338 Matching Annotations
  1. Last 7 days
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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  3. Dec 2024
  4. 52.53.155.43 52.53.155.43
    can-24-0456-html.html
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    Maternal gut microbiota influence stem cell function in offspring
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    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells
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  9. Nov 2024
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
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  11. Oct 2024
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    Midkine as a driver of age-related changes and increase in mammary tumorigenesis
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    sciencedirect.com/science/article/pii/S1535610824003507
  13. Sep 2024
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    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia
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    RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
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    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease
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  18. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development
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    Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy
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    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
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    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
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    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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  27. Jul 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
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    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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  32. Jun 2024
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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  35. May 2024
  36. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury
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    Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
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    52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
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    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
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    sciencedirect.com/science/article/pii/S0002944024001743
  42. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  45. Apr 2024
  46. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6282
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    Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline
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  49. Mar 2024
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma
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  145. Aug 2022
  146. www.sciencedirect.com www.sciencedirect.com
    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
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    Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine metabolism modulates chondrocyte inflammatory response
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    Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity
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  150. Jul 2022
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    Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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    Context-dependent regulation of ferroptosis sensitivity
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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  156. Jun 2022
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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  159. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Translational Strategies for Repotrectinib in Neuroblastoma
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    Patient-derived models of brain metastases recapitulate human disseminated disease
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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  169. Apr 2022
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    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  173. Mar 2022
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    Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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  178. Feb 2022
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  182. Jan 2022
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  185. Dec 2021
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    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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  188. Nov 2021
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    Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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  191. 52.53.155.43 52.53.155.43
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