3,591 Matching Annotations
  1. Jul 2025
  2. 52.53.155.43 52.53.155.43
    watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html
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    52.53.155.43/42423fb21c90eb6b2282f89153f3787d8f44c56d/watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html
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    Triglycerides are an important fuel reserve for synapse function in the brain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286841/
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    Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier
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    nature.com/articles/s41467-025-62105-1
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    An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
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    sciencedirect.com/science/article/pii/S221112472500840X
  6. 52.53.155.43 52.53.155.43
    2025.07.14.664742v1.full-html.html
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    Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610825002715
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    Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70085
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    Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12277487/
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    High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
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    science.org/doi/10.1126/science.adx3800
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    Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer
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    science.org/doi/10.1126/sciadv.adu0847
  12. www.biorxiv.org www.biorxiv.org
    Mitotic slippage causes nuclear instability in polyploid cells
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    biorxiv.org/content/10.1101/2025.07.21.665898v1
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    Co-option of mitochondrial nucleic acid–sensing pathways by HSV-1 UL12.5 for reactivation from latent infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11789124/
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    MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281688/
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    19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
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    cell.com/cell-reports/abstract/S2211-1247(25)00812-5
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265667/
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    A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
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    science.org/doi/10.1126/sciadv.ads9164
  18. www.biorxiv.org www.biorxiv.org
    Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma
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    biorxiv.org/content/10.1101/2025.07.11.663903v1
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    CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation
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    cell.com/cell-reports/fulltext/S2211-1247(25)00786-7
  20. www.biorxiv.org www.biorxiv.org
    An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia
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    biorxiv.org/content/10.1101/2025.07.16.664180v1
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248030/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complete loss of PAX4 causes transient neonatal diabetes in humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12275979/
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    An SRRM3-regulated neural alternative splicing program is subverted to promote tumor progression in pancreatic neuroendocrine cells
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    cell.com/cell-reports/fulltext/S2211-1247(25)00793-4
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224001/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223781/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    METTL3-mediated m6A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12256411/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Butyrylcholinesterase (BChE) downregulation in taxane resistance: implications for prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12266350/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLID is a drug-responsive target of FOXO3a and multi-omics analysis reveals survival mechanisms and therapeutic vulnerabilities in BLID-deficient breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12217432/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270383/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clusterin facilitates glioma progression via BCL2L1-dependent regulation of apoptotic resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216978/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240770/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185487/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12180443/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208438/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Obesity and cervical intraepithelial neoplasia: regulation of mitochondrial energy metabolism via the Kisspeptin/GPR54 signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12175464/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering biomimetic bone marrow niche with gene modified mesenchymal stromal cells for ex vivo culture of human hematopoietic stem and progenitor cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12211287/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSCs engineered with secreted Klotho alleviate blood–brain barrier disruption and reduce neuroinflammation more effectively than MSCs in experimental autoimmune encephalomyelitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220179/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12239490/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12239510/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12243136/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24
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    pmc.ncbi.nlm.nih.gov/articles/PMC12272974/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12205516/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12247323/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Methodological approach for allele-specific antibody responses to HEK-293T-based cell lines expressing single MHC class I chain-related gene B antigens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265220/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12165809/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208539/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell and Spatial Transcriptomics Identified Fatty Acid–Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension
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    pmc.ncbi.nlm.nih.gov/articles/PMC12188824/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167936/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFITM proteins are key entry factors for porcine epidemic diarrhea coronavirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172462/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172457/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differentiating Peromyscus leucopus bone marrow-derived macrophages for characterization of responses to Borrelia burgdorferi and lipopolysaccharide
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    pmc.ncbi.nlm.nih.gov/articles/PMC12234436/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A universal chimeric antigen receptor (CAR)–fragment antibody binder (FAB) split system for cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227065/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227071/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273786/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cypin regulates K63-linked polyubiquitination to shape synaptic content
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248297/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p53 Deficiency in Colon Cancer Cells Promotes Tumor Progression Through the Modulation of Meflin in Fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210049/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12266763/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12266762/
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    A distal enhancer with ETV4 binding is critical for UCP1 expression and thermogenesis in brown fat
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    pmc.ncbi.nlm.nih.gov/articles/PMC12211996/
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    Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236469/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12205996/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12207882/
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    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
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    Signal peptide–independent secretion of keratin-19 by pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260553/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BaCoN (Balanced Correlation Network) improves prediction of gene buffering
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    pmc.ncbi.nlm.nih.gov/articles/PMC12222496/
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    Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216251/
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    Mechanistic insight into anaphase bridge signaling to the abscission checkpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC12217976/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259471/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238383/
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    Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185695/
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    Identification of host cell surface proteins inhibiting furin dependent proteolytic processing of viral glycoproteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259872/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ANTP-SmacN7 enhances radiosensitivity in TPC-1 cells through XIAP-mediated activation of apoptotic protein
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    pmc.ncbi.nlm.nih.gov/articles/PMC12267587/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223117/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development and validation of a basement membrane inflammatory response gene signature in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219087/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208882/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NINJ1 regulates plasma membrane fragility under mechanical strain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210241/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Native nucleosomes intrinsically encode genome organization principles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240700/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NR4A3 potentials M1-like macrophage polarization to facilitate anti-tumor immune responses in breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12234874/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human glycogenins maintain glucose homeostasis by regulating glycogen metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12267440/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12271527/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227609/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198384/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluating cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216923/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219648/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Isoform characterization of m6A in single cells identifies its role in RNA surveillance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219666/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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