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Cell-type-specific damage scores reveal kidney and liver disease trajectories in single-cell and spatial transcriptomics

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Cutaneous nonpeptidergic neurons sense extracellular ATP to augment barrier repair and C. albicans host defense

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ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models

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Aug 2026
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Neuron type-specific translatomes in dorsal hippocampus during early memory consolidation

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Jul 2026
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Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling

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ER-mitochondria contacts and mitochondrial fusion correlate with increased mitochondrial activity during vertebrate embryogenesis

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huang-et-al-2025-cdk5rap3-mediated-regulation-of-lysosomal-and-er-membrane-proteins-is-pivotal-for-the-survival-and-html.html

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Jun 2026
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De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity

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Overcoming adaptive resistance to KRASG12D blockade in pancreatic cancer through vertical pathway inhibition

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PI3Kα inhibitor and degrader inavolisib can co-opt FGFR2 to enhance responses in patients with PIK3CA-mutated solid tumors and in preclinical models

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Suppression of ATM kinase signaling accelerates cellular senescence

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MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities

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May 2026
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Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling

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JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC

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The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management

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Apr 2026
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mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway

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PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tumor immune escape in ovarian cancer

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Mar 2026
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NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors

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Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers

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The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice

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S6K1 Modulates STAT3 Activation to Promote Resistance to Radiotherapy in Lung Cancer

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Feb 2026
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1-s2.0-S2589004226003718-main-html.html

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Jan 2026
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Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation

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Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness

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Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects

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Retrograde control of sympathetic neuron-satellite glia interactions by target-derived NGF signaling

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1-s2.0-S2589004225025404-main-html.html

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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis

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Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing

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2025.11.05.686656v1.full-html.html

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Oct 2025
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Ribosome dysregulation and intervention in age-related infertility

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Adrenergic signaling coordinates distant and local responses to amputation in axolotl

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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

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hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html

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Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures

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Ketone body β-Hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

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Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells

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Impaired pheromone detection and abnormal sexual behavior in female mice deficient for ancV1R

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PTEN deletion in the adult dentate gyrus induces epilepsy

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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981

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Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis

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Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels

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  DOI: 10.1093/hmg/ddae135
  
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mTOR activity paces human blastocyst stage developmental progression

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Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

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Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

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A mouse model of endometriosis mimicking the natural spread of invasive endometrium

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  DOI: 10.1093/humrep/dez253
  
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Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease

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PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY

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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients

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BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism

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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

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  DOI: 10.1163/2210-7886_asc-30294
  
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Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

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Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease

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Hyperactive mTORC1 Disrupts Habenula Function and Light Preference in Zebrafish Model of Tuberous Sclerosis Complex

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May 2024
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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC

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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

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  DOI: 10.21203/rs.3.rs-4114038/v1
  
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Apr 2024
pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com

Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model

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12958_2024_1204_MOESM1_ESM-html.html

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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway

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An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

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GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity

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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

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An oncogenic phenoscape of colonic stem cell polarization

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Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses

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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

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Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest

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s11684-022-0959-5 (1)-html.html

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Brain regions controlling courtship behavior in the bluehead wrasse

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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

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Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses

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Synergistic effect of chemogenetic activation of corticospinal motoneurons and physical exercise in promoting functional recovery after spinal cord injury

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FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia

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RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

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A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.

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mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway

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Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

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FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress

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Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

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Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

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Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases

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cd-23-0475-html.html

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IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

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Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months

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Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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s11684-022-0959-5-html.html

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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

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The p-rpS6-zone delineates wounding responses and the healing process

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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

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Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers

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Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells

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TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

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Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

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TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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Ring domains are essential for GATOR2-dependent mTORC1 activation

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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

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Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells

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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction

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Satellite glia modulate sympathetic neuron survival, activity, and autonomic function

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Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells

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Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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Context-dependent regulation of ferroptosis sensitivity

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Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response

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Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model

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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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Translational Strategies for Repotrectinib in Neuroblastoma

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IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide

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Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy

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Coordinated changes in glycosylation regulate the germinal center through CD22

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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

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The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia

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A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice

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Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

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AKT signaling downstream of KGF is necessary and sufficient for blocking cyclophosphamide bladder injury

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Mosaic dysfunction of mitophagy in mitochondrial muscle disease

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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth

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GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases

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Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice

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The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability

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Oxytocin-like receptor expression in evolutionarily conserved nodes of a vocal network associated with male courtship in a teleost fish

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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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