1,452 Matching Annotations
  1. May 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075652/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12022042/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048556/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12055005/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated thermal proteome and thermal proximity co-aggregation profiling identifies ATP6V1C1 as a novel anti-cancer drug target
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    pmc.ncbi.nlm.nih.gov/articles/PMC12080387/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-Throughput Screening to Identify Novel Compounds Affecting the Genome Editing Efficiency of CRISPR System
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    pmc.ncbi.nlm.nih.gov/articles/PMC12029788/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Protective Role of DUSP4 in Retinal Pigment Epithelium Senescence and Degeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12027498/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALDH1A3 Regulates Cellular Senescence and Senescence-Associated Secretome in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11987895/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021886/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12054253/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12040169/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gas1-high quiescent neural stem cells are multipotent and produce oligodendrocytes during aging and after demyelinating injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC11990765/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046326/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of placental trophoblast fusion by guanylate-binding protein 5
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    pmc.ncbi.nlm.nih.gov/articles/PMC12057675/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12034038/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069520/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Feedback-responsive cell factories for dynamic modulation of the unfolded protein response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048557/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12062253/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056021/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12041315/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12045962/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Congenital enteropathy caused by ezrin deficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12033192/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non‐Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077270/
  25. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/581690a87db32a6cd802c9bdccaa776024adf4bf/PDF-html.html
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12024519/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002136/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12022045/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997214/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide screen identifies genes required for erythroid differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11993733/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986000/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATF6α inhibits ΔNp63α expression to promote breast cancer metastasis by the GRP78-AKT1-FOXO3a signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11994819/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1α/HIF2α regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12009364/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997380/
  35. www.sciencedirect.com www.sciencedirect.com
    Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
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    sciencedirect.com/science/article/pii/S2211124725004280
  36. www.sciencedirect.com www.sciencedirect.com
    ERBB4 selectively amplifies TGF-β pro-metastatic responses
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    sciencedirect.com/science/article/pii/S2211124724015614
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lineage-specific CDK activity dynamics characterize early mammalian development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070373/
  38. Apr 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12013414/
  40. www.sciencedirect.com www.sciencedirect.com
    Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses
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    sciencedirect.com/science/article/pii/S1097276525003053
  41. elifesciences.org elifesciences.org
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    elifesciences.org/reviewed-preprints/106492
  42. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70099
  43. www.sciencedirect.com www.sciencedirect.com
    The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
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    sciencedirect.com/science/article/pii/S109727652500303X
  44. www.sciencedirect.com www.sciencedirect.com
    Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
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    sciencedirect.com/science/article/pii/S153561082500128X
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952453/
  46. 52.53.155.43 52.53.155.43
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    52.53.155.43/4c68cb20c96f9831d654e32b29866141bc56f76e/PDF-html.html
  47. www.sciencedirect.com www.sciencedirect.com
    Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance
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    sciencedirect.com/science/article/pii/S1535610825001321
  48. www.nature.com www.nature.com
    Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling
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    nature.com/articles/s41594-025-01522-8
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225006248-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12053632/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951516/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell sequencing combined with urinary multi-omics analysis reveals that the non-invasive biomarker PRDX5 regulates bladder cancer progression through ferroptosis signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11931876/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest
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    pmc.ncbi.nlm.nih.gov/articles/PMC11934320/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    G0S2 modulates normal vitreous-induced proliferation in endothelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11971441/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11947120/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11929817/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic OASL expression licenses interferon induction during influenza A virus infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11956916/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952405/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
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    pmc.ncbi.nlm.nih.gov/articles/PMC11933316/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11968822/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11926384/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene Zeste White 10 in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11954606/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11955114/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11954966/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bone Marrow-Targeted Liposomes Loaded with Bortezomib Overcome Multiple Myeloma Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11966756/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11965687/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The impact of a high fat diet and platelet activation on pre-metastatic niche formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11965330/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957774/
  69. www.biorxiv.org www.biorxiv.org
    NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
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    biorxiv.org/content/10.1101/2025.03.29.646096v1
  70. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124725002232
  71. www.sciencedirect.com www.sciencedirect.com
    Dicer deficiency affects microglial function during demyelination and impairs remyelination
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    sciencedirect.com/science/article/pii/S0969996125000956
  72. www.sciencedirect.com www.sciencedirect.com
    Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury
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    sciencedirect.com/science/article/pii/S2589004225004377
  73. Mar 2025
  74. www.sciencedirect.com www.sciencedirect.com
    ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2666379125001119
  75. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  76. www.sciencedirect.com www.sciencedirect.com
    Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth
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    sciencedirect.com/science/article/pii/S2211124725002414
  77. www.biorxiv.org www.biorxiv.org
    Knocking out Arl13b completely abolishes primary ciliogenesis
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    biorxiv.org/content/10.1101/2025.03.17.643595v1
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response
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    pmc.ncbi.nlm.nih.gov/articles/PMC6144792/
  79. 52.53.155.43 52.53.155.43
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    52.53.155.43/9f932175def02910028aeef91fa3dbdc5f9789b5/PDF-html.html
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11900931/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC11899812/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11912599/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4
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    pmc.ncbi.nlm.nih.gov/articles/PMC11912690/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11907909/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915864/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915848/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ectopic expression of testis-specific transcription elongation factor in driving cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908497/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11923746/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FABP4 as a therapeutic host target controlling SARS-CoV-2 infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904229/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive genomic dependency landscape of a human colon cancer organoid
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  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
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