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    Adipocyte-derived ferroptotic signaling mitigates obesity
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  3. Dec 2024
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    Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys
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    Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
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  8. Nov 2024
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    MOTS-c modulates skeletal muscle function by directly binding and activating CK2
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    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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  11. Oct 2024
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    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
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    Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  17. Sep 2024
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    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
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    IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    Endothelial metabolic control of insulin sensitivity through resident macrophages
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    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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    Aldehydes alter TGF-β signaling and induce obesity and cancer
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  28. Aug 2024
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    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
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    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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  38. Jul 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway
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    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
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    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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  46. Jun 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.
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    Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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  52. May 2024
  53. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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  60. journals.physiology.org journals.physiology.org
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening
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    DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling
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    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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    Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2
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    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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    An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation
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  128. Sep 2023
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    Mechanism of Hyperproteinemia-Induced Damage to Female Reproduction in a Genetic Silkworm Model
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    Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency
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    PARP1 inhibition protects mice against Japanese encephalitis virus infection
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer
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  137. www.biorxiv.org www.biorxiv.org
    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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  145. Jul 2023
  146. dx.doi.org dx.doi.org
    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Cell Competition Shapes Metastatic Latency and Relapse
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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  154. Jun 2023
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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  171. May 2023
  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials
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    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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    Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
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    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
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    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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    Epithelial cells activate fibroblasts to promote esophageal cancer development
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    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
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    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation
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    Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy
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    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
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    Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
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    The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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