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Nov 2025
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Genome‐Wide CRISPR/Cas9 Screening Identifies the COMMANDER Recycling Complex as a Key Player in EV Uptake

1
1. scibot 23 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1002/jev2.70166
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12456102/
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A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

1
1. scibot 23 Nov 2025
  
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  Addgene_12
  
  DOI: 10.1186/s13024-025-00889-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12465293/
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2025.11.15.688565v1.full-html.html

1
1. scibot 22 Nov 2025
  
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  12259
  
  DOI: 10.1101/2025.11.15.688565
  
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54.241.53.176/3259fae050498259be3938591f9171ada23644a0/2025.11.15.688565v1.full-html.html
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

1
1. scibot 22 Nov 2025
  
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  AddgeneCat#12259
  
  DOI: 10.1016/j.molcel.2025.10.030
  
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sciencedirect.com/science/article/pii/S1097276525008913
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Single-cell activation screen identifies hepatic maturation regulators with zonal resolution

1
1. scibot 22 Nov 2025
  
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  Addgene 12259
  
  DOI: 10.1016/j.devcel.2025.10.014
  
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sciencedirect.com/science/article/pii/S1534580725006653
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Chromatin remodeler Chd7 regulates reactive astrogliosis after ischemic stroke

2
1. scibot 22 Nov 2025
  
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  Addgene #12259
  
  DOI: 10.1016/j.celrep.2025.116590
  
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2. scibot 22 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1016/j.celrep.2025.116590
  
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sciencedirect.com/science/article/pii/S2211124725013622
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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

1
1. scibot 22 Nov 2025
  
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  Addgene12259
  
  DOI: 10.1016/j.celrep.2025.116588
  
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sciencedirect.com/science/article/pii/S2211124725013609
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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

2
1. scibot 22 Nov 2025
  
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  Addgene#12259
  
  DOI: 10.1016/j.cell.2025.10.028
  
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2. scibot 22 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1016/j.cell.2025.10.028
  
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sciencedirect.com/science/article/pii/S0092867425012334
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Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway

1
1. scibot 22 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.molcel.2025.10.028
  
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sciencedirect.com/science/article/pii/S1097276525008895
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Mechanosensitive interactions between Jag1 and Myo1c control Jag1 trafficking in endothelial cells

1
1. scibot 22 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.isci.2025.113879
  
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sciencedirect.com/science/article/pii/S2589004225021406
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting the FoxJ3/FoxO6 axis suppresses hepatocellular carcinoma growth by inducing cell cycle arrest and apoptosis

1
1. scibot 21 Nov 2025
  
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  12259
  
  DOI: 10.62347/PVIG8848
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12628247/
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A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1‐inducible model

1
1. scibot 21 Nov 2025
  
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  12259
  
  DOI: 10.1111/bjh.70130
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12624197/
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RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis

1
1. scibot 21 Nov 2025
  
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  12259
  
  DOI: 10.1038/s41467-025-65012-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12623739/
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Hypoxia promotes airway differentiation in the human lung epithelium

1
1. scibot 21 Nov 2025
  
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  12259
  
  DOI: 10.1016/j.stem.2025.09.007
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618356/
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The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

1
1. scibot 21 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.7554/eLife.103484
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12629595/
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Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid–like structures and enhance antitumor immunity

1
1. scibot 21 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1073/pnas.2409560122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12625823/
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UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN

1
1. scibot 21 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1038/s41467-025-64977-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
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Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models

1
1. scibot 18 Nov 2025
  
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  RRID: Addgene_12259
  
  DOI: 10.1172/JCI193370
  
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  Curator: @evieth
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12618067/
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UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance

1
1. scibot 18 Nov 2025
  
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  Addgene12259
  
  DOI: 10.1016/j.molcel.2025.10.011
  
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sciencedirect.com/science/article/pii/S1097276525008287
www.biorxiv.org www.biorxiv.org

Therapeutic Inducers of NK cell Killing (ThINKK)-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia: unraveling the dual role of TRAIL leads to the establishment of an efficacy biomarker

1
1. scibot 18 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1101/2025.11.12.687655
  
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biorxiv.org/content/10.1101/2025.11.12.687655v1
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A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1

1
1. scibot 18 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1038/s41467-025-64939-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12615601/
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Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14

1
1. scibot 16 Nov 2025
  
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  Addgene#12259
  
  DOI: 10.1016/j.celrep.2025.116553
  
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sciencedirect.com/science/article/pii/S2211124725013245
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PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

1
1. scibot 15 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/0008-5472.CAN-24-4501
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

1
1. scibot 15 Nov 2025
  
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.immuni.2025.10.020
  
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sciencedirect.com/science/article/pii/S1074761325004741
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Extracellular vesicle R-Ras is a potential biomarker for human peripheral artery disease

1
1. scibot 15 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.isci.2025.113859
  
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sciencedirect.com/science/article/pii/S2589004225021200
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Protocol for specific induction of apoptosis or necroptosis in established murine tumors

1
1. scibot 13 Nov 2025
  
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  Addgene12259
  
  DOI: 10.1016/j.xpro.2025.104185
  
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sciencedirect.com/science/article/pii/S266616672500591X
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An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels

1
1. scibot 13 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.chembiol.2025.10.006
  
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sciencedirect.com/science/article/pii/S2451945625003435
elifesciences.org elifesciences.org

Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During Ligand-Mediated Transcriptional Burst Events

1
1. scibot 11 Nov 2025
  
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  Addgene 12259
  
  DOI: 10.7554/eLife.108726.1
  
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elifesciences.org/reviewed-preprints/108726
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TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma

1
1. scibot 11 Nov 2025
  
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  Addgene, Plasmid # 12259
  
  DOI: 10.1101/2025.11.03.686399
  
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biorxiv.org/content/10.1101/2025.11.03.686399v1
www.nature.com www.nature.com

Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells

1
1. scibot 11 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s42003-025-08907-x
  
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nature.com/articles/s42003-025-08907-x
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for simplified parallel perturbations using an abridged long non-coding RNA CRISPR library

1
1. scibot 10 Nov 2025
  
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  12259
  
  DOI: 10.1016/j.xpro.2025.104110
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12509891/
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Lineage-resolved atlas of the developing human cortex

1
1. scibot 08 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1038/s41586-025-09033-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12589122/
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Nuclear-lamin-guided plastic positioning and folding of the human genome

1
1. scibot 08 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1016/j.celrep.2025.116529
  
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sciencedirect.com/science/article/pii/S2211124725013002
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity

1
1. scibot 07 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1158/2643-3230.BCD-24-0140
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12050964/
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Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons

1
1. scibot 07 Nov 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1111/jnc.70284
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12580966/
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A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking

1
1. scibot 07 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1073/pnas.2514956122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12582296/
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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

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Disparate leukemia mutations converge on nuclear phase-separated condensates

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1-s2.0-S2589004225021583-main-html.html

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The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts

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Reporter-Mediated Evaluation of the Circadian Oscillations of SNAIL Across In Vitro Models

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Targeting of SKP2 to combat drug resistance in multiple myeloma

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Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation

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Mitochondrial ROS Drive Adipogenic Differentiation in Osteoporosis by Suppressing Protein Synthesis

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A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential

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Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

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1-s2.0-S2589004225020942-main-html.html

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Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling

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Development of antigen multimers for detection and evaluation of CAR T cells

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XXYLT1 inhibits NOTCH1 activation in Jurkat cells while promoting cell proliferation

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PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape

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Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21

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Genetically tractable embryonic cell lines from sea urchins Lytechinus variegatus and Strongylocentrotus purpuratus

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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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A non-canonical immunometabolic function of BRD3 during sepsis

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CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma

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The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis

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CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma

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Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc

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WNK1 promotes head and neck squamous cell carcinoma progression through activation of NF-κB signaling pathway

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Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis

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The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

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A novel Frizzled 7 antibody disrupts the Wnt pathway and inhibits Wilms tumor growth

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Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis

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Tuning insulin receptor signaling using de novo-designed agonists

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Vitamin C conveys geroprotection on primate ovaries

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CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression

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pmc.ncbi.nlm.nih.gov/articles/PMC12511632/
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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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A nanobody-based tri-specific NK cell engager targeting CD5 triggers antitumor immunity

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The upregulation of GDF15 is controlled epigenetically by oncogenic TCF19 signaling in human hepatocellular carcinoma

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The role of MRGPRX1 in the melanogenesis of human primary epidermal melanocytes

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Mechanochemical waves in focal adhesions during cell migration

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1-s2.0-S2589004225019741-main-html.html

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Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer

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ssrn-5552539-html.html

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Development of a Porcine Cell Line Stably Expressing Ephrin-B2 for Nipah Virus Research and Diagnostic Testing

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DDHD2 provides a flux of saturated fatty acids for neuronal energy and function

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Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

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Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy

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Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiation Therapy

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USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

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Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

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Non-cell-autonomous tumor promotion in DICER1 cancer predisposition

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KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer

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Multidimensional analysis of host–virus interactions using the virus-encoded CRISPR-based direct readout system (VECOS)

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IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation

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Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1

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dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening

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pmc.ncbi.nlm.nih.gov/articles/PMC11977238/
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Neuropeptide adrenomedullin remodels stemness and macrophage dynamics in glioblastoma

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Direct Activity Measurement of Heterotrimeric Gi Proteins and Gq Protein By Effector Pulldown

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12336858/
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Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics

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pmc.ncbi.nlm.nih.gov/articles/PMC11839039/
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Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding

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  Addgene, plasmid no. 12259
  
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Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids

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Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

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  Addgene 12259
  
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells

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Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding

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HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors

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SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages

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pmc.ncbi.nlm.nih.gov/articles/PMC12445670/
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JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein

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pmc.ncbi.nlm.nih.gov/articles/PMC12446446/
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Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation

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pmc.ncbi.nlm.nih.gov/articles/PMC12443345/
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Targeting inflammation with chimeric antigen receptor macrophages using a signal switch

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  PMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12443588/
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TKTL1: a new candidate gene in non-obstructive azoospermia

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pmc.ncbi.nlm.nih.gov/articles/PMC12448108/
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Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth

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pmc.ncbi.nlm.nih.gov/articles/PMC12446975/
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Newcastle disease virus exploits the phospholipid flippase ATP11c–CDC50A complex to promote viral infection

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pmc.ncbi.nlm.nih.gov/articles/PMC12446626/
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Targeting mutated KRAS by HLA-A*02:01 restricted anti-KRAS TCR-mimic CAR and bispecific T cell engager

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12449438/
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A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening

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  Addgene_12
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12445041/
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Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12420363/
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The axonal ER couples translation and secretion machineries for local delivery of axonal transmembrane proteins to promote axonal development

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Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

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Protocol for detecting ligand-induced ubiquitination of LAG3 in human T cells

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PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis

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Protocol for noninvasive imaging of hematopoietic reconstitution in live mice using Akaluc bioluminescence

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The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

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Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis

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ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

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Glycogen synthase kinase-3 is essential for Treg development and function

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C9orf72 ALS-causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

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α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

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Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

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Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8

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Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

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aacrjournals.org/bloodcancerdiscov/article/6/5/484/764335/Microbiota-Shape-Metabolic-and-Immune-Determinants
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Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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aacrjournals.org/mcr/article/23/9/765/764255/Novel-Metastasis-Suppressor-PI3KC2-Is-Mediated-by
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Cooperativity between Ras pathway mutations in colonic tumorigenesis

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Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis: Cx58 promotes the metastasis of NSCLC

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AKR1C3 protects cardiomyocytes against hypoxia-induced cell apoptosis through the Nrf-2/NF-κB pathway: AKR1C3 protects against cardiomyocyte apoptosis

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2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction

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PIBF1 expression and survival outcome in TNBC and Non-TNBC breast cancer patients with lymph node metastasis who undertaken chemotherapy

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AVJ16 inhibits lung carcinoma by targeting IGF2BP1

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MED12 mutation induces RTK inhibitor resistance in NSCLC via MEK/ERK pathway activation by inflammatory cytokines

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<em>Clinical & Translational Immunology</em> | ASI Journal | Wiley Online Library

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CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

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MicroRNA-885-5p regulates cell cycle progression in liver cancer cells

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Inorganic Polyphosphate Triggers NLRP3 Inflammasome and Promotes the Epithelial-to-Mesenchymal Transition and Migration of Colorectal Cancer Cells Through TRPM8 Receptor

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Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma

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Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy

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PKN2 is a dependency of the mesenchymal-like cancer cell state

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Sympathetic Neurons Promote Small Cell Lung Cancer Through the Beta-2 Adrenergic Receptor

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Resilience and vulnerabilities of tumor cells under purine shortage stress

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Development of Degraders and 2-pyridinecarboxyaldehyde (2-PCA) as a recruitment Ligand for FBXO22

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The p400 complex promotes HIV-1 latency by suppressing viral transcription and altering the host cell state

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Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function

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pmc.ncbi.nlm.nih.gov/articles/PMC12367984/
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GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma Progression

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PCV2 Infection Upregulates SOCS3 Expression to Facilitate Viral Replication in PK-15 Cells

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Introducing CAR-T Therapy in Kazakhstan: Establishing Academic-Scale Lentiviral Vector and CAR-T Cell Production

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pmc.ncbi.nlm.nih.gov/articles/PMC12385160/
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Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways

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Protein arginine methyltransferase 5 sustains Tip60-EP400 complex via SRSF1 in Merkel cell carcinoma

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Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E

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pmc.ncbi.nlm.nih.gov/articles/PMC12407461/
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Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation

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Atypical cadherin FAT1 promotes tumorigenesis by suppressing autophagic cell death in glioblastoma under hypoxia or nutrient stress

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Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity

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Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma

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α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin

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Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer

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Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During Ligand-Mediated Transcriptional Burst Events

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Targeting FSP1 triggers ferroptosis in lung cancer

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TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation

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AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription

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pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
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Maspin/SerpinB5 is a cytoskeleton-binding protein that regulates epithelial cell shape

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Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons

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Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity

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Nuclear pore complex dysfunction drives TDP-43 pathology in ALS

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pmc.ncbi.nlm.nih.gov/articles/PMC12390953/
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SALSA: a novel flow cytometry assay to detect ascorbate at the single-cell level

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Syncytial death mediated by oncolytic rVSV-NDV dynamically activates immunogenic apoptosis and necroptosis in human lung cancer cells

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Metabolomics analysis of SNAT2-deficient cells: Implications for the discovery of selective small-molecule inhibitors of an amino acid transporter

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Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through in vivo expression

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pmc.ncbi.nlm.nih.gov/articles/PMC12410412/
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TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer

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Cancer Cell‐Secreted miR‐33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis

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pmc.ncbi.nlm.nih.gov/articles/PMC12408367/
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Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

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pmc.ncbi.nlm.nih.gov/articles/PMC12407345/
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NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA

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ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

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pmc.ncbi.nlm.nih.gov/articles/PMC12376547/
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PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma

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Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics

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CRISPR-Cas13d-Mediated Targeting of a Context-Specific Essential Gene Enables Selective Elimination of Uveal Melanoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12393512/
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Pooled CRISPR screens identifies key regulators of bovine stem cell expansion for cultured meat

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pmc.ncbi.nlm.nih.gov/articles/PMC12398484/
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Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target

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Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system

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pmc.ncbi.nlm.nih.gov/articles/PMC12392329/
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Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming

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Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity

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A Polyomavirus-Positive Merkel Cell Carcinoma Mouse Model Supports a Unified Origin for Somatic and Germ Cell Cancers

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Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinoma

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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems

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  DOI: 10.1038/s41467-025-63570-4
  
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nature.com/articles/s41467-025-63570-4
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Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets

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1. scibot 03 Sep 2025
  
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  Addgene_12259
  
  DOI: 10.1016/j.celrep.2025.116211
  
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sciencedirect.com/science/article/pii/S2211124725009829
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K29-Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response

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1. scibot 03 Sep 2025
  
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  Addgene_12259
  
  DOI: 10.1002/advs.202509817
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202509817
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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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1. scibot 30 Aug 2025
  
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  AddgenePlasmid 12259
  
  DOI: 10.1016/j.xcrm.2025.102317
  
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sciencedirect.com/science/article/pii/S2666379125003908
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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

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1. scibot 30 Aug 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.immuni.2025.08.001
  
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sciencedirect.com/science/article/pii/S1074761325003358
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L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

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1. scibot 27 Aug 2025
  
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  Addgene #12259
  
  DOI: 10.1101/2025.08.22.671773
  
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biorxiv.org/content/10.1101/2025.08.22.671773v1
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DFFB suppresses interferon to enable cancer persister cell regrowth

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1. scibot 27 Aug 2025
  
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  Addgene, #12259
  
  DOI: 10.1101/2025.08.15.670603
  
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biorxiv.org/content/10.1101/2025.08.15.670603v1
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Evolution of the SARS-CoV-2 spike protein in utilizing host transmembrane serine proteases

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1. scibot 27 Aug 2025
  
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  AddgeneCat#12259
  
  DOI: 10.1016/j.isci.2025.113318
  
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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1. scibot 27 Aug 2025
  
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  Addgene12259
  
  DOI: 10.1016/j.devcel.2025.07.023
  
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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

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1. scibot 26 Aug 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.xgen.2025.100979
  
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Generation of human embryonic stem cell line expressing dCas9-TET1 fusion protein for epigenetic editing

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1. scibot 26 Aug 2025
  
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  Addgene_12259
  
  DOI: 10.1016/j.scr.2025.103811
  
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sciencedirect.com/science/article/pii/S1873506125001618
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ROS-dependent localization of glycolytic enzymes to mitochondria

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1. scibot 21 Aug 2025
  
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  Addgene_12259
  
  DOI: 10.1016/j.redox.2025.103812
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12359183/
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Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

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1. scibot 21 Aug 2025
  
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  Plasmid_12259
  
  DOI: 10.1002/advs.202502074
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202502074
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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1. scibot 19 Aug 2025
  
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  Plasmid_12259
  
  DOI: 10.1016/j.devcel.2025.07.016
  
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sciencedirect.com/science/article/pii/S1534580725004733

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