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Aug 2025
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A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response

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1. scibot 27 Aug 2025
  
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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

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Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance

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  DOI: 10.1016/j.immuni.2025.07.013
  
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NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy

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  DOI: 10.1016/j.devcel.2019.03.013
  
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Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

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  DOI: 10.7554/eLife.106657
  
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Jul 2025
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Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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  DOI: 10.1126/sciadv.adu6354
  
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An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia

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  DOI: 10.1101/2025.07.16.664180
  
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

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CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinoma

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  DOI: 10.1016/j.xcrm.2025.102208
  
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Jun 2025
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RIPK4 promotes epidermal differentiation through phase separation and activation of LATS1/2

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Genetic profiling of synchronous pituitary corticotroph adenomas

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1. scibot 24 Jun 2025
  
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  DOI: 10.1007/s11102-025-01549-6
  
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link.springer.com/article/10.1007/s11102-025-01549-6
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Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

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  DOI: 10.1016/j.celrep.2025.115810
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00581-9
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Genetic Profiling of Synchronous Pituitary Corticotroph Adenomas

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  DOI: 10.21203/rs.3.rs-6356485/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12083677/
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  DOI: 10.1158/1535-7163.mct-24-0944
  
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52.53.155.43/ede022ae23233744b77af4278ec3faa8fd0a91c6/PDF-html.html
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Disruption of Retriever Function Impacts Retrograde Trafficking From Endosomes

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1. scibot 11 Jun 2025
  
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  DOI: 10.1002/cbin.70037
  
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onlinelibrary.wiley.com/doi/10.1002/cbin.70037
May 2025
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A novel nonsense mutation of the glucocorticoid receptor gene causing glucocorticoid resistance with infertility

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1. scibot 28 May 2025
  
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  DOI: 10.1007/s12020-025-04280-1
  
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ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115737
  
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Apr 2025
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

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Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression

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FMNL2/SRC-mediated androgen receptor translocation into the nucleus promotes enzalutamide resistance of prostate cancer

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  DOI: 10.1016/j.isci.2025.112205
  
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Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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  DOI: 10.1158/1541-7786.mcr-24-0496
  
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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

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DAP12-associated synthetic antigen receptors enable multi-targeting of T cells with independent chimeric receptors in a small genetic payload

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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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  DOI: 10.1126/sciadv.adt1241
  
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Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis

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Engineering mtDNA deletions by reconstituting end joining in human mitochondria

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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

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Feb 2025
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1-s2.0-S2589004225003785-main-html.html

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Identification of Meibomian gland stem cell populations and mechanisms of aging

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  DOI: 10.1038/s41467-025-56907-6
  
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Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes

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  DOI: 10.1016/j.chembiol.2025.01.007
  
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CCN6 suppresses metaplastic breast carcinoma by antagonizing WNT/β-catenin signaling to inhibit EZH2-driven EMT

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-4054
  
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aacrjournals.org/cancerres/article/84/19/3235/748708/CCN6-Suppresses-Metaplastic-Breast-Carcinoma-by
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Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons

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Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass

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Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions

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A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

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Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision

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ERBB4 selectively amplifies TGF-β pro-metastatic responses

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Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation

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DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma

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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

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Revisiting phosphoregulation of Cdc25C during M-phase induction

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A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules

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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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Molecular protocol for genome-wide and cell-type-selective profiling of in vivo small noncoding RNA:target RNA interactions by CIMERA-seq

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Article PDF-html.html

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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

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  DOI: 10.1038/s44318-024-00276-1
  
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Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

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  DOI: 10.1038/s44318-024-00290-3
  
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wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html

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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

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Inhibition of the Notch signal transducer CSL by Pkc53E-mediated phosphorylation to fend off parasitic immune challenge in Drosophila

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CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny

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The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

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BPS Publications

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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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Multimodal Hox5 activity generates motor neuron diversity

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Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis

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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

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Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity - ScienceDirect

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Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO2-Stimulated Breathing

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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

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Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer

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Genome-wide and cell-type-selective profiling of in vivo small noncoding RNA:target RNA interactions by chimeric RNA sequencing

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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation

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cell.com/cell-reports/fulltext/S2211-1247(24)00493-5
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Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects

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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

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  DOI: 10.1126/science.adk0850
  
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus

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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

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Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

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Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity

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Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis

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SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration

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Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities

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Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue

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Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1

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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia

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Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility

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A comparative analysis of paxillin and Hic-5 proximity interactomes

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Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

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May 2024
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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

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Functional Analysis of a Novel HNF4A Variant Identified in a Patient with MODY1

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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling

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Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation

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Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

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Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

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The role of microtubule-associated protein tau in netrin-1 attractive signaling

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Mar 2024
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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

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Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses

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Multimodal Hox5 activity generates motor neuron diversity

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Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion

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ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation

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The soil emergence-related transcription factor PIF3 controls root penetration by interacting with the receptor kinase FER

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Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer

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Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

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Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities

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ER chaperones use a protein folding and quality control glyco-code

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The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

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Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling

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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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ADAMTS-4 enhances oligodendrocyte differentiation and remyelination by cleaving NG2 proteoglycan and attenuating PDGFRα signaling

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Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

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Yeast lunapark regulates the formation of trans-Sey1p complexes for homotypic ER membrane fusion

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Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer

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Proteostasis is differentially modulated by inhibition of translation initiation or elongation

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TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2

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AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis

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The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

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Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer

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Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling

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Enzymolysis-based RNA pull-down identifies YTHDC2 as an inhibitor of antiviral innate response

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Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis

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Dynamic association of the intramembrane proteases SPPL2a/b and their substrates with tetraspanin-enriched microdomains

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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

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  DOI: 10.1038/s41422-023-00874-4
  
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Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

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E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation

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RhoB Promotes Salmonella survival by Regulating Autophagy

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GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

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USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

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Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function

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PIIS2211124723009713-html.html

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5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability. 5-HT receptor cross-talks shape 5-HT neuron activity

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SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations

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Jul 2023
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Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

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  DOI: 10.1101/2023.06.27.546707
  
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Ninein domains required for its localization, association with partners dynein and ensconsin, and microtubule organization

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  DOI: 10.1101/2023.06.22.546109
  
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Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1

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  DOI: 10.1016/j.celrep.2023.112726
  
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TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1

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4405.full-html.html

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Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa

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PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma

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Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1

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Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice

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The Transmembrane Protein TM4SF3 Interacts with AR and AR-V7 and is Recruited to AR Target Genes

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain

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May 2023
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Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

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Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

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DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β

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Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases

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Coordination of tissue homeostasis and growth by the Scribble-α-Catenin-Septate junction complex

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Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication

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RhoB promotes Salmonella survival by regulating autophagy

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The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining

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The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells

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TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells

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Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

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The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

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The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells

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Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach

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Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway

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Developmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium

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METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2

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COP I and II dependent trafficking controls ER-associated degradation in mammalian cells

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Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye

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Linking chromatin acylation mark-defined proteome and genome in living cells

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Regulation of DNA damage response by trimeric G-proteins

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Jan 2023
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A novel period mutation implicating nuclear export in temperature compensation of the Drosophila circadian clock

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Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation

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VGLL4 and MENIN function as TEAD1 corepressors to block pancreatic β cell proliferation

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  DOI: 10.1016/j.celrep.2022.111904
  
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Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

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The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

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Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration

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Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice

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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

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HBO1 catalyzes lysine benzoylation in mammalian cells

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Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size

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Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy

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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

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Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells

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Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis

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Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis

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Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

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