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  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and transcriptomic landscape of human gastrointestinal stromal tumors
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    1. scibot 21 Dec 2024
      plasmid_52961

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532483/
  3. www.sciencedirect.com www.sciencedirect.com
    Global versus local matrix remodeling drives rotational versus invasive collective migration of epithelial cells
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    sciencedirect.com/science/article/pii/S1534580724007214
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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      plasmid_52961

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  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling
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    1. scibot 21 Dec 2024
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    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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    1. scibot 20 Dec 2024
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  7. Dec 2024
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    Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice
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    sciencedirect.com/science/article/pii/S2211124724014207
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer
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  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Control of cell proliferation by memories of mitosis
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  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    1. scibot 10 Dec 2024
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
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    Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition
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    1. scibot 06 Dec 2024
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    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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    1. scibot 02 Dec 2024
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  16. Nov 2024
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
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    1. scibot 26 Nov 2024
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  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting
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    1. scibot 26 Nov 2024
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    Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
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    1. scibot 21 Nov 2024
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    sciencedirect.com/science/article/pii/S1550413124004121
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    Profound synthetic lethality between SMARCAL1 and FANCM
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  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization
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  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation
    1
    1. scibot 10 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11080644/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
    1
    1. scibot 08 Nov 2024
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
    1
    1. scibot 07 Nov 2024
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      DOI: 10.7554/eLife.88318

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  26. www.mdpi.com www.mdpi.com
    Comparative Analysis of Host Cell Entry Efficiency and Neutralization Sensitivity of Emerging SARS-CoV-2 Lineages KP.2, KP.2.3, KP.3, and LB.1
    1
    1. scibot 07 Nov 2024
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      DOI: 10.3390/vaccines12111236

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    mdpi.com/2076-393X/12/11/1236
  27. Oct 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
    1
    1. scibot 09 Oct 2024
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    sciencedirect.com/science/article/pii/S0092867424010729
  29. www.biorxiv.org www.biorxiv.org
    Metabolic mapping of the human solute carrier superfamily
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    1. scibot 03 Oct 2024
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    biorxiv.org/content/10.1101/2024.09.23.614124v1
  30. Sep 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction
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      DOI: 10.1126/sciadv.adl5638

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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-loop resolution by ARIP4 helicase promotes androgen-mediated transcription induction
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting conserved TIM3+VISTA+ tumor-associated macrophages overcomes resistance to cancer immunotherapy
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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343217/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BL-918 activates PINK1/Parkin signaling pathway to ameliorate the progression of Parkinson’s disease
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming
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  37. academic.oup.com academic.oup.com
    TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice
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    academic.oup.com/nar/article/52/15/9230/7697529
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel insights into vancomycin-loaded calcium sulfate and negative pressure wound therapy in preventing infections in open fractures
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemical genetic screens reveal defective lysosomal trafficking as synthetic lethal with NF1 loss
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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of TIM-1 and CD300a in Zika Virus Infection Investigated with Cell-Based Electrical Impedance
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11362803/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364388/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
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      DOI: 10.1007/s11064-024-04213-w

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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2
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      52961

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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Fluorinated NAD Precursors Enhance FK866 Cytotoxicity by Activating SARM1 in Glioblastoma Cells
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      52961

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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HRS Facilitates Newcastle Disease Virus Replication in Tumor Cells by Promoting Viral Budding
    1
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      lentiCRISPR v2

      DOI: 10.3390/ijms251810060

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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
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    Dihydrotestosterone Enhances MICA-Mediated Immune Responses to Epstein–Barr Virus-Associated Gastric Carcinoma
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      52961

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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation
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      lentiCRISPRv2

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    PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT
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    RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis
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    The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
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    USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling
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    N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
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    Cyclophilin J limits linear ubiquitin signaling and controls colorectal cancer progression
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    DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment
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    Mitochondrial RNA cytosolic leakage drives the SASP
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glaesserella parasuis serotype 4 exploits fibronectin via RlpA for tracheal colonization following porcine circovirus type 2 infection
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      lentiCRISPR v2

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24
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      lentiCRISPR v2

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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases*
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      (https://media.addgene.or

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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of immortal-like and functional CAR T cells by defined factors
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC
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      52 961

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    Saturation mutagenesis-reinforced functional assays for disease-related genes
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  73. www.biorxiv.org www.biorxiv.org
    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains
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      Addgene_52961

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling
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    A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma
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      lentiCRISPR v2

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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
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      Lenti-CRISPR v2

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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
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    Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48
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      plasmid_52961

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    Characterization of the AGR2-NPM3 axis uncovers the AGR2 involvement in PD-L1 regulation in colorectal cancer
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASCT2 is a major contributor to serine uptake in cancer cells
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway
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  89. www.sciencedirect.com www.sciencedirect.com
    A Platform to Deliver Single and Bi-specific Cas9/guide RNA to Perturb Genes in Vitro and in Vivo
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      DOI: 10.1016/j.ymthe.2024.07.025

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  90. www.sciencedirect.com www.sciencedirect.com
    Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis
    1
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-XL in a murine cell model of myeloid differentiation
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differential utilization of vitamin B12-dependent and independent pathways for propionate metabolism across human cells
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  93. www.sciencedirect.com www.sciencedirect.com
    A TBK1-independent primordial function of STING in lysosomal biogenesis
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The expression of PD-L1 on tumor-derived exosomes enhances infiltration and anti-tumor activity of αCD3 × αPD-L1 bispecific antibody-armed T cells
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enzalutamide Sensitizes Castration‐Resistant Prostate Cancer to Copper‐Mediated Cell Death
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression
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  100. www.sciencedirect.com www.sciencedirect.com
    The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions
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  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FHL2 expression by cancer-associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin-1 and UNC5B Cooperate with Integrins to Mediate YAP-Driven Cytostasis
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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic landscape profiling of primary prostate cancer reveals a 16-protein panel for prognosis prediction
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    1. scibot 14 Sep 2024
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
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  107. www.sciencedirect.com www.sciencedirect.com
    Pooled endogenous protein tagging and recruitment for systematic profiling of protein function
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes
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  109. www.sciencedirect.com www.sciencedirect.com
    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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  110. Aug 2024
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression
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    1. scibot 30 Aug 2024
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ANGPTL4 suppresses clear cell renal cell carcinoma via inhibition of lysosomal acid lipase
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  113. www.sciencedirect.com www.sciencedirect.com
    Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria
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      52961

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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UNC13B regulates the sensitivity of Wilms' tumor cells to doxorubicin by modulating lysosomes
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      52961

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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation
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      lentiCRISPRv2

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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification
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      52,961

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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanine
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy
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      lentiCRISPRv2

      DOI: 10.1631/jzus.B2300555

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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment
    1
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      lenti‐CRISPR v2

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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A plug-and-play monofunctional platform for targeted degradation of extracellular proteins and vesicles
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression
    1
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      lentiCRISPR V2

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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 | mBio
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      plasmid_52961

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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a highly sensitive platform for protein–protein interaction detection and regulation of T cell function
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair
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      Addgene_52961

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  133. www.sciencedirect.com www.sciencedirect.com
    A genetic basis for sex differences in Xp11 translocation renal cell carcinoma
    1
    1. scibot 22 Aug 2024
      Plasmid_52961

      DOI: 10.1016/j.cell.2024.07.038

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    sciencedirect.com/science/article/pii/S0092867424008328
  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Valproic acid targets IDH1 mutants through alteration of lipid metabolism
    1
    1. scibot 22 Aug 2024
      RRID:Addgene_52961

      DOI: 10.1038/s44324-024-00021-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321993/
  135. www.sciencedirect.com www.sciencedirect.com
    Functional characterization of the SDR42E1 reveals its role in vitamin D biosynthesis
    1
    1. scibot 22 Aug 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.heliyon.2024.e36466

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    sciencedirect.com/science/article/pii/S2405844024124978
  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds
    1
    1. scibot 22 Aug 2024
      Addgene_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11302795/
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response
    1
    1. scibot 22 Aug 2024
      Addgene_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11300780/
  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CA19-9-Positive Extracellular Vesicle Is a Risk Factor for Cancer-Associated Thrombosis in Pancreatic Cancer
    1
    1. scibot 22 Aug 2024
      Plasmid_52961

      DOI: 10.1016/j.gastha.2024.02.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC11308089/
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function
    2
    1. scibot 22 Aug 2024
      Addgene_52961

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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11316047/
  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair
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    1. scibot 22 Aug 2024
      Plasmid_52961

      DOI: 10.1093/nar/gkae501

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    ncbi.nlm.nih.gov/pmc/articles/PMC11317144/
  141. www.sciencedirect.com www.sciencedirect.com
    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    1. scibot 22 Aug 2024
      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S2211124724009720
  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein
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    1. scibot 21 Aug 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11330172/
  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The caspase-activated DNase promotes cellular senescence
    1
    1. scibot 21 Aug 2024
      lentiCRISPR v2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11329656/
  144. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S1535610824002708
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication
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    1. scibot 21 Aug 2024
      RRID:Addgene_52961

      DOI: 10.3389/fcimb.2024.1383917

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    ncbi.nlm.nih.gov/pmc/articles/PMC11306179/
  146. www.biorxiv.org www.biorxiv.org
    Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
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    1. scibot 20 Aug 2024
      LentiCRISPR.V2

      DOI: 10.1101/2024.07.10.602941

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    biorxiv.org/content/10.1101/2024.07.10.602941v2
  147. www.cell.com www.cell.com
    SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo
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      RRID:Addgene_52961

      DOI: 10.1016/j.neuron.2024.07.007

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    cell.com/neuron/abstract/S0896-6273(24)00529-4
  148. www.sciencedirect.com www.sciencedirect.com
    Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy
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    1. scibot 19 Aug 2024
      Plasmid_52961

      DOI: 10.1016/j.isci.2024.110537

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    sciencedirect.com/science/article/pii/S2589004224017620
  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
    1
    1. scibot 19 Aug 2024
      RRID:Addgene_52961

      DOI: 10.7554/eLife.84875

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    ncbi.nlm.nih.gov/pmc/articles/PMC11296703/
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
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    1. scibot 18 Aug 2024
      52961

      DOI: 10.1038/s12276-024-01264-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC11297042/
  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation
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    1. scibot 18 Aug 2024
      52961

      DOI: 10.1016/j.jbc.2024.107494

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301355/
  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epitranscriptomic m5C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection
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    1. scibot 18 Aug 2024
      lentiCRISPR-v2

      DOI: 10.1126/sciadv.adn9519

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    ncbi.nlm.nih.gov/pmc/articles/PMC11305390/
  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Necroptosis‐Mediated Synergistic Photodynamic and Glutamine‐Metabolic Therapy Enabled by a Biomimetic Targeting Nanosystem for Cholangiocarcinoma
    1
    1. scibot 18 Aug 2024
      52 961

      DOI: 10.1002/advs.202309203

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    ncbi.nlm.nih.gov/pmc/articles/PMC11304281/
  154. www.biorxiv.org www.biorxiv.org
    Transcriptional regulation of adipocyte lipolysis by IRF2BP2
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    1. scibot 18 Aug 2024
      plasmid_52961

      DOI: 10.1101/2024.07.31.605689

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    biorxiv.org/content/10.1101/2024.07.31.605689v1
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer
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      Addgene_52961

      DOI: 10.1038/s43018-023-00671-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11277537/
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TXNRD1 drives innate immune response in senescent cells with implications in age-associated inflammation
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      Addgene_52961

      DOI: 10.1038/s43587-023-00564-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11210448/
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer
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    1. scibot 17 Aug 2024
      lentiCRISPRv2

      DOI: 10.1038/s41467-024-51242-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11316045/
  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis
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      52961

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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LACTB suppresses liver cancer progression through regulation of ferroptosis
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    1. scibot 17 Aug 2024
      52961

      DOI: 10.1016/j.redox.2024.103270

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321384/
  160. www.sciencedirect.com www.sciencedirect.com
    OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
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    1. scibot 14 Aug 2024
      Cat# 52961

      DOI: 10.1016/j.molcel.2024.07.020

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    sciencedirect.com/science/article/pii/S109727652400618X
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors
    1
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11286358/
  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
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      52961

      DOI: 10.1038/s41588-023-01626-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11005318/
  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A digital microfluidic device integrated with electrochemical sensor and 3D matrix for detecting soluble PD-L1
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      52961

      DOI: 10.1016/j.biosx.2024.100490

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    ncbi.nlm.nih.gov/pmc/articles/PMC11290324/
  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
    1
    1. scibot 13 Aug 2024
      LentiCRISPR V2

      DOI: 10.1016/j.xcrm.2024.101510

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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer
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      52961

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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility
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      Addgene_52961

      DOI: 10.1186/s13046-024-03064-1

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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    2024.04.26.591029v1.full-html.html
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  168. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Frontiers | The Nonvesicular Sterol Transporter Aster-C Plays a Minor Role in Whole Body Cholesterol Balance
    1
    1. scibot 13 Aug 2024
      Lenti-CRISPER v2

      DOI: 10.3389/fphys.2024.1371096

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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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      52961

      DOI: 10.1016/j.molcel.2023.12.016

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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tangible method to assess native ferroptosis suppressor activity
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10985226/
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress
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    1. scibot 02 Aug 2024
      LentiCrispr v2

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  172. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
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      RRID:Addgene_52961

      DOI: 10.1186/s12964-023-01335-6

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    biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01335-6
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
    1
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      Addgene52961

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  174. www.pnas.org www.pnas.org
    Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia
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    1. scibot 02 Aug 2024
      Addgene plasmid No. 52961

      DOI: 10.1073/pnas.2123227119

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    pnas.org/doi/10.1073/pnas.2123227119
  175. journals.sagepub.com journals.sagepub.com
    Mismatch repair deficiency in canine neoplasms - Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Mika Tanabe, Nozomi Shimonohara, Kazuhito Itamoto, Munekazu Nakaichi, Takuya Mizuno, 2021
    1
    1. scibot 02 Aug 2024
      RRID: Addgene 52961

      DOI: 10.1177/03009858211022704

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    journals.sagepub.com/doi/full/10.1177/03009858211022704
  176. www.embopress.org www.embopress.org
    A method for benchmarking genetic screens reveals a predominant mitochondrial bias
    1
    1. scibot 02 Aug 2024
      Cat #52961

      DOI: 10.15252/msb.202010013

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    embopress.org/doi/full/10.15252/msb.202010013
  177. www.science.org www.science.org
    The KAT module of the SAGA complex maintains the oncogenic gene expression program in MYCN-amplified neuroblastoma
    1
    1. scibot 02 Aug 2024
      RRID:Addgene_52961

      DOI: 10.1126/sciadv.adm9449

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    science.org/doi/10.1126/sciadv.adm9449
  178. Jul 2024
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Artesunate induces melanoma cell ferroptosis and augments antitumor immunity through targeting Ido1
    1
    1. scibot 31 Jul 2024
      52961

      DOI: 10.1186/s12964-024-01759-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11282746/
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
    2
    1. scibot 31 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1158/2159-8290.CD-23-0539

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      RRID:Addgene_52961

      DOI: 10.1158/2159-8290.CD-23-0539

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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
    1
    1. scibot 30 Jul 2024
      plasmid_52961

      DOI: 10.1016/j.neuron.2024.06.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
    1
    1. scibot 27 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.isci.2024.110285

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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
  183. www.sciencedirect.com www.sciencedirect.com
    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
    1
    1. scibot 24 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.molcel.2024.06.001

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    sciencedirect.com/science/article/pii/S1097276524004799
  184. www.sciencedirect.com www.sciencedirect.com
    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
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    1. scibot 23 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.molcel.2024.05.030

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    sciencedirect.com/science/article/pii/S1097276524004775
  185. www.cell.com www.cell.com
    The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway
    1
    1. scibot 23 Jul 2024
      Addgene_52961

      DOI: 10.1016/j.molcel.2024.06.031

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    cell.com/molecular-cell/fulltext/S1097-2765(24)00538-0
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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    1. scibot 20 Jul 2024
      RRID:Addgene_52961

      DOI: 10.7554/eLife.91766

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    ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
  187. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
    1
    1. scibot 18 Jul 2024
      #52961, Addgene

      DOI: 10.1038/s41422-024-00985-6

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    pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
  188. www.science.org www.science.org
    HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1126/sciadv.adl6083

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    science.org/doi/10.1126/sciadv.adl6083
  189. rupress.org rupress.org
    PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1084/jem.20221721

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    rupress.org/jem/article/221/7/e20221721/276807/PD-L1-promotes-oncolytic-virus-infection-via-a
  190. 52.53.155.43 52.53.155.43
    The_identification_of_CELSR3_and_other_p-html.html
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1158/2767-9764.crc-22-0491

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    52.53.155.43/5ac19ff673ff96d677267abfd1a7395ae6436334/The_identification_of_CELSR3_and_other_p-html.html
  191. www.tandfonline.com www.tandfonline.com
    Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense
    1
    1. scibot 16 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1080/15548627.2024.2374692

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    tandfonline.com/doi/abs/10.1080/15548627.2024.2374692
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
    1
    1. scibot 14 Jul 2024
      Addgene_52961

      DOI: 10.1038/s41467-021-27192-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC8636641/
  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The COMPASS complex maintains the metastatic capacity imparted by a subpopulation of cells in UPS
    1
    1. scibot 14 Jul 2024
      Addgene_52961

      DOI: 10.1016/j.isci.2024.110187

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233968/
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-defensin binding expands human adenovirus tropism
    1
    1. scibot 14 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1371/journal.ppat.1012317

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    ncbi.nlm.nih.gov/pmc/articles/PMC11230588/
  195. www.sciencedirect.com www.sciencedirect.com
    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
    1
    1. scibot 12 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2024.114477

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    sciencedirect.com/science/article/pii/S2211124724008064
  196. www.cell.com www.cell.com
    SigmaR1 shapes rough endoplasmic reticulum membrane sheets
    1
    1. scibot 12 Jul 2024
      Addgene_52961

      DOI: 10.1016/j.devcel.2024.06.005

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    cell.com/developmental-cell/fulltext/S1534-5807(24)00382-4
  197. www.cell.com www.cell.com
    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
    1
    1. scibot 11 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.cell.2024.06.019

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    cell.com/cell/fulltext/S0092-8674(24)00693-7
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration
    1
    1. scibot 07 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2024.113999

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    ncbi.nlm.nih.gov/pmc/articles/PMC11216409/
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model
    1
    1. scibot 06 Jul 2024
      RRID:Addgene_52961

      DOI: 10.3389/fonc.2024.1402126

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    ncbi.nlm.nih.gov/pmc/articles/PMC11223524/
  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Precise excision of HTLV-1 provirus with a designer-recombinase
    1
    1. scibot 06 Jul 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.ymthe.2023.03.014

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    ncbi.nlm.nih.gov/pmc/articles/PMC10362392/
  201. www.sciencedirect.com www.sciencedirect.com
    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
    1
    1. scibot 04 Jul 2024
      plasmid_52961

      DOI: 10.1016/j.atherosclerosis.2024.118531

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    sciencedirect.com/science/article/pii/S0021915024010992
  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    γ-secretase facilitates retromer-mediated retrograde transport
    1
    1. scibot 01 Jul 2024
      pLentiCRISPRv2

      DOI: 10.1101/2024.06.07.597932

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    ncbi.nlm.nih.gov/pmc/articles/PMC11185792/
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low BCL-xL expression in triple-negative breast cancer cells favors chemotherapy efficacy, and this effect is limited by cancer-associated fibroblasts
    1
    1. scibot 01 Jul 2024
      plasmid_52961

      DOI: 10.1038/s41598-024-64696-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11187150/
  204. Jun 2024
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism
    1
    1. scibot 30 Jun 2024
      52961

      DOI: 10.1038/s41420-024-02072-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11193757/