338 Matching Annotations
  1. Jul 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
    1
    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.cell.2021.07.005

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    sciencedirect.com/science/article/pii/S009286742100831X
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    ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors
    1
    1. scibot 22 Jul 2021
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      DOI: 10.1016/j.xcrm.2021.100350

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    sciencedirect.com/science/article/pii/S2666379121001993
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    Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
    1
    1. scibot 16 Jul 2021
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    sciencedirect.com/science/article/pii/S1550413121002837
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
    1
    1. scibot 10 Jul 2021
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      DOI: 10.1016/j.molcel.2021.06.017

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    sciencedirect.com/science/article/pii/S1097276521004974
  6. www.sciencedirect.com www.sciencedirect.com
    Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function
    1
    1. scibot 09 Jul 2021
      Cat #2217S

      DOI: 10.1016/j.celrep.2021.109339

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    sciencedirect.com/science/article/pii/S2211124721007154
  7. Jun 2021
  8. www.cell.com www.cell.com
    TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
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    1. scibot 23 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109277

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    cell.com/cell-reports/fulltext/S2211-1247(21)00644-6
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
    1
    1. scibot 22 Jun 2021
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      DOI: 10.1016/j.molcel.2021.05.031

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    sciencedirect.com/science/article/pii/S1097276521004445
  10. May 2021
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
    1
    1. scibot 27 May 2021
      cat# 2217S

      DOI: 10.1038/s41467-021-23271-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC8134423/
  12. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
    1
    1. scibot 19 May 2021
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      DOI: 10.1016/j.celrep.2021.109128

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    sciencedirect.com/science/article/pii/S2211124721004678
  13. academic.oup.com academic.oup.com
    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
    1
    1. scibot 10 May 2021
      AB_331355

      DOI: 10.1210/endocr/bqaa133

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    academic.oup.com/endo/article/161/10/bqaa133/5881724
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    Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
    1
    1. scibot 09 May 2021
      RRID:AB_331355

      DOI: 10.1016/j.stem.2020.08.002

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    sciencedirect.com/science/article/pii/S1934590920303982
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    Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.molcel.2020.10.023

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    sciencedirect.com/science/article/pii/S1097276520307309
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
    1
    1. scibot 07 May 2021
      RRID:AB_331355

      DOI: 10.1016/j.molcel.2020.10.004

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    sciencedirect.com/science/article/pii/S1097276520306870
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    3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.10.010

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    sciencedirect.com/science/article/pii/S1097276520306936
  18. www.sciencedirect.com www.sciencedirect.com
    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
    1
    1. scibot 03 May 2021
      RRID:AB_331355

      DOI: 10.1016/j.stem.2021.02.008

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    sciencedirect.com/science/article/pii/S1934590921000588
  19. www.sciencedirect.com www.sciencedirect.com
    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
    1
    1. scibot 01 May 2021
      AB_331355

      DOI: 10.1016/j.cmet.2021.02.001

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    sciencedirect.com/science/article/pii/S1550413121000577
  20. Apr 2021
  21. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.10.018

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    sciencedirect.com/science/article/pii/S1550413120305519
  22. www.sciencedirect.com www.sciencedirect.com
    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.08.004

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    sciencedirect.com/science/article/pii/S1550413120304174
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    SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition
    1
    1. scibot 29 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.cmet.2020.06.020

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    sciencedirect.com/science/article/pii/S1550413120303582
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
    1
    1. scibot 28 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.molcel.2021.03.037

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    sciencedirect.com/science/article/pii/S109727652100232X
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
    1
    1. scibot 27 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.chembiol.2020.10.003

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    sciencedirect.com/science/article/pii/S2451945620303822
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    A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
    1
    1. scibot 23 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.cell.2020.05.012

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    sciencedirect.com/science/article/pii/S0092867420305742
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
    1
    1. scibot 22 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.cmet.2021.03.025

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    sciencedirect.com/science/article/pii/S1550413121001662
  28. www.sciencedirect.com www.sciencedirect.com
    Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
    1
    1. scibot 13 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.molcel.2021.03.018

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    sciencedirect.com/science/article/pii/S1097276521002136
  29. www.sciencedirect.com www.sciencedirect.com
    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
    1
    1. scibot 07 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2021.108944

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    sciencedirect.com/science/article/pii/S2211124721002588
  30. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
    1
    1. scibot 02 Apr 2021
      RRID:AB_331355

      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  31. Mar 2021
  32. www.sciencedirect.com www.sciencedirect.com
    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
    1
    1. scibot 03 Mar 2021
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      DOI: 10.1016/j.celrep.2021.108796

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    sciencedirect.com/science/article/pii/S2211124721001108
  33. www.sciencedirect.com www.sciencedirect.com
    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
    1
    1. scibot 01 Mar 2021
      RRID:AB_331355

      DOI: 10.1016/j.cell.2020.11.018

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    sciencedirect.com/science/article/pii/S009286742031535X
  34. Feb 2021
  35. journals.sagepub.com journals.sagepub.com
    ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation - Limin Wu, Mohammad R Islam, Janice Lee, Hajime Takase, Shuzhen Guo, Allison M Andrews, Tetyana P Buzhdygan, Justin Mathew, Wenlu Li, Ken Arai, Eng H Lo, Servio H Ramirez, Josephine Lok, 2021
    1
    1. scibot 25 Feb 2021
      S6

      DOI: 10.1177/0271678X20984976

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    journals.sagepub.com/doi/abs/10.1177/0271678X20984976
  36. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
    1
    1. scibot 25 Feb 2021
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      DOI: 10.1016/j.molcel.2020.11.036

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4
  37. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
    1
    1. scibot 25 Feb 2021
      RRID:AB_331355

      DOI: 10.1016/j.molcel.2020.11.027

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30827-3
  38. mct.aacrjournals.org mct.aacrjournals.org
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
    1
    1. scibot 24 Feb 2021
      RRID:AB_331355

      DOI: 10.1158/1535-7163.MCT-19-0284

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    mct.aacrjournals.org/content/19/1/292
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive pharmacogenomic characterization of gastric cancer
    1
    1. scibot 24 Feb 2021
      RRID:AB_331355

      DOI: 10.1186/s13073-020-0717-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC7029441/
  40. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
    1
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      DOI: 10.1113/JP278933

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP278933
  41. www.fasebj.org www.fasebj.org
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
    1
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      AB_331355

      DOI: 10.1096/fj.201900991R

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    fasebj.org/doi/abs/10.1096/fj.201900991R
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response
    1
    1. scibot 09 Feb 2021
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      DOI: 10.1016/j.chom.2021.01.015

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    ncbi.nlm.nih.gov/pmc/articles/PMC7846228/
  43. Jan 2021
  44. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
    1
    1. scibot 26 Jan 2021
      AB_331355

      DOI: 10.1096/fj.202002203R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202002203R
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
    1
    1. scibot 26 Jan 2021
      RRID:AB_331355

      DOI: 10.1111/acel.13302

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    onlinelibrary.wiley.com/doi/full/10.1111/acel.13302
  46. Dec 2020
  47. www.cell.com www.cell.com
    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
    1
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      RRID:AB_331355

      DOI: 10.1016/j.molcel.2020.10.016

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30723-1
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    RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  52. Oct 2020
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    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
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  54. Sep 2020
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    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
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    Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway
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    mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model
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    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2
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    FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
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    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
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  79. Jan 2020
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    Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia
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    mTORC1/rpS6 and spermatogenic function in the testis – insights from the adjudin model
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
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  134. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
    1
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      RRID:AB_331355

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  135. www.sciencedirect.com www.sciencedirect.com
    KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
    1
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      RRID:AB_331355

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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
    2
    1. scibot 05 Nov 2018
      RRID:AB_331355

      Curator: @evieth

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    2. scibot 05 Nov 2018
      RRID:AB_331355

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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
  137. academic.oup.com academic.oup.com
    Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice
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    1. scibot 05 Nov 2018
      AB_331355

      Curator: @evieth

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    academic.oup.com/endo/article/159/1/519/4562294
  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5714502/
  139. www.sciencedirect.com www.sciencedirect.com
    Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut
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  140. www.sciencedirect.com www.sciencedirect.com
    Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
    1
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      RRID:AB_331355

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    sciencedirect.com/science/article/pii/S1074761317304727
  141. Nov 2017
  142. www.sciencedirect.com www.sciencedirect.com
    mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @Jmenke

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  143. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
    1
    1. scibot 08 Nov 2017
      RRID:AB_331355

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  144. www.sciencedirect.com www.sciencedirect.com
    Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
    1
    1. scibot 08 Nov 2017
      Rabbit anti-S6 ribosomal Protein (5G10)Cell Signaling TechnologyCat#2217

      Curator: @Jmenke

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  145. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      CSTCat#2217

      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S1074761317302339
  146. elifesciences.org elifesciences.org
    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @chewbeccax

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    elifesciences.org/articles/25237
  147. www.sciencedirect.com www.sciencedirect.com
    Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1097276517303611
  148. www.sciencedirect.com www.sciencedirect.com
    Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S2352396417302098
  149. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @Zeljana_Babic

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  150. www.sciencedirect.com www.sciencedirect.com
    An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
    1
    1. scibot 08 Nov 2017
      Rabbit monoclonal anti-S6 Ribosomal Protein (5G10)

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0092867416316671
  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational control of auditory imprinting and structural plasticity by eIF2α
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC5245967/
  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice
    1
    1. scibot 08 Nov 2017
      Cell Signaling 2217S

      Curator: @bandrow

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    ncbi.nlm.nih.gov/pmc/articles/PMC5061884/