HSP90 Driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
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    Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels
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    PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
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    Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
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    Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis
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    Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
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    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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