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  1. Feb 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The methyltransferase N6AMT1 participates in the cell cycle by regulating cyclin E levels
    1
    1. scibot 29 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10889616/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
    1
    1. scibot 29 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10881399/
  4. www.sciencedirect.com www.sciencedirect.com
    The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
    2
    1. scibot 28 Feb 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2020.101698

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    2. scibot 28 Feb 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2020.101698

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    sciencedirect.com/science/article/pii/S2589004220308907
  5. 52.53.155.43 52.53.155.43
    HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins
    1
    1. scibot 23 Feb 2024
      Addgene_62988

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    52.53.155.43/893a986f25098b75e101f0b7cb970068940c81b3/2023.10.16.562477v2.full-html.html
  6. 52.53.155.43 52.53.155.43
    can-23-1129-html.html
    1
    1. scibot 23 Feb 2024
      plasmid_62988

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    52.53.155.43/f18faff86a38ad159824c95dcf032e1a8bb0e968/133-html.html
  7. www.biorxiv.org www.biorxiv.org
    New submission 11/02/2024, 13:59:09
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1101/2023.09.25.559321

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    biorxiv.org/content/10.1101/2023.09.25.559321v3
  8. www.pnas.org www.pnas.org
    Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase
    1
    1. scibot 15 Feb 2024
      RRID:Addgene_62988

      DOI: 10.1073/pnas.2312621121

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    pnas.org/doi/abs/10.1073/pnas.2312621121
  9. www.biorxiv.org www.biorxiv.org
    The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function
    1
    1. scibot 15 Feb 2024
      Addgene_62988

      DOI: 10.1101/2024.02.04.578804

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    biorxiv.org/content/10.1101/2024.02.04.578804v1
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma
    1
    1. scibot 13 Feb 2024
      plasmid_62988

      DOI: 10.1038/s41467-023-44576-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762148/
  11. www.sciencedirect.com www.sciencedirect.com
    Persistence of backtracking by human RNA polymerase II
    1
    1. scibot 13 Feb 2024
      Addgene_62988

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    sciencedirect.com/science/article/pii/S1097276524000558
  12. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell line derived from Becker muscular dystrophy patient with CRISPR/Cas9-mediated correction of DMD gene mutation
    1
    1. scibot 09 Feb 2024
      Addgene_62988

      DOI: 10.1016/j.scr.2024.103327

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    sciencedirect.com/science/article/pii/S1873506124000254
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
    1
    1. scibot 08 Feb 2024
      62988

      DOI: 10.1038/s41419-023-06371-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766976/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
    1
    1. scibot 08 Feb 2024
      62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC10784524/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
    1
    1. scibot 05 Feb 2024
      62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC10789791/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency
    1
    1. scibot 05 Feb 2024
      plasmid_62988

      DOI: 10.1101/2023.12.26.573357

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802475/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular Targets and Lysine Selectivity of the HERC5 ISG15 Ligase
    1
    1. scibot 03 Feb 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2024.108820

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831901/
  18. journals.plos.org journals.plos.org
    Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene
    1
    1. scibot 03 Feb 2024
      Addgene_62988

      DOI: 10.1371/journal.pone.0294146

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    journals.plos.org/plosone/article
  19. www.mdpi.com www.mdpi.com
    Biomarker RIPK3 Is Silenced by Hypermethylation in Melanoma and Epigenetic Editing Reestablishes Its Tumor Suppressor Function
    1
    1. scibot 02 Feb 2024
      Addgene_62988

      DOI: 10.3390/genes15020175

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    mdpi.com/2073-4425/15/2/175
  20. Jan 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity
    1
    1. scibot 30 Jan 2024
      Addgene, 62988

      DOI: 10.1038/s41467-024-44989-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10821916/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Strategies for single base gene editing in an immortalized human cell line by CRISPR/Cas9 technology
    1
    1. scibot 30 Jan 2024
      plasmid_62988

      DOI: 10.1007/s13205-023-03878-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798938/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells
    1
    1. scibot 30 Jan 2024
      plasmid_62988

      DOI: 10.1371/journal.pone.0296928

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802951/
  24. www.sciencedirect.com www.sciencedirect.com
    Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase
    1
    1. scibot 12 Jan 2024
      Addgene_62988

      DOI: 10.1016/j.jbc.2024.105644

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    sciencedirect.com/science/article/pii/S0021925824000206
  25. www.sciencedirect.com www.sciencedirect.com
    Direct observation of a condensate effect on super-enhancer controlled gene bursting
    1
    1. scibot 09 Jan 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.cell.2023.12.005

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    sciencedirect.com/science/article/pii/S0092867423013375
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
    1
    1. scibot 05 Jan 2024
      RRID:Addgene_62988

      DOI: 10.1083/jcb.202304026

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    ncbi.nlm.nih.gov/pmc/articles/PMC10309186/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer
    1
    1. scibot 05 Jan 2024
      plasmid_62988

      DOI: 10.1158/0008-5472.CAN-23-1129

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    ncbi.nlm.nih.gov/pmc/articles/PMC10758689/
  28. www.sciencedirect.com www.sciencedirect.com
    N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy
    1
    1. scibot 03 Jan 2024
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      DOI: 10.1053/j.gastro.2022.11.018

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    sciencedirect.com/science/article/pii/S001650852201294X
  29. www.jneurosci.org www.jneurosci.org
    Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
    1
    1. scibot 02 Jan 2024
      RRID:Addgene_62988

      DOI: 10.1523/JNEUROSCI.1318-23.2023

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    jneurosci.org/content/43/50/8812
  30. Dec 2023
  31. onlinelibrary.wiley.com onlinelibrary.wiley.com
    REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response
    1
    1. scibot 29 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1111/cas.16044

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    onlinelibrary.wiley.com/doi/10.1111/cas.16044
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
    1
    1. scibot 28 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1158/0008-5472.CAN-23-1252

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    ncbi.nlm.nih.gov/pmc/articles/PMC10740391/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction
    1
    1. scibot 28 Dec 2023
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      DOI: 10.1101/2023.12.05.570115

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    ncbi.nlm.nih.gov/pmc/articles/PMC10723268/
  34. www.sciencedirect.com www.sciencedirect.com
    Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
    1
    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.019

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    sciencedirect.com/science/article/pii/S0092867423012734
  35. www.sciencedirect.com www.sciencedirect.com
    Interactome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
    1
    1. scibot 20 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1016/j.mcpro.2023.100701

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    sciencedirect.com/science/article/pii/S1535947623002128
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF524 directly interacts with telomeric DNA and supports telomere integrity
    1
    1. scibot 15 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1038/s41467-023-43397-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10716145/
  37. www.mdpi.com www.mdpi.com
    Heterozygous Knockout of ARID4B Using CRISPR/Cas9 Attenuates Some Aggressive Phenotypes in a Breast Cancer Cell Line
    1
    1. scibot 14 Dec 2023
      RRID:Addgene_62988

      DOI: 10.3390/genes14122184

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    mdpi.com/2073-4425/14/12/2184
  38. link.springer.com link.springer.com
    The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
    1
    1. scibot 08 Dec 2023
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      DOI: 10.1038/s41467-023-43775-1

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    link.springer.com/article/10.1038/s41467-023-43775-1
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitotic bookmarking by SWI/SNF subunits
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      DOI: 10.1038/s41586-023-06085-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10303083/
  40. www.biorxiv.org www.biorxiv.org
    Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
    1
    1. scibot 02 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1101/2023.11.28.568893

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    biorxiv.org/content/10.1101/2023.11.28.568893v1
  41. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  42. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1126/sciimmunol.adj5097

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    science.org/doi/10.1126/sciimmunol.adj5097
  43. www.sciencedirect.com www.sciencedirect.com
    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
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    1. scibot 01 Dec 2023
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      DOI: 10.1016/j.isci.2023.108485

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    sciencedirect.com/science/article/pii/S2589004223025622
  44. 52.53.155.43 52.53.155.43
    can-23-1129-html.html
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    1. scibot 01 Dec 2023
      plasmid_62988

      DOI: 10.1158/0008-5472.can-23-1129

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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for the saturation and multiplexing of genetic variants using CRISPR-Cas9
    1
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  46. Nov 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Generation of a CRISPR/Cas9-edited Plakoglobin (JUP)knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma
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  50. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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  52. Oct 2023
  53. www.sciencedirect.com www.sciencedirect.com
    β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
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  55. www.biorxiv.org www.biorxiv.org
    Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma
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  57. 52.53.155.43 52.53.155.43
    gene-editing-of-yipf3-yipf4-calcoco1-fip200-and-at-cx6nxrde-html.html
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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  59. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
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  60. Sep 2023
  61. www.sciencedirect.com www.sciencedirect.com
    Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner
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  62. www.biorxiv.org www.biorxiv.org
    Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts
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  63. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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  65. dx.doi.org dx.doi.org
    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
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  66. link.springer.com link.springer.com
    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
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  67. Aug 2023
  68. www.science.org www.science.org
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  70. www.nature.com www.nature.com
    Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
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  71. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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  72. www.biorxiv.org www.biorxiv.org
    Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma
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  74. 52.53.155.43 52.53.155.43
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma
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  76. Jul 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP
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  78. www.mdpi.com www.mdpi.com
    Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability
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  79. www.embopress.org www.embopress.org
    An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates
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  81. Jun 2023
  82. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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    Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
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  84. www.sciencedirect.com www.sciencedirect.com
    Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation
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  85. www.biorxiv.org www.biorxiv.org
    Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells
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    A furin-deficient HEK293 cell line suggests a role for furin trafficking in the intoxication pathway of recombinant immunotoxins based on Pseudomonas exotoxin A
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  87. May 2023
  88. www.nature.com www.nature.com
    Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction
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  89. 52.53.155.43 52.53.155.43
    FEBS Press
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  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
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  91. www.biorxiv.org www.biorxiv.org
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells
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  92. www.biorxiv.org www.biorxiv.org
    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
    1
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  93. www.biorxiv.org www.biorxiv.org
    Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
    1
    1. scibot 11 May 2023
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor
    1
    1. scibot 06 May 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10154874/
  95. gut.bmj.com gut.bmj.com
    Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models
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    1. scibot 05 May 2023
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    gut.bmj.com/content/early/2022/06/21/gutjnl-2022-327121
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities
    1
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
    1
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      DOI: 10.21203/rs.3.rs-2721176/v1

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  98. www.biorxiv.org www.biorxiv.org
    Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly
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    biorxiv.org/content/10.1101/2023.04.26.538303v1
  99. Apr 2023
  100. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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      DOI: 10.15252/emmm.202217078

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  101. link.springer.com link.springer.com
    CRISPR/Cas9 System Mediated SIRT7 Gene Knockout Promotes Melanogenesis by MITF via MAPKS and BMP Activation in Melanoma Cells
    1
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      DOI: 10.1134/S0003683823020114

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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    1. scibot 12 Apr 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10054921/
  103. www.nature.com www.nature.com
    Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs
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    nature.com/articles/s41551-023-01011-7
  104. reader.elsevier.com reader.elsevier.com
    Phosphorylation barcodes direct biased chemokine signaling at CXCR3
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    reader.elsevier.com/reader/sd/pii/S2451945623000855
  105. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/59c2c44ef9fd23ec3f589d6f61da9a58c25f8ad4/Molecular Oncology - 2023 - Fernandes - MET exon 14 skipping mutation is a hepatocyte growth factor HGF -dependent-html.html
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
    1
    1. scibot 04 Apr 2023
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      DOI: 10.7554/eLife.85135

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  107. Mar 2023
  108. rupress.org rupress.org
    cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities
    1
    1. scibot 16 Mar 2023
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    rupress.org/jgp/article/155/4/e202213204/213929/cMyBP-C-ablation-in-human-engineered-cardiac
  109. www.embopress.org www.embopress.org
    Two Hippo signaling modules orchestrate liver size and tumorigenesis
    2
    1. scibot 16 Mar 2023
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  110. www.sciencedirect.com www.sciencedirect.com
    Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
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    1. scibot 16 Mar 2023
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    sciencedirect.com/science/article/pii/S1535610823000338
  111. www.sciencedirect.com www.sciencedirect.com
    Generation of an induced pluripotent stem cell line carrying a biallelic deletion (SCTCi019-A) in GCDH using CRISPR/Cas9
    1
    1. scibot 16 Mar 2023
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  112. www.sciencedirect.com www.sciencedirect.com
    Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway
    1
    1. scibot 10 Mar 2023
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    sciencedirect.com/science/article/pii/S1931312823000720
  113. www.cell.com www.cell.com
    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
    1
    1. scibot 10 Mar 2023
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    cell.com/molecular-cell/abstract/S1097-2765(23)00150-8
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6A Methylation
    1
    1. scibot 09 Mar 2023
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      DOI: 10.1002/advs.202300314

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  115. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
    1
    1. scibot 09 Mar 2023
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  116. www.biorxiv.org www.biorxiv.org
    Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  117. Feb 2023
  118. www.sciencedirect.com www.sciencedirect.com
    High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells
    1
    1. scibot 23 Feb 2023
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  119. www.sciencedirect.com www.sciencedirect.com
    Generation of induced pluripotent stem cell line carrying frameshift variants in NPHP1 (UCSFi001-A-68) using CRISPR/Cas9
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    sciencedirect.com/science/article/pii/S1873506123000399
  120. www.biorxiv.org www.biorxiv.org
    Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration
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    1. scibot 23 Feb 2023
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    biorxiv.org/content/10.1101/2021.10.28.465024v1
  121. www.sciencedirect.com www.sciencedirect.com
    Generation of miR-15a/16-1 cluster-deficient human induced pluripotent stem cell line (DMBi001-A-2) using CRISPR/Cas9 gene editing
    1
    1. scibot 16 Feb 2023
      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S1873506123000326
  122. www.sciencedirect.com www.sciencedirect.com
    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
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      DOI: 10.1016/j.stem.2023.01.007

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    sciencedirect.com/science/article/pii/S1934590923000073
  123. www.sciencedirect.com www.sciencedirect.com
    The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
    1
    1. scibot 09 Feb 2023
      Plasmid_62988

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    sciencedirect.com/science/article/pii/S2589004223000706
  124. www.sciencedirect.com www.sciencedirect.com
    Recycling of modified H2A-H2B provides short-term memory of chromatin states
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    1. scibot 09 Feb 2023
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system
    2
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      DOI: 10.3389/fncel.2022.1094291

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  126. elifesciences.org elifesciences.org
    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
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      DOI: 10.7554/eLife.83077

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    elifesciences.org/articles/83077
  127. www.sciencedirect.com www.sciencedirect.com
    Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC) line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing
    1
    1. scibot 02 Feb 2023
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  128. Jan 2023
  129. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
    2
    1. scibot 28 Jan 2023
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    sciencedirect.com/science/article/pii/S221112472201796X
  130. www.mdpi.com www.mdpi.com
    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
    1
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      DOI: 10.3390/cancers15010241

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    mdpi.com/2072-6694/15/1/241
  131. Dec 2022
  132. link.springer.com link.springer.com
    Sushi domain-containing protein 4 binds to epithelial growth factor receptor and initiates autophagy in an EGFR phosphorylation independent manner
    1
    1. scibot 30 Dec 2022
      plasmid_62988

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  133. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    sciencedirect.com/science/article/pii/S2211124722017260
  134. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene
    1
    1. scibot 17 Dec 2022
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  135. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system
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      RRID:Addgene_62988

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  136. Nov 2022
  137. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
    1
    1. scibot 29 Nov 2022
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      DOI: 10.1126/sciadv.abq6324

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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry
    1
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      DOI: 10.1016/j.isci.2022.105481

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    ncbi.nlm.nih.gov/pmc/articles/PMC9668739/
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
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    1. scibot 18 Nov 2022
      plasmid_62988

      DOI: 10.7554/eLife.81606

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  140. 52.53.155.43 52.53.155.43
    Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
    1
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      DOI: 10.21203/rs.3.rs-1913714/v1

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  141. 52.53.155.43 52.53.155.43
    Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
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  142. www.sciencedirect.com www.sciencedirect.com
    WNK kinases sense molecular crowding and rescue cell volume via phase separation
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    sciencedirect.com/science/article/pii/S0092867422012612
  143. Oct 2022
  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells
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      DOI: 10.3390/ijms231911649

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    ncbi.nlm.nih.gov/pmc/articles/PMC9569948/
  145. www.nature.com www.nature.com
    Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
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  146. link.springer.com link.springer.com
    Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
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  147. Sep 2022
  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
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    1. scibot 30 Sep 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9510713/
  149. www.sciencedirect.com www.sciencedirect.com
    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
    2
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    sciencedirect.com/science/article/pii/S221112472201172X
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALS-linked loss of Cyclin-F function affects HSP90
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      RRID:Addgene_62988

      DOI: 10.26508/lsa.202101359

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    ncbi.nlm.nih.gov/pmc/articles/PMC9481933/
  151. www.nature.com www.nature.com
    Quantitative analysis of CRISPR/Cas9-mediated provirus deletion in blue egg layer chicken PGCs by digital PCR
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  152. www.sciencedirect.com www.sciencedirect.com
    Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system
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    sciencedirect.com/science/article/pii/S2666166722005408
  153. www.sciencedirect.com www.sciencedirect.com
    The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction
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    sciencedirect.com/science/article/pii/S1931312822004073
  154. Aug 2022
  155. www.sciencedirect.com www.sciencedirect.com
    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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  156. www.embopress.org www.embopress.org
    Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1
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      RRID:Addgene_62988

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  158. www.sciencedirect.com www.sciencedirect.com
    APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
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      AddgeneCat#62988

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      plasmid_62988

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    sciencedirect.com/science/article/pii/S2211124722010178
  159. aacrjournals.org aacrjournals.org
    Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification
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      RRID:Addgene_62988

      DOI: 10.1158/0008-5472.CAN-22-0225

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    aacrjournals.org/cancerres/article/82/14/2576/706950/Proteomic-Mapping-and-Targeting-of-Mitotic
  160. www.sciencedirect.com www.sciencedirect.com
    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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      Addgene_62988

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    sciencedirect.com/science/article/pii/S1097276522006633
  161. jasn.asnjournals.org jasn.asnjournals.org
    Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease
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      DOI: 10.1681/ASN.2022010053

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    jasn.asnjournals.org/content/33/8/1501
  162. www.sciencedirect.com www.sciencedirect.com
    Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
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      Plasmid_62988

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    sciencedirect.com/science/article/pii/S2211124722009883
  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The selenoprotein P 3’ untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation
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      DOI: 10.1371/journal.pone.0271453

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    ncbi.nlm.nih.gov/pmc/articles/PMC9337670/
  164. Jul 2022
  165. www.sciencedirect.com www.sciencedirect.com
    GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
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      Addgene_62988

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    sciencedirect.com/science/article/pii/S2211124722009160
  166. www.medrxiv.org www.medrxiv.org
    A Progeroid Syndrome Caused by RAF1 deficiency Underscores the importance of RTK signaling for Human Development
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    medrxiv.org/content/10.1101/2022.02.20.22271260v1
  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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      DOI: 10.3390/cancers14133152

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    ncbi.nlm.nih.gov/pmc/articles/PMC9264918/
  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex
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      plasmid_62988

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  169. Jun 2022
  170. link.springer.com link.springer.com
    Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance
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      Addgene_62988

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  171. academic.oup.com academic.oup.com
    mTORC1 functional assay reveals SZT2 loss-of-function variants and a founder in-frame deletion
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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awab451/6598235
  172. www.nature.com www.nature.com
    Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function
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  173. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
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  174. rupress.org rupress.org
    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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  175. elifesciences.org elifesciences.org
    Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells
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  176. May 2022
  177. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
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  178. www.sciencedirect.com www.sciencedirect.com
    Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL13Rα2 promotes proliferation and outgrowth of breast cancer brain metastases
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  180. www.sciencedirect.com www.sciencedirect.com
    Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
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  181. www.nature.com www.nature.com
    Saturation variant interpretation using CRISPR prime editing
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  182. Apr 2022
  183. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
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      DOI: 10.1002/advs.202200626

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  184. www.sciencedirect.com www.sciencedirect.com
    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    1. scibot 29 Apr 2022
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    sciencedirect.com/science/article/pii/S1534580722002507
  185. www.sciencedirect.com www.sciencedirect.com
    CRISPR/Cas9 treatment partially restores the amyloid-β 42/40 ratio in human fibroblasts carrying the early onset Alzheimer’s disease presenilin 1 M146L mutation
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      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S2162253122000713
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells
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      DOI: 10.1038/s41598-022-10153-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC9012786/
  187. www.sciencedirect.com www.sciencedirect.com
    The role of cell-autonomous circadian oscillation of Cry transcription in circadian rhythm generation
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    sciencedirect.com/science/article/pii/S2211124722004612
  188. www.sciencedirect.com www.sciencedirect.com
    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    sciencedirect.com/science/article/pii/S1097276522002659
  189. www.sciencedirect.com www.sciencedirect.com
    Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex
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    1. scibot 14 Apr 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.celrep.2022.110673

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    sciencedirect.com/science/article/pii/S2211124722004259
  190. www.sciencedirect.com www.sciencedirect.com
    Rapid and efficient degradation of endogenous proteins in vivo identifies stage-specific roles of RNA Pol II pausing in mammalian development
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    1. scibot 14 Apr 2022
      addgene_62988

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    sciencedirect.com/science/article/pii/S1534580722002076
  191. www.sciencedirect.com www.sciencedirect.com
    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    1. scibot 13 Apr 2022
      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S1074761322001303
  192. www.sciencedirect.com www.sciencedirect.com
    Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells
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    sciencedirect.com/science/article/pii/S2213671122001333
  193. Mar 2022
  194. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system
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    sciencedirect.com/science/article/pii/S1873506122001131
  195. www.sciencedirect.com www.sciencedirect.com
    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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      Addgene62988

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    sciencedirect.com/science/article/pii/S2211124722002820
  196. www.sciencedirect.com www.sciencedirect.com
    Generation of induced pluripotent stem cell lines carrying monoallelic (UCSFi001-A-60) or biallelic (UCSFi001-A-61; UCSFi001-A-62) frameshift variants in CACNA1A using CRISPR/Cas9
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    sciencedirect.com/science/article/pii/S1873506122000794
  197. Feb 2022
  198. www.sciencedirect.com www.sciencedirect.com
    C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation
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    sciencedirect.com/science/article/pii/S0014482722000568
  199. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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      Plasmid_62988

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    pubmed.ncbi.nlm.nih.gov/35172133/
  200. www.sciencedirect.com www.sciencedirect.com
    Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death
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    sciencedirect.com/science/article/pii/S2211124722000274
  201. Jan 2022
  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration
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    1. scibot 28 Jan 2022
      RRID:Addgene_62988

      DOI: 10.1126/scisignal.abg3555

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    ncbi.nlm.nih.gov/pmc/articles/PMC8486338/
  203. www.sciencedirect.com www.sciencedirect.com
    The mammalian trafficking chaperone protein UNC93B1 maintains the ER calcium sensor STIM1 in a dimeric state primed for translocation to the ER cortex.
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      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S0021925822000473
  204. www.sciencedirect.com www.sciencedirect.com
    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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      Plasmid_62988

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    sciencedirect.com/science/article/pii/S1097276521011424
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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      DOI: 10.3390/cancers14020326

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    ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
  206. www.sciencedirect.com www.sciencedirect.com
    The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation
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      plasmid_62988

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    sciencedirect.com/science/article/pii/S0021925822000308
  207. www.embopress.org www.embopress.org
    Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
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      DOI: 10.15252/embj.2021109108

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    embopress.org/doi/abs/10.15252/embj.2021109108
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid fuels pancreatic cancer cell growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC8730721/
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models
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    ncbi.nlm.nih.gov/pmc/articles/PMC8710557/
  210. www.nature.com www.nature.com
    A design optimized prime editor with expanded scope and capability in plants
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      DOI: 10.1038/s41477-021-01043-4

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    nature.com/articles/s41477-021-01043-4
  211. Dec 2021
  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
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    ncbi.nlm.nih.gov/pmc/articles/PMC8673838/
  213. www.sciencedirect.com www.sciencedirect.com
    Emergence and patterning dynamics of mouse-definitive endoderm
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    1. scibot 21 Dec 2021
      plasmid_62

      DOI: 10.1016/j.isci.2021.103556

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      plasmid_62988

      DOI: 10.1016/j.isci.2021.103556

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  214. www.sciencedirect.com www.sciencedirect.com
    TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules
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      Plasmid_62988

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    sciencedirect.com/science/article/pii/S1534580721009394
  215. www.sciencedirect.com www.sciencedirect.com
    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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    sciencedirect.com/science/article/pii/S1534580721008947
  216. Nov 2021
  217. www.sciencedirect.com www.sciencedirect.com
    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
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      plasmid_62988

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    sciencedirect.com/science/article/pii/S2211124721014820
  218. link.springer.com link.springer.com
    CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer
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      RRID:Addgene_62988

      DOI: 10.1007/s00428-021-03230-2

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  219. www.sciencedirect.com www.sciencedirect.com
    Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes
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      Cat# 62988

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