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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity
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    aacrjournals.org/cancerres/article/84/5/703/734936/Adipose-Triglyceride-Lipase-Is-a-Therapeutic
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    Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes
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    Oncogenic KRAS drives lipo-fibrogenesis to promote angiogenesis and colon cancer progression
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    aacrjournals.org/cancerdiscovery/article/13/12/2652/731609/Oncogenic-KRAS-Drives-Lipofibrogenesis-to-Promote
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    PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma
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    FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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    Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction
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    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
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    Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification
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    Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome
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      plasmid_52961

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    Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
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    Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma
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      plasmid_52961

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    AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis
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    Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
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  17. Apr 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
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    DePARylation is critical for S phase progression and cell survival
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    iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
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    Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity
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    Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology
    1
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      lentiCRISPRv2

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    EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
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    The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
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  30. Mar 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma
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    Targeting the receptor tyrosine kinase MerTK shows therapeutic value in gastric adenocarcinoma
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation
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    DISRUPTION OF POLYUNSATURATED FATTY ACID BIOSYNTHESIS DRIVES STING-DEPENDENT ACUTE MYELOID LEUKEMIA CELL MATURATION AND DEATH
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      plasmid_52961

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer
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      plasmid_52961

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    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
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    sciencedirect.com/science/article/pii/S221112472400264X
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    A kinetic dichotomy between mitochondrial and nuclear gene expression processes
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis
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      LentiCRISPR v2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10938814/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking TGF-β- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of vessel-associated mural cells in glioblastoma impacts tumor angiogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10919159/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity
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      plentiCRISPR v2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10919859/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth
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      lentiCRISPRv2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10921702/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
    1
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      52961

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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
    1
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An efficient and cost-effective method for disrupting genes in RAW264.7 macrophages using CRISPR-Cas9
    1
    1. scibot 17 Mar 2024
      plasmid_52961

      DOI: 10.1371/journal.pone.0299513

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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression
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      plasmid_52961

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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury
    1
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      52961

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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Multiple Alternative Mitogenic Signaling Pathways Accompanies the Emergence of Drug-Tolerant Cancer Cells
    1
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      52961

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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression
    1
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      plasmid_52961

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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 ablation in the liver causes fatty liver that increases cancer risky by upregulating Serpina12
    1
    1. scibot 15 Mar 2024
      lentiCRISPR v2

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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity
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      plasmid_52961

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  54. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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      Addgene_52961

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    sciencedirect.com/science/article/pii/S2211124724002730
  55. www.sciencedirect.com www.sciencedirect.com
    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
    3
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    sciencedirect.com/science/article/pii/S1535610824000606
  56. www.nature.com www.nature.com
    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IFI35 limits antitumor immunity in triple-negative breast cancer via CCL2 secretion
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
    1
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      lentiCRISPRv2

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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication
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      Addgene_52961

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma
    1
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      plasmid_52961

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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer
    1
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      lentiCRISPR v2

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  65. www.sciencedirect.com www.sciencedirect.com
    Generation and characterization of three CRISPR/Cas9 edited RB1 null hiPSC lines for retinoblastoma disease modelling
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      Plasmid_52961

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational response to mitochondrial stresses is orchestrated by tRNA modifications
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      52961

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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A conserved ion channel function of STING mediates noncanonical autophagy and cell death
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis
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      DOI: 10.7554/eLife.86168

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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiation and leukemia
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      plasmid_52961

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  72. www.sciencedirect.com www.sciencedirect.com
    PEDV nucleocapsid antagonizes Zinc-finger Antiviral Protein by disrupting the interaction with its obligate co-factor, TRIM25.
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      DOI: 10.1016/j.vetmic.2024.110033

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  73. Feb 2024
  74. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
    1
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      AddgeneCat#52961

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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
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  76. www.sciencedirect.com www.sciencedirect.com
    CRISPR editing to mimic porphyria combined with light: a new preclinical approach for prostate cancer
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma
    1
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular trafficking of HIV-1 Gag via Syntaxin 6-positive compartments/vesicles: Involvement in tumor necrosis factor secretion
    1
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      Lenti-CRISPRv2

      DOI: 10.1016/j.jbc.2024.105687

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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells
    1
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma
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  81. 52.53.155.43 52.53.155.43
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  82. 52.53.155.43 52.53.155.43
    419-html.html
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  83. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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      Addgene Cat # 52961

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  84. www.biorxiv.org www.biorxiv.org
    New submission 27/09/2023, 09:17:54
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    biorxiv.org/content/10.1101/2023.07.31.551317v3
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6
    1
    1. scibot 21 Feb 2024
      52961

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
    1
    1. scibot 21 Feb 2024
      52961

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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells
    1
    1. scibot 21 Feb 2024
      52961

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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus
    1
    1. scibot 21 Feb 2024
      pLentiCRISPR v2

      DOI: 10.1038/s41467-024-45852-5

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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
    1
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1
    1
    1. scibot 21 Feb 2024
      lentiCRISPRV2

      DOI: 10.1186/s12967-024-04970-w

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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A landscape of gene expression regulation for synovium in arthritis
    1
    1. scibot 21 Feb 2024
      Addgene_52961

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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
    1
    1. scibot 18 Feb 2024
      RRID:Addgene_52961

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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor-derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors
    1
    1. scibot 16 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.CAN-22-2220

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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos
    1
    1. scibot 15 Feb 2024
      lenti-CRISPRv2

      DOI: 10.1038/s41420-024-01838-2

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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels
    1
    1. scibot 15 Feb 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10864035/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma
    1
    1. scibot 15 Feb 2024
      plasmid_52961

      DOI: 10.3390/cells13030216

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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations
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      Addgene_52961

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  98. www.biorxiv.org www.biorxiv.org
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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      Addgene_52961

      DOI: 10.1101/2024.02.06.579191

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    biorxiv.org/content/10.1101/2024.02.06.579191v1
  99. www.biorxiv.org www.biorxiv.org
    Circadian period is compensated for repressor protein turnover rates in single cells
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      RRID:Addgene_52961

      DOI: 10.1101/2024.02.06.579141

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    biorxiv.org/content/10.1101/2024.02.06.579141v1
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
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    1. scibot 15 Feb 2024
      Addgene_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10861560/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1
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    1. scibot 13 Feb 2024
      52961

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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
    1
    1. scibot 13 Feb 2024
      lentiCRISPR v2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761718/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
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    1. scibot 13 Feb 2024
      lentiCRISPR v2

      DOI: 10.1038/s41467-023-44466-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761827/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive Plasma Membrane Turnover in T-REx293 cells via Ordered Membrane Domain Endocytosis under Mitochondrial Control
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    1. scibot 13 Feb 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10827192/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation
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      52961

      DOI: 10.1371/journal.ppat.1011934

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    ncbi.nlm.nih.gov/pmc/articles/PMC10846743/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
    1
    1. scibot 10 Feb 2024
      Addgene_52961

      DOI: 10.1016/j.isci.2024.109015

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    ncbi.nlm.nih.gov/pmc/articles/PMC10847737/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism
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    1. scibot 09 Feb 2024
      plasmid_52961

      DOI: 10.1016/j.isci.2024.109107

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879702/
  108. www.biorxiv.org www.biorxiv.org
    RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
    2
    1. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.10.570873

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      RRID:Addgene_52961

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    biorxiv.org/content/10.1101/2023.12.10.570873v1
  109. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
    1. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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      RRID:Addgene_52961

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
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    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-43650-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762000/
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses
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    1. scibot 08 Feb 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10764363/
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence
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    1. scibot 08 Feb 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10764958/
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1
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      52961

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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
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    1. scibot 08 Feb 2024
      52961

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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis
    1
    1. scibot 08 Feb 2024
      LentiCRISPRv2

      DOI: 10.1186/s12964-023-01456-y

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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.3390/cancers16010224

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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease
    1
    1. scibot 08 Feb 2024
      Addgene_52961

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  118. www.sciencedirect.com www.sciencedirect.com
    p53 promotes antiviral innate immunity by driving hexosamine metabolism
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    1. scibot 07 Feb 2024
      Addgene_52961

      DOI: 10.1016/j.celrep.2024.113724

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    sciencedirect.com/science/article/pii/S2211124724000524
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
    1
    1. scibot 06 Feb 2024
      52961

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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1172/JCI170054

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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
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    1. scibot 05 Feb 2024
      52961

      DOI: 10.1172/JCI170882

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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEL1L-HRD1 ER-associated degradation regulates leptin receptor maturation and signaling in POMC neurons in diet-induced obesity
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.21203/rs.3.rs-3768472/v1

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  124. www.biorxiv.org www.biorxiv.org
    Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
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    1. scibot 05 Feb 2024
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1016/j.isci.2024.108840

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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronucleus is not a potent inducer of the cGAS/STING pathway
    1
    1. scibot 05 Feb 2024
      52961

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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative splicing of latrophilin-3 controls synapse formation
    1
    1. scibot 04 Feb 2024
      52961

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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1
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    1. scibot 04 Feb 2024
      RRID:Addgene_52961

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  129. www.nature.com www.nature.com
    Activation of recombinases at specific DNA loci by zinc-finger domain insertions
    1
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      RRID:Addgene_52961

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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein
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      52,961

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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EPAC1 enhances brown fat growth and beige adipogenesis
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin
    1
    1. scibot 01 Feb 2024
      52961

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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer
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      Addgene_52961

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  136. Jan 2024
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
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    1. scibot 31 Jan 2024
      plasmid_52961

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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset
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    1. scibot 30 Jan 2024
      Addgene, Watertown, MA, #52961

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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL
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      plasmid_52961

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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
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    1. scibot 30 Jan 2024
      plasmid_52961

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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas
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      plasmid_52961

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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway
    1
    1. scibot 29 Jan 2024
      Addgene_52961

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  143. www.sciencedirect.com www.sciencedirect.com
    ATG14 plays a critical role in hepatic lipid droplet homeostasis
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    1. scibot 25 Jan 2024
      RRID: Addgene_52,961

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    sciencedirect.com/science/article/pii/S0026049523002974
  144. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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      Addgene_52961

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  145. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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      Addgene_52961

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  147. www.sciencedirect.com www.sciencedirect.com
    Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins
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      RRID:Addgene_52961

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  148. www.sciencedirect.com www.sciencedirect.com
    Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
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      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S2211124723016248
  149. www.biorxiv.org www.biorxiv.org
    RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
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  150. Dec 2023
  151. www.sciencedirect.com www.sciencedirect.com
    Human inherited CCR2 deficiency underlies progressive polycystic lung disease
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    1. scibot 29 Dec 2023
      plasmid_52961

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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KIF16B Mediates Anterograde Transport and Modulates Lysosomal Degradation of the HIV-1 Envelope Glycoprotein
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  153. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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      RRID:Addgene_52961

      DOI: 10.1016/j.neuron.2023.11.020

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    Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth
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    High-throughput PRIME-editing screens identify functional DNA variants in the human genome
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      plasmid_52961

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  156. www.sciencedirect.com www.sciencedirect.com
    FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration
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      plasmid_52961

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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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      plasmid_52961

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  158. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases
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  160. www.biorxiv.org www.biorxiv.org
    Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint
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      plasmid_52961

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    biorxiv.org/content/10.1101/2021.04.21.440825v1
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity
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  163. www.sciencedirect.com www.sciencedirect.com
    Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
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  164. www.nature.com www.nature.com
    Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
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  165. link.springer.com link.springer.com
    Drug dependence in cancer is exploitable by optimally constructed treatment holidays
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  166. www.biorxiv.org www.biorxiv.org
    De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma
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  167. 52.53.155.43 52.53.155.43
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  168. www.sciencedirect.com www.sciencedirect.com
    Generation of a human embryonic stem cell reporter line, TMEM119-EGFP, for the visualisation of in vitro differentiated human microglia
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  169. Nov 2023
  170. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
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  171. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    1. scibot 22 Nov 2023
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  172. www.biorxiv.org www.biorxiv.org
    One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
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    biorxiv.org/content/10.1101/2023.11.06.565713v1
  173. www.science.org www.science.org
    Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer
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      plasmid_52961

      DOI: 10.1126/scitranslmed.adf6732

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  174. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
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    1. scibot 10 Nov 2023
      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S1074761323004442
  175. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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      RRID:Addgene_52961

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  176. Oct 2023
  177. www.sciencedirect.com www.sciencedirect.com
    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    1. scibot 28 Oct 2023
      RRID:Addgene_52961

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  178. www.sciencedirect.com www.sciencedirect.com
    SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing
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    1. scibot 28 Oct 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.immuni.2023.10.001

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  179. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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    1. scibot 28 Oct 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.stem.2023.09.007

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  180. www.sciencedirect.com www.sciencedirect.com
    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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  181. www.biorxiv.org www.biorxiv.org
    Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination
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    1. scibot 27 Oct 2023
      RRID:Addgene_52961

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  182. www.biorxiv.org www.biorxiv.org
    Synaptic Activity Causes Minute-scale Changes in BAF Complex Composition and Function
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    1. scibot 24 Oct 2023
      RRID:Addgene_52961

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  183. www.sciencedirect.com www.sciencedirect.com
    Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer
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      RRID: Addgene_52,961

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  184. www.cell.com www.cell.com
    MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
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      RRID:Addgene_52961

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    cell.com/cell-reports/abstract/S2211-1247(23)01034-3
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells
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    1. scibot 06 Oct 2023
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      DOI: 10.3390/ijms241814030

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  186. Sep 2023
  187. www.sciencedirect.com www.sciencedirect.com
    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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      RRID:Addgene_52961

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  188. www.sciencedirect.com www.sciencedirect.com
    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
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      Addgene_52961

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  189. www.embopress.org www.embopress.org
    IκB kinase-α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy
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      plasmid_52961

      DOI: 10.15252/embj.2023114719

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    embopress.org/doi/10.15252/embj.2023114719
  190. www.tandfonline.com www.tandfonline.com
    A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation
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      RRID:Addgene_52961

      DOI: 10.1080/15476286.2023.2258028

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  191. dx.doi.org dx.doi.org
    RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
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      DOI: 10.1093/nar/gkad733

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    dx.doi.org/10.1093/nar/gkad733
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10505912/
  193. dx.doi.org dx.doi.org
    Loss of CDKN2A Cooperates with WWTR1(TAZ)–CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma
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      plasmid_52961

      DOI: 10.1158/1078-0432.CCR-22-2497

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    dx.doi.org/10.1158/1078-0432.CCR-22-2497
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation
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      RRID:Addgene_52961

      DOI: 10.1016/j.isci.2023.107777

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502413/
  195. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    1. scibot 07 Sep 2023
      plasmid_52961

      DOI: 10.1016/j.celrep.2023.113070

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    sciencedirect.com/science/article/pii/S2211124723010811