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Jul 2021
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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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1. scibot 14 Jul 2021
  
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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells

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  DOI: 10.1016/j.devcel.2021.06.011
  
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sciencedirect.com/science/article/pii/S1534580721005189
Jun 2021
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TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis

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cell.com/cell-reports/fulltext/S2211-1247(21)00644-6
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Pumilio2 and Staufen2 selectively balance the synaptic proteome

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1. scibot 23 Jun 2021
  
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sciencedirect.com/science/article/pii/S221112472100646X
May 2021
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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

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The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407

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1. scibot 10 May 2021
  
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  DOI: 10.1210/endocr/bqaa196
  
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academic.oup.com/endo/article/162/1/bqaa196/5936120
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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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academic.oup.com/endo/article/161/10/bqaa133/5881724
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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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sciencedirect.com/science/article/pii/S1934590921000588
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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

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sciencedirect.com/science/article/pii/S1550413121000577
Apr 2021
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Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

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1. scibot 30 Apr 2021
  
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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

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1. scibot 29 Apr 2021
  
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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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1. scibot 20 Apr 2021
  
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sciencedirect.com/science/article/pii/S153561082030369X
Feb 2021
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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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1. scibot 25 Feb 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7219759/
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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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1. scibot 25 Feb 2021
  
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  DOI: 10.7554/eLife.61406
  
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elifesciences.org/articles/61406
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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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1. scibot 25 Feb 2021
  
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  DOI: 10.1002/mc.23284
  
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onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
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Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models

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mct.aacrjournals.org/content/19/1/292
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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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1. scibot 24 Feb 2021
  
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An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia

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sciencedirect.com/science/article/pii/S2211124721000656
Jan 2021
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Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function

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  DOI: 10.1096/fj.202002203R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202002203R
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
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Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

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ncbi.nlm.nih.gov/pmc/articles/PMC7839063/
Dec 2020
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Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth

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Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

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  DOI: 10.7554/eLife.62377
  
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elifesciences.org/articles/62377
Nov 2020
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Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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ncbi.nlm.nih.gov/pmc/articles/PMC6894087/
Oct 2020
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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

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cell.com/cell-stem-cell/abstract/S1934-5909(20)30206-X
Sep 2020
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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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Tau Reduction Prevents Key Features of Autism in Mouse Models

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  DOI: 10.1016/j.neuron.2020.01.038
  
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Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

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Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins

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  DOI: 10.1371/journal.pone.0233863
  
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journals.plos.org/plosone/article
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The Dopamine D5 receptor contributes to activation of cholinergic interneurons during L-DOPA induced dyskinesia

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  DOI: 10.1038/s41598-020-59011-5
  
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mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model

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Mitochondrial Regulation of the 26S Proteasome

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Mating Behavioral Function of Preoptic Galanin Neurons Is Shared between Fish with Alternative Male Reproductive Tactics and Tetrapods

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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

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Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

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Kinetic Heterogeneity of Cancer Cell Fractional Killing

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Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

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Cartilage ablation of Sirt1 causes inhibition of growth plate chondrogenesis by hyperactivation of mTORC1 signaling

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Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons

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mTORC1/rpS6 and spermatogenic function in the testis – insights from the adjudin model

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation

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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

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Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation

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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

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Regulation of BTB dynamics in spermatogenesis – insights from the adjudin toxicant model

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Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Activity-dependent dendritic elaboration requires Pten

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The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

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Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

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Untitled document

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity

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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition

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Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

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FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

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Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

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Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration

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Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

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Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma

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B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

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Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

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Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons

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Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

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Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

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Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry

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A Method for the Acute and Rapid Degradation of Endogenous Proteins

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Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice

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IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase

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Loss of foxo rescues stem cell aging in Drosophila germ line

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Nov 2017
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The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells

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CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc

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Untitled document

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Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism

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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

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Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

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Dynamics of mTORC1 activation in response to amino acids

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Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

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