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Nov 2025
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Moesin controls cell–cell fusion and osteoclast function

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  DOI: 10.1083/jcb.202409169
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12558046/
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Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication

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  pMD2
  
  DOI: 10.1080/21505594.2025.2585639
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12599336/
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Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility

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  DOI: 10.1073/pnas.2426917122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12519202/
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LeGO-3D: 3D imaging of lung metastases and vascularisation using light sheet fluorescence microscopy

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  DOI: 10.1038/s44303-025-00111-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12595114/
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Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding

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  DOI: 10.1038/s42003-025-08938-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12615796/
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ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver

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  DOI: 10.1038/s42003-025-08818-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12491593/
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DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens

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  DOI: 10.1038/s41698-025-01111-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12589559/
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Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer

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  DOI: 10.1038/s41598-025-23137-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
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Combined effects of restriction factors and transduction adjuvants on lentiviral vector gene transfer efficacy

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pmc.ncbi.nlm.nih.gov/articles/PMC12586428/
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Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC

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  DOI: 10.1038/s41598-025-21495-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12569157/
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Immunocompetent C57BL/6 syngeneic mouse ovarian cancer models with defined genetic alterations

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  DOI: 10.1038/s41598-025-18960-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12504517/
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Dipeptidase 1 is a functional receptor for a porcine coronavirus

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  DOI: 10.1038/s41564-025-02111-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12578638/
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Epigenetic alterations facilitate transcriptional and translational programs in hypoxia

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  DOI: 10.1038/s41556-025-01786-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12611764/
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Optical mapping of the interface between iPSC-derived grafts and swine myocardium suggests potential arrhythmia mechanisms

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  DOI: 10.1038/s41536-025-00434-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12583502/
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Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancer

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  DOI: 10.1038/s41523-025-00843-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12586714/
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A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

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  DOI: 10.1038/s41467-025-65995-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
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LUBAC modulates CBM complex functions downstream of TRAF6 in T cells

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  DOI: 10.1038/s41467-025-65879-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12602705/
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A yeast surface display platform for characterizing CAR T cell responses to cancer antigens

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  DOI: 10.1038/s41467-025-65236-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12638309/
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Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

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  DOI: 10.1038/s41467-025-65178-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12638947/
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Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies

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  DOI: 10.1038/s41467-025-65148-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12579598/
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Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes

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pmc.ncbi.nlm.nih.gov/articles/PMC12638796/
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The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

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  DOI: 10.1038/s41467-025-64983-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12618888/
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qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative imaging of intracellular ATP

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  DOI: 10.1038/s41467-025-64946-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12615622/
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WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

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pmc.ncbi.nlm.nih.gov/articles/PMC12511557/
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MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes

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  DOI: 10.1038/s41467-025-63880-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12494973/
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The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity

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  DOI: 10.1038/s41467-025-63876-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12495022/
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Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia

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  DOI: 10.1038/s41420-025-02810-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12537973/
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Chemically induced dimerization of GSDMD C-terminal domain blocks GSDMD N-terminal domain-mediated pyroptosis

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  DOI: 10.1038/s41420-025-02733-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12518871/
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PFKFB3 as a multifaceted driver and therapeutic target in castration-resistant prostate cancer

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  DOI: 10.1038/s41419-025-08089-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12552466/
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CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival

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  pMD2G
  
  DOI: 10.1038/s41419-025-08063-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12579238/
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Targeting the Met-RIPK1 signaling axis to enforce apoptosis and necroptosis in colorectal cancer

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  DOI: 10.1038/s41419-025-08054-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12537949/
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Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases

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  DOI: 10.1038/s41413-025-00470-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12528370/
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shRNAI: A deep neural network for the design of highly potent shRNAs

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  DOI: 10.1016/j.omtn.2025.102738
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12596542/
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SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production

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  DOI: 10.1016/j.omtm.2025.101619
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12639841/
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1-s2.0-S258900422501987X-main-html.html

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  DOI: 10.1016/j.isci.2025.113726
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12595127/
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rs604702 confers breast cancer risk by influencing PCAT18/miR-759/SPRR3 axis

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  DOI: 10.1007/s12672-025-03889-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12589711/
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Malignant progression of MES-like cells mediated by COL22A1 in the spatial heterogeneity of glioblastoma

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  DOI: 10.1007/s12672-025-03559-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12500492/
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A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma

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  DOI: 10.1007/s00262-025-04195-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12612327/
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Epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and its impact on the hedgehog signaling pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12615883/
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Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

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  pMD2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12575060/
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Generation of Human 3D Airway Assembloids for Advanced Modeling

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Promoter Frame Position Affects Strength and Nature of Circadian Oscillations in hPER2 Luciferase Reporters

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pmc.ncbi.nlm.nih.gov/articles/PMC12608312/
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HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission

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pmc.ncbi.nlm.nih.gov/articles/PMC12513584/
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Mammalian antiviral proteins ZAP and KHNYN can independently restrict CpG-enriched avian viruses

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pmc.ncbi.nlm.nih.gov/articles/PMC12582503/
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Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming

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pmc.ncbi.nlm.nih.gov/articles/PMC12535130/
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Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response

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BTK autoinhibition analyzed by high-throughput swaps of SH2 domains

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pmc.ncbi.nlm.nih.gov/articles/PMC12541323/
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MMP9 shapes cell mechanics to enable collective invasion in cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12572407/
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Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation

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pmc.ncbi.nlm.nih.gov/articles/PMC12578846/
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Molecular basis for selection and inhibition of HIV-1 escape virus by T cells and KIR2DL2+NK cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12592487/
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Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response

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pmc.ncbi.nlm.nih.gov/articles/PMC12569010/
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Large transient assemblies of Apaf1 constitute the apoptosome in cells

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Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles

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pmc.ncbi.nlm.nih.gov/articles/PMC12528695/
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A microRNA CRISPR screen reveals microRNA-483-3p as an apoptotic regulator in prostate cancer cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12552650/
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Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling

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pmc.ncbi.nlm.nih.gov/articles/PMC12613839/
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SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis

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pmc.ncbi.nlm.nih.gov/articles/PMC12594208/
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The Antisense Protein ASP of HIV-1 Enhances Viral Entry in CD4+ T Cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12568219/
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Human Retinal Organoid Modeling Defines Developmental Window and Therapeutic Vulnerabilities in MYCN-Amplified Retinoblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12429095/
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The Influence of Short Peptides on Cell Senescence and Neuronal Differentiation

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pmc.ncbi.nlm.nih.gov/articles/PMC12468822/
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A Novel Early Memory-Enriched Allogeneic NKG2D CAR-T Cell Therapy Based on CRISPR/Cas9 Technology for Solid Tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC12523248/
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Hemopexin Suppresses Hepatocellular Carcinoma via TNF-α-Mediated Mitochondrial Apoptosis

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  pVSV-G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12468737/
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Integrative analysis identifies TEAD4 as a universal prognostic biomarker in human cancers

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12518352/
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NUPA10hd-immortalized and genetically engineered progenitors allow studying dendritic cell immune functions

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pmc.ncbi.nlm.nih.gov/articles/PMC12434078/
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CRISPR-mediated generation of a tumor-associated antigen-deficient Raji platform to investigate antigen loss in CAR-T cell therapy

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pmc.ncbi.nlm.nih.gov/articles/PMC12515939/
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FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks

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pmc.ncbi.nlm.nih.gov/articles/PMC12497744/
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The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms

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pmc.ncbi.nlm.nih.gov/articles/PMC12425323/
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A novel function of RHOA as a host-dependent factor in Glaesserella parasuis infection of LLC-PK1 cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12465878/
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APP SUMOylation prevents BACE1 cleavage of APP and increases BACE1 degradation to promote the nonamyloidogenic pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12482303/
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CRISPRa genome-wide screen identifies novel gene targets for osteogenic cell engineering

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pmc.ncbi.nlm.nih.gov/articles/PMC12618816/
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Tumor heterogeneity underlies clinical outcome and MEK inhibitor response in somatic NF1-mutant glioblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12487855/
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SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12483608/
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Higher Throughput Assays for Understanding the Pathogenicity of Variants of Unknown Significance in the RPE65 Gene

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pmc.ncbi.nlm.nih.gov/articles/PMC12514977/
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PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12477665/
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Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus

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pmc.ncbi.nlm.nih.gov/articles/PMC12505966/
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The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

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pmc.ncbi.nlm.nih.gov/articles/PMC12429026/
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USP13 stabilizes NLRP3 to facilitate inflammasome activation by preventing TRIM31-mediated NLRP3 ubiquitination and degradation

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pmc.ncbi.nlm.nih.gov/articles/PMC12466843/
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Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost

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pmc.ncbi.nlm.nih.gov/articles/PMC12637294/
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RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis

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pmc.ncbi.nlm.nih.gov/articles/PMC12429019/
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ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration

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pmc.ncbi.nlm.nih.gov/articles/PMC12551705/
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In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC12485727/
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A live cell biosensor protocol for high-resolution screening of therapy-resistant cancer cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12485920/
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Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC12485957/
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Identification of novel interacting proteins of FUZ and GPR161

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pmc.ncbi.nlm.nih.gov/articles/PMC12458929/
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Mapping transcriptional responses to cellular perturbation dictionaries with RNA fingerprinting

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pmc.ncbi.nlm.nih.gov/articles/PMC12458102/
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BRD2 Upregulation as a Pan-Cancer Adaptive Resistance Mechanism to BET Inhibition

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pmc.ncbi.nlm.nih.gov/articles/PMC12424687/
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Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

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pmc.ncbi.nlm.nih.gov/articles/PMC12424808/
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LIM Domain Proteins link molecular and global tension by recognizing strained actin in adhesions

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pmc.ncbi.nlm.nih.gov/articles/PMC12338669/
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Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12191234/
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11761749/
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The E3 ligase MEX3B forms a tripartite complex with Rest and Hotair to determine the proliferative capacity of neural progenitor cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12419896/
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ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation

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pmc.ncbi.nlm.nih.gov/articles/PMC12458079/
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Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression

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pmc.ncbi.nlm.nih.gov/articles/PMC12455591/
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Development of programmable RNA imaging with RNA-guided GFP via click chemistry

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pmc.ncbi.nlm.nih.gov/articles/PMC12597101/
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The Kaposi’s sarcoma-associated herpesvirus TBP mimic uses a noncanonical DNA-binding mode to promote viral late gene transcription

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pmc.ncbi.nlm.nih.gov/articles/PMC12529657/
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Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction

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pmc.ncbi.nlm.nih.gov/articles/PMC12456215/
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Emergence of activation or repression in transcriptional control under a fixed molecular context

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pmc.ncbi.nlm.nih.gov/articles/PMC12501156/
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An atlas of protein phosphorylation dynamics during interferon signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC12002234/
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Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

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pmc.ncbi.nlm.nih.gov/articles/PMC12592532/
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Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism

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pmc.ncbi.nlm.nih.gov/articles/PMC12460162/
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Targeting dual-specificity phosphatase 23 to overcome chemoresistance and stem cell-like behavior in non-small cell lung cancer cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12630825/
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Uncovering hidden protein modifications with native top-down mass spectrometry

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pmc.ncbi.nlm.nih.gov/articles/PMC12510877/
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Covariation MS uncovers a protein that controls cysteine catabolism

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pmc.ncbi.nlm.nih.gov/articles/PMC12589099/
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A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation

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pmc.ncbi.nlm.nih.gov/articles/PMC12630741/
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Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC12484827/
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Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation

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pmc.ncbi.nlm.nih.gov/articles/PMC12480842/
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High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques

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pmc.ncbi.nlm.nih.gov/articles/PMC12474910/
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ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis

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pmc.ncbi.nlm.nih.gov/articles/PMC12518142/
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Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PLpro) Inhibitors

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  pVSV-G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12461331/
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Protocol for monitoring the stability of transcription factor EB using global protein stability assay

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pmc.ncbi.nlm.nih.gov/articles/PMC12547729/
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Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

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pmc.ncbi.nlm.nih.gov/articles/PMC11970383/
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Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis

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pmc.ncbi.nlm.nih.gov/articles/PMC12637266/
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Requirements for establishment and epigenetic stability of mammalian heterochromatin

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pmc.ncbi.nlm.nih.gov/articles/PMC12478525/
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Hydrogen sulfide–dependent activation of human sulfide quinone oxidoreductase

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pmc.ncbi.nlm.nih.gov/articles/PMC12510033/
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Robust calibration and quantification of FRET signals using multiplexed biosensor barcoding

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  12259
  
  DOI: 10.1016/j.isci.2025.113743
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12595091/
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SESTD1 as a potential prognostic biomarker associated with tumor aggressiveness and immune infiltration in hepatocellular carcinoma

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1. scibot 23 Nov 2025
  
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  pMD2.G
  
  DOI: 10.1016/j.clinsp.2025.100796
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12510035/
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ZNF469 promotes extracellular matrix production in normal and keloid dermal fibroblasts

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  plasmid_12259
  
  DOI: 10.3892/mmr.2025.13668
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12457930/
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Theranostic Potential of a New 64Cu-Labeled NOTA-R954 Peptide Conjugate for Kinin B1R Expressing Prostate Cancer

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1. scibot 23 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.3390/pharmaceutics17091215
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12473165/
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A Novel Serum-Free Triculture Model of Glioblastoma, Astrocytes, and Macrophages

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  Plasmid_12259
  
  DOI: 10.3390/ijms26199335
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12524639/
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A Model of Breast Cancer Micrometastasis in a Three-Dimensional (3D) Liver Spheroid for Testing an Antimetastatic Therapy

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  plasmid_12259
  
  DOI: 10.21769/BioProtoc.5454
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12457848/
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Molecular requirements for mammalian crinophagy highlight a key role for Ca2+-dependent Munc13-4

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  DOI: 10.21203/rs.3.rs-7349548/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12425082/
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Poxvirus H5 mediates the formation of liquid-liquid phase separation condensates which promote virus factory assembly

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12633886/
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Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

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pmc.ncbi.nlm.nih.gov/articles/PMC12469161/
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The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells

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  addgene_12259
  
  DOI: 10.1371/journal.pbio.3003369
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12416842/
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PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer

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  RRID:Addgene_12259
  
  DOI: 10.1261/rna.080637.125
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12530129/
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Enhancement of lentiviral vectors gene delivery against VEGFR2 expressing cells by co-display of the binding and fusogenic moieties: a two molecules targeting approach

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12461958/
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BM-MSC-derived migrasomes reverse stroke-induced thymic atrophy and immunosuppression via Pin1 delivery to thymic epithelial cells

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  Addgene_12259
  
  DOI: 10.1186/s12974-025-03604-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12619471/
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Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding

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  RRID:Addgene_12259
  
  DOI: 10.1158/2159-8290.CD-25-0647
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12631751/
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Genome editing or small molecule inhibition of KMT5A in CAR-T cells enhances antitumor immunity

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  Addgene_12259
  
  DOI: 10.1136/jitc-2025-012160
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12519333/
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Genome-wide mapping of EBV-induced genomic variations identifies the role of MUC19 in EBV latency

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  Addgene_12259
  
  DOI: 10.1128/mbio.02055-25
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12607598/
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Peptide-MHC–targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells

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  RRID:Addgene_12259
  
  DOI: 10.1126/sciadv.adv2331
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12594172/
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Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain‐ and Isoform‐Dependent in Human iPSC‐Derived Neurons

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12611310/
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Local RhoA activation induces septin recruitment

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  Plasmid_12259
  
  DOI: 10.1101/2025.09.29.679255
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12622031/
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Mapping of the hSOX10 protein interactome in human melanoma

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  Plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424987/
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EBNA1 SUMOylation by PIAS1 Suppresses EBV Lytic Replication and Enhances Episome Maintenance

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  plasmid_12259
  
  DOI: 10.1101/2025.09.01.673444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424706/
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Cysteine reactivity profiling identifies host regulators of Mycobacterium tuberculosis replication in human macrophages

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  Plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424734/
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CHD7 binds to insulators during neuronal differentiation

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974851/
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Tissue Fluidity Mediates a Trade-off Between the Speed and Accuracy of Multicellular Patterning by Cell Sorting

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  plasmid_12259
  
  DOI: 10.1101/2025.03.01.640992
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12485938/
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Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11703154/
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Nanoscale restructuring of the immune synapse with an engager enhances NK cell function

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pmc.ncbi.nlm.nih.gov/articles/PMC12478185/
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Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells

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  DOI: 10.1038/s44318-025-00539-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12528397/
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Analysis of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Interactome

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  DOI: 10.1021/acs.jproteome.5c00121
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12604043/
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Genome‐Wide CRISPR/Cas9 Screening Identifies the COMMANDER Recycling Complex as a Key Player in EV Uptake

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  DOI: 10.1002/jev2.70166
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12456102/
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A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

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  Addgene_12
  
  DOI: 10.1186/s13024-025-00889-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12465293/
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2025.11.15.688565v1.full-html.html

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54.241.53.176/3259fae050498259be3938591f9171ada23644a0/2025.11.15.688565v1.full-html.html
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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  AddgeneCat#12259
  
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sciencedirect.com/science/article/pii/S1097276525008913
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Single-cell activation screen identifies hepatic maturation regulators with zonal resolution

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  DOI: 10.1016/j.devcel.2025.10.014
  
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sciencedirect.com/science/article/pii/S1534580725006653
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Chromatin remodeler Chd7 regulates reactive astrogliosis after ischemic stroke

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  Addgene #12259
  
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  plasmid_12259
  
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sciencedirect.com/science/article/pii/S2211124725013622
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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

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sciencedirect.com/science/article/pii/S2211124725013609
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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

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  Addgene#12259
  
  DOI: 10.1016/j.cell.2025.10.028
  
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  plasmid_12259
  
  DOI: 10.1016/j.cell.2025.10.028
  
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sciencedirect.com/science/article/pii/S0092867425012334
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Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway

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Mechanosensitive interactions between Jag1 and Myo1c control Jag1 trafficking in endothelial cells

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Targeting the FoxJ3/FoxO6 axis suppresses hepatocellular carcinoma growth by inducing cell cycle arrest and apoptosis

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1. scibot 21 Nov 2025
  
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A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1‐inducible model

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1. scibot 21 Nov 2025
  
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RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis

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Hypoxia promotes airway differentiation in the human lung epithelium

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The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

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Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid–like structures and enhance antitumor immunity

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UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN

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Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models

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UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance

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Therapeutic Inducers of NK cell Killing (ThINKK)-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia: unraveling the dual role of TRAIL leads to the establishment of an efficacy biomarker

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A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1

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Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14

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PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

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Extracellular vesicle R-Ras is a potential biomarker for human peripheral artery disease

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Protocol for specific induction of apoptosis or necroptosis in established murine tumors

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An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels

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Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During Ligand-Mediated Transcriptional Burst Events

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TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma

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Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells

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Protocol for simplified parallel perturbations using an abridged long non-coding RNA CRISPR library

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pmc.ncbi.nlm.nih.gov/articles/PMC12509891/
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Lineage-resolved atlas of the developing human cortex

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Nuclear-lamin-guided plastic positioning and folding of the human genome

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SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity

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Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons

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A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking

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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

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Disparate leukemia mutations converge on nuclear phase-separated condensates

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1-s2.0-S2589004225021583-main-html.html

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The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts

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Reporter-Mediated Evaluation of the Circadian Oscillations of SNAIL Across In Vitro Models

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  DOI: 10.3390/clockssleep7040054
  
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Targeting of SKP2 to combat drug resistance in multiple myeloma

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  DOI: 10.1038/s41598-025-21719-7
  
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Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation

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Oct 2025
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Mitochondrial ROS Drive Adipogenic Differentiation in Osteoporosis by Suppressing Protein Synthesis

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  DOI: 10.1096/fj.202502869R
  
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faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202502869R
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A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential

1
1. scibot 30 Oct 2025
  
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  Plasmid_12259
  
  DOI: 10.1016/j.celrep.2025.116496
  
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sciencedirect.com/science/article/pii/S2211124725012677
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Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

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1. scibot 29 Oct 2025
  
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  Addgene_12259
  
  DOI: 10.1016/j.molcel.2025.10.002
  
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sciencedirect.com/science/article/pii/S1097276525008196
54.241.53.176 54.241.53.176

1-s2.0-S2589004225020942-main-html.html

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1. scibot 28 Oct 2025
  
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  Addgene Cat # 12259
  
  DOI: 10.1016/j.isci.2025.113833
  
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54.241.53.176/9931d96af6f8103e3fb3a39d1aeb31f8c965c5cf/1-s2.0-S2589004225020942-main-html.html
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Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling

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1. scibot 28 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.stem.2025.09.011
  
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sciencedirect.com/science/article/pii/S1934590925003674
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Development of antigen multimers for detection and evaluation of CAR T cells

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1. scibot 28 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1007/s00262-025-04134-9
  
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link.springer.com/article/10.1007/s00262-025-04134-9
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

XXYLT1 inhibits NOTCH1 activation in Jurkat cells while promoting cell proliferation

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1. scibot 25 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.18999/nagjms.87.3.431
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12549121/
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PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape

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1. scibot 25 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2025.115590
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12548782/
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Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21

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1. scibot 23 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1101/2025.10.16.681972
  
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biorxiv.org/content/10.1101/2025.10.16.681972v1
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Genetically tractable embryonic cell lines from sea urchins Lytechinus variegatus and Strongylocentrotus purpuratus

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1. scibot 23 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s42003-025-08890-3
  
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nature.com/articles/s42003-025-08890-3
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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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1. scibot 23 Oct 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.cub.2024.08.058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11496028/
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A non-canonical immunometabolic function of BRD3 during sepsis

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1. scibot 22 Oct 2025
  
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  Addgene Cat# 12259
  
  DOI: 10.1016/j.devcel.2025.09.016
  
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sciencedirect.com/science/article/pii/S153458072500601X

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