1,451 Matching Annotations
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    Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinoma
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    biorxiv.org/content/10.1101/2025.08.24.671070v1
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    Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy
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    sciencedirect.com/science/article/pii/S2666379125003908
  4. Aug 2025
  5. rupress.org rupress.org
    Identification of organelle-specific autophagy regulators from tandem CRISPR screens
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    rupress.org/jcb/article/224/10/e202405138/278221/Identification-of-organelle-specific-autophagy
  6. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Transcriptomics assisted by metabolomics analysis provides insights into regulation mechanisms during carcinogenic process in a hydrodynamically transfected liver cancer model
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    cancerci.biomedcentral.com/articles/10.1186/s12935-025-03937-1
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    SCAMP3 is essential for proper formation and function of neutrophil granules
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    biorxiv.org/content/10.1101/2025.08.15.670532v1
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    Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis
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    biorxiv.org/content/10.1101/2025.08.15.670286v1
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    Transient gene melting governs the timing of oligodendrocyte maturation
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    sciencedirect.com/science/article/pii/S009286742500861X
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiple golgins are required to support extracellular matrix secretion, modification, and assembly
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    pmc.ncbi.nlm.nih.gov/articles/PMC12360289/
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    The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition
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    science.org/doi/10.1126/scisignal.adr9131
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    E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12349880/
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    Ribo-ITP expands the translatome of limited input samples
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    biorxiv.org/content/10.1101/2025.08.04.668486v1
  14. 52.53.155.43 52.53.155.43
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    HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
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    cell.com/cell-metabolism/fulltext/S1550-4131(25)00334-1
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRMT1 oligomerization regulates RNA-binding protein cascade to promote pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12272085/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270211/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286382/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    QRICH1 mediates an intracellular checkpoint for CD8+ T cell activation via the CARD11 signalosome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12291065/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FRA1 drives melanoma metastasis through an actionable transcriptional network
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    pmc.ncbi.nlm.nih.gov/articles/PMC12258986/
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    STIM-IP3R crosstalk regulates migration of breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302952/
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    Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286850/
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    Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307719/
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    Development of conformation-selective antibodies targeting human SLC15A4
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    pmc.ncbi.nlm.nih.gov/articles/PMC12334626/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    METTL9 sustains vertebrate neural development primarily via non-catalytic functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12313917/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12290104/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12276299/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SPAT inhibits LUAD metastasis by targeting SF1-mediated splicing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12334704/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282438/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12284560/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12271924/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278629/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302615/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADAM17 is an HIV-1 Restriction Factor Antagonized by Nef
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270201/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vitro and in vivo characterization of a bat merbecovirus with ACE2- and DPP4-independent cell entry
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282129/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Med14 phosphorylation shapes genomic response to GLP-1 Agonist
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262311/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259158/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262235/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12289969/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metastatic breast cancer cells are selectively dependent on the mitochondrial cristae-shaping protein OPA1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12279937/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D
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    pmc.ncbi.nlm.nih.gov/articles/PMC12284152/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314328/
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    Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6
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    pmc.ncbi.nlm.nih.gov/articles/PMC12331723/
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    TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329661/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host
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    pmc.ncbi.nlm.nih.gov/articles/PMC12321070/
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    Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12326723/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314529/
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    HSP90 deficiency promotes cholesteryl ester accumulation in lipid droplets via endocytosis of low-density lipoprotein
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328731/
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    Translation efficiency covariation identifies conserved coordination patterns across cell types
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    R9AP is a common receptor for EBV infection in epithelial cells and B cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328216/
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    Endo180 and basement membrane stiffness induce OXPHOS and neoplastic transformation in aging prostate epithelia
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    PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules
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    pmc.ncbi.nlm.nih.gov/articles/PMC12331966/
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    Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322040/
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    DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC12325982/
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    Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317996/
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    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
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    The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling
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    A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP
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    biorxiv.org/content/10.1101/2025.07.29.667405v1
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    Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314522/
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    Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12315713/
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    De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
  63. www.nature.com www.nature.com
    Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma
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    nature.com/articles/s41417-025-00946-0
  64. www.sciencedirect.com www.sciencedirect.com
    PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
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  65. Jul 2025
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12303731/
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    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
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    BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma
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    sciencedirect.com/science/article/pii/S2666379125003313
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    Sidt2 Inhibits Islet β-Cell Dedifferentiation by Regulating Insulin Secretion
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    sciencedirect.com/science/article/pii/S0021925825023956
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    NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
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    nature.com/articles/s41586-025-09303-5
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Knocking out ARL13B completely abolishes primary ciliogenesis in cell lines
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    pmc.ncbi.nlm.nih.gov/articles/PMC12289987/
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    An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
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    sciencedirect.com/science/article/pii/S221112472500840X
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282021/
  74. www.biorxiv.org www.biorxiv.org
    An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia
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    biorxiv.org/content/10.1101/2025.07.16.664180v1
  75. www.biorxiv.org www.biorxiv.org
    Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma
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    biorxiv.org/content/10.1101/2025.07.11.663903v1
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Butyrylcholinesterase (BChE) downregulation in taxane resistance: implications for prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12266350/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for Generation of Single-Gene Knockout in Hard-to-Transfect THP1 Cell Lines Using CRISPR/Cas9
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    pmc.ncbi.nlm.nih.gov/articles/PMC12245624/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically
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    pmc.ncbi.nlm.nih.gov/articles/PMC12204619/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Discovery of oligodendrocyte enhancers that regulate Sox10 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12266436/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12239510/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12243136/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208539/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fibulin-4 is highly expressed in metastatic breast cancer and can serve as a target of peptide-based imaging probes and experimental therapeutics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224531/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-mediated proximity labeling unveils ABHD14B as a host factor to regulate HBV cccDNA transcriptional activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12263051/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12254393/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM33 loss reduces androgen receptor transcriptional output and H2BK120 ubiquitination
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    pmc.ncbi.nlm.nih.gov/articles/PMC12254212/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Eml1 alters microtubule-associated protein networks in mouse brain heterotopia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12229495/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype
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  172. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  173. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  174. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  175. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  176. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  177. 52.53.155.43 52.53.155.43
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  178. www.embopress.org www.embopress.org
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  179. elifesciences.org elifesciences.org
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  180. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  181. www.sciencedirect.com www.sciencedirect.com
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  182. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  183. www.sciencedirect.com www.sciencedirect.com
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  184. May 2025
  185. elifesciences.org elifesciences.org
    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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  186. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  187. www.sciencedirect.com www.sciencedirect.com
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  188. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway
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  189. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  190. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  192. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  193. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  194. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  195. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  196. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  197. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  198. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  199. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  200. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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