356 Matching Annotations
  1. Oct 2021
  2. www.sciencedirect.com www.sciencedirect.com
    A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle
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    1. scibot 19 Oct 2021
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      DOI: 10.1016/j.cub.2021.09.050

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    sciencedirect.com/science/article/pii/S0960982221012902
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    Biosensors based on peptide exposure show single molecule conformations in live cells
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    1. scibot 12 Oct 2021
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      DOI: 10.1016/j.cell.2021.09.026

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    sciencedirect.com/science/article/pii/S0092867421011090
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    Proteome-wide mapping of short-lived proteins in human cells
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    1. scibot 09 Oct 2021
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      DOI: 10.1016/j.molcel.2021.09.015

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    sciencedirect.com/science/article/pii/S1097276521007498
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    1. scibot 05 Oct 2021
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      DOI: 10.1016/j.devcel.2021.09.008

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    sciencedirect.com/science/article/pii/S1534580721007267
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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    1. scibot 05 Oct 2021
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      DOI: 10.1016/j.cub.2021.09.022

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    sciencedirect.com/science/article/pii/S0960982221012628
  7. Sep 2021
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    Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
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    1. scibot 24 Sep 2021
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      DOI: 10.1016/j.devcel.2021.09.007

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    sciencedirect.com/science/article/pii/S1534580721007255
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    1. scibot 11 Sep 2021
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      DOI: 10.1016/j.molcel.2021.08.016

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    sciencedirect.com/science/article/pii/S1097276521006833
  10. Aug 2021
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    The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
    1
    1. scibot 25 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109616

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    sciencedirect.com/science/article/pii/S2211124721010548
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    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
    1
    1. scibot 21 Aug 2021
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      DOI: 10.7554/eLife.64846

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    ncbi.nlm.nih.gov/pmc/articles/PMC8370767/
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
    1
    1. scibot 18 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109549

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    sciencedirect.com/science/article/pii/S2211124721009839
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
    1
    1. scibot 14 Aug 2021
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      DOI: 10.1016/j.cell.2019.04.038

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    ncbi.nlm.nih.gov/pmc/articles/PMC6579486/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 11 Aug 2021
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      DOI: 10.1016/j.celrep.2018.11.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC6324198/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.12.071

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    ncbi.nlm.nih.gov/pmc/articles/PMC6334229/
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    1. scibot 10 Aug 2021
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      DOI: 10.1016/j.celrep.2018.12.071

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    sciencedirect.com/science/article/pii/S2211124718320163
  18. www.jneurosci.org www.jneurosci.org
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    1. scibot 08 Aug 2021
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      DOI: 10.1523/JNEUROSCI.0503-18.2018

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    jneurosci.org/content/38/44/9579
  19. www.mdpi.com www.mdpi.com
    The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells
    1
    1. scibot 07 Aug 2021
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      DOI: 10.3390/cells10081928

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    mdpi.com/2073-4409/10/8/1928
  20. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 06 Aug 2021
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      DOI: 10.1002/cne.24025

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24025
  21. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.ebiom.2018.11.037

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    sciencedirect.com/science/article/pii/S2352396418305401
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    Molecular basis for substrate recruitment to the PRMT5 methylosome
    1
    1. scibot 06 Aug 2021
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      DOI: 10.1016/j.molcel.2021.07.019

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    sciencedirect.com/science/article/pii/S1097276521005888
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    Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
    1
    1. scibot 05 Aug 2021
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      DOI: 10.1016/j.devcel.2021.07.006

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    sciencedirect.com/science/article/pii/S1534580721005621
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
    1
    1. scibot 02 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109455

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    sciencedirect.com/science/article/pii/S221112472100872X
  25. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 01 Aug 2021
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      DOI: 10.1016/j.celrep.2018.11.024

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    sciencedirect.com/science/article/pii/S2211124718317704
  26. Jul 2021
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes
    1
    1. scibot 31 Jul 2021
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      DOI: 10.1523/JNEUROSCI.0503-18.2018

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    ncbi.nlm.nih.gov/pmc/articles/PMC6706001/
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    Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
    1
    1. scibot 30 Jul 2021
      Monoclonal Anti-Vinculin antibody produced in mouse

      DOI: 10.1016/j.str.2019.09.006

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    sciencedirect.com/science/article/pii/S0969212619303120
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    Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity
    1
    1. scibot 30 Jul 2021
      Mouse polyclonal anti Vinculin

      DOI: 10.1016/j.celrep.2019.08.019

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    sciencedirect.com/science/article/pii/S2211124719310526
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.11.019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6314484/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase
    1
    1. scibot 29 Jul 2021
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      DOI: 10.1016/j.ebiom.2018.11.037

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    ncbi.nlm.nih.gov/pmc/articles/PMC6306395/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition
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    1. scibot 28 Jul 2021
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      DOI: 10.18632/oncotarget.26677

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    ncbi.nlm.nih.gov/pmc/articles/PMC6402720/
  33. www.sciencedirect.com www.sciencedirect.com
    De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma
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    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.stem.2019.01.003

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    sciencedirect.com/science/article/pii/S1934590919300037
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.11.099

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    ncbi.nlm.nih.gov/pmc/articles/PMC6364303/
  35. www.cell.com www.cell.com
    Transcription-mediated supercoiling regulates genome folding and loop formation
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      DOI: 10.1016/j.molcel.2021.06.009

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    cell.com/molecular-cell/fulltext/S1097-2765(21)00456-1
  36. www.nature.com www.nature.com
    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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    1. scibot 10 Jul 2021
      V9131

      DOI: 10.1038/s41598-021-92408-4

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    nature.com/articles/s41598-021-92408-4
  37. www.sciencedirect.com www.sciencedirect.com
    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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      DOI: 10.1016/j.molcel.2021.06.016

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    sciencedirect.com/science/article/pii/S1097276521004962
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    Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides
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    sciencedirect.com/science/article/pii/S2211124721006884
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    Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
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      DOI: 10.1016/j.chembiol.2021.06.003

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    sciencedirect.com/science/article/pii/S2451945621003020
  40. Jun 2021
  41. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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      DOI: 10.1016/j.celrep.2021.109291

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    sciencedirect.com/science/article/pii/S2211124721006628
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    Translation stress and collided ribosomes are co-activators of cGAS
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      DOI: 10.1016/j.molcel.2021.05.018

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    sciencedirect.com/science/article/pii/S1097276521004020
  43. www.sciencedirect.com www.sciencedirect.com
    Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function
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      DOI: 10.1016/j.cub.2021.05.021

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    sciencedirect.com/science/article/pii/S0960982221006801
  44. May 2021
  45. www.nature.com www.nature.com
    Loss of Ambra1 promotes melanoma growth and invasion
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      DOI: 10.1038/s41467-021-22772-2

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    nature.com/articles/s41467-021-22772-2
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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      DOI: 10.1016/j.immuni.2021.04.019

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    sciencedirect.com/science/article/pii/S1074761321001813
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    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.molcel.2021.04.010

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    Hydrogel Network Dynamics Regulate Vascular Morphogenesis
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    Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin
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    Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension
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    A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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    Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells
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    Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis
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    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
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    Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis
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    Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells
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  59. Apr 2021
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    Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis
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    Coordinate regulation of the senescent state by selective autophagy
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
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    Functional interrogation of DNA damage response variants with base editing screens
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    Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2
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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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  67. www.nature.com www.nature.com
    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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    Protocol for analysis of integrin-mediated cell adhesion of lateral plate mesoderm cells isolated from zebrafish embryos
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  69. Mar 2021
  70. elifesciences.org elifesciences.org
    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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    Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
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  73. Feb 2021
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    Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation
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    Translation in amino-acid-poor environments is limited by tRNAGln charging
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    Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model
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    Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins
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  80. Jan 2021
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    The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway
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  83. Dec 2020
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    Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism
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    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
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  88. Nov 2020
  89. elifesciences.org elifesciences.org
    GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
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  90. Oct 2020
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    Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing
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    Gene therapy with secreted acid alpha-glucosidase rescues Pompe disease in a novel mouse model with early-onset spinal cord and respiratory defects
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  93. Sep 2020
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    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
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    Telophase correction refines division orientation in stratified epithelia
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    Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
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    Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
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      DOI: 10.1016/j.devcel.2019.03.023

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    Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity
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      DOI: 10.1016/j.celrep.2018.11.019

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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    1. scibot 12 Jan 2020
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      DOI: 10.1016/j.ebiom.2019.03.027

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  138. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.cell.2019.04.038

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  139. Nov 2018
  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  141. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
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  142. www.sciencedirect.com www.sciencedirect.com
    Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody
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    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
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  146. www.sciencedirect.com www.sciencedirect.com
    Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  148. journals.plos.org journals.plos.org
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  149. www.sciencedirect.com www.sciencedirect.com
    A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation
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    An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
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    c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism
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  155. www.nature.com www.nature.com
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  157. www.sciencedirect.com www.sciencedirect.com
    Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions
    1
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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    As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
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    Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers
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  162. europepmc.org europepmc.org
    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
    1
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  163. Nov 2017
  164. academic.oup.com academic.oup.com
    Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway
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      Curator: @patriciaelyse_

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  165. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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      Curator: @chewbeccax

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  166. www.jneurosci.org www.jneurosci.org
    Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance
    1
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      Curator: @chewbeccax

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    The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling
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    Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules
    1
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  169. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis
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  170. www.sciencedirect.com www.sciencedirect.com
    Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
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    Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
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