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Sep 2022
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GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A

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  DOI: 10.1016/j.isci.2022.104952
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9440292/
Aug 2022
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk

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1. scibot 26 Aug 2022
  
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A small RNA-guided PRC2 complex eliminates DNA as an extreme form of transposon silencing

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In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification

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  DOI: 10.1016/j.neuron.2022.07.027
  
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Tripartite Motif 38 Attenuates Cardiac Fibrosis after Myocardial Infarction by Suppressing TAK1 Activation via TAB2/3 Degradation

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Jul 2022
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Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing

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  DOI: 10.1210/clinem/dgac368
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac368/6609232
Jun 2022
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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

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Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function

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  DOI: 10.1158/0008-5472.CAN-21-2300
  
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aacrjournals.org/cancerres/article/82/11/2185/699105/Phosphorylation-and-Stabilization-of-PD-L1-by-CK2
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Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis

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The ER ladder is a unique morphological feature of developing mammalian axons

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sciencedirect.com/science/article/pii/S1534580722003306
Apr 2022
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Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma

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1. scibot 21 Apr 2022
  
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sciencedirect.com/science/article/pii/S2211124722004739
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Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

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  DOI: 10.1038/s41418-022-00983-4
  
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nature.com/articles/s41418-022-00983-4
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Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats

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  DOI: 10.1097/j.pain.0000000000002119
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7969388/
Mar 2022
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Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models

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SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

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  DOI: 10.7554/eLife.72073
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8923662/
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Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination

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  DOI: 10.1016/j.molcel.2022.01.021
  
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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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Feb 2022
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A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells

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sciencedirect.com/science/article/pii/S1097276522000879
Jan 2022
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Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis

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  DOI: 10.1016/j.xpro.2021.101101
  
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sciencedirect.com/science/article/pii/S2666166721008078
Dec 2021
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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel

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ncbi.nlm.nih.gov/pmc/articles/PMC8605177/
Nov 2021
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Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription

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Oct 2021
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Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

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PUPIL enables mapping and stamping of transient electrical connectivity in developing nervous systems

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sciencedirect.com/science/article/pii/S2211124721013206
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Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

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  DOI: 10.15252/embr.202052254
  
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embopress.org/doi/full/10.15252/embr.202052254
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SUMOylation contributes to proteostasis of the chloroplast protein import receptor TOC159 during early development

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  DOI: 10.7554/eLife.60968
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8497054/
Sep 2021
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Senescent immune cells release grancalcin to promote skeletal aging

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Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

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Aug 2021
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Late endosomal/lysosomal accumulation of a neurotransmitter receptor in a cellular model of Smith-Lemli-Opitz syndrome

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  DOI: 10.1111/tra.12811
  
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The Amot/integrin protein complex transmits mechanical forces required for vascular expansion

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Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila

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  DOI: 10.1016/j.isci.2021.102819
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8333185/
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Untitled document

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  DOI: 10.7554/eLife.28270
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5640428/
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Untitled document

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  DOI: 10.1016/j.str.2017.05.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5501724/
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Untitled document

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  DOI: 10.1016/j.cub.2019.01.043
  
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Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition

1
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Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

1
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Mitochondrial estrogen receptors alter mitochondrial priming and response to endocrine therapy in breast cancer cells

1
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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

1
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  Mouse anti-Myc
  
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Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs

1
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  Mouse anti-MYC
  
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Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

1
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FipoQ/FBXO33, a Cullin‐1‐based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein

2
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  RRID:AB_331783
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14669
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  DOI: 10.1523/JNEUROSCI.0154-18.2018
  
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Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion

1
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  Myc-Tag (9B11) Mouse mAb
  
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Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140

1
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Early growth response‐1‐mediated down‐regulation of drebrin correlates with loss of dendritic spines

1
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Phosphorylation-Dependent control of arc protein by TNIK

1
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Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition.

1
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  RRID:AB_331783
  
  DOI: 10.7554/eLife.28270
  
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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

1
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BPS Publications

1
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  RRID:AB_331783
  
  DOI: 10.1111/bph.15490
  
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Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

5
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  RRID:AB_2314825
  
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  AB_2314825
  
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  RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:AB_331783
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  AB_2314825
  
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  AB_2314825
  
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  AB_2314825
  
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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

1
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  AB_10693333
  
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sciencedirect.com/science/article/pii/S0092867416316853
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Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm

1
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  2276
  
  DOI: 10.1016/j.ajhg.2021.06.016
  
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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

1
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  RRID:AB_331783
  
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sciencedirect.com/science/article/pii/S1534580721005177
Jun 2021
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Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

1
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  RRID:AB_331783
  
  DOI: 10.1016/j.chembiol.2021.05.019
  
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KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

1
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  RRID:AB_331783
  
  DOI: 10.1016/j.isci.2021.102649
  
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In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development

1
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  RRID:AB_331783
  
  DOI: 10.1016/j.cub.2021.05.045
  
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CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells

1
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  RRID:AB_331783
  
  DOI: 10.1016/j.neuron.2021.05.007
  
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May 2021
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A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression

1
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  DOI: 10.15252/embj.2020106696
  
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Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor

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Missense mutations in small muscle protein X-linked ( SMPX ) cause distal myopathy with protein inclusions

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Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

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Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation

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Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth

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Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells

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A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens

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Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design

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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury

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Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

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Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes

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A pan-cancer transcriptome analysis of exitron splicing identifies novel cancer driver genes and neoepitopes

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Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes

1
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations

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Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

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AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

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Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis

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TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

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Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

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Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes

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Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage

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Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation

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Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice

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Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway

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A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y

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The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

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Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

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Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses

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Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

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Mitophagy, Autophagy and Cell Death: The novel cyclophilin-D-interacting protein FASTKD1 protects cells against oxidative stress-induced cell death

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Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

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NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation

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Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

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Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer

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BPS Publications

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Structural and Functional Analyses of the FAM46C/Plk4 Complex

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Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum

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A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer

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The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling

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RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids

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Efficient Golgi Forward Trafficking Requires GOLPH3-Driven, PI4P-Dependent Membrane Curvature

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Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

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Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons

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Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition

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Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate

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Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication

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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network

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TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

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TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1

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N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

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Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo

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N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

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BPS Publications

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Untitled document

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Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum

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Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

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FipoQ/FBXO33, a Cullin‐1‐based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein

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Untitled document

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Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss

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MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells

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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

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Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness

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Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

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Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1

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Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture

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Chloroplast Biogenesis Controlled by DELLA-TOC159 Interaction in Early Plant Development

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

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Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential

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Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia

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An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein

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The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

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Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation

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NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

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A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

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Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

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A Split-Abl Kinase for Direct Activation in Cells

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Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes

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In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing

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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

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sciencedirect.com/science/article/pii/S1097276517304586
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Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle

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1. scibot 08 Nov 2017
  
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  AB_331783
  
  Curator: @chewbeccax
  
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  (Cell Signaling Technology Cat# 2276, RRID:AB_331783)
  
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sciencedirect.com/science/article/pii/S0092867417306475
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PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise

1
1. scibot 08 Nov 2017
  
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  AB_331783
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S155041311730236X
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The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_331783
  
  Curator: @chewbeccax
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5462538/
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_331783
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1097276517303945
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Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP

1
1. scibot 08 Nov 2017
  
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  AB_331783
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S0969212617301399
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Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses

1
1. scibot 08 Nov 2017
  
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  AB_331783
  
  Curator: @chewbeccax
  
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  (Cell Signaling Technology Cat# 2276, RRID:AB_331783)
  
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sciencedirect.com/science/article/pii/S1931312817302032
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RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_331783
  
  Curator: @gabimpine
  
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sciencedirect.com/science/article/pii/S1535610817301575
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Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_331783
  
  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S2451945617300922
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CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_331783
  
  Curator: @Zeljana_Babic
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5352711/
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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

1
1. scibot 08 Nov 2017
  
  in Public
  
  anti-myc tag antibody (9B11; CST #2276)
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5241118/
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

1
1. scibot 08 Nov 2017
  
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  2276
  
  Curator: @bandrow
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4931344/
www.jneurosci.org www.jneurosci.org

Miro's N-Terminal GTPase Domain Is Required for Transport of Mitochondria into Axons and Dendrites

1
1. scibot 08 Nov 2017
  
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  2276
  
  Curator: @gabimpine
  
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  (Cell Signaling Technology Cat# 2276, RRID:AB_331783)
  
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jneurosci.org/content/35/14/5754.full

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