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    Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
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    Molecular protocol for genome-wide and cell-type-selective profiling of in vivo small noncoding RNA:target RNA interactions by CIMERA-seq
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  4. Dec 2024
  5. 52.53.155.43 52.53.155.43
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  7. Nov 2024
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    Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
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    Inhibition of the Notch signal transducer CSL by Pkc53E-mediated phosphorylation to fend off parasitic immune challenge in Drosophila
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  12. Oct 2024
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    CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
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  15. Sep 2024
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    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis
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    Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
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    Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO2-Stimulated Breathing
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    Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity
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    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
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    Genome-wide and cell-type-selective profiling of in vivo small noncoding RNA:target RNA interactions by chimeric RNA sequencing
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation
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  31. Jul 2024
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    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
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    Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome
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    Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
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    Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity
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    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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    SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
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    Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities
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    Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue
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  43. Jun 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1
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    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
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    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    Functional Analysis of a Novel HNF4A Variant Identified in a Patient with MODY1
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    Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
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    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1
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    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
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    Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling
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    Dynamic association of the intramembrane proteases SPPL2a/b and their substrates with tetraspanin-enriched microdomains
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    Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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