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    Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis
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  3. Dec 2024
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    CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
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    Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)
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  6. Nov 2024
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    STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
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    Autophagy-dependent splicing control directs translation toward inflammation during senescence
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    Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint
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    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    A functional connection between the Microprocessor and a variant NEXT complex
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    Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and in human cells
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  13. Oct 2024
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    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
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    Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application
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  16. Sep 2024
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    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    Saturation mutagenesis-reinforced functional assays for disease-related genes
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    Androgens Suppress Corticosteroid Binding Globulin in Male Mice, Affecting the Endocrine Stress Response
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    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
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    Dynamic remodeling of Septin structures fine-tunes myogenic differentiation
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    MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
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    PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
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    Aldehydes alter TGF-β signaling and induce obesity and cancer
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  25. Aug 2024
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    Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC
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    Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II
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    RAD51 protects abasic sites to prevent replication fork breakage
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
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    Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation
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    Retinal pigment epithelial integrity is compromised in the developing albino mouse retina
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  37. Jul 2024
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    ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins
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    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis
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    Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome
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  44. Jun 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.
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    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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    The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress
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    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
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    Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after hypomethylating agent failure in chronic myelomonocytic leukemia
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
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    Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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    A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development
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    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  68. Feb 2024
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    Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas
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    YAP mediates apoptosis through failed integrin adhesion reinforcement
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    IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels
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    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
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    Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension
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    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
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    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
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    Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
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    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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    A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin
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    CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance
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    GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration
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    Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly
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    Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition
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  138. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
    1
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      DOI: 10.1158/1078-0432.CCR-21-4291

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  139. www.sciencedirect.com www.sciencedirect.com
    Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V
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      DOI: 10.1016/j.scr.2023.103108

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  140. Apr 2023
  141. www.sciencedirect.com www.sciencedirect.com
    Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V
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  142. www.sciencedirect.com www.sciencedirect.com
    A tissue injury sensing and repair pathway distinct from host pathogen defense
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      DOI: 10.1016/j.cell.2023.03.031

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  143. www.sciencedirect.com www.sciencedirect.com
    Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions
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  144. www.nature.com www.nature.com
    Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
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      DOI: 10.1038/s41467-023-37617-3

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  145. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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  146. Mar 2023
  147. www.sciencedirect.com www.sciencedirect.com
    Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest
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  148. www.sciencedirect.com www.sciencedirect.com
    Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
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      DOI: 10.1016/j.immuni.2023.02.018

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  149. www.sciencedirect.com www.sciencedirect.com
    Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
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  150. Feb 2023
  151. www.sciencedirect.com www.sciencedirect.com
    Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers
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  152. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
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  153. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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  155. Jan 2023
  156. www.sciencedirect.com www.sciencedirect.com
    MDC1 maintains active elongation complexes of RNA polymerase II
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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      DOI: 10.1158/2159-8290.CD-22-0489

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  158. www.sciencedirect.com www.sciencedirect.com
    Evolutionarily conserved regulators of tau identify targets for new therapies
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  159. Dec 2022
  160. www.mdpi.com www.mdpi.com
    Concentration Dependent Effect of Quaternary Amines on the Adhesion of U251-MG Cells
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  161. Nov 2022
  162. www.sciencedirect.com www.sciencedirect.com
    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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      DOI: 10.1084/jem.20220837

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  164. Oct 2022
  165. www.science.org www.science.org
    Ketogenic diet uncovers differential metabolic plasticity of brain cells
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      DOI: 10.1126/sciadv.abo7639

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  166. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
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    sciencedirect.com/science/article/pii/S2211124722013250
  168. Sep 2022
  169. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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      DOI: 10.15252/embr.202154136

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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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  171. www.sciencedirect.com www.sciencedirect.com
    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging
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      DOI: 10.1016/j.cub.2022.08.040

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  173. www.cell.com www.cell.com
    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
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  174. Aug 2022
  175. www.science.org www.science.org
    Functional and biological heterogeneity of KRASQ61 mutations
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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  177. Jul 2022
  178. www.sciencedirect.com www.sciencedirect.com
    Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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  180. Jun 2022
  181. www.sciencedirect.com www.sciencedirect.com
    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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  182. www.sciencedirect.com www.sciencedirect.com
    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2
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  184. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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  185. www.sciencedirect.com www.sciencedirect.com
    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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  186. May 2022
  187. www.sciencedirect.com www.sciencedirect.com
    Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
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  188. www.sciencedirect.com www.sciencedirect.com
    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A superior loading control for the cellular thermal shift assay
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    Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration
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    Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model
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    Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion
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    Vinculin controls endothelial cell junction dynamics during vascular lumen formation
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    Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner
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    Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas
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    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development
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    Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier
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    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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    Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition
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    Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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    5-FU blocks shuttling of HuR mediated by PKCδ in gastric cancer cells
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    Heat shock induces premature transcript termination and reconfigures the human transcriptome
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    Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development
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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
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    Platelet rich plasma affects gap junctional features in myofibroblasts in vitro via Vascular Endothelial Growth Factor (VEGF)-A/VEGF receptor
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    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  219. Dec 2021
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    Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1
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    Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1
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    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
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    Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
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    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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