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2,057 Matching Annotations

Dec 2024
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METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma

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  DOI: 10.1038/s44318-024-00299-8
  
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Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay

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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

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Control of 3′ splice site selection by the yeast splicing factor Fyv6

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  DOI: 10.7554/eLife.100449
  
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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

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  DOI: 10.1126/sciadv.adp7423
  
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Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine

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  DOI: 10.1038/s41467-024-55033-z
  
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nature.com/articles/s41467-024-55033-z
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Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway

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Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes

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DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells

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CCDC134 controls TLR biogenesis through the ER chaperone Gp96

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  DOI: 10.1084/jem.20240825
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11629888/
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Molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells

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1-s2.0-S2589004224027652-main-html.html

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Reactive oxygen species control protein degradation at the mitochondrial import gate

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

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  DOI: 10.1038/s44318-024-00276-1
  
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p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis

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DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states

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Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module

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cell.com/molecular-cell/fulltext/S1097-2765(24)00734-2
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DDX18 influences chemotherapy sensitivity in colorectal cancer by regulating genomic stability

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  DOI: 10.1016/j.yexcr.2024.114344
  
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lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing

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  DOI: 10.1016/j.molcel.2024.10.036
  
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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

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AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection

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Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss

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Autophagy-dependent splicing control directs translation toward inflammation during senescence

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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

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Regulatory mechanisms of strigolactone perception in rice

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SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells

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Porcine NLRC3 specially binds short dsDNA to regulate cGAS activation

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Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

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  DOI: 10.1038/s44318-024-00290-3
  
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wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html

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Degradome analysis to identify direct protein substrates of small-molecule degraders

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Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment

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A functional connection between the Microprocessor and a variant NEXT complex

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SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons

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  DOI: 10.1016/j.isci.2024.111156
  
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Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction

1
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  DOI: 10.1038/s44318-024-00233-y
  
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Protocol to identify E3 ligases amenable to biodegraders using a cell-based screening

1
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Reduced mesencephalic astrocyte-derived neurotrophic factor ... : Neural Regeneration Research

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  DOI: 10.4103/NRR.NRR-D-23-01666
  
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Targeting vasohibins to promote axon regeneration

1
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  DOI: 10.1523/JNEUROSCI.2031-23.2024
  
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Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon

1
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  DOI: 10.1016/j.cmet.2024.09.002
  
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ERK1/2 mitogen-activated protein kinase dimerization is essential for the regulation of cell motility

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  DOI: 10.1002/1878-0261.13732
  
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Pervasive mislocalization of pathogenic coding variants underlying human disorders

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Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance

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EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization

1
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An AAGAB-to-CCDC32 handover mechanism controls the assembly of the AP2 adaptor complex

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  DOI: 10.1073/pnas.2409341121
  
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Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

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Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function

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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

1
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  DOI: 10.1016/j.isci.2024.110693
  
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C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes

1
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  DOI: 10.1016/j.molcel.2024.08.037
  
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A TBK1-independent primordial function of STING in lysosomal biogenesis

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  AB_262044
  
  DOI: 10.1016/j.molcel.2024.08.026
  
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gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination

1
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  AB_262044
  
  DOI: 10.1016/j.isci.2024.110847
  
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ZIKV Induces P62-Mediated Autophagic Degradation of TRAF6 through TRAF6-NS1 Interaction

1
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  AB_262044
  
  DOI: 10.1016/j.isci.2024.110757
  
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Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity

1
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  DOI: 10.1016/j.celrep.2024.114674
  
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Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles

1
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  AB_262044
  
  DOI: 10.1016/j.immuni.2024.08.013
  
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The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance

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  RRID:AB_1537400
  
  DOI: 10.1016/j.celrep.2020.108102
  
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Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions

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  DOI: 10.1016/j.molcel.2020.01.006
  
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PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks

1
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  RRID:AB_259529
  
  DOI: 10.1016/j.celrep.2019.09.054
  
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Determination of the Gene Regulatory Network of a Genome-Reduced Bacterium Highlights Alternative Regulation Independent of Transcription Factors

1
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  DOI: 10.1016/j.cels.2019.07.001
  
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Untitled document

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  RRID:AB_439685
  
  DOI: 10.7554/eLife.40806
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.099
  
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Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems

1
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  RRID:AB_2620044
  
  DOI: 10.1016/j.molcel.2018.04.010
  
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Thermo-Induced Maintenance of Photo-oxidoreductases Underlies Plant Autotrophic Development

1
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  SCR_008988
  
  DOI: 10.1016/j.devcel.2017.03.005
  
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Nuclear actin is a critical regulator of Drosophila female germline stem cell maintenance

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  DOI: 10.1101/2024.08.27.609996
  
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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

1
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  AB_262044
  
  DOI: 10.1016/j.celrep.2024.114739
  
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Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function

1
1. scibot 13 Sep 2024
  
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  DOI: 10.1016/j.neuron.2024.08.009
  
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Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis

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  DOI: 10.1016/j.isci.2024.110683
  
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TGF-β and RAS jointly unmask primed enhancers to drive metastasis

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  AB_262044
  
  DOI: 10.1016/j.cell.2024.08.014
  
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Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ

1
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  AB_262044
  
  DOI: 10.1016/j.celrep.2024.114695
  
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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

1
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  AB_262044
  
  DOI: 10.1016/j.molcel.2024.08.014
  
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CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

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  DOI: 10.7554/eLife.94245
  
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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

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Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection

1
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Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS

1
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  DOI: 10.1016/j.neuron.2024.07.025
  
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The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton

1
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Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

1
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CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

1
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Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis

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Acetate enables metabolic fitness and cognitive performance during sleep disruption

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TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

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Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA

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  DOI: 10.1093/genetics/iyae120
  
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A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development

1
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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

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  DOI: 10.1085/jgp.202313518
  
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Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m6A modification in the nucleus

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  DOI: 10.1016/j.molcel.2024.07.017
  
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The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network

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  DOI: 10.1016/j.celrep.2024.114617
  
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SLC25A48 controls mitochondrial choline import and metabolism

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RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes

1
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  DOI: 10.1016/j.celrep.2024.114594
  
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Small GTPase ActIvitY ANalyzing (SAIYAN) system: A method to detect GTPase activation in living cells

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  DOI: 10.1083/jcb.202403179
  
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

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Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease

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FolIws1-driven nuclear translocation of deacetylated FolTFIIS ensures conidiation of Fusarium oxysporum

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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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Quantifying genome-wide transcription factor binding affinities for chromatin using BANC-seq

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  DOI: 10.1038/s41596-024-01026-7
  
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CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex

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Sestrin2 drives ER-phagy in response to protein misfolding

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A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

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SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways

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  DOI: 10.1126/scisignal.abc7611
  
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M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival

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  DOI: 10.1080/15548627.2021.1938912
  
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molecularbrain.biomedcentral.com molecularbrain.biomedcentral.com

LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron

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  DOI: 10.1186/s13041-020-00708-z
  
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Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain

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onlinelibrary.wiley.com/doi/10.1111/jnc.13369/full
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Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain

1
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  DOI: 10.1002/cne.24048
  
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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

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A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

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ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins

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  DOI: 10.1016/j.celrep.2024.114473
  
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A CPF-like phosphatase module links transcription termination to chromatin silencing

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1-s2.0-S2589004224017851-main-html.html

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Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis

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Arabidopsis COP1 suppresses root hair development by targeting type I ACS proteins for ubiquitination and degradation

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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

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Structural insights into the role and targeting of EGFRvIII

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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism

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PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html

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Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma

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Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis

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PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1

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Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection

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Dimerization of hub protein DYNLL1 and bZIP transcription factor CREB3L1 enhances transcriptional activation of CREB3L1 target genes like arginine vasopressin

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The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules

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Regulation of the DLC3 tumor suppressor by a novel phosphoswitch

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Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

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Leep2A and Leep2B function as a RasGAP complex to regulate macropinosome formation

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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

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ASGR1 Is a Promising Target for Lipid Reduction in Pigs with PON2 As Its Inhibitor

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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

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Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1

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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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Drosophila model to study Retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion

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Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1

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Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching

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Chromosome compaction is triggered by an autonomous DNA-binding module within condensin

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Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation

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CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

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The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation

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RDH12 allows cone photoreceptors to regenerate opsin visual pigments from a chromophore precursor to escape competition with rods

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Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells

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Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation

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The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

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Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

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ROS are required for the germinative cell proliferation and metacestode larval growth of Echinococcus multilocularis

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KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

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LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos

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Dzip1 is dynamically expressed in the vertebrate germline and regulates the development of Xenopus primordial germ cells

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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state

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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels

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Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing

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SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms

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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells

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Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function

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Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro

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RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly

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TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

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Conversion of natural cytokine receptors into orthogonal synthetic biosensors

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Distinct roles of TREM2 in central nervous system cancers and peripheral cancers

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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor

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Active nuclear positioning and actomyosin contractility maintain leader cell integrity during gonadogenesis

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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease

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Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

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TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks

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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

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Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains

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Whi5 hypo- and hyper-phosphorylation dynamics control cell-cycle entry and progression

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EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells

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The deubiquitylating enzyme Fat Facets modulates Fat signalling and regulates tissue growth

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Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders

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Synchronizing Drosophila larvae with the salivary gland reporter Sgs3-GFP for discovery of phenotypes in the late third instar stage.

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway

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bqae039-html.html

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Ubiquitin-mediated regulation of APE2 protein abundance

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  DOI: 10.1016/j.jbc.2024.107337
  
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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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  DOI: 10.1126/sciadv.adl6082
  
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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling

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  DOI: 10.1158/0008-5472.CAN-23-2268
  
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CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1-loop300

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  DOI: 10.1016/j.celrep.2024.114155
  
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Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

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The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration

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  DOI: 10.1016/j.celrep.2024.114177
  
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A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture

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  DOI: 10.1016/j.cub.2024.04.028
  
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A critical suppression feedback loop determines soybean photoperiod sensitivity

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  DOI: 10.1016/j.devcel.2024.04.004
  
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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  DOI: 10.1016/j.celrep.2024.113924
  
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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  DOI: 10.1093/narcan/zcae018
  
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Protocol for efficient CRISPR-Cas9-mediated fluorescent tag knockin in hard-to-transfect erythroid cell lines

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  DOI: 10.1016/j.xpro.2024.103016
  
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ISGylation by HERCs facilitates STING activation

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  DOI: 10.1016/j.celrep.2024.114135
  
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The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture

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  DOI: 10.1158/0008-5472.CAN-22-3950
  
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New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol

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  DOI: 10.1161/ATVBAHA.122.318839
  
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Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome

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  DOI: 10.1016/j.celrep.2024.114111
  
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Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition

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  DOI: 10.1016/j.celrep.2024.114118
  
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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

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  DOI: 10.1016/j.devcel.2024.03.030
  
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Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking

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1. scibot 12 Apr 2024
  
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  DOI: 10.1101/2024.04.05.587610
  
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SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion

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  DOI: 10.1016/j.isci.2024.109607
  
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TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect

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  DOI: 10.1016/j.isci.2024.109541
  
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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

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  DOI: 10.1038/s41593-024-01615-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11088998/

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