410 Matching Annotations
  1. Last 7 days
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    Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney
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    sciencedirect.com/science/article/pii/S2211124726000847
  3. Feb 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screens identify core regulators of cell surface prion protein expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12894898/
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    The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4
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    pmc.ncbi.nlm.nih.gov/articles/PMC12837743/
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    Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710741/
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    Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12757029/
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    Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12689628/
  9. Jan 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12828773/
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    Dissecting cellular ecosystem with single-cell CRISPR screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12680425/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FGFR signaling and neddylation facilitate SARS-CoV-2 infection by modulating interferon induction and viral entry, respectively
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    pmc.ncbi.nlm.nih.gov/articles/PMC12828524/
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    Long non-coding RNA UCA1 modulates SMARCA2-containing SWI/SNF chromatin remodeling complexes in human colorectal cancer
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    sciencedirect.com/science/article/pii/S2589004225025441
  14. Dec 2025
  15. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    ARAP2 regulates responses to interferon-gamma by restricting SOCS1
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    sciencedirect.com:5037/science/article/pii/S2211124725014391
  16. 54.241.53.176 54.241.53.176
    2025.12.02.691971.full-html.html
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    54.241.53.176/695ba3cd832ab083eede24d6d780be9a3b357862/2025.12.02.691971.full-html.html
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    FAME-CRISPR improves CRISPR-Cas9 genome editing via HDAC inhibition and engineered virus-like particle delivery
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    sciencedirect.com:5037/science/article/pii/S266723752500284X
  18. Nov 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysine-specific histone demethylase complex restricts Epstein-Barr virus lytic reactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616731/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancer activation from transposable elements in extrachromosomal DNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC12611757/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A microRNA CRISPR screen reveals microRNA-483-3p as an apoptotic regulator in prostate cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552650/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12497744/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Up-regulating methylation of CAP1 promoter can promote apoptosis and inhibit migration and invasion of lung adenocarcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12465864/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome editing or small molecule inhibition of KMT5A in CAR-T cells enhances antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12519333/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12429027/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering acquired resistance mechanisms to sustained auxin-inducible protein degradation in cells and mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485725/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis, Mycobacterium kansasii and Rhodococcus equi induce macrophage necroptosis in the presence of a caspase inhibitor acting on a non-canonical target(s)
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    pmc.ncbi.nlm.nih.gov/articles/PMC12424694/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Druggable genome CRISPR screening identifies the KEAP1/NRF2 axis as a mediator of PD-L1 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12630863/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Class I histone deacetylases catalyze lysine lactylation[image]
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    pmc.ncbi.nlm.nih.gov/articles/PMC12624779/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12530129/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12458112/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epstein-Barr Virus Latent Membrane Protein 1 targets cIAP1, cIAP2 and TRAF2 for Proteasomal Degradation to Activate the Non-canonical NF-κB Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12424949/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12431854/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR screen identifies BAP1 as a deubiquitinase regulating SPIN4 stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12512048/
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    Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S0092867425012334
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium
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    pmc.ncbi.nlm.nih.gov/articles/PMC12618076/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screen in Mycobacterium tuberculosis infected macrophages reveals innate regulation of antibacterial mediators by IRF2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12621954/
  39. www.biorxiv.org www.biorxiv.org
    Therapeutic Inducers of NK cell Killing (ThINKK)-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia: unraveling the dual role of TRAIL leads to the establishment of an efficacy biomarker
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    biorxiv.org/content/10.1101/2025.11.12.687655v1
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    StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models
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    sciencedirect.com/science/article/pii/S0092867425011365
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    SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050964/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12557688/
  43. Oct 2025
  44. www.sciencedirect.com www.sciencedirect.com
    Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
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    sciencedirect.com/science/article/pii/S1097276525008196
  45. www.nature.com www.nature.com
    Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
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    nature.com/articles/s41596-025-01251-8
  46. www.biorxiv.org www.biorxiv.org
    Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
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    biorxiv.org/content/10.1101/2025.09.26.678370v1
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis
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    Biphasic control of the B cell transcriptome by mTORC1 and GSK3
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  49. Sep 2025
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    RSK1 reprograms the ubiquitin pathway to promote immune suppression
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    sciencedirect.com/science/article/pii/S2211124725010940
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12446975/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12443969/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening
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    pmc.ncbi.nlm.nih.gov/articles/PMC12445041/
  54. www.science.org www.science.org
    Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism
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    science.org/doi/10.1126/sciadv.adw9158
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oxidative Phosphorylation is a Metabolic Vulnerability of Endocrine Therapy-Tolerant Persister Cells in ER+ Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908958/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373508/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12371041/
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    Insights into absence of lymphoma despite fulminant Epstein-Barr virus infection in patients with XIAP deficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406724/
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    Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396134/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma
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  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pooled CRISPR screens identifies key regulators of bovine stem cell expansion for cultured meat
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398484/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular basis for shifted receptor recognition by an encephalitic arbovirus
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  63. elifesciences.org elifesciences.org
    A Commander-independent function of COMMD3 in endosomal trafficking
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    elifesciences.org/articles/105264
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    Epigenetic modulation of BARD1 to enhance anti-VEGF therapy
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    sciencedirect.com/science/article/pii/S2666379125004021
  65. www.nature.com www.nature.com
    Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems
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    nature.com/articles/s41467-025-63570-4
  66. Aug 2025
  67. rupress.org rupress.org
    Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity
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    rupress.org/jem/article/222/10/e20242360/278219/Perturbation-of-calreticulin-potentiates-CD8-T
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    Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
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    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
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  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12274581/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TAS-seq enables subcellular single-stranded adenosine profiling by signal peptide-assisted adenosine deamination
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    pmc.ncbi.nlm.nih.gov/articles/PMC12296453/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302604/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Removal of promoter CpG methylation by epigenome editing reverses HBG silencing
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  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single cell and spatial alternative splicing analysis with Nanopore long read sequencing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12276307/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12272419/
  77. www.nature.com www.nature.com
    Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential
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    nature.com/articles/s41467-025-62668-z
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311787/
  79. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70080
  80. Jul 2025
  81. www.science.org www.science.org
    Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer
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    science.org/doi/10.1126/sciadv.adu0847
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220951/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236469/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NINJ1 regulates plasma membrane fragility under mechanical strain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210241/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169587/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-BEasy: a free web-based service for designing sgRNA tiling libraries for CRISPR-dependent base editing screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12230738/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181958/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circular RNA landscape in extracellular vesicles from human biofluids
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    pmc.ncbi.nlm.nih.gov/articles/PMC11526565/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response
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    pmc.ncbi.nlm.nih.gov/articles/PMC11806854/
  91. www.biorxiv.org www.biorxiv.org
    EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation
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    biorxiv.org/content/10.1101/2025.07.07.663486v1
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    An alternate receptor for adeno-associated viruses
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    sciencedirect.com/science/article/pii/S0092867425006920
  93. link.springer.com link.springer.com
    Spatiotemporally Resolved Profiling of Protein Movement by TransitID
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    link.springer.com/protocol/10.1007/978-1-0716-4694-6_16
  94. Jun 2025
  95. www.sciencedirect.com www.sciencedirect.com
    Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation
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    sciencedirect.com/science/article/pii/S1097276525004721
  96. www.sciencedirect.com www.sciencedirect.com
    The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
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  107. May 2025
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  118. Apr 2025
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  128. Mar 2025
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  145. www.science.org www.science.org
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  150. Feb 2025
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  165. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  166. www.nature.com www.nature.com
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  167. Dec 2024
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  172. Nov 2024
  173. www.biorxiv.org www.biorxiv.org
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  176. Sep 2024
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  183. www.biorxiv.org www.biorxiv.org
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  187. www.biorxiv.org www.biorxiv.org
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  193. www.sciencedirect.com www.sciencedirect.com
    Protein UFMylation regulates early events during ribosomal DNA-damage response
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  194. www.sciencedirect.com www.sciencedirect.com
    MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer
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  195. Aug 2024
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma
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  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for VLDLR recognition by eastern equine encephalitis virus
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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming
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  203. www.biorxiv.org www.biorxiv.org
    An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus
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  204. www.cell.com www.cell.com
    Calcineurin is an adaptor required for assembly of the TCR signaling complex
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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  206. www.cell.com www.cell.com
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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity
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  209. www.nature.com www.nature.com
    3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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