2,193 Matching Annotations
  1. Jun 2025
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    CRAMP1 drives linker histone expression to enable Polycomb repression
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    sciencedirect.com/science/article/pii/S1097276525004708
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    The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible
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    sciencedirect.com/science/article/pii/S1097276525004654
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    A Commander-independent function of COMMD3 in endosomal trafficking
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    elifesciences.org/reviewed-preprints/105264
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel loss-of-function variant in STAT1 causes Mendelian susceptibility to mycobacterial disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12146302/
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    Enhanced memory despite severe sleep loss in Drosophila insomniac mutants
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    pmc.ncbi.nlm.nih.gov/articles/PMC12135902/
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    GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake
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    science.org/doi/10.1126/science.adp3989
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    Methionine-triggered growth arrest reveals activation of Gcn2 by methionine transporter endocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132241/
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    Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling
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    sciencedirect.com/science/article/pii/S2211124725005820
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    Synaptic activity causes minute-scale changes in BAF complex composition and function
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    sciencedirect.com/science/article/pii/S1097276525004563
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    Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51
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    cell.com/molecular-cell/abstract/S1097-2765(25)00446-0
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    Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
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    Rifampin mediated decapsulation and enhanced bacterial clearance: a new mechanism of rifamycins
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    PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity
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    sciencedirect.com/science/article/pii/S221112472500556X
  15. May 2025
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    Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
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    sciencedirect.com/science/article/pii/S2211124725005376
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    A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment
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    science.org/doi/10.1126/sciadv.adv1281
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    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627325003459
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    β-synuclein blocks α-synuclein condensate fusion to disrupt the maturation of phase separation
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    Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes
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    A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12101511/
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    CapdevilaCastillo_columbia_0054D_18600-html.html
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    ATP-release pannexin channels are gated by lysophospholipids
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    elifesciences.org/articles/107067
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    SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7
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    elifesciences.org/articles/102277
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
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    Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70079
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    A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation
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    Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle
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    eIF5A controls mitoprotein import by relieving ribosome stalling at TIM50 translocase mRNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11551009/
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    Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging
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    ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
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    nature.com/articles/s41556-025-01651-8
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    Engineering ARMMs for improved intracellular delivery of CRISPR-Cas9
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    DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation
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    Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells
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    OsHYPK/NatA-mediated N-terminal acetylation regulates the homeostasis of NLR immune protein to fine-tune rice immune responses and growth
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    Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation
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    NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis
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    Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
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    EFA6A, a Guanine Nucleotide Exchange Factor for Arf6, Regulates Developmental Stage-Dependent Spine Morphogenesis, Synaptic Plasticity, and Long-Term Memory in the Hippocampus
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  40. 52.53.155.43 52.53.155.43
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  41. Apr 2025
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    Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing
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    Dynamic control of H2A.Zub and H3K27me3 by ambient temperature during cell fate determination in Arabidopsis
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    Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction
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    sciencedirect.com/science/article/pii/S1550413125002116
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    The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005378/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MIA40 suppresses cell death induced by apoptosis-inducing factor 1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11976965/
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    Distinct roles of spindle checkpoint proteins in meiosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617576/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
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    pmc.ncbi.nlm.nih.gov/articles/PMC11980836/
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    ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
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    science.org/doi/10.1126/sciadv.adu5091
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    Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics
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    Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement
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    Proton perception and activation of a proton-sensing GPCR
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    DUX-mediated configuration of p300/CBP drives minor zygotic genome activation independent of its catalytic activity
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    Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137002/
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    A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance
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    RAF1 kinase contributes to autophagic lysosome reformation
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  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis
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    Identification of the core regulatory program driving NEUROD1-induced neuronal reprogramming
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    Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription
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    Complementary Ribo-seq approaches map the translatome and provide a small protein census in the foodborne pathogen Campylobacter jejuni
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    pmc.ncbi.nlm.nih.gov/articles/PMC11955535/
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    The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibition
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    cell.com/cell-reports/fulltext/S2211-1247(25)00259-1
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    Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity
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    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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  64. Mar 2025
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    PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth
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    The HAVCR1-centric host factor network drives Zika virus vertical transmission
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    An in vivo screen identifies NAT10 as a master regulator of brain metastasis
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    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870510/
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    Binding domain mutations provide insight into CTCF’s relationship with chromatin and its contribution to gene regulation
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    cell.com/cell-genomics/fulltext/S2666-979X(25)00069-2
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    Small-molecule RNA therapeutics to target prostate cancer
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    cell.com/cancer-cell/abstract/S1535-6108(25)00079-0
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914429/
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    Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
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    Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
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    Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906161/
  77. elifesciences.org elifesciences.org
    A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
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    elifesciences.org/articles/98704
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    Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration
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    PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
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    The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti-Tumor Effector Cytotoxic T Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202410241
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    Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12124131/
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    Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC7480018/
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    SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
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    HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
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  85. Feb 2025
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    Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality
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    Florigen-producing cells express FPF1-LIKE PROTEIN 1 to accelerate flowering and stem growth in Arabidopsis
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    TFEB/3 govern repair Schwann cell generation and function following peripheral nerve injury
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    jneurosci.org/content/44/35/e0198242024
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    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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    Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations
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    sciencedirect.com/science/article/pii/S2666979X25000345
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    A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin
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