923 Matching Annotations
  1. Jul 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12186606/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal adhesion-related non-ciliary functions of CEP290
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240322/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHD7 regulates definitive endodermal and mesodermal development from human embryonic stem cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12175391/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HELLS is required for maintaining proper DNA modification at human satellite repeats
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273238/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptomic analysis of the m6A reader YTHDF2 in the maintenance and differentiation of human embryonic stem cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12202760/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198624/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWITCHER, a CRISPR-inducible floxed wild-type Cre regulating CRISPR activity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214773/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12215557/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12254500/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exploring the m5C epitranscriptome of mRNAs in breast cancer cells through genome engineering and long-read sequencing approaches
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12187793/
  12. www.sciencedirect.com www.sciencedirect.com
    Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing
    1
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    sciencedirect.com/science/article/pii/S2211124725007806
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
  14. www.embopress.org www.embopress.org
    Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer
    1
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    embopress.org/doi/10.1038/s44319-025-00515-4
  15. www.biorxiv.org www.biorxiv.org
    NDR2 Kinase Regulate Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity
    1
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    biorxiv.org/content/10.1101/2025.06.12.659313v1
  16. www.embopress.org www.embopress.org
    Loss of p300 in proximal tubular cells reduces renal fibrosis and endothelial-mesenchymal transition | EMBO Molecular Medicine
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    embopress.org/doi/full/10.1038/s44321-025-00243-1
  17. www.cell.com www.cell.com
    A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation
    1
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    cell.com/developmental-cell/abstract/S1534-5807(25)00361-2
  18. www.embopress.org www.embopress.org
    Loss of p300 in proximal tubular cells reduces renal fibrosis and endothelial-mesenchymal transition
    1
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    embopress.org/doi/10.1038/s44321-025-00243-1
  19. www.nature.com www.nature.com
    The Vps13-like protein BLTP2 regulates phosphatidylethanolamine levels to maintain plasma membrane fluidity and breast cancer aggressiveness
    1
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    nature.com/articles/s41556-025-01672-3
  20. www.nature.com www.nature.com
    Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma
    1
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    nature.com/articles/s41598-025-07215-y
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intracellular trafficking of furin enhances cellular intoxication by recombinant immunotoxins based on Pseudomonas exotoxin A
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208400/
  22. Jun 2025
  23. www.sciencedirect.com www.sciencedirect.com
    The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
    1
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    sciencedirect.com/science/article/pii/S1097276525005027
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of SNX17 impedes activation of Retriever-mediated sorting
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12182294/
  25. clinicalepigeneticsjournal.biomedcentral.com clinicalepigeneticsjournal.biomedcentral.com
    Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer
    1
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    clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-025-01911-2
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12117712/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12085833/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic inactivation of FAAP100 causes Fanconi anemia due to disruption of the monoubiquitin ligase core complex
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12126235/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A new role of RAB21 and VARP in autophagy and autophagic exocytosis of ATP
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077462/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12125367/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12102168/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of sex-determining region Y-box 2 (Sox2) captures embryonic stem cells in a primed pluripotent state
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12135381/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12088964/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12100856/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132566/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role of cell cycle-related gene SAC3 domain containing 1 as a potential target of nitidine chloride in hepatocellular carcinoma progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12149825/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147292/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12143138/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNF213‐Dependent EGFR and HER2 Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160686/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139963/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147029/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of the SLC26A4 c.919-2A>G Variant
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12155412/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RalGAP complexes control secretion and primary cilia in pancreatic disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12149561/
  44. www.sciencedirect.com www.sciencedirect.com
    Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1
    1
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    sciencedirect.com/science/article/pii/S2211124725005947
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9 Screening Highlights PFKFB3 Gene as a Major Contributor to 5-Fluorouracil Resistance in Esophageal Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12109790/
  46. www.sciencedirect.com www.sciencedirect.com
    Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
    1
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    sciencedirect.com/science/article/pii/S1097276525004587
  47. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial fumarate inhibits Parkin-mediated mitophagy
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    sciencedirect.com/science/article/pii/S1097276525004605
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Physiological role and mechanisms of action for a long noncoding haplotype region
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    pmc.ncbi.nlm.nih.gov/articles/PMC12263090/
  49. www.cell.com www.cell.com
    Pro-ferroptotic lipids as key control points for caveola formation and disassembly
    1
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    cell.com/cell-reports/fulltext/S2211-1247(25)00560-1
  50. May 2025
  51. www.sciencedirect.com www.sciencedirect.com
    Quantification profiles of enzyme activity, secretion and psychosine levels of Krabbe disease galactosylceramidase missense variants
    1
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    sciencedirect.com/science/article/pii/S0021925825021659
  52. www.sciencedirect.com www.sciencedirect.com
    IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner
    1
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    sciencedirect.com/science/article/pii/S193459092500181X
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Super Enhancer-Derived Enhancer RNA Acts Together with CTCF/Cohesin in Trans to Regulate Erythropoiesis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12026470/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome or the FXN locus in Friedreich’s ataxia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12036138/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11983960/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11534545/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12066708/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12058134/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077661/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12032844/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reciprocal rescue of Wolfram syndrome by two causative genes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069674/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    O-GlcNAcylation of NONO regulates paraspeckle component assembly and contributes to colon cancer cell proliferation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075841/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatocyte TM4SF5-mediated cytosolic NCOA3 stabilization and macropinocytosis support albumin uptake and bioenergetics for hepatocellular carcinoma progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046047/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12059692/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome‐Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079485/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rewiring of SINE-MIR enhancer topology and Esrrb modulation in expanded and naive pluripotency
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12036290/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12037915/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11980836/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Effective recognition of double-stranded RNA does not require activation of cellular inflammation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11980852/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11809316/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Characterization of dsRNA binding proteins through solubility analysis identifies ZNF385A as a dsRNA homeostasis regulator
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11985509/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-throughput screening of human genetic variants by pooled prime editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12008803/
  74. www.sciencedirect.com www.sciencedirect.com
    DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation
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    sciencedirect.com/science/article/pii/S1097276525003612
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005277/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984920/
  77. Apr 2025
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12006300/
  79. www.sciencedirect.com www.sciencedirect.com
    Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing
    1
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    sciencedirect.com/science/article/pii/S1097276525003016
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The INO80 Chromatin Remodeling Complex Regulates Histone H2A.Z Mobility and the G1‐S Transition in Oligodendrocyte Precursors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12012327/
  81. www.sciencedirect.com www.sciencedirect.com
    RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity
    1
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    sciencedirect.com/science/article/pii/S2211124725003705
  82. www.sciencedirect.com www.sciencedirect.com
    Integrator loss leads to dsRNA formation that triggers the integrated stress response
    1
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    sciencedirect.com/science/article/pii/S0092867425003435
  83. www.science.org www.science.org
    ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
    1
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    science.org/doi/10.1126/sciadv.adu5091
  84. elifesciences.org elifesciences.org
    Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
    1
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    elifesciences.org/articles/98166
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Saturation mapping of MUTYH variant effects using DNA repair reporters
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908140/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC11947266/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pamoic acid and carbenoxolone specifically inhibit CRISPR/Cas9 in bacteria, mammalian cells, and mice in a DNA topology-specific manner
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951523/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retromer promotes the lysosomal turnover of mtDNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11970507/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNM1L-mediated fission governs mitophagy & mitochondrial biogenesis during myogenic differentiation
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  141. Jan 2025
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  168. Dec 2024
  169. elifesciences.org elifesciences.org
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