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    Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
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    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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    BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
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    ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion
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    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
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    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
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    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer
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    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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  14. Mar 2024
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    TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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    Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells
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  19. Feb 2024
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    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase
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    Stromal-derived MAOB promotes prostate cancer growth and progression
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    Protocol for gene knockdown using siRNA in primary cultured neonatal murine microglia
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
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    EHD2 regulates plasma membrane integrity and downstream insulin receptor signalling events
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    Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening
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    DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling
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  30. Jan 2024
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    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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    EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events
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  38. Dec 2023
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    Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2
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    An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling
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    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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    Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
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    Lysoglycosphingolipids have the ability to induce cell death through direct PI3K inhibition
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    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation
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    Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons
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    Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  59. Oct 2023
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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    An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation
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    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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  66. Sep 2023
  67. 52.53.155.43 52.53.155.43
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    Mechanism of Hyperproteinemia-Induced Damage to Female Reproduction in a Genetic Silkworm Model
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    Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency
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    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
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    PARP1 inhibition protects mice against Japanese encephalitis virus infection
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration
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  83. Jul 2023
  84. dx.doi.org dx.doi.org
    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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    Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation
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    Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy
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    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
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  137. Jan 2023
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    Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance
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    The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
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    The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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    Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation
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    Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
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    Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers
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    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
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    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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    Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    Protocol for assessing ex vivo lipolysis of murine adipose tissue
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH
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    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
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    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  202. May 2022
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
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  206. Apr 2022
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    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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    Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration
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    Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress
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    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
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    ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination
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