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    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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  3. Jun 2024
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    Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer
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    Monomethyl fumarate attenuates lung Ischemia/Reperfusion injury by disrupting the GAPDH/Siah1 signaling cascade
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    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    SARS-CoV-2 envelope protein regulates innate immune tolerance
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
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    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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  11. May 2024
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    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    LncRNA IRAIN overcomes imatinib resistance in chronic myeloid leukemia via NF-κB/CD44 pathway inhibition
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    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
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    Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemia
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    Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury
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    Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity
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    The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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  22. Apr 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer’s disease by inhibiting neuroinflammation and neuronal necroptosis
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    Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway
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    Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury
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    The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
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    SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion
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    Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
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    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation
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  33. Mar 2024
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    Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress
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    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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  41. Feb 2024
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    CYP7B1-mediated 25-hydroxycholesterol degradation maintains quiescence-activation balance and improves therapeutic potential of mesenchymal stem cells
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  52. Jan 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
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  61. Dec 2023
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  63. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nanocurcumin attenuates pyroptosis and inflammation through inhibiting NF-κB/GSDMD signal in high altitude-associated acute liver injury
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  64. Nov 2023
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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  70. Oct 2023
  71. link.springer.com link.springer.com
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  78. Sep 2023
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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  82. Aug 2023
  83. www.embopress.org www.embopress.org
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  85. 52.53.155.43 52.53.155.43
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  86. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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  178. Oct 2022
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    Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
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    Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection
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    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
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    Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord
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    Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy
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    Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1 β-Induced Endothelium Injury
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    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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    N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis
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    CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
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    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination
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    Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification
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  200. Jun 2022
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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  206. May 2022
  207. www.nature.com www.nature.com
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    Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO-dependent mechanism
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    Long-term and potent IOP-lowering effect of IκBα-siRNA in a nonhuman primate model of chronic ocular hypertension
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