252 Matching Annotations
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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
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    Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease
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    1. scibot 27 Dec 2024
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    TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
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    1. scibot 24 Dec 2024
      AddgeneCat# 52963

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  5. Dec 2024
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    TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
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    1. scibot 21 Dec 2024
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    Control of cell proliferation by memories of mitosis
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    1. scibot 11 Dec 2024
      RRID:Addgene_52963

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  8. Nov 2024
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    Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylation
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    1. scibot 20 Nov 2024
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    biorxiv.org/content/10.1101/2024.09.26.615177v1
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromatin protein complexes involved in gene repression in lamina-associated domains
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    1. scibot 08 Nov 2024
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  12. Sep 2024
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    Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction
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    1. scibot 29 Sep 2024
      52963

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    The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation
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    1. scibot 29 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350265/
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    Phospholipid scrambling induced by an ion channel/metabolite transporter complex
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    1. scibot 29 Sep 2024
      52963

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    Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution
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    1. scibot 29 Sep 2024
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer
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    1. scibot 29 Sep 2024
      52963

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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
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    1. scibot 29 Sep 2024
      plasmid_52963

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  19. www.biorxiv.org www.biorxiv.org
    Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
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    1. scibot 28 Sep 2024
      RRID:Addgene_52963

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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for in vivo CRISPR screening targeting murine testicular cells
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    1. scibot 27 Sep 2024
      52963

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases*
    1
    1. scibot 27 Sep 2024
      (https://media.addgene.org

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    Saturation mutagenesis-reinforced functional assays for disease-related genes
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      Plasmid_52963

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  23. www.biorxiv.org www.biorxiv.org
    Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems
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      plasmid_52963

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  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses
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      Addgene_52963

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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites
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      52963

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  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancer activation from transposable elements in extrachromosomal DNA
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    1. scibot 26 Sep 2024
      Plasmid_52963

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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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      Addgene_52963

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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cells tightly regulate dead cell clearance to maintain tissue fitness
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      Addgene_52963

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    Protein UFMylation regulates early events during ribosomal DNA-damage response
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      Addgene_52963

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    MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer
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      #52963, Addgene

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    sciencedirect.com/science/article/pii/S0304383524006153
  31. Aug 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma
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      52963

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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Specific multivalent molecules boost CRISPR-mediated transcriptional activation
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    1. scibot 26 Aug 2024
      52963

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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shifts in receptors during submergence of an encephalitic arbovirus
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      Addgene_52963

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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant
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      RRID:Addgene_52963

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for VLDLR recognition by eastern equine encephalitis virus
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming
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    1. scibot 21 Aug 2024
      RRID:Addgene_52963

      DOI: 10.1126/sciadv.adj8862

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  39. www.biorxiv.org www.biorxiv.org
    An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus
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    1. scibot 20 Aug 2024
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    biorxiv.org/content/10.1101/2024.08.05.606586v2
  40. www.cell.com www.cell.com
    Calcineurin is an adaptor required for assembly of the TCR signaling complex
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      RRID:Addgene_52963

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    cell.com/cell-reports/fulltext/S2211-1247(24)00897-0
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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  42. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
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      RRID:Addgene_52963

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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs
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      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310080/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity
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  45. www.nature.com www.nature.com
    3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes
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      DOI: 10.1371/journal.ppat.1012256

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    ncbi.nlm.nih.gov/pmc/articles/PMC11288436/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973475/
  49. Jul 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1
    1
    1. scibot 27 Jul 2024
      plasmid_52963

      DOI: 10.1038/s41556-021-00813-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC9022944/
  51. www.embopress.org www.embopress.org
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
    1
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      plasmid_52963

      DOI: 10.1038/s44321-024-00088-0

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    embopress.org/doi/10.1038/s44321-024-00088-0
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
    1
    1. scibot 18 Jul 2024
      plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11251193/
  53. www.biorxiv.org www.biorxiv.org
    Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer
    1
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      RRID:Addgene_52963

      DOI: 10.1101/2024.07.09.602803

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    biorxiv.org/content/10.1101/2024.07.09.602803v1
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB
    1
    1. scibot 01 Jul 2024
      lentiGuide-Puro

      DOI: 10.1016/j.tranon.2024.102016

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    ncbi.nlm.nih.gov/pmc/articles/PMC11214528/
  55. Jun 2024
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential
    1
    1. scibot 21 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11160910/
  57. www.sciencedirect.com www.sciencedirect.com
    An enhancer RNA recruits KMT2A to regulate transcription of Myb
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    1. scibot 21 Jun 2024
      plasmid_52963

      DOI: 10.1016/j.celrep.2024.114378

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    sciencedirect.com/science/article/pii/S221112472400706X
  58. www.sciencedirect.com www.sciencedirect.com
    SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution
    1
    1. scibot 21 Jun 2024
      Addgene_52963

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    sciencedirect.com/science/article/pii/S2666979X24001678
  59. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    1. scibot 21 Jun 2024
      plasmid_52963

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    sciencedirect.com/science/article/pii/S0092867424005762
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane
    1
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      plasmid_52963

      DOI: 10.21203/rs.3.rs-4259395/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11092817/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The balance between antiviral and antibacterial responses during M. tuberculosis infection is regulated by the ubiquitin ligase CBL
    1
    1. scibot 21 Jun 2024
      Plasmid_52963

      DOI: 10.1101/2024.05.15.594178

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    ncbi.nlm.nih.gov/pmc/articles/PMC11118416/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9
    1
    1. scibot 21 Jun 2024
      plasmid_52963

      DOI: 10.21203/rs.3.rs-4413958/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11160916/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation
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    1. scibot 20 Jun 2024
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11182672/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
    1
    1. scibot 15 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11165854/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
    1
    1. scibot 07 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11112799/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
    1
    1. scibot 07 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11114247/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans
    1
    1. scibot 07 Jun 2024
      Plasmid_52963

      DOI: 10.1084/jem.20232005

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    ncbi.nlm.nih.gov/pmc/articles/PMC11116816/
  68. www.sciencedirect.com www.sciencedirect.com
    ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma
    1
    1. scibot 04 Jun 2024
      plasmid_52963

      DOI: 10.1016/j.canlet.2024.216999

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    sciencedirect.com/science/article/pii/S0304383524003938
  69. May 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression
    1
    1. scibot 19 May 2024
      Addgene_52963

      DOI: 10.1038/s41467-024-48333-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099029/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germinal center cytokine driven epigenetic control of Epstein-Barr virus latency gene expression
    1
    1. scibot 12 May 2024
      plasmid_52963

      DOI: 10.1371/journal.ppat.1011939

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    ncbi.nlm.nih.gov/pmc/articles/PMC11081508/
  72. www.sciencedirect.com www.sciencedirect.com
    NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits
    1
    1. scibot 10 May 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.chom.2024.04.014

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    sciencedirect.com/science/article/pii/S1931312824001343
  73. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
    1
    1. scibot 09 May 2024
      plasmid_52963

      DOI: 10.1016/j.celrep.2024.114211

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    sciencedirect.com/science/article/pii/S2211124724005394
  74. www.sciencedirect.com www.sciencedirect.com
    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
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    1. scibot 09 May 2024
      Addgene_52963

      DOI: 10.1016/j.molcel.2024.04.010

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    sciencedirect.com/science/article/pii/S1097276524003253
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
    2
    1. scibot 05 May 2024
      Addgene_52963

      DOI: 10.7554/eLife.94075

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      Addgene_52963

      DOI: 10.7554/eLife.94075

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060711/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks
    1
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      52963

      DOI: 10.1186/s12915-024-01896-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11059712/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NFATC2IP is a mediator of SUMO-dependent genome integrity
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    1. scibot 05 May 2024
      52963

      DOI: 10.1101/gad.350914.123

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    ncbi.nlm.nih.gov/pmc/articles/PMC11065178/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr-Virus-Driven Cardiolipin Synthesis Sustains Metabolic Remodeling During B-cell Lymphomagenesis
    1
    1. scibot 05 May 2024
      plasmid_52963

      DOI: 10.21203/rs.3.rs-4013392/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11042403/
  79. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    1. scibot 03 May 2024
      RRID:Addgene_52963

      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
  80. www.biorxiv.org www.biorxiv.org
    Epstein–Barr Virus BALF0/1 Subverts the Caveolin and ERAD Pathways to Target B-cell Receptor Complexes for Degradation
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    1. scibot 02 May 2024
      RRID:Addgene_52963

      DOI: 10.1101/2024.01.04.574276

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    biorxiv.org/content/10.1101/2024.01.04.574276v1
  81. www.sciencedirect.com www.sciencedirect.com
    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
    2
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      RRID:Addgene_52963

      DOI: 10.1016/j.stem.2024.04.002

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    sciencedirect.com/science/article/pii/S1934590924001292
  82. Apr 2024
  83. www.sciencedirect.com www.sciencedirect.com
    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
    1
    1. scibot 30 Apr 2024
      Addgene: 52963

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    sciencedirect.com/science/article/pii/S1097276524002843
  84. www.sciencedirect.com www.sciencedirect.com
    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
    2
    1. scibot 26 Apr 2024
      Addgene, Cat# 52963

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      plasmid_52963

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    sciencedirect.com/science/article/pii/S0092867424003131
  85. www.sciencedirect.com www.sciencedirect.com
    IGSF8 is an innate immune checkpoint and cancer immunotherapy target
    1
    1. scibot 24 Apr 2024
      AddgeneCat# 52963

      DOI: 10.1016/j.cell.2024.03.039

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    sciencedirect.com/science/article/pii/S0092867424003556
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity
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    1. scibot 23 Apr 2024
      Addgene_52963

      DOI: 10.1073/pnas.2316447121

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    ncbi.nlm.nih.gov/pmc/articles/PMC11009675/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
    1
    1. scibot 23 Apr 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11009108/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells
    1
    1. scibot 23 Apr 2024
      52963

      DOI: 10.1134/S1607672923700722

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    ncbi.nlm.nih.gov/pmc/articles/PMC11021245/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent loss of FAM126A expression in colorectal cancer results in selective FAM126B dependency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11025007/
  90. www.sciencedirect.com www.sciencedirect.com
    Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
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    1. scibot 16 Apr 2024
      plasmid_52963

      DOI: 10.1016/j.celrep.2024.114105

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    sciencedirect.com/science/article/pii/S2211124724004339
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
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      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000523/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
    1
    1. scibot 14 Apr 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2
    1
    1. scibot 14 Apr 2024
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983909/
  94. www.sciencedirect.com www.sciencedirect.com
    BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response
    2
    1. scibot 09 Apr 2024
      Addgene52963

      DOI: 10.1016/j.molcel.2024.03.011

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      plasmid_52963

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    sciencedirect.com/science/article/pii/S1097276524002211
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
    1
    1. scibot 03 Apr 2024
      AddgeneCat# 52963

      DOI: 10.1016/j.xcrm.2024.101471

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
  96. www.sciencedirect.com www.sciencedirect.com
    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
    1. scibot 02 Apr 2024
      Plasmid_52963

      DOI: 10.1016/j.cell.2024.03.002

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      Plasmid_52963

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    sciencedirect.com/science/article/pii/S0092867424002502
  97. Mar 2024
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects
    1
    1. scibot 31 Mar 2024
      52,963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10978915/
  99. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
    1
    1. scibot 29 Mar 2024
      Addgene52963

      DOI: 10.1016/j.crmeth.2024.100737

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    sciencedirect.com/science/article/pii/S2667237524000626
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells
    1
    1. scibot 17 Mar 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920982/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repeat DNA methylation is modulated by adherens junction signaling
    1
    1. scibot 17 Mar 2024
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920906/
  102. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening directly targeting testicular cells
    1
    1. scibot 06 Mar 2024
      Addgene: #52963

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    sciencedirect.com/science/article/pii/S2666979X24000375
  103. Feb 2024
  104. www.sciencedirect.com www.sciencedirect.com
    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
    1
    1. scibot 29 Feb 2024
      AddgeneCat#52963

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    sciencedirect.com/science/article/pii/S1097276524000984
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium
    1
    1. scibot 29 Feb 2024
      pLentiGuide-puro

      DOI: 10.1038/s42003-024-05817-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879184/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes
    1
    1. scibot 29 Feb 2024
      Plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879117/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
    1
    1. scibot 21 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10849656/
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models
    1
    1. scibot 21 Feb 2024
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10870824/
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
    1
    1. scibot 15 Feb 2024
      plasmid_52963

      DOI: 10.1126/sciadv.adj4767

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
    1
    1. scibot 13 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761718/
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aneuploid embryonic stem cells drive teratoma metastasis
    1
    1. scibot 13 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844504/
  112. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
    1
    1. scibot 09 Feb 2024
      Addgene_52963

      DOI: 10.1371/journal.pgen.1011138

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    journals.plos.org/plosgenetics/article
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
    1
    1. scibot 08 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761986/
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of senescence using machine learning algorithms based on nuclear features
    1
    1. scibot 08 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10838307/
  115. www.sciencedirect.com www.sciencedirect.com
    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
    1
    1. scibot 06 Feb 2024
      AddgeneCat# 52963

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    sciencedirect.com/science/article/pii/S1097276524000091
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9
    1
    1. scibot 06 Feb 2024
      52,963

      DOI: 10.1186/s13059-023-03149-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronucleus is not a potent inducer of the cGAS/STING pathway
    1
    1. scibot 05 Feb 2024
      52963

      DOI: 10.26508/lsa.202302424

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    ncbi.nlm.nih.gov/pmc/articles/PMC10837050/
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression
    1
    1. scibot 05 Feb 2024
      plasmid_52963

      DOI: 10.1101/2024.01.02.573986

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802360/
  119. www.sciencedirect.com www.sciencedirect.com
    Two-step evolution of HIV-1 budding system leading to pandemic in the human population
    1
    1. scibot 02 Feb 2024
      Addgene_52963

      DOI: 10.1016/j.celrep.2024.113697

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    sciencedirect.com/science/article/pii/S2211124724000251
  120. Jan 2024
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
    1. scibot 20 Jan 2024
      RRID:Addgene_52963

      DOI: 10.1128/mbio.02444-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10790771/
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.tvr.2023.200276

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000110/
  123. Dec 2023
  124. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
    1
    1. scibot 17 Dec 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.immuni.2023.11.008

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    sciencedirect.com/science/article/pii/S1074761323004909
  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
    1
    1. scibot 15 Dec 2023
      RRID:Addgene_52963

      DOI: 10.7554/eLife.87098

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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  126. journals.asm.org journals.asm.org
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
    1. scibot 14 Dec 2023
      RRID:Addgene_52963

      DOI: 10.1128/mbio.02444-23

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    journals.asm.org/doi/10.1128/mbio.02444-23
  127. Nov 2023
  128. www.sciencedirect.com www.sciencedirect.com
    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
    1
    1. scibot 22 Nov 2023
      Addgene_52963

      DOI: 10.1016/j.xcrm.2023.101282

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    sciencedirect.com/science/article/pii/S2666379123004767
  129. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
    1
    1. scibot 18 Nov 2023
      RRID:Addgene_52963

      DOI: 10.1186/s12964-023-01335-6

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    biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01335-6
  130. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
    1
    1. scibot 17 Nov 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.113352

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    sciencedirect.com/science/article/pii/S2211124723013645
  131. Oct 2023
  132. www.biorxiv.org www.biorxiv.org
    Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus
    1
    1. scibot 27 Oct 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.10.20.563362

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    biorxiv.org/content/10.1101/2023.10.20.563362v1
  133. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
    1
    1. scibot 06 Oct 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.113041

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    cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
  134. Sep 2023
  135. www.nature.com www.nature.com
    CRISPR prime editing for unconstrained correction of oncogenic KRAS variants
    1
    1. scibot 20 Sep 2023
      52963

      DOI: 10.1038/s42003-023-05052-1

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    nature.com/articles/s42003-023-05052-1
  136. www.sciencedirect.com www.sciencedirect.com
    Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression
    1
    1. scibot 19 Sep 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.ajhg.2023.07.003

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    sciencedirect.com/science/article/pii/S0002929723002434
  137. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
    1
    1. scibot 16 Sep 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.113098

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    sciencedirect.com/science/article/pii/S2211124723011099
  138. Aug 2023
  139. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
    1. scibot 16 Aug 2023
      plasmid_52963

      DOI: 10.1101/2023.07.26.550648

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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  140. www.biorxiv.org www.biorxiv.org
    The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC reprogramming
    2
    1. scibot 12 Aug 2023
      plasmids #52963

      DOI: 10.1101/2023.07.31.551297

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    2. scibot 12 Aug 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.07.31.551297

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    biorxiv.org/content/10.1101/2023.07.31.551297v3
  141. Jul 2023
  142. 52.53.155.43 52.53.155.43
    Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal
    1
    1. scibot 15 Jul 2023
      52963

      DOI: 10.1101/2023.05.03.539283

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    52.53.155.43/8add9715cb6d409825df8305aa589d745e83436f/2023.05.03.539283.full-html.html
  143. Jun 2023
  144. www.sciencedirect.com www.sciencedirect.com
    Generation of Myoglobin (MB)-Knockout human embryonic stem cell (hESC) line (KAIMRCe002- A-1S) using CRISPR/Cas9 technology
    1
    1. scibot 28 Jun 2023
      Addgene_52963

      DOI: 10.1016/j.scr.2023.103158

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    sciencedirect.com/science/article/pii/S1873506123001447
  145. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
    1
    1. scibot 23 Jun 2023
      RRID: Addgene_52963

      DOI: 10.1016/j.ccell.2023.06.001

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    sciencedirect.com/science/article/pii/S1535610823002088
  146. www.biorxiv.org www.biorxiv.org
    Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis
    1
    1. scibot 22 Jun 2023
      plasmid_52963

      DOI: 10.1101/2023.06.14.544493

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    biorxiv.org/content/10.1101/2023.06.14.544493v1
  147. www.sciencedirect.com www.sciencedirect.com
    An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
    1
    1. scibot 16 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.molcel.2023.05.018

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    sciencedirect.com/science/article/pii/S109727652300374X
  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
    1
    1. scibot 14 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.immuni.2022.10.021

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614333/
  149. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
    1
    1. scibot 10 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1158/2159-8290.CD-22-0825

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    aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
  150. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
    1
    1. scibot 03 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1158/0008-5472.CAN-22-1549

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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
  151. www.biorxiv.org www.biorxiv.org
    Stem cells tightly regulate dead cell clearance to maintain tissue fitness
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    1. scibot 01 Jun 2023
      Addgene_52963

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    biorxiv.org/content/10.1101/2023.05.22.541773v1
  152. May 2023
  153. www.biorxiv.org www.biorxiv.org
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation and proteomic profiles in Burkitt lymphoma
    1
    1. scibot 25 May 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.05.19.538556

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    biorxiv.org/content/10.1101/2023.05.19.538556v1
  154. www.biorxiv.org www.biorxiv.org
    Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia
    1
    1. scibot 25 May 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.05.18.541265

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    biorxiv.org/content/10.1101/2023.05.18.541265v1
  155. www.sciencedirect.com www.sciencedirect.com
    Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
    1
    1. scibot 25 May 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.112538

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    sciencedirect.com/science/article/pii/S2211124723005491
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
    1
    1. scibot 25 May 2023
      Addgene_52963

      DOI: 10.1101/gad.328336.119

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    ncbi.nlm.nih.gov/pmc/articles/PMC6942053/
  157. Apr 2023
  158. www.sciencedirect.com www.sciencedirect.com
    Proteomic discovery of chemical probes that perturb protein complexes in human cells
    1
    1. scibot 21 Apr 2023
      Addgene_52963

      DOI: 10.1016/j.molcel.2023.03.026

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    sciencedirect.com/science/article/pii/S1097276523002393
  159. Mar 2023
  160. www.nature.com www.nature.com
    The protective role of conjunctival goblet cell mucin sialylation
    1
    1. scibot 18 Mar 2023
      RRID:Addgene_52963

      DOI: 10.1038/s41467-023-37101-y

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    nature.com/articles/s41467-023-37101-y
  161. Feb 2023
  162. www.embopress.org www.embopress.org
    Immune surveillance of brain metastatic cancer cells is mediated by IFITM1
    1
    1. scibot 18 Feb 2023
      RRID:Addgene_52963

      DOI: 10.15252/embj.2022111112

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    embopress.org/doi/10.15252/embj.2022111112
  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
    1
    1. scibot 15 Feb 2023
      Addgene_52963

      DOI: 10.1371/journal.pbio.3001967

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    ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
  164. Jan 2023
  165. www.sciencedirect.com www.sciencedirect.com
    Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
    1
    1. scibot 28 Jan 2023
      plasmid_52963

      DOI: 10.1016/j.cmet.2022.12.005

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    sciencedirect.com/science/article/pii/S1550413122005423
  166. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    1. scibot 25 Jan 2023
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111965

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    sciencedirect.com/science/article/pii/S2211124722018691
  167. www.sciencedirect.com www.sciencedirect.com
    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    1. scibot 19 Jan 2023
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111966

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    sciencedirect.com/science/article/pii/S2211124722018708
  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens
    1
    1. scibot 11 Jan 2023
      RRID:Addgene_52963

      DOI: 10.1371/journal.ppat.1010800

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    ncbi.nlm.nih.gov/pmc/articles/PMC9829182/
  169. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage
    1
    1. scibot 10 Jan 2023
      RRID:Addgene_52963

      DOI: 10.1111/jnc.15751

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15751
  170. www.sciencedirect.com www.sciencedirect.com
    Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation
    1
    1. scibot 10 Jan 2023
      plasmid_52963

      DOI: 10.1016/j.cell.2022.11.029

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    sciencedirect.com/science/article/pii/S0092867422015045
  171. Dec 2022
  172. www.embopress.org www.embopress.org
    IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia
    1
    1. scibot 02 Dec 2022
      Addgene_52963

      DOI: 10.15252/emmm.202115631

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    embopress.org/doi/10.15252/emmm.202115631
  173. Nov 2022
  174. www.sciencedirect.com www.sciencedirect.com
    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
    1
    1. scibot 24 Nov 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111675

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    sciencedirect.com/science/article/pii/S2211124722015492
  175. www.sciencedirect.com www.sciencedirect.com
    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
    1
    1. scibot 03 Nov 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111581

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    sciencedirect.com/science/article/pii/S2211124722014462
  176. Oct 2022
  177. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages
    1
    1. scibot 08 Oct 2022
      plasmid_52963

      DOI: 10.1002/cbf.3752

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    onlinelibrary.wiley.com/doi/10.1002/cbf.3752
  178. www.nature.com www.nature.com
    Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression
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    1. scibot 08 Oct 2022
      plasmid_52963

      DOI: 10.1038/s41596-022-00741-3

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    nature.com/articles/s41596-022-00741-3
  179. Sep 2022
  180. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer
    1
    1. scibot 15 Sep 2022
      plasmid_52963

      DOI: 10.1111/cas.15558

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    onlinelibrary.wiley.com/doi/10.1111/cas.15558
  181. www.sciencedirect.com www.sciencedirect.com
    Methionine metabolism controls the B cell EBV epigenome and viral latency
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    1. scibot 07 Sep 2022
      plasmid_52963

      DOI: 10.1016/j.cmet.2022.08.008

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    sciencedirect.com/science/article/pii/S1550413122003515
  182. Aug 2022
  183. www.sciencedirect.com www.sciencedirect.com
    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
    1
    1. scibot 31 Aug 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2022.111268

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    sciencedirect.com/science/article/pii/S2211124722010865
  184. www.sciencedirect.com www.sciencedirect.com
    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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    1. scibot 17 Aug 2022
      Addgene52963

      DOI: 10.1016/j.cell.2022.06.048

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    sciencedirect.com/science/article/pii/S0092867422008418
  185. www.sciencedirect.com www.sciencedirect.com
    Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing
    1
    1. scibot 17 Aug 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111192

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    sciencedirect.com/science/article/pii/S2211124722010099
  186. Jun 2022
  187. www.sciencedirect.com www.sciencedirect.com
    Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
    1
    1. scibot 29 Jun 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111001

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    sciencedirect.com/science/article/pii/S2211124722007902
  188. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability
    1
    1. scibot 17 Jun 2022
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      DOI: 10.1016/j.molcel.2022.05.024

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    pmc.ncbi.nlm.nih.gov/articles/PMC9356996/
  189. www.nature.com www.nature.com
    RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition
    1
    1. scibot 11 Jun 2022
      RRID:Addgene_52963

      DOI: 10.1038/s41467-022-30794-7

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    nature.com/articles/s41467-022-30794-7
  190. May 2022
  191. www.sciencedirect.com www.sciencedirect.com
    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
    1
    1. scibot 25 May 2022
      AddgeneCat#52963

      DOI: 10.1016/j.molcel.2022.04.031

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    sciencedirect.com/science/article/pii/S109727652200394X
  192. aacrjournals.org aacrjournals.org
    Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis
    1
    1. scibot 13 May 2022
      RRID:Addgene_52963

      DOI: 10.1158/2159-8290.CD-21-1006

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    aacrjournals.org/cancerdiscovery/article/12/5/1314/694563/Melanoma-Secreted-Amyloid-Beta-Suppresses
  193. www.sciencedirect.com www.sciencedirect.com
    ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer
    1
    1. scibot 05 May 2022
      Addgene_52963

      DOI: 10.1016/j.devcel.2022.04.014

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    sciencedirect.com/science/article/pii/S1534580722002544
  194. Apr 2022
  195. www.sciencedirect.com www.sciencedirect.com
    Functional elements of the cis-regulatory lincRNA-p21
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    1. scibot 20 Apr 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2022.110687

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    sciencedirect.com/science/article/pii/S2211124722004454
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
    1
    1. scibot 15 Apr 2022
      plasmid_52963

      DOI: 10.7554/eLife.76963

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  197. Mar 2022
  198. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection
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    1. scibot 30 Mar 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2022.110559

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    sciencedirect.com/science/article/pii/S2211124722003035
  199. www.sciencedirect.com www.sciencedirect.com
    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
    2
    1. scibot 09 Mar 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.110411

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    2. scibot 09 Mar 2022
      plasmid_52963

      DOI: 10.1016/j.celrep.2022.110411

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    sciencedirect.com/science/article/pii/S2211124722001358
  200. www.sciencedirect.com www.sciencedirect.com
    Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors
    1
    1. scibot 09 Mar 2022
      Addgene52963

      DOI: 10.1016/j.cell.2022.02.002

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    sciencedirect.com/science/article/pii/S0092867422001428
  201. www.sciencedirect.com www.sciencedirect.com
    Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
    1
    1. scibot 09 Mar 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.110476

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    sciencedirect.com/science/article/pii/S2211124722002091
  202. www.nature.com www.nature.com
    APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
    1
    1. scibot 05 Mar 2022
      Addgene_52963

      DOI: 10.1038/s41380-022-01454-5

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    nature.com/articles/s41380-022-01454-5
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
    1
    1. scibot 04 Mar 2022
      RRID:Addgene_52963

      DOI: 10.1158/2159-8290.CD-20-1213

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    ncbi.nlm.nih.gov/pmc/articles/PMC8419012/
  204. Feb 2022
  205. www.sciencedirect.com www.sciencedirect.com
    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
    1
    1. scibot 23 Feb 2022
      Addgene: Cat#52963

      DOI: 10.1016/j.celrep.2022.110417

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    sciencedirect.com/science/article/pii/S2211124722001413
  206. www.sciencedirect.com www.sciencedirect.com
    Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion
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    1. scibot 23 Feb 2022
      AddgeneCat#: 52963

      DOI: 10.1016/j.celrep.2022.110414

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    sciencedirect.com/science/article/pii/S2211124722001383
  207. www.sciencedirect.com www.sciencedirect.com
    HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization
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    1. scibot 23 Feb 2022
      RRID: Addgene_52963

      DOI: 10.1016/j.molcel.2022.01.023

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    sciencedirect.com/science/article/pii/S1097276522000983
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration
    1
    1. scibot 16 Feb 2022
      RRID:Addgene_52963

      DOI: 10.3390/cells11030405

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    ncbi.nlm.nih.gov/pmc/articles/PMC8833998/
  209. www.sciencedirect.com www.sciencedirect.com
    ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells
    1
    1. scibot 16 Feb 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.canlet.2022.215601

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    sciencedirect.com/science/article/pii/S0304383522000763
  210. www.sciencedirect.com www.sciencedirect.com
    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
    2
    1. scibot 11 Feb 2022
      Addgene 52963

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      Addgene 52963

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    sciencedirect.com/science/article/pii/S2451945622000022
  211. Jan 2022
  212. www.nature.com www.nature.com
    Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins
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    1. scibot 15 Jan 2022
      RRID:Addgene_52963

      DOI: 10.1038/s42003-021-02953-x

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    nature.com/articles/s42003-021-02953-x
  213. Dec 2021
  214. www.sciencedirect.com www.sciencedirect.com
    Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus
    1
    1. scibot 21 Dec 2021
      Plasmid_52963

      DOI: 10.1016/j.molcel.2021.11.023

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    sciencedirect.com/science/article/pii/S109727652101025X
  215. www.sciencedirect.com www.sciencedirect.com
    Chronic calcium signaling in IgE+ B cells limits plasma cell differentiation and survival
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    1. scibot 08 Dec 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.immuni.2021.11.006

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    sciencedirect.com/science/article/pii/S1074761321004970
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetically Edited Hepatic Cells Expressing the NTCP-S267F Variant are Resistant to Hepatitis B Virus Infection
    1
    1. scibot 02 Dec 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.omtm.2021.11.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC8608598/
  217. Sep 2021
  218. www.sciencedirect.com www.sciencedirect.com
    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
    1
    1. scibot 23 Sep 2021
      Addgene_52963

      DOI: 10.1016/j.molcel.2021.09.005

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    sciencedirect.com/science/article/pii/S1097276521007395
  219. iovs.arvojournals.org iovs.arvojournals.org
    Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma
    1
    1. scibot 16 Sep 2021
      RRID:Addgene_52963

      DOI: 10.1167/iovs.62.12.7

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    iovs.arvojournals.org/article.aspx
  220. www.sciencedirect.com www.sciencedirect.com
    Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome
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      Addgene: 52963

      DOI: 10.1016/j.celrep.2021.109597

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    sciencedirect.com/science/article/pii/S2211124721010354
  221. Aug 2021
  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
    1
    1. scibot 28 Aug 2021
      RRID:Addgene_52963

      DOI: 10.1186/s13059-021-02460-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC8385949/
  223. www.sciencedirect.com www.sciencedirect.com
    A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells
    1
    1. scibot 25 Aug 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2021.109576

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    sciencedirect.com/science/article/pii/S221112472101010X
  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network
    1
    1. scibot 14 Aug 2021
      Plasmid_52963

      DOI: 10.1016/j.molcel.2019.03.025

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    ncbi.nlm.nih.gov/pmc/articles/PMC6671628/
  225. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 12 Aug 2021
      Addgene_52963

      DOI: 10.1016/j.cels.2017.08.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC5639711/
  226. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
    1
    1. scibot 12 Aug 2021
      Addgene_52963

      DOI: 10.7554/eLife.22540

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    ncbi.nlm.nih.gov/pmc/articles/PMC5241118/
  227. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 11 Aug 2021
      Plasmid_52963

      DOI: 10.1016/j.cmet.2017.08.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC5677551/
  228. www.sciencedirect.com www.sciencedirect.com
    The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D
    2
    1. scibot 11 Aug 2021
      Plasmid_52963

      DOI: 10.1016/j.cmet.2017.08.024

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      Plasmid_52963

      DOI: 10.1016/j.cmet.2017.08.024

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    sciencedirect.com/science/article/pii/S155041311730551X
  229. www.sciencedirect.com www.sciencedirect.com
    A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR
    1
    1. scibot 07 Aug 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.ajhg.2021.07.002

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    sciencedirect.com/science/article/pii/S0002929721002706