472 Matching Annotations
  1. Dec 2022
  2. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    1. scibot 31 Dec 2022
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      DOI: 10.15252/embj.2022111961

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    embopress.org/doi/10.15252/embj.2022111961
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor necrosis factor is a necroptosis-associated alarmin
    1
    1. scibot 30 Dec 2022
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      DOI: 10.3389/fimmu.2022.1074440

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    ncbi.nlm.nih.gov/pmc/articles/PMC9791252/
  4. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Allicin ameliorates IMQ-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A
    1
    1. scibot 23 Dec 2022
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      DOI: 10.1111/bph.15983

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15983
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vagus nerve stimulation is a potential treatment for ischemic stroke
    1
    1. scibot 02 Dec 2022
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      DOI: 10.4103/1673-5374.350698

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    ncbi.nlm.nih.gov/pmc/articles/PMC9700118/
  6. Nov 2022
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 19 Nov 2022
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      DOI: 10.1111/bph.15949

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15949
  8. www.embopress.org www.embopress.org
    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
    1
    1. scibot 19 Nov 2022
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      DOI: 10.15252/embj.2022112006

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    embopress.org/doi/10.15252/embj.2022112006
  9. www.science.org www.science.org
    An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice
    1
    1. scibot 12 Nov 2022
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      DOI: 10.1126/scisignal.abi8713

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    science.org/doi/10.1126/scisignal.abi8713
  10. www.sciencedirect.com www.sciencedirect.com
    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
    1
    1. scibot 10 Nov 2022
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      DOI: 10.1016/j.jcmgh.2022.09.006

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    sciencedirect.com/science/article/pii/S2352345X22001989
  11. www.cell.com www.cell.com
    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
    1
    1. scibot 10 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111497

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    cell.com/cell-reports/abstract/S2211-1247(22)01347-X
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage
    1
    1. scibot 10 Nov 2022
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      DOI: 10.3389/fnagi.2022.967825

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    ncbi.nlm.nih.gov/pmc/articles/PMC9637852/
  13. link.springer.com link.springer.com
    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
    1
    1. scibot 05 Nov 2022
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      DOI: 10.1007/s13402-022-00737-x

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    link.springer.com/article/10.1007/s13402-022-00737-x
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell intrinsic TIM-3 induces glioblastoma progression
    1
    1. scibot 04 Nov 2022
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      DOI: 10.1016/j.isci.2022.105329

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    ncbi.nlm.nih.gov/pmc/articles/PMC9618784/
  15. Oct 2022
  16. www.sciencedirect.com www.sciencedirect.com
    Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
    2
    1. scibot 11 Oct 2022
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      DOI: 10.1016/j.devcel.2022.09.002

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      RRID:AB_331284

      DOI: 10.1016/j.devcel.2022.09.002

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    sciencedirect.com/science/article/pii/S1534580722006323
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
    1
    1. scibot 02 Oct 2022
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      DOI: 10.1016/j.isci.2022.105118

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    ncbi.nlm.nih.gov/pmc/articles/PMC9519628/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection
    1
    1. scibot 01 Oct 2022
      RRID:AB_331284

      DOI: 10.1016/j.celrep.2022.111441

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    ncbi.nlm.nih.gov/pmc/articles/PMC9474420/
  19. Sep 2022
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
    1
    1. scibot 30 Sep 2022
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      DOI: 10.1016/j.isci.2022.105145

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    ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
  21. link.springer.com link.springer.com
    Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1007/s11064-022-03751-5

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    link.springer.com/article/10.1007/s11064-022-03751-5
  22. www.sciencedirect.com www.sciencedirect.com
    Synergistic effect of mild traumatic brain injury and alcohol aggravates neuroinflammation, amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations: Impact on psychological stress
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1016/j.expneurol.2022.114222

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    sciencedirect.com/science/article/pii/S0014488622002473
  23. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy
    1
    1. scibot 09 Sep 2022
      RRID:AB_331284

      DOI: 10.1002/jcla.24631

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    onlinelibrary.wiley.com/doi/10.1002/jcla.24631
  24. Aug 2022
  25. www.sciencedirect.com www.sciencedirect.com
    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
    1
    1. scibot 30 Aug 2022
      RRID:AB_331284

      DOI: 10.1016/j.isci.2022.104923

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    sciencedirect.com/science/article/pii/S2589004222011956
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1 β-Induced Endothelium Injury
    1
    1. scibot 26 Aug 2022
      RRID:AB_331284

      DOI: 10.3390/antiox11081455

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    ncbi.nlm.nih.gov/pmc/articles/PMC9394259/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-inflammatory effects of neutral lipids, glycolipids, phospholipids from Halocynthia aurantium tunic by suppressing the activation of NF-κB and MAPKs in LPS-stimulated RAW264.7 macrophages
    1
    1. scibot 22 Aug 2022
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      DOI: 10.1371/journal.pone.0270794

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    ncbi.nlm.nih.gov/pmc/articles/PMC9377571/
  28. www.sciencedirect.com www.sciencedirect.com
    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
    1
    1. scibot 17 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111225

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    sciencedirect.com/science/article/pii/S2211124722010427
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
    1
    1. scibot 13 Aug 2022
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      DOI: 10.1016/j.cell.2016.07.019

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    ncbi.nlm.nih.gov/pmc/articles/PMC5002269/
  30. www.sciencedirect.com www.sciencedirect.com
    Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling
    1
    1. scibot 12 Aug 2022
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      DOI: 10.1016/j.neuron.2022.07.015

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    sciencedirect.com/science/article/pii/S0896627322006602
  31. www.sciencedirect.com www.sciencedirect.com
    N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis
    1
    1. scibot 04 Aug 2022
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      DOI: 10.1016/j.devcel.2022.07.006

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    sciencedirect.com/science/article/pii/S1534580722004956
  32. www.sciencedirect.com www.sciencedirect.com
    CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
    1
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      DOI: 10.1016/j.cmet.2022.07.005

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    sciencedirect.com/science/article/pii/S1550413122003047
  33. Jul 2022
  34. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 29 Jul 2022
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      DOI: 10.1111/bph.15912

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      DOI: 10.1111/bph.15912

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15912
  35. www.sciencedirect.com www.sciencedirect.com
    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination
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      DOI: 10.1016/j.isci.2022.104607

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    sciencedirect.com/science/article/pii/S2589004222008793
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification
    1
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      DOI: 10.3389/fcvm.2022.885293

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    ncbi.nlm.nih.gov/pmc/articles/PMC9251177/
  37. Jun 2022
  38. www.sciencedirect.com www.sciencedirect.com
    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
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      DOI: 10.1016/j.isci.2022.104561

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    sciencedirect.com/science/article/pii/S2589004222008331
  39. www.sciencedirect.com www.sciencedirect.com
    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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      DOI: 10.1016/j.isci.2022.104519

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    sciencedirect.com/science/article/pii/S2589004222007908
  40. academic.oup.com academic.oup.com
    Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1/2 and inflammasome activation in PCOS
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      DOI: 10.1210/clinem/dgac281

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac281/6581607
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury
    1
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      DOI: 10.3390/toxins14050337

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    ncbi.nlm.nih.gov/pmc/articles/PMC9147548/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
    1
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  43. May 2022
  44. www.nature.com www.nature.com
    Effects of interleukin 1β on long noncoding RNA and mRNA expression profiles of human synovial fluid derived mesenchymal stem cells
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      DOI: 10.1038/s41598-022-12190-9

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    nature.com/articles/s41598-022-12190-9
  45. www.sciencedirect.com www.sciencedirect.com
    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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      DOI: 10.1016/j.celrep.2022.110796

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    sciencedirect.com/science/article/pii/S2211124722005630
  46. www.nature.com www.nature.com
    Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration
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      DOI: 10.1038/s41598-022-11116-9

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    Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death
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    ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,
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    Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species
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    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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    Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intercellular adhesion molecule-1-induced post-traumatic brain injury neuropathology in the prefrontal cortex and hippocampus leads to sensorimotor function deficits and psychological stress
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  139. www.sciencedirect.com www.sciencedirect.com
    The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
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    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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  142. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: interactions and redundancies with TNF and IL-6
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  143. Jun 2021
  144. academic.oup.com academic.oup.com
    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
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    Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model
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    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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  149. www.embopress.org www.embopress.org
    Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy
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  150. www.hindawi.com www.hindawi.com
    HO-1/CO Maintains Intestinal Barrier Integrity through NF-κB/MLCK Pathway in Intestinal HO-1-/- Mice
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  151. elifesciences.org elifesciences.org
    Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta
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  152. May 2021
  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis
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  154. www.sciencedirect.com www.sciencedirect.com
    Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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  156. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood–brain barrier leakage in mice
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  157. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
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  158. www.sciencedirect.com www.sciencedirect.com
    RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
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      Phospho-NF-κB p65 (Ser536) (clone 93H1)

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    Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
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    Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition
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    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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    Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells
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    N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation
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    Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function
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  165. Apr 2021
  166. www.sciencedirect.com www.sciencedirect.com
    TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation
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    The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development
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    Coordinate regulation of the senescent state by selective autophagy
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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    Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optogenetic activation of spinal microglia triggers chronic pain in mice
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  174. Mar 2021
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression
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  176. academic.oup.com academic.oup.com
    CXCR4 signaling at the fetal-maternal interface may drive inflammation and syncytia formation during ovine pregnancy †
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  177. Feb 2021
  178. www.sciencedirect.com www.sciencedirect.com
    Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
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  179. www.cell.com www.cell.com
    Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
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    cell.com/cancer-cell/abstract/S1535-6108(20)30375-5
  180. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways
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    Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1‐dependent mitochondrial fission
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    Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
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    Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
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    Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
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    Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection
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    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
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    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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      Curator: @Naa003

      SciCrunch record: RRID:AB_331284

      Curator comments: Rabbit Anti-NF-KappaB p65, phospho (Ser536) Monoclonal Antibody, Unconjugated, Clone 93H1 Cell Signaling Technology Cat# 3033

      What is this?
      RRID:AB_331284
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14809
  224. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
    1
    1. scibot 03 Sep 2020
      phosphorylated RELA

      DOI: 10.1111/jcmm.15774

      Resource: (Cell Signaling Technology Cat# 3033, RRID:AB_331284)

      Curator: @Naa003

      SciCrunch record: RRID:AB_331284

      Curator comments: Rabbit Anti-NF-KappaB p65, phospho (Ser536) Monoclonal Antibody, Unconjugated, Clone 93H1 Cell Signaling Technology Cat# 3033

      What is this?
      RRID:AB_331284 RRIDCUR:Missing
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    pubmed.ncbi.nlm.nih.gov/32858764/
  225. jvi.asm.org jvi.asm.org
    Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling
    1
    1. scibot 03 Sep 2020
      phospho-NF-κB p65

      DOI: 10.1128/JVI.00099-20

      Resource: (Cell Signaling Technology Cat# 3033, RRID:AB_331284)

      Curator: @Naa003

      SciCrunch record: RRID:AB_331284

      Curator comments: Rabbit Anti-NF-KappaB p65, phospho (Ser536) Monoclonal Antibody, Unconjugated, Clone 93H1 Cell Signaling Technology Cat# 3033

      What is this?
      RRID:AB_331284 RRIDCUR:Missing
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    jvi.asm.org/content/94/13/e00099-20