282 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease
    1
    1. scibot 11 Dec 2024
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      DOI: 10.1371/journal.pone.0314858

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    pmc.ncbi.nlm.nih.gov/articles/PMC11620608/
  3. www.sciencedirect.com www.sciencedirect.com
    Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells
    1
    1. scibot 06 Dec 2024
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    sciencedirect.com/science/article/pii/S1534580724006725
  4. Nov 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Impaired pheromone detection and abnormal sexual behavior in female mice deficient for ancV1R
    1
    1. scibot 24 Nov 2024
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      DOI: 10.1016/j.cub.2024.10.077

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    sciencedirect.com/science/article/pii/S0960982224015045
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    PTEN deletion in the adult dentate gyrus induces epilepsy
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    1. scibot 21 Nov 2024
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      DOI: 10.1016/j.nbd.2024.106736

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    sciencedirect.com/science/article/pii/S0969996124003383
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
    1
    1. scibot 15 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11544388/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
    1
    1. scibot 10 Nov 2024
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      DOI: 10.7554/eLife.97854

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    pmc.ncbi.nlm.nih.gov/articles/PMC11542922/
  9. Oct 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Midkine as a driver of age-related changes and increase in mammary tumorigenesis
    1
    1. scibot 04 Oct 2024
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    sciencedirect.com/science/article/pii/S1535610824003507
  11. Sep 2024
  12. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
    1
    1. scibot 27 Sep 2024
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      DOI: 10.1093/hmg/ddae135

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    dx.doi.org/10.1093/hmg/ddae135
  13. www.sciencedirect.com www.sciencedirect.com
    mTOR activity paces human blastocyst stage developmental progression
    1
    1. scibot 27 Sep 2024
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    sciencedirect.com/science/article/pii/S0092867424009772
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.neuron.2017.12.036

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    ncbi.nlm.nih.gov/pmc/articles/PMC5777326/
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    Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
    1
    1. scibot 25 Sep 2024
      RRID:AB_390782

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    sciencedirect.com/science/article/pii/S1097276521002136
  16. www.sciencedirect.com www.sciencedirect.com
    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
    1
    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124721001108
  17. www.sciencedirect.com www.sciencedirect.com
    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2020.108366

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    sciencedirect.com/science/article/pii/S2211124720313553
  18. academic.oup.com academic.oup.com
    A mouse model of endometriosis mimicking the natural spread of invasive endometrium
    1
    1. scibot 25 Sep 2024
      RRID:AB_2721245

      DOI: 10.1093/humrep/dez253

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    academic.oup.com/humrep/advance-article/doi/10.1093/humrep/dez253/5689797
  19. www.sciencedirect.com www.sciencedirect.com
    Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.cmet.2019.09.012

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  20. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
    1
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      DOI: 10.1016/j.molcel.2019.07.021

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice
    1
    1. scibot 06 Sep 2024
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      DOI: 10.1210/endocr/bqad133

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502789/
  22. 52.53.155.43 52.53.155.43
    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease
    1
    1. scibot 05 Sep 2024
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      DOI: 10.1101/2024.07.19.604372

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    52.53.155.43/094bf1894e7037610818c8319cb16bd0730a5b11/2024.07.19.604372v1.full-html.html
  23. Aug 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY
    1
    1. scibot 27 Aug 2024
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      DOI: 10.1101/2024.08.07.606938

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    ncbi.nlm.nih.gov/pmc/articles/PMC11326251/
  25. www.sciencedirect.com www.sciencedirect.com
    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
    1
    1. scibot 22 Aug 2024
      AB_916156

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    sciencedirect.com/science/article/pii/S1097276524006191
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    Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.isci.2024.110550

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    sciencedirect.com/science/article/pii/S2589004224017759
  27. www.sciencedirect.com www.sciencedirect.com
    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
    1
    1. scibot 19 Aug 2024
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    sciencedirect.com/science/article/pii/S1931312824002713
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  29. www.cell.com www.cell.com
    Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1163/2210-7886_asc-30294

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    cell.com/cell-metabolism/abstract/S1550-4131(17)30294-2
  30. Jul 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.isci.2024.109912

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    ncbi.nlm.nih.gov/pmc/articles/PMC11225835/
  32. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
    1
    1. scibot 04 Jul 2024
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      DOI: 10.7554/eLife.98649

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    elifesciences.org/articles/98649
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperactive mTORC1 Disrupts Habenula Function and Light Preference in Zebrafish Model of Tuberous Sclerosis Complex
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11214417/
  34. May 2024
  35. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.molcel.2024.04.026

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    sciencedirect.com/science/article/pii/S1097276524003939
  36. aacrjournals.org aacrjournals.org
    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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      DOI: 10.1158/1078-0432.CCR-23-2951

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    aacrjournals.org/clincancerres/article/30/8/1582/742134/Discovery-of-a-Novel-Potent-EGFR-Inhibitor-Against
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
    1
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      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  38. Apr 2024
  39. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6282
  40. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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      DOI: 10.1186/s12958-024-01204-y

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  41. Mar 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
  44. Feb 2024
  45. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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      DOI: 10.1101/2023.08.23.554263

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    52.53.155.43/d64025fcba7405c73976a9e0dc65e9989e0d835f/2023.08.23.554263v1.full-html.html
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    GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity
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      DOI: 10.1016/j.celrep.2024.113739

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    sciencedirect.com/science/article/pii/S2211124724000676
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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      RRID:AB_3075349

      DOI: 10.1016/j.cmet.2024.01.005

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  48. Dec 2023
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    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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  82. May 2023
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  94. Feb 2023
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  96. Jan 2023
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    Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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  104. Nov 2022
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    Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells
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  118. Jul 2022
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    Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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    F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model
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  194. www.sciencedirect.com www.sciencedirect.com
    Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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    Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells
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  198. Jun 2021
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    TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
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  201. May 2021
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407
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    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
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    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
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  208. Apr 2021
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    Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
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    Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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  214. Feb 2021
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    The kinase PDK1 is critical for promoting T follicular helper cell differentiation
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    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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    An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia
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  221. Jan 2021
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    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
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    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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    Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity
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  225. Dec 2020
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    Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth
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  228. Nov 2020
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    Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  231. Oct 2020
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    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
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  233. Sep 2020
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
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    Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins
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    The Dopamine D5 receptor contributes to activation of cholinergic interneurons during L-DOPA induced dyskinesia
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    mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model
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    Mitochondrial Regulation of the 26S Proteasome
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