460 Matching Annotations
  1. Jun 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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    1. scibot 08 Jun 2022
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    sciencedirect.com/science/article/pii/S1550413122001875
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    Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
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    sciencedirect.com/science/article/pii/S1550413122001863
  4. www.nature.com www.nature.com
    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
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    1. scibot 07 Jun 2022
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      DOI: 10.1038/s41419-022-04988-2

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    nature.com/articles/s41419-022-04988-2
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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    1. scibot 07 Jun 2022
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      DOI: 10.1158/2159-8290.CD-21-0209

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  6. academic.oup.com academic.oup.com
    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
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    1. scibot 03 Jun 2022
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      DOI: 10.1210/clinem/dgac270

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac270/6577152
  7. academic.oup.com academic.oup.com
    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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      DOI: 10.1210/endocr/bqac048

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    academic.oup.com/endo/article/163/6/bqac048/6569208
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
    1
    1. scibot 01 Jun 2022
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  9. May 2022
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    1. scibot 20 May 2022
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      DOI: 10.1016/j.molcel.2022.04.030

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    sciencedirect.com/science/article/pii/S1097276522003938
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    sciencedirect.com/science/article/pii/S2211124722005952
  12. aacrjournals.org aacrjournals.org
    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
    1
    1. scibot 13 May 2022
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      DOI: 10.1158/1541-7786.MCR-21-0699

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    aacrjournals.org/mcr/article/20/5/810/694642/Tumor-Microenvironment-Acidity-Triggers-Lipid
  13. Apr 2022
  14. academic.oup.com academic.oup.com
    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
    1
    1. scibot 29 Apr 2022
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      DOI: 10.1210/endocr/bqac035

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    academic.oup.com/endo/article/163/5/bqac035/6550639
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    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    sciencedirect.com/science/article/pii/S221112472200482X
  16. www.sciencedirect.com www.sciencedirect.com
    IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming
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    1. scibot 26 Apr 2022
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    sciencedirect.com/science/article/pii/S2589004222004795
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
    1
    1. scibot 15 Apr 2022
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    sciencedirect.com/science/article/pii/S2211124722004223
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration
    1
    1. scibot 14 Apr 2022
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      DOI: 10.7554/eLife.77610

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    ncbi.nlm.nih.gov/pmc/articles/PMC9005187/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8983383/
  20. www.sciencedirect.com www.sciencedirect.com
    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
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    sciencedirect.com/science/article/pii/S221112472200393X
  21. www.jneurosci.org www.jneurosci.org
    ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination
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      DOI: 10.1523/JNEUROSCI.1341-21.2022

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    jneurosci.org/content/42/12/2433
  22. Mar 2022
  23. www.sciencedirect.com www.sciencedirect.com
    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
    1
    1. scibot 23 Mar 2022
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    sciencedirect.com/science/article/pii/S2211124722002893
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
    1
    1. scibot 11 Mar 2022
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      DOI: 10.1038/s41598-022-07600-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
  25. journals.lww.com journals.lww.com
    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
    1
    1. scibot 10 Mar 2022
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      DOI: 10.4103/1673-5374.335163

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    journals.lww.com/nrronline/Fulltext/2022/17090/Urolithin_A_alleviates_blood_brain_barrier.32.aspx
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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    1. scibot 09 Mar 2022
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      DOI: 10.1016/j.isci.2022.103912

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    sciencedirect.com/science/article/pii/S2589004222001821
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
    1
    1. scibot 02 Mar 2022
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      DOI: 10.1016/j.devcel.2022.02.004

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    sciencedirect.com/science/article/pii/S1534580722000703
  28. Feb 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
    1
    1. scibot 16 Feb 2022
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      DOI: 10.3390/nu14030583

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    ncbi.nlm.nih.gov/pmc/articles/PMC8840593/
  30. www.sciencedirect.com www.sciencedirect.com
    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
    1
    1. scibot 13 Feb 2022
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    sciencedirect.com/science/article/pii/S0021925822001569
  31. www.sciencedirect.com www.sciencedirect.com
    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
    2
    1. scibot 11 Feb 2022
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    sciencedirect.com/science/article/pii/S2451945622000022
  32. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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      DOI: 10.1371/journal.pbio.3001502

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    journals.plos.org/plosbiology/article
  33. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
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    sciencedirect.com/science/article/pii/S1550413121006896
  35. Jan 2022
  36. link.springer.com link.springer.com
    Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis
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    link.springer.com/article/10.1186/s12915-021-01225-8
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    Acetylation-dependent regulation of BRAF oncogenic function
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    sciencedirect.com/science/article/pii/S2211124721017629
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    An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance
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    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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    sciencedirect.com/science/article/pii/S1074761321005343
  40. Dec 2021
  41. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
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    sciencedirect.com/science/article/pii/S2589004221016151
  42. www.sciencedirect.com www.sciencedirect.com
    MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells
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  43. academic.oup.com academic.oup.com
    TRIB3 is highly expressed in the adipose tissue of obese patients and is associated with insulin resistance
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      DOI: 10.1210/clinem/dgab780

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab780/6410848
  44. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15693
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner
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      DOI: 10.7554/eLife.68695

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    ncbi.nlm.nih.gov/pmc/articles/PMC8676342/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
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      DOI: 10.7554/eLife.73753

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    ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
  47. www.sciencedirect.com www.sciencedirect.com
    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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      DOI: 10.1016/j.isci.2021.103517

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    Efferocytosis induces macrophage proliferation to help resolve tissue injury
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
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    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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  63. Sep 2021
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    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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  66. Aug 2021
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    An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells
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    Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6
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    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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  86. Jul 2021
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    Sex difference in corticosterone-induced insulin resistance in mice
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    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling
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    Protein kinase B mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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    Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation
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    Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice
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    Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2
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    Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
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    Impact of WIN site inhibitor on the WDR5 interactome
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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
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    Effect of Hyperbaric Oxygen Therapy on Acute Liver Injury and Survival in a Rat Cecal Slurry Peritonitis Model
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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  161. Sep 2020
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    Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance
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    PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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      AKT

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    High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer
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      Akt (pan) (C67E7) rabbit mAb

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  186. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal rabbit Akt

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    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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    Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation
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    Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
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    Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
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    HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
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    Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    Involvement of Akt-dependent CREB signaling pathway in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced early growth response protein-1 (Egr-1) expression in vascular smooth muscle cells - Canadian Journal of Physiology and Pharmacology
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  198. dev.biologists.org dev.biologists.org
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    VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance
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    Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine
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    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    BPS Publications
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
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    Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
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    Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis
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    Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes
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    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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    Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis
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    Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway
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    Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors
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    Risperidone ameliorates prefrontal cortex neural atrophy and oxidative/nitrosative stress in brain and peripheral blood of rats with neonatal ventral hippocampus lesion
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice
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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy
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