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Sep 2023
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CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways

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Aug 2023
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Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome

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IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells

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PIIS2589004223016784-html.html

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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate

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PROTAC targeting cyclophilin A controls virus-induced cytokine storm

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TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

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TSC22D3 as an immune-related prognostic biomarker for acute myeloid leukemia

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Hedgehog receptors exert immune-surveillance roles in the epidermis across species

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IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy

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IRP1 Mediated Ferroptosis Reverses Temozolomide Resistance in Glioblastoma via Affecting LCN2/FPN1 Signaling Axis Depended on NFKB2

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Jul 2023
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Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia

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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH

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Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-γ-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation

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Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin

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Jun 2023
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BPS Publications

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The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity

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Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design

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Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration

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UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders

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Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s

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SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury

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DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

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A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer

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The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB

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Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis

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Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in severe patients with COVID-19

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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Cancer cell-autonomous cGAS-STING response confers drug resistance

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May 2023
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IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance

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Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma

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A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response

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MicroRNA-31 induced by Fusobacterium nucleatum infection promotes colorectal cancer tumorigenesis

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cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

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Circulating exosomes from patients with Graves’ disease induce an inflammatory immune response

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Thyroid Stem Cell Speciation – A Major Role for PKC

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Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury

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Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies

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Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway

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Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1

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Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain

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Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction

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PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1

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FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants

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A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy

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Combination therapy with ultrasound and 2D nanomaterials promotes recovery after spinal cord injury via Piezo1 downregulation

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Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

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LMAN1 is a receptor for house dust mite allergens

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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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BPS Publications

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

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Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

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Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model

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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

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Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect

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Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research

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Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma

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Resurrection of endogenous retroviruses during aging reinforces senescence

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Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis

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Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice

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ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis

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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

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Tumor necrosis factor is a necroptosis-associated alarmin

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Allicin ameliorates IMQ-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A

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Vagus nerve stimulation is a potential treatment for ischemic stroke

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BPS Publications

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LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus

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An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice

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STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.

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Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

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TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage

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Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin

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Cancer cell intrinsic TIM-3 induces glioblastoma progression

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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

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Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

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Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

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cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

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Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord

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Synergistic effect of mild traumatic brain injury and alcohol aggravates neuroinflammation, amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations: Impact on psychological stress

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Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy

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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1 β-Induced Endothelium Injury

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Anti-inflammatory effects of neutral lipids, glycolipids, phospholipids from Halocynthia aurantium tunic by suppressing the activation of NF-κB and MAPKs in LPS-stimulated RAW264.7 macrophages

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The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling

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N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis

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CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder

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BPS Publications

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  DOI: 10.1111/bph.15912
  
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LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination

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Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification

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The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1/2 and inflammasome activation in PCOS

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Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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Effects of interleukin 1β on long noncoding RNA and mRNA expression profiles of human synovial fluid derived mesenchymal stem cells

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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration

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Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

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Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO-dependent mechanism

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Long-term and potent IOP-lowering effect of IκBα-siRNA in a nonhuman primate model of chronic ocular hypertension

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Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses

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Secreted NF-κB suppressive microbial metabolites modulate gut inflammation

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Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization

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Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control

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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma

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CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors

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SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis

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Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization

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Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

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Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research

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Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury

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Corticotropin-releasing factor aggravates ischemic stroke injury by the inflammatory activation of microglia

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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

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Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

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A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

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Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis

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CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson’s disease

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Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity

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Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome

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Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis

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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

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A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

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Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity

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Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

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Olfactory receptor 5B21 drives breast cancer metastasis

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CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

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Inhibition of extracellular vesicle-associated MMP2 abrogates intercellular hepatic miR-122 transfer to liver macrophages and curtails inflammation

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STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

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The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

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Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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BPS Publications

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BPS Publications

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Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors

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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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St. John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism

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Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

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Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling

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SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages

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Activating a collaborative innate-adaptive immune response to control metastasis

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Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

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Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency

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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis

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Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

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Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection

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  RRID:AB_331284
  
  DOI: 10.7554/eLife.40396
  
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Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer

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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

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  DOI: 10.1016/j.chom.2018.11.001
  
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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

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1. scibot 31 Jul 2021
  
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  Rabbit monoclonal anti-phospho-NF-κB p65 (Ser536)
  
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Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

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ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,

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1. scibot 30 Jul 2021
  
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  anti–phosphorylated NF-κB p65
  
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Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

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1. scibot 30 Jul 2021
  
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  Phospho-NFκB p65 (Ser536), rabbit monoclonal
  
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Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways

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  p65
  
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Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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  Phosphor-NF-kB p65 Ser536 (93H1) Rabbit mAb antibody
  
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Japanese Encephalitis Virus‐induced let‐7a/b interacted with the NOTCH‐TLR7 pathway in microglia and facilitated neuronal death via caspase activation

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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

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Adjuvant treatment and molecular mechanism of probiotic compounds in patients with gastric cancer after gastrectomy

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Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

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Intercellular adhesion molecule-1-induced post-traumatic brain injury neuropathology in the prefrontal cortex and hippocampus leads to sensorimotor function deficits and psychological stress

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The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

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