396 Matching Annotations
  1. Jun 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11165854/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11112799/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11114247/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11116816/
  6. www.sciencedirect.com www.sciencedirect.com
    ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma
    1
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    sciencedirect.com/science/article/pii/S0304383524003938
  7. May 2024
  8. www.nature.com www.nature.com
    The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression
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    nature.com/articles/s41467-024-48333-x
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germinal center cytokine driven epigenetic control of Epstein-Barr virus latency gene expression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11081508/
  10. www.sciencedirect.com www.sciencedirect.com
    NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits
    1
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    sciencedirect.com/science/article/pii/S1931312824001343
  11. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
    1
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    sciencedirect.com/science/article/pii/S2211124724005394
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    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
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    sciencedirect.com/science/article/pii/S1097276524003253
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11060711/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059712/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NFATC2IP is a mediator of SUMO-dependent genome integrity
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11065178/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr-Virus-Driven Cardiolipin Synthesis Sustains Metabolic Remodeling During B-cell Lymphomagenesis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042403/
  17. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
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    elifesciences.org/articles/90683
  18. www.biorxiv.org www.biorxiv.org
    Epstein–Barr Virus BALF0/1 Subverts the Caveolin and ERAD Pathways to Target B-cell Receptor Complexes for Degradation
    1
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    biorxiv.org/content/10.1101/2024.01.04.574276v1
  19. www.sciencedirect.com www.sciencedirect.com
    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
    2
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    sciencedirect.com/science/article/pii/S1934590924001292
  20. Apr 2024
  21. www.sciencedirect.com www.sciencedirect.com
    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
    1
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    sciencedirect.com/science/article/pii/S1097276524002843
  22. www.sciencedirect.com www.sciencedirect.com
    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
    2
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    sciencedirect.com/science/article/pii/S0092867424003131
  23. www.sciencedirect.com www.sciencedirect.com
    IGSF8 is an innate immune checkpoint and cancer immunotherapy target
    1
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    sciencedirect.com/science/article/pii/S0092867424003556
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11009675/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11009108/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11021245/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent loss of FAM126A expression in colorectal cancer results in selective FAM126B dependency
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11025007/
  28. www.sciencedirect.com www.sciencedirect.com
    Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
    1
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    sciencedirect.com/science/article/pii/S2211124724004339
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000523/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983909/
  32. www.sciencedirect.com www.sciencedirect.com
    BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response
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    sciencedirect.com/science/article/pii/S1097276524002211
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
  34. www.sciencedirect.com www.sciencedirect.com
    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
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    sciencedirect.com/science/article/pii/S0092867424002502
  35. Mar 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10978915/
  37. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
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    sciencedirect.com/science/article/pii/S2667237524000626
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920982/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repeat DNA methylation is modulated by adherens junction signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920906/
  40. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening directly targeting testicular cells
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    sciencedirect.com/science/article/pii/S2666979X24000375
  41. Feb 2024
  42. www.sciencedirect.com www.sciencedirect.com
    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
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    sciencedirect.com/science/article/pii/S1097276524000984
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879184/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879117/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10849656/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10870824/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10761718/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aneuploid embryonic stem cells drive teratoma metastasis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844504/
  50. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
    1
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    journals.plos.org/plosgenetics/article
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10761986/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of senescence using machine learning algorithms based on nuclear features
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    ncbi.nlm.nih.gov/pmc/articles/PMC10838307/
  53. www.sciencedirect.com www.sciencedirect.com
    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    sciencedirect.com/science/article/pii/S1097276524000091
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronucleus is not a potent inducer of the cGAS/STING pathway
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10837050/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802360/
  57. www.sciencedirect.com www.sciencedirect.com
    Two-step evolution of HIV-1 budding system leading to pandemic in the human population
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    sciencedirect.com/science/article/pii/S2211124724000251
  58. Jan 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10790771/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000110/
  61. Dec 2023
  62. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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    sciencedirect.com/science/article/pii/S1074761323004909
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  64. journals.asm.org journals.asm.org
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
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    journals.asm.org/doi/10.1128/mbio.02444-23
  65. Nov 2023
  66. www.sciencedirect.com www.sciencedirect.com
    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
    1
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    sciencedirect.com/science/article/pii/S2666379123004767
  67. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
    1
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    biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01335-6
  68. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
  69. Oct 2023
  70. www.biorxiv.org www.biorxiv.org
    Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus
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    biorxiv.org/content/10.1101/2023.10.20.563362v1
  71. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
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    cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
  72. Sep 2023
  73. www.nature.com www.nature.com
    CRISPR prime editing for unconstrained correction of oncogenic KRAS variants
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    nature.com/articles/s42003-023-05052-1
  74. www.sciencedirect.com www.sciencedirect.com
    Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression
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    sciencedirect.com/science/article/pii/S0002929723002434
  75. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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    sciencedirect.com/science/article/pii/S2211124723011099
  76. Aug 2023
  77. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  78. www.biorxiv.org www.biorxiv.org
    The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC reprogramming
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    biorxiv.org/content/10.1101/2023.07.31.551297v3
  79. Jul 2023
  80. 52.53.155.43 52.53.155.43
    Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal
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    52.53.155.43/8add9715cb6d409825df8305aa589d745e83436f/2023.05.03.539283.full-html.html
  81. Jun 2023
  82. www.sciencedirect.com www.sciencedirect.com
    Generation of Myoglobin (MB)-Knockout human embryonic stem cell (hESC) line (KAIMRCe002- A-1S) using CRISPR/Cas9 technology
    1
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    sciencedirect.com/science/article/pii/S1873506123001447
  83. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    sciencedirect.com/science/article/pii/S1535610823002088
  84. www.biorxiv.org www.biorxiv.org
    Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis
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    biorxiv.org/content/10.1101/2023.06.14.544493v1
  85. www.sciencedirect.com www.sciencedirect.com
    An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
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    sciencedirect.com/science/article/pii/S109727652300374X
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
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    ncbi.nlm.nih.gov/pmc/articles/PMC7614333/
  87. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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    aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
  88. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
  89. www.biorxiv.org www.biorxiv.org
    Stem cells tightly regulate dead cell clearance to maintain tissue fitness
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    biorxiv.org/content/10.1101/2023.05.22.541773v1
  90. May 2023
  91. www.biorxiv.org www.biorxiv.org
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation and proteomic profiles in Burkitt lymphoma
    1
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    biorxiv.org/content/10.1101/2023.05.19.538556v1
  92. www.biorxiv.org www.biorxiv.org
    Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia
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    biorxiv.org/content/10.1101/2023.05.18.541265v1
  93. www.sciencedirect.com www.sciencedirect.com
    Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
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    sciencedirect.com/science/article/pii/S2211124723005491
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6942053/
  95. Apr 2023
  96. www.sciencedirect.com www.sciencedirect.com
    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    sciencedirect.com/science/article/pii/S1097276523002393
  97. Mar 2023
  98. www.nature.com www.nature.com
    The protective role of conjunctival goblet cell mucin sialylation
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    nature.com/articles/s41467-023-37101-y
  99. Feb 2023
  100. www.embopress.org www.embopress.org
    Immune surveillance of brain metastatic cancer cells is mediated by IFITM1
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    embopress.org/doi/10.15252/embj.2022111112
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
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    ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
  102. Jan 2023
  103. www.sciencedirect.com www.sciencedirect.com
    Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
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