1,652 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905269/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12913883/
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    BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
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    sciencedirect.com/science/article/pii/S1097276526000328
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    1-s2.0-S2589004226004311-main-html.html
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    Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
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    sciencedirect.com/science/article/pii/S009286742600111X
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    NRF2 co-opts the SWI/SNF complex to drive liver cell plasticity
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    biorxiv.org/content/10.64898/2026.02.09.704724v1
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    Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney
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    sciencedirect.com/science/article/pii/S2211124726000847
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    Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12893420/
  10. Feb 2026
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    Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death
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    sciencedirect.com/science/article/pii/S2211124726000422
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    Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12876832/
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    Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
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    sciencedirect.com/science/article/pii/S1097276526000651
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    Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202507238
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    The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12864753/
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    Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING
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    pmc.ncbi.nlm.nih.gov/articles/PMC12868630/
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    C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes
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    sciencedirect.com/science/article/pii/S0896627325009328
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    Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors
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    sciencedirect.com/science/article/pii/S1074761326000361
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    Loss of BOK increases vulnerability of p53 deficient non-small cell lung cancer cells to ATR inhibition through its role in uridine metabolism
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    nature.com/articles/s41418-026-01666-0
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    NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis
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    sciencedirect.com/science/article/pii/S2211124726000070
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    Menin-driven mTOR signaling sustains taxane resistance in CRPC and reveals a targetable vulnerability for combination therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12853843/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP22 dephosphorylates LGALS1 to enhance T cell-driven antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12853559/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12637489/
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    Screening strategy to identify Cas9 variants with higher HDR activity based on diphtheria toxin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673799/
  25. Jan 2026
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    CRISPR activation screens map the genomic landscape of cancer glycome remodeling
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    sciencedirect.com/science/article/pii/S2666979X26000017
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12690534/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-canonical EGFR signaling promotes MAPK-dependent extrusion of epithelial cells
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  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12721884/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissecting cellular ecosystem with single-cell CRISPR screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12680425/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The hemopexin domain of matrix metalloproteinase-9 attenuates lipopolysaccharide-induced interleukin-6 secretion in liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC12820117/
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    Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance
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    sciencedirect.com/science/article/pii/S0896627325009390
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    YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12802833/
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    Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12808752/
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    Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations
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    Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium
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    onlinelibrary.wiley.com/doi/10.1111/apha.70157
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    Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia
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    Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage
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    sciencedirect.com/science/article/pii/S1535610825005471
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    Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation
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    sciencedirect.com/science/article/pii/S1550413125005303
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    Crosstalk between the ribosome quality control-associated E3 ubiquitin ligases LTN1 and RNF10
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70230
  42. Dec 2025
  43. www.science.org www.science.org
    SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes
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    science.org/doi/10.1126/sciadv.adt7982
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    Mitochondrial VHL rewires cell metabolism in hypoxia
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    The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis
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    Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors
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  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12713097/
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    Targeting CTGF overcomes resistance to CSF1R inhibitors by preventing CAF activation in colorectal cancer
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    sciencedirect.com:5037/science/article/pii/S2666379125005531
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    Activation of the ciliary kinase CDKL5 is mediated by the cyclin-dependent kinase CDK20/LF2 to control flagellar length
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    Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency
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    sciencedirect.com:5037/science/article/pii/S2211124725014147
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    Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
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    Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport
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    pmc.ncbi.nlm.nih.gov/articles/PMC12698191/
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    Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity
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    A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
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    Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127007/
  56. Nov 2025
  57. www.sciencedirect.com www.sciencedirect.com
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    Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival
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    Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing
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    Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
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    sciencedirect.com/science/article/pii/S0092867425012516
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    DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12642826/
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    Senescent human fibroblasts have increased FasL expression and impair the tumor immune response
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel feline herpesvirus vector subunit FCV VP1 and FPV VP2 vaccine protects cats against FHV-1 and FPV challenge and induces serum neutralizing antibody responses against FCV
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    Development of CRISPR/Cas9-mediated CD16b-/- and CD32a-/- promyelocytic cell lines to study FcγR signaling in human neutrophils
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    pmc.ncbi.nlm.nih.gov/articles/PMC12528219/
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    SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging
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    pmc.ncbi.nlm.nih.gov/articles/PMC12419459/
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    Breaking the link between morphology and potency for mESCs
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  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARFGAP1 serves as a critical host factor during E30 infection: QS11 inhibits viral pathogenesis in hFcRn-IFNAR−/− mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12573814/
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    Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12604278/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639959/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Notch signal pathway related gene signature predicts overall survival in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12506287/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EP300 compromises antitumor immunity by increasing SOCS1 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12530425/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12542747/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638251/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identifying TP53RK as a key regulator of colorectal cancer survival and a potential therapeutic target
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533122/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12586714/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639132/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid
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    pmc.ncbi.nlm.nih.gov/articles/PMC12612160/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A motif preferred adenine base editor with minimal bystander and off-targets editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12528748/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VRK2 targeting potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma through MYC destabilization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12514316/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromatin looping-based CRISPR screen identifies TLK2 as chromatin loop formation regulator in cancer stemness plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12540834/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12508145/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the Met-RIPK1 signaling axis to enforce apoptosis and necroptosis in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12537949/
  83. www.nature.com www.nature.com
    A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
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    nature.com/articles/s41388-025-03603-w
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Wnt/β-catenin signaling enhances the efficacy of anti-CD38 immunotherapy in multiple myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12593212/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12611935/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC12491593/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12595089/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment
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  136. Oct 2025
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  171. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  176. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mycn Is Essential for Pubertal Mammary Gland Development and Promotes the Activation of Bcl11b-Maintained Quiescent Stem Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12384323/
  177. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407461/
  178. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12409284/
  179. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  180. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12389981/
  181. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393724/
  182. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel SOX6 + melanoma cell subtype promotes early microsatellite invasion in Asian acral melanoma through fatty acid transport disorder
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    pmc.ncbi.nlm.nih.gov/articles/PMC12382077/
  183. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12372299/
  184. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12404763/
  185. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396134/
  186. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    B7-H3 CAR T-cells are effective against ependymomas, but limited by tumor size and immune response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402791/
  187. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Polarity Gene PARD6B Promotes Tumor Growth of Colorectal Cancer via Increasing MYC Expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12400055/
  188. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interferon-stimulated gene screening identifies CCND3 as a host restriction factor against emerging high-pathogenic bandaviruses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12381284/
  189. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12394641/
  190. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12380595/
  191. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Macrophages and macrophage extracellular vesicles confer cancer ferroptosis resistance via PRDX6-mediated mitophagy inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12391288/
  192. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SALSA: a novel flow cytometry assay to detect ascorbate at the single-cell level
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398858/
  193. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Syncytial death mediated by oncolytic rVSV-NDV dynamically activates immunogenic apoptosis and necroptosis in human lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390950/
  194. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396411/
  195. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The oncogenic role of hypomethylated ZNF793 in gastric carcinoma: a focus on cell survival and stemness
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    pmc.ncbi.nlm.nih.gov/articles/PMC12378280/
  196. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer Cell‐Secreted miR‐33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12408367/
  197. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC12376557/
  198. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
  199. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sidt2 Inhibits Islet β-Cell Dedifferentiation by Regulating Insulin Secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406273/