4,071 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12599336/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BTK autoinhibition analyzed by high-throughput swaps of SH2 domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC12541323/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12519202/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding
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    pmc.ncbi.nlm.nih.gov/articles/PMC12615796/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12589559/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12569157/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dipeptidase 1 is a functional receptor for a porcine coronavirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12578638/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12578846/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optical mapping of the interface between iPSC-derived grafts and swine myocardium suggests potential arrhythmia mechanisms
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    pmc.ncbi.nlm.nih.gov/articles/PMC12583502/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12534460/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12586714/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12579598/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639132/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638796/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12615601/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12606338/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12511557/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12494973/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12495022/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cellular activity upregulation of the thermolabile p53 cancer mutant Y220C by small molecule indazole derivatives
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594860/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemically induced dimerization of GSDMD C-terminal domain blocks GSDMD N-terminal domain-mediated pyroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12518871/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A microRNA CRISPR screen reveals microRNA-483-3p as an apoptotic regulator in prostate cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552650/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PFKFB3 as a multifaceted driver and therapeutic target in castration-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552466/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12613839/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639841/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S258900422501987X-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12595127/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Malignant progression of MES-like cells mediated by COL22A1 in the spatial heterogeneity of glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500492/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12612327/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12575060/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Promoter Frame Position Affects Strength and Nature of Circadian Oscillations in hPER2 Luciferase Reporters
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    pmc.ncbi.nlm.nih.gov/articles/PMC12608312/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission
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    pmc.ncbi.nlm.nih.gov/articles/PMC12513584/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mammalian antiviral proteins ZAP and KHNYN can independently restrict CpG-enriched avian viruses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12582503/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-omics analysis reveals the crosstalk of epigenetic regulatory networks in cutaneous squamous cell carcinoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12613370/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC12535130/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Off-pore nucleoporin sPOM121 transcriptionally propels β-Catenin driven tumor progression and immune escape in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580793/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12529931/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12596725/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA binding of GAPDH controls transcript stability and protein translation in acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12582121/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC12491593/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysine-specific histone demethylase complex restricts Epstein-Barr virus lytic reactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616731/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MMP9 shapes cell mechanics to enable collective invasion in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12572407/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12602705/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638947/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12569010/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Large transient assemblies of Apaf1 constitute the apoptosome in cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552632/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12528695/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12528370/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZEB1, a novel junctional adhesion molecule A regulator, impacts sensitivity of pancreatic cancer-associated fibroblasts to reovirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12617759/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    shRNAI: A deep neural network for the design of highly potent shRNAs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12596542/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594208/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    rs604702 confers breast cancer risk by influencing PCAT18/miR-759/SPRR3 axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12589711/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and its impact on the hedgehog signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12615883/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Chromosome 19 miRNA cluster guards trophoblasts against overacting innate immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12575609/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZNF469 promotes extracellular matrix production in normal and keloid dermal fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12457930/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Antisense Protein ASP of HIV-1 Enhances Viral Entry in CD4+ T Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12568219/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human Retinal Organoid Modeling Defines Developmental Window and Therapeutic Vulnerabilities in MYCN-Amplified Retinoblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12429095/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Influence of Short Peptides on Cell Senescence and Neuronal Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12468822/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Novel Early Memory-Enriched Allogeneic NKG2D CAR-T Cell Therapy Based on CRISPR/Cas9 Technology for Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12523248/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hemopexin Suppresses Hepatocellular Carcinoma via TNF-α-Mediated Mitochondrial Apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12468737/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative analysis identifies TEAD4 as a universal prognostic biomarker in human cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12518352/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NUPA10hd-immortalized and genetically engineered progenitors allow studying dendritic cell immune functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12434078/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12518231/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12497744/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12435675/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out
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    pmc.ncbi.nlm.nih.gov/articles/PMC12469161/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12416842/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features
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    pmc.ncbi.nlm.nih.gov/articles/PMC12465293/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12483608/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Higher Throughput Assays for Understanding the Pathogenicity of Variants of Unknown Significance in the RPE65 Gene
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    pmc.ncbi.nlm.nih.gov/articles/PMC12514977/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting SQLE-mediated cholesterol metabolism to enhance CD8+ T cell activation and immunotherapy efficacy in hepatocellular carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12481379/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome editing or small molecule inhibition of KMT5A in CAR-T cells enhances antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12519333/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide mapping of EBV-induced genomic variations identifies the role of MUC19 in EBV latency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12607598/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12456129/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12429026/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP13 stabilizes NLRP3 to facilitate inflammasome activation by preventing TRIM31-mediated NLRP3 ubiquitination and degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12466843/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost
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    pmc.ncbi.nlm.nih.gov/articles/PMC12637294/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12429019/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12429027/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12551705/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain‐ and Isoform‐Dependent in Human iPSC‐Derived Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12611310/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A live cell biosensor protocol for high-resolution screening of therapy-resistant cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485920/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors
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