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  1. Sep 2023
  2. www.science.org www.science.org
    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
    1
    1. scibot 27 Sep 2023
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      DOI: 10.1126/sciadv.adh8228

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    science.org/doi/10.1126/sciadv.adh8228
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
    1
    1. scibot 20 Sep 2023
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      DOI: 10.15252/embj.2022113190

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    ncbi.nlm.nih.gov/pmc/articles/PMC10505916/
  4. www.nature.com www.nature.com
    m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency
    1
    1. scibot 14 Sep 2023
      RRID:Addgene_48138

      DOI: 10.1038/s41556-023-01212-x

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    nature.com/articles/s41556-023-01212-x
  5. www.sciencedirect.com www.sciencedirect.com
    The interplay of TARG1 and PARG protects against genomic instability
    1
    1. scibot 12 Sep 2023
      plasmid_48138

      DOI: 10.1016/j.celrep.2023.113113

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    sciencedirect.com/science/article/pii/S2211124723011245
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    Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy
    1
    1. scibot 01 Sep 2023
      Plasmid_48138

      DOI: 10.1016/j.xcrm.2023.101171

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    sciencedirect.com/science/article/pii/S2666379123003245
  7. Aug 2023
  8. www.sciencedirect.com www.sciencedirect.com
    RhoB Promotes Salmonella survival by Regulating Autophagy
    1
    1. scibot 31 Aug 2023
      RRID:Addgene_48138

      DOI: 10.1016/j.ejcb.2023.151358

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    sciencedirect.com/science/article/pii/S0171933523000730
  9. www.sciencedirect.com www.sciencedirect.com
    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
    1
    1. scibot 27 Aug 2023
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      DOI: 10.1016/j.celrep.2023.113045

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    sciencedirect.com/science/article/pii/S2211124723010562
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.
    1
    1. scibot 26 Aug 2023
      RRID:Addgene_48138

      DOI: 10.1016/j.isci.2023.107511

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    ncbi.nlm.nih.gov/pmc/articles/PMC10448114/
  11. www.sciencedirect.com www.sciencedirect.com
    Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
    1
    1. scibot 25 Aug 2023
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    sciencedirect.com/science/article/pii/S2666979X23001866
  12. www.biorxiv.org www.biorxiv.org
    Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
    1
    1. scibot 16 Aug 2023
      plasmid_48138

      DOI: 10.1101/2023.08.10.552882

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    biorxiv.org/content/10.1101/2023.08.10.552882v1
  13. www.sciencedirect.com www.sciencedirect.com
    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
    1
    1. scibot 03 Aug 2023
      plasmid_48138

      DOI: 10.1016/j.celrep.2023.112927

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    sciencedirect.com/science/article/pii/S2211124723009385
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors
    1
    1. scibot 02 Aug 2023
      RRID:Addgene_48138

      DOI: 10.1021/acs.jmedchem.3c00254

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    ncbi.nlm.nih.gov/pmc/articles/PMC10388299/
  15. Jul 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRPS1 modulates chromatin accessibility to regulate estrogen receptor (ER) binding and ER target gene expression in luminal breast cancer cells
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1101/2023.07.03.547524

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    ncbi.nlm.nih.gov/pmc/articles/PMC10349936/
  17. www.sciencedirect.com www.sciencedirect.com
    Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112887

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    sciencedirect.com/science/article/pii/S2211124723008987
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The uncharacterized transcript KIAA0930 confers a cachexic phenotype on cancer cells
    1
    1. scibot 25 Jul 2023
      RRID:Addgene_48138

      DOI: 10.18632/oncotarget.28476

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    ncbi.nlm.nih.gov/pmc/articles/PMC10360925/
  19. www.biorxiv.org www.biorxiv.org
    ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
    1
    1. scibot 25 Jul 2023
      RRID:Addgene_48138

      DOI: 10.1101/2023.07.18.549509

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    biorxiv.org/content/10.1101/2023.07.18.549509v2
  20. www.sciencedirect.com www.sciencedirect.com
    SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
    1
    1. scibot 21 Jul 2023
      RRID:Addgene_48138

      DOI: 10.1016/j.celrep.2023.112823

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    sciencedirect.com/science/article/pii/S2211124723008343
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
    1
    1. scibot 14 Jul 2023
      RRID:Addgene_48138

      DOI: 10.1038/s41419-023-05957-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10336053/
  22. Jun 2023
  23. www.pnas.org www.pnas.org
    Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors
    1
    1. scibot 30 Jun 2023
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      DOI: 10.1073/pnas.2216857120

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    pnas.org/doi/abs/10.1073/pnas.2216857120
  24. www.nature.com www.nature.com
    Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules
    1
    1. scibot 24 Jun 2023
      RRID:Addgene_48138

      DOI: 10.1038/s41467-023-39277-9

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    nature.com/articles/s41467-023-39277-9
  25. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
    1
    1. scibot 21 Jun 2023
      plasmid_48138

      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  26. www.sciencedirect.com www.sciencedirect.com
    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.cell.2023.05.043

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    sciencedirect.com/science/article/pii/S0092867423005950
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells
    1
    1. scibot 17 Jun 2023
      RRID:Addgene_48138

      DOI: 10.1128/mcb.00174-22

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    ncbi.nlm.nih.gov/pmc/articles/PMC9753722/
  28. link.springer.com link.springer.com
    Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology
    1
    1. scibot 13 Jun 2023
      RRID:Addgene_48138

      DOI: 10.1007/s00018-023-04804-w

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    link.springer.com/article/10.1007/s00018-023-04804-w
  29. link.springer.com link.springer.com
    Production of Duchenne muscular dystrophy cellular model using CRISPR-Cas9 exon deletion strategy
    1
    1. scibot 10 Jun 2023
      RRID:Addgene_48138

      DOI: 10.1007/s11010-023-04759-3

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    link.springer.com/article/10.1007/s11010-023-04759-3
  30. www.nature.com www.nature.com
    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
    1
    1. scibot 08 Jun 2023
      RRID:Addgene_48138

      DOI: 10.1038/s41467-023-38512-7

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    nature.com/articles/s41467-023-38512-7
  31. www.embopress.org www.embopress.org
    Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV
    1
    1. scibot 06 Jun 2023
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      DOI: 10.15252/embr.202256430

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    embopress.org/doi/10.15252/embr.202256430
  32. www.sciencedirect.com www.sciencedirect.com
    Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112533

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    sciencedirect.com/science/article/pii/S2211124723005442
  33. May 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Proteomics of immune cells from liver tumors reveals immunotherapy targets
    1
    1. scibot 31 May 2023
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      DOI: 10.1016/j.xgen.2023.100331

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    sciencedirect.com/science/article/pii/S2666979X2300099X
  35. www.sciencedirect.com www.sciencedirect.com
    ADAR1-mediated RNA editing promotes B cell lymphomagenesis
    1
    1. scibot 26 May 2023
      RRID:Addgene_48138

      DOI: 10.1016/j.isci.2023.106864

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    sciencedirect.com/science/article/pii/S2589004223009410
  36. www.sciencedirect.com www.sciencedirect.com
    Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
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    1. scibot 19 May 2023
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      DOI: 10.1016/j.molcel.2023.04.021

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    sciencedirect.com/science/article/pii/S1097276523002927
  37. www.biorxiv.org www.biorxiv.org
    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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    1. scibot 18 May 2023
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      DOI: 10.1101/2023.05.11.540429

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    biorxiv.org/content/10.1101/2023.05.11.540429v1
  38. www.sciencedirect.com www.sciencedirect.com
    Generation of three CRISPR/Cas9 edited human induced pluripotent stem cell lines (DHMi005-A-5, DHMi005-A-6 and DHMi005-A-7) carrying a Holt-Oram Syndrome patient-specific TBX5 mutation with known cardiac phenotype and a FLAG-tag after exon 9 of the TBX5 gene
    2
    1. scibot 17 May 2023
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      DOI: 10.1016/j.scr.2023.103123

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      RRID:Addgene_48138

      DOI: 10.1016/j.scr.2023.103123

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    sciencedirect.com/science/article/pii/S1873506123001095
  39. www.sciencedirect.com www.sciencedirect.com
    LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation
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      DOI: 10.1016/j.molcel.2023.04.017

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    sciencedirect.com/science/article/pii/S1097276523002885
  40. www.embopress.org www.embopress.org
    Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC-driven lymphoma
    1
    1. scibot 10 May 2023
      plasmid_48138

      DOI: 10.15252/emmm.202216910

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    embopress.org/doi/10.15252/emmm.202216910
  41. www.tandfonline.com www.tandfonline.com
    UBE3D Regulates mRNA 3′-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells
    1
    1. scibot 05 May 2023
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      DOI: 10.1128/mcb.00174-22

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    tandfonline.com/doi/abs/10.1128/mcb.00174-22
  42. www.biorxiv.org www.biorxiv.org
    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
    1
    1. scibot 04 May 2023
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      DOI: 10.1101/2023.03.19.533346

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    biorxiv.org/content/10.1101/2023.03.19.533346v1
  43. www.nature.com www.nature.com
    Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
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      DOI: 10.1038/s41467-023-38132-1

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    nature.com/articles/s41467-023-38132-1
  44. Apr 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Fanconi anemia-associated chromosomal radial formation is dependent on POLθ-mediated alternative end joining
    1
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      DOI: 10.1016/j.celrep.2023.112428

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    sciencedirect.com/science/article/pii/S2211124723004394
  46. aacrjournals.org aacrjournals.org
    Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance
    1
    1. scibot 21 Apr 2023
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      DOI: 10.1158/1078-0432.CCR-22-1764

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    aacrjournals.org/clincancerres/article/29/8/1496/725070/Membranous-NECTIN-4-Expression-Frequently
  47. www.biorxiv.org www.biorxiv.org
    Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities
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    1. scibot 20 Apr 2023
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      DOI: 10.1101/2023.03.28.534648

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    biorxiv.org/content/10.1101/2023.03.28.534648v1
  48. www.biorxiv.org www.biorxiv.org
    RhoB promotes Salmonella survival by regulating autophagy
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      DOI: 10.1101/2023.04.05.535690

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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2
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    Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids
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    Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs
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    The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling
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    RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status
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    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
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  58. Mar 2023
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    FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
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    Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density
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    Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis
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    Whole-genome doubling drives oncogenic loss of chromatin segregation
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    A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages
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    Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs
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    FAM193A is a positive regulator of p53 activity
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    m6A RNA methylation orchestrates transcriptional dormancy during developmental pausing
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation
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  68. Feb 2023
  69. www.sciencedirect.com www.sciencedirect.com
    EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
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    Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant
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    Homology-directed repair of an MYBPC3 gene mutation in a rat model of hypertrophic cardiomyopathy
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells
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    Generation of two CRISPR/Cas edited human induced pluripotent stem cell lines (DHMi005-A-3 and DHMi005-A-4) carrying a FLAG-tag after exon 9 of the TBX5 gene
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  75. Jan 2023
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    Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis
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    Neutrophil-activating therapy for the treatment of cancer
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    ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts
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    A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
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    T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis
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    Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models
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    Histone Methyltransferase KMT2B Promotes Metastasis and Angiogenesis of Cervical Cancer by Upregulating EGF Expression
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    ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
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  87. Dec 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9-mediated LRP10 Knockout in HuTu-80 and HEK 293T Cell Lines
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  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Crosstalk between tumor acidosis, p53, and extracellular matrix regulates pancreatic cancer aggressiveness
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome Editing Is Induced in a Binary Manner in Single Human Cells
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    Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
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    Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
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  94. Nov 2022
  95. www.sciencedirect.com www.sciencedirect.com
    Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies
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  96. www.sciencedirect.com www.sciencedirect.com
    Autophagy promotes cell survival by maintaining NAD levels
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP10 Mediates Mono-ADP-Ribosylation of Aurora-A Regulating G2/M Transition of the Cell Cycle
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  98. www.molbiolcell.org www.molbiolcell.org
    Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
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      plasmid_48138

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  99. www.researchsquare.com www.researchsquare.com
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  100. www.sciencedirect.com www.sciencedirect.com
    IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
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      plasmid_48138

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  102. Oct 2022
  103. www.sciencedirect.com www.sciencedirect.com
    Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis
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      plasmid_48138

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  104. academic.oup.com academic.oup.com
    Two type I topoisomerases maintain DNA topology in human mitochondria
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  105. www.sciencedirect.com www.sciencedirect.com
    Generation of a human embryonic stem cell line targeted homozygous deletion of BMP10 (WAe007-A-2) by CRISPR/Cas9-dgRNA
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  106. www.nature.com www.nature.com
    Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments
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  107. www.sciencedirect.com www.sciencedirect.com
    Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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      Cat#48138

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    Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
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  110. Sep 2022
  111. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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      plasmid_48138

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  112. www.sciencedirect.com www.sciencedirect.com
    Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome
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    Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization
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      RRID:Addgene_48138

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    Sublethal cytochrome c release generates drug-tolerant persister cells
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  115. Aug 2022
  116. 52.53.155.43 52.53.155.43
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  117. www.sciencedirect.com www.sciencedirect.com
    SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells
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  118. www.sciencedirect.com www.sciencedirect.com
    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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      Plasmid_48138

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    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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      addgene_48138

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  120. www.sciencedirect.com www.sciencedirect.com
    Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal
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      Plasmid_48138

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    sciencedirect.com/science/article/pii/S2589004222010768
  121. www.nature.com www.nature.com
    A multimodal iPSC platform for cystic fibrosis drug testing
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      RRID:Addgene_48138

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  122. Jul 2022
  123. www.sciencedirect.com www.sciencedirect.com
    Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
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      Plasmid_48138

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  124. www.sciencedirect.com www.sciencedirect.com
    “Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes
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      Addgene_48138

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    sciencedirect.com/science/article/pii/S1097276522006128
  125. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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      Plasmid_48138

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  126. Jun 2022
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat
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      DOI: 10.7554/eLife.78044

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  128. elifesciences.org elifesciences.org
    GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells
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      DOI: 10.7554/eLife.64430

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  129. www.sciencedirect.com www.sciencedirect.com
    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
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      AddgeneCat#48138

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  130. rupress.org rupress.org
    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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      RRID:Addgene_48138

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  131. www.sciencedirect.com www.sciencedirect.com
    A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells
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      Addgene # 48138

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    sciencedirect.com/science/article/pii/S1934590922002041
  132. May 2022
  133. www.nature.com www.nature.com
    Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy
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      plasmid_48138

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  134. www.sciencedirect.com www.sciencedirect.com
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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      plasmid_48138

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  135. www.mdpi.com www.mdpi.com
    First Characterization of Human Dermal Fibroblasts Showing a Decreased Xylosyltransferase-I Expression Induced by the CRISPR/Cas9 System
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      RRID:Addgene_48138

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  136. www.sciencedirect.com www.sciencedirect.com
    Generation of a MIR5004 knockout cell line from human induced Pluripotent Stem Cells by CRISPR/Cas9 gene editing
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  137. www.sciencedirect.com www.sciencedirect.com
    The Mettl3 epitranscriptomic writer amplifies p53 stress responses
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  138. Apr 2022
  139. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
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  140. academic.oup.com academic.oup.com
    A rationalized definition of general tumor suppressor microRNAs excludes miR-34a
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac277/6574673
  141. www.sciencedirect.com www.sciencedirect.com
    The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection
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  142. www.sciencedirect.com www.sciencedirect.com
    RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development
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  143. www.biorxiv.org www.biorxiv.org
    ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by driving the Warburg effect and apoptosis resistance
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    biorxiv.org/content/10.1101/2021.10.27.466184v1
  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC4848516/
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
    1
    1. scibot 02 Apr 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8970586/
  146. Mar 2022
  147. www.sciencedirect.com www.sciencedirect.com
    Genome-wide analysis of haploinsufficiency in human embryonic stem cells
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    1. scibot 30 Mar 2022
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    sciencedirect.com/science/article/pii/S2211124722003175
  148. www.sciencedirect.com www.sciencedirect.com
    Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cells
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      Plasmid_48138

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  149. www.sciencedirect.com www.sciencedirect.com
    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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    1. scibot 26 Mar 2022
      plasmid_48138

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    sciencedirect.com/science/article/pii/S0960982222003281
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8938320/
  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC8926068/
  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
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      plasmid_48138

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    ncbi.nlm.nih.gov/pmc/articles/PMC8919618/
  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain
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      RRID:Addgene_48138

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    ncbi.nlm.nih.gov/pmc/articles/PMC8921082/
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The m6A(m)-independent role of FTO in regulating WNT signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC8860091/
  155. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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      AddgeneCat# 48138

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    sciencedirect.com/science/article/pii/S2211124722002583
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8903836/
  157. www.nature.com www.nature.com
    Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling
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      RRID:Addgene_48138

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    nature.com/articles/s42003-022-03129-x
  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ciliopathy complex builds distal appendages to initiate ciliogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8276316/
  159. www.sciencedirect.com www.sciencedirect.com
    A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system
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    sciencedirect.com/science/article/pii/S266616672200096X
  160. www.sciencedirect.com www.sciencedirect.com
    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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      Plasmid_48138

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  161. www.sciencedirect.com www.sciencedirect.com
    Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells
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      Plasmid_48138

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    sciencedirect.com/science/article/pii/S0006291X22003059
  162. www.sciencedirect.com www.sciencedirect.com
    An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function
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      plasmid_48138

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    sciencedirect.com/science/article/pii/S2211124722001498
  163. www.sciencedirect.com www.sciencedirect.com
    BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states
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      plasmid_48138

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    sciencedirect.com/science/article/pii/S2211124722001656
  164. Feb 2022
  165. www.sciencedirect.com www.sciencedirect.com
    Gene architecture directs splicing outcome in separate nuclear spatial regions
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    sciencedirect.com/science/article/pii/S109727652200106X
  166. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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    1. scibot 16 Feb 2022
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    pubmed.ncbi.nlm.nih.gov/35172133/
  167. www.nature.com www.nature.com
    The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner
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      DOI: 10.1038/s41388-021-02161-1

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    nature.com/articles/s41388-021-02161-1
  168. Jan 2022
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation
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    1. scibot 20 Jan 2022
      RRID:Addgene_48138

      DOI: 10.1007/s12031-021-01943-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC8763444/
  170. link.springer.com link.springer.com
    Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells
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      DOI: 10.1007/s00018-021-04095-z

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    link.springer.com/article/10.1007/s00018-021-04095-z
  171. www.sciencedirect.com www.sciencedirect.com
    Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA
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      RRID:Addgene_48138

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    sciencedirect.com/science/article/pii/S2211124721017009
  172. www.mdpi.com www.mdpi.com
    Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
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      plasmid_183

      DOI: 10.3390/vaccines9121446

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    mdpi.com/2076-393X/9/12/1446
  173. Dec 2021
  174. www.sciencedirect.com www.sciencedirect.com
    Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC
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      RRID:Addgene_48138

      DOI: 10.1016/j.ymthe.2021.11.011

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    sciencedirect.com/science/article/pii/S1525001621005827
  175. www.mdpi.com www.mdpi.com
    Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
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      RRID:Addgene_48138

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    mdpi.com/2076-393X/9/12/1446
  176. link.springer.com link.springer.com
    Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin
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      RRID:Addgene_48138

      DOI: 10.1186/s40170-021-00277-2

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    link.springer.com/article/10.1186/s40170-021-00277-2
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel live-cell imaging assay reveals regulation of endosome maturation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8635980/
  178. www.sciencedirect.com www.sciencedirect.com
    Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair
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      RRID:Addgene_48138

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    sciencedirect.com/science/article/pii/S2211124721015795
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    Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops
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    sciencedirect.com/science/article/pii/S0092867421013271
  180. academic.oup.com academic.oup.com
    Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation
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      plasmid_48138

      DOI: 10.1093/glycob/cwab055

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    academic.oup.com/glycob/article/31/9/1102/6299516
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic Analysis of 4E-BP1 Phosphorylation in Neurons with Tsc2 or Depdc5 Knockout
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      addgene_48138

      DOI: 10.1016/j.expneurol.2020.113432

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    ncbi.nlm.nih.gov/pmc/articles/PMC8170708/
  182. academic.oup.com academic.oup.com
    Detection of Neanderthal Adaptively Introgressed Genetic Variants that Modulate Reporter Gene Expression in Human Immune Cells
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      RRID:Addgene_48138

      DOI: 10.1093/molbev/msab304

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    academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab304/6400258
  183. Nov 2021
  184. www.sciencedirect.com www.sciencedirect.com
    Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells
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      Addgene_48138

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    sciencedirect.com/science/article/pii/S2666166721006559
  185. www.sciencedirect.com www.sciencedirect.com
    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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      RRID:Addgene_48138

      DOI: 10.1016/j.molcel.2021.10.017

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  186. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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      DOI: 10.1002/1878-0261.13115

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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13115
  187. www.sciencedirect.com www.sciencedirect.com
    Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina
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      Addgene_48138

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    sciencedirect.com/science/article/pii/S221112472101473X
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
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      RRID:Addgene_48138

      DOI: 10.3390/ijms222111336

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    ncbi.nlm.nih.gov/pmc/articles/PMC8583042/
  189. www.sciencedirect.com www.sciencedirect.com
    Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes
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      Cat# 48138

      DOI: 10.1016/j.celrep.2021.109960

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    sciencedirect.com/science/article/pii/S2211124721014376
  190. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling
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    1. scibot 10 Nov 2021
      plasmid_48138

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    sciencedirect.com/science/article/pii/S2211124721014686
  191. link.springer.com link.springer.com
    Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
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      RRID:Addgene_48138

      DOI: 10.1007/s10571-021-01163-7

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    link.springer.com/article/10.1007/s10571-021-01163-7
  192. www.sciencedirect.com www.sciencedirect.com
    Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
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    1. scibot 05 Nov 2021
      Addgene Cat # 48138

      DOI: 10.1016/j.str.2021.10.007

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    sciencedirect.com/science/article/pii/S0969212621003750
  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
    1
    1. scibot 05 Nov 2021
      RRID:Addgene_48138

      DOI: 10.7554/eLife.65759

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    ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
  194. Oct 2021
  195. www.sciencedirect.com www.sciencedirect.com
    A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
    1
    1. scibot 28 Oct 2021
      Plasmid_48138

      DOI: 10.1016/j.devcel.2021.10.004

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    sciencedirect.com/science/article/pii/S1534580721008054
  196. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
    1
    1. scibot 21 Oct 2021
      Cat. No. 48138

      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  197. www.sciencedirect.com www.sciencedirect.com
    Syndromic RNA Polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A
    1
    1. scibot 20 Oct 2021
      plasmid_48138

      DOI: 10.1016/j.scr.2021.102577

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    sciencedirect.com/science/article/pii/S1873506121004244
  198. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system
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    1. scibot 20 Oct 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.scr.2021.102580

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    sciencedirect.com/science/article/pii/S187350612100427X
  199. www.sciencedirect.com www.sciencedirect.com
    NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
    1
    1. scibot 12 Oct 2021
      plasmid_48138

      DOI: 10.1016/j.molcel.2021.09.020

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    sciencedirect.com/science/article/pii/S1097276521007541
  200. www.sciencedirect.com www.sciencedirect.com
    NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
    1
    1. scibot 08 Oct 2021
      Addgene_48138

      DOI: 10.1016/j.molcel.2021.09.016

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    sciencedirect.com/science/article/pii/S1097276521007504
  201. Sep 2021
  202. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons
    1
    1. scibot 30 Sep 2021
      plasmid_48138

      DOI: 10.1111/jnc.15502

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15502
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mouse model of brittle cornea syndrome caused by mutation in Zfp469
    1
    1. scibot 30 Sep 2021
      RRID:Addgene_48138

      DOI: 10.1242/dmm.049175

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    ncbi.nlm.nih.gov/pmc/articles/PMC8476817/
  204. link.springer.com link.springer.com
    Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma
    1
    1. scibot 25 Sep 2021
      RRID:Addgene_48138

      DOI: 10.1007/s00262-021-03059-3

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    link.springer.com/article/10.1007/s00262-021-03059-3
  205. www.sciencedirect.com www.sciencedirect.com
    MultiEditR: The first tool for detection and quantification of multiple RNA editing sites from Sanger sequencing demonstrates comparable fidelity to RNA-seq
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    1. scibot 24 Sep 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.omtn.2021.07.008

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    sciencedirect.com/science/article/pii/S2162253121001761
  206. www.sciencedirect.com www.sciencedirect.com
    The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
    1
    1. scibot 23 Sep 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.molcel.2021.08.033

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    sciencedirect.com/science/article/pii/S1097276521007139
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line
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    1. scibot 18 Sep 2021
      RRID:Addgene_48138

      DOI: 10.1371/journal.pone.0257473

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    ncbi.nlm.nih.gov/pmc/articles/PMC8445474/
  208. www.sciencedirect.com www.sciencedirect.com
    RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy
    1
    1. scibot 16 Sep 2021
      48138

      DOI: 10.1016/j.stem.2021.08.006

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    sciencedirect.com/science/article/pii/S193459092100343X
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif
    1
    1. scibot 14 Sep 2021
      plasmid_48138

      DOI: 10.1093/nar/gkab657

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    ncbi.nlm.nih.gov/pmc/articles/PMC8421206/
  210. Aug 2021
  211. www.sciencedirect.com www.sciencedirect.com
    Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination
    1
    1. scibot 27 Aug 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.molcel.2021.07.037

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    sciencedirect.com/science/article/pii/S1097276521006158
  212. www.sciencedirect.com www.sciencedirect.com
    Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis
    1
    1. scibot 26 Aug 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.molcel.2021.07.041

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    sciencedirect.com/science/article/pii/S1097276521006250
  213. www.nature.com www.nature.com
    Topological isolation of developmental regulators in mammalian genomes
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    1. scibot 17 Aug 2021
      RRID:Addgene_48138

      DOI: 10.1038/s41467-021-24951-7

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    nature.com/articles/s41467-021-24951-7
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction
    1
    1. scibot 17 Aug 2021
      RRID:Addgene_48138

      DOI: 10.1167/iovs.62.9.39

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    ncbi.nlm.nih.gov/pmc/articles/PMC8322709/
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
    1
    1. scibot 16 Aug 2021
      plasmid_48138

      DOI: 10.1091/mbc.E20-06-0382

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    ncbi.nlm.nih.gov/pmc/articles/PMC8351540/
  216. www.sciencedirect.com www.sciencedirect.com
    Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity
    1
    1. scibot 15 Aug 2021
      Addgene_48138

      DOI: 10.1016/j.celrep.2021.109525

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    sciencedirect.com/science/article/pii/S2211124721009566
  217. www.embopress.org www.embopress.org
    The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder
    1
    1. scibot 15 Aug 2021
      RRID:Addgene_48138

      DOI: 10.15252/embr.202051991

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    embopress.org/doi/abs/10.15252/embr.202051991
  218. journals.plos.org journals.plos.org
    The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells
    1
    1. scibot 15 Aug 2021
      RRID:Addgene_48138

      DOI: 10.1371/journal.ppat.1009787

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    journals.plos.org/plospathogens/article
  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability
    1
    1. scibot 14 Aug 2021
      plasmid_48138

      DOI: 10.1523/JNEUROSCI.2282-17.2018

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    ncbi.nlm.nih.gov/pmc/articles/PMC6705897/
  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy
    1
    1. scibot 14 Aug 2021
      RRID:Addgene_48138

      DOI: 10.3390/cells8040327

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    ncbi.nlm.nih.gov/pmc/articles/PMC6523555/
  221. www.biorxiv.org www.biorxiv.org
    Untitled document
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    1. scibot 13 Aug 2021
      RRID:Addgene_48138

      DOI: 10.1101/633685

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    biorxiv.org/content/10.1101/633685v1
  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 13 Aug 2021
      Plasmid_48138

      DOI: 10.1016/j.molcel.2017.04.026

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    ncbi.nlm.nih.gov/pmc/articles/PMC5521213/
  223. europepmc.org europepmc.org
    In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
    1
    1. scibot 12 Aug 2021
      plasmid_48138

      DOI: 10.1038/s41467-019-08288-w

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    europepmc.org/articles/PMC6344529/
  224. www.sciencedirect.com www.sciencedirect.com
    A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family
    1
    1. scibot 12 Aug 2021
      plasmid_48138

      DOI: 10.1016/j.cell.2017.03.002

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    sciencedirect.com/science/article/pii/S0092867417302507