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  1. Last 7 days
  2. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Biallelic excision of the CTG18.1 repeat expansion in two FUCHS endothelial corneal dystrophy-derived iPSC lines and one control (SCTCi046-A-1, SCTCi047-A-1 and SCTCi041-A-1) using an episomal vector-based CRISPR/Cas9 approach
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    sciencedirect.com:5037/science/article/pii/S1873506125002314
  3. Nov 2025
  4. 54.241.53.176 54.241.53.176
    2025.11.18.688276v1.full-html.html
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  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromatin activity of IκBα mediates the exit from naïve pluripotency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12543326/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NRDE2 Interacts with an Early Transcription Elongation Complex and Widely Impacts Gene Expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12524662/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12592050/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PD-L1 regulates c-MET phosphorylation and contributes to MET-dependent resistance to osimertinib in EGFR-mutant NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12509346/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RCC2 and CD24 cooperate to modulate prostate cancer progression through vimentin ubiquitination and β-catenin activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520681/
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    Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12632499/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12529931/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modelling arrhythmogenic cardiomyopathy fattyfibro pathology with PKP2-deficient epicardial cells derived from human iPSCs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12559194/
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    5-Formylcytosine is not a prevalent RNA modification in mammalian cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12606350/
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    A Rho GTPase-effector ensemble governs cell migration behavior
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    pmc.ncbi.nlm.nih.gov/articles/PMC12579213/
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    Mitotic DNA repair by TMEJ suppresses replication stress-induced nuclear envelope reassembly defect
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    Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12565254/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A porcine model of Fanconi anemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12578174/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Secretory IgA amplification during immune checkpoint blockade enhances the control of tumor growth by enterotropic T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12494019/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12602705/
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    Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501060/
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    The mitochondrial disulphide relay substrate FAM136A safeguards IMS proteostasis and cellular fitness
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    pmc.ncbi.nlm.nih.gov/articles/PMC12557607/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generating a Cell Model to Study ER Stress in iPSC-Derived Medium Spiny Neurons from a Patient with Huntington’s Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12469972/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential cell survival outcomes in response to diverse amino acid stress
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  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD46 is a cellular receptor for species D human adenovirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12607895/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen
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    pmc.ncbi.nlm.nih.gov/articles/PMC12631164/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601339/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
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    pmc.ncbi.nlm.nih.gov/articles/PMC12456972/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Highly stable Cas9 promotes HBV genome destruction by antagonizing HSC70-mediated degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12456051/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12514221/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA2 enables growth by restricting recombination-restarted replication
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA-binding proteins mediate the maturation of chromatin topology during differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12431861/
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    A novel peptide-based strategy to enhance GBA1 expression for treating Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12630718/
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    Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12432183/
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    Genetic Engineering of Humanized Telomere Mice
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    STING-mediated antiviral response: insights into MVA replication control in avian cells
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
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    Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
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    Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer
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    Identification of Potential Therapeutic Agents for Type I Interferonopathy Using iPSC-Based Disease Modeling
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    Neuroimmune-competent human brain organoid model of diffuse midline glioma
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    C8orf33 dictates DNA double-strand break repair choice by modulating KAT8-mediated H4K16 acetylation
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    Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
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    RAF inhibitors activate the integrated stress response by direct activation of GCN2
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  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantitative Cell Type Specific Immunopeptidome Analysis of Macrophage and Tumor Co-evolution Reveals Therapeutic MHC-I Peptides in Glioblastoma
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural and epistatic regulatory variants cause hallmark white spotting in cattle
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    pmc.ncbi.nlm.nih.gov/articles/PMC12617462/
  49. www.science.org www.science.org
    Structural and epistatic regulatory variants cause hallmark white spotting in cattle
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    science.org/doi/10.1126/sciadv.adt5913
  50. www.sciencedirect.com www.sciencedirect.com
    Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14
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    sciencedirect.com/science/article/pii/S2211124725013245
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    The pan-cancer mutational landscape of MLL3 and its impact on prognosis and immunochemotherapy
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    sciencedirect.com/science/article/pii/S2211124725013191
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    The Multifaceted Role of EXOC6A in Ciliogenesis
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    elifesciences.org/reviewed-preprints/108271
  53. Oct 2025
  54. www.sciencedirect.com www.sciencedirect.com
    The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
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    sciencedirect.com/science/article/pii/S1097276525008226
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    Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
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    sciencedirect.com/science/article/pii/S1097276525008196
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    Generation of a FAM189A2/ENTREP1 knockout human induced pluripotent stem cell line using CRISPR/Cas9 technology
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    sciencedirect.com/science/article/pii/S1873506125002077
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    Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils
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    sciencedirect.com/science/article/pii/S1933021925001060
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    Sp100A isoform promotes localization of the histone chaperone HIRA to PML nuclear bodies
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  59. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
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    AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis
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    biorxiv.org/content/10.1101/2025.10.01.679670v1
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    Biphasic control of the B cell transcriptome by mTORC1 and GSK3
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  63. Sep 2025
  64. academic.oup.com academic.oup.com
    DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex sequence motifs
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  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery
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  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decreasing Lamin A Triggers Cell Fate Transitions through Heterochromatin-Nuclear Periphery Detethering
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  67. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MARCKS N-terminal sequence-derived inhibitor peptides impair monocytic ROS production and migration via MARCKS-independent effects
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  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12445808/
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    An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells
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    nature.com/articles/s42255-025-01366-y
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    Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation
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    sciencedirect.com/science/article/pii/S2211124725010575
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    Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis
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  73. www.biorxiv.org www.biorxiv.org
    Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
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    biorxiv.org/content/10.1101/2025.08.20.671247v1
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    Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
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    The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism
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    Experience-induced NPAS4 reduces dendritic inhibition from CCK+ inhibitory neurons and enhances plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12372623/
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    The Immunoproteasome Is Expressed but Dispensable for a Leukemia Infected Cell Vaccine
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  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evidence that mitochondria in macrophages are destroyed by microautophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398504/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12391391/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The RNA-binding protein YTHDF3 affects gastric cancer cell migration and response to paclitaxel by regulating EZRIN
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    pmc.ncbi.nlm.nih.gov/articles/PMC12378723/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Melanin Heterogeneity in Metastatic Melanoma: A Dual‐Tumour Mouse Melanoma Model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405743/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393524/
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    CRISPR/Cas9-mediated editing of COQ4 in induced pluripotent stem cells: A model for investigating COQ4-associated human coenzyme Q10 deficiency
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    sciencedirect.com/science/article/pii/S1873506125001758
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405493/
  85. www.biorxiv.org www.biorxiv.org
    Sister chromatid separation determines the proliferative characteristics upon whole-genome duplication through homologous chromosome rearrangement
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    biorxiv.org/content/10.1101/2025.08.27.672736v1
  86. www.cell.com www.cell.com
    Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci
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    cell.com/cell-genomics/abstract/S2666-979X(25)00238-1
  87. Aug 2025
  88. www.biorxiv.org www.biorxiv.org
    Paralog-specific intrabodies for PSD-93 and SAP102 expand the molecular toolkit to resolve excitatory synapse organization
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    biorxiv.org/content/10.1101/2025.08.24.671450v1
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    Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis
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    biorxiv.org/content/10.1101/2025.08.15.670286v1
  90. 52.53.155.43 52.53.155.43
    A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
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