403 Matching Annotations
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  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Numb positively regulates Hedgehog signaling at the ciliary pocket
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    1. scibot 29 Apr 2024
      Addgene_62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC11045789/
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    RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence
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    1. scibot 28 Apr 2024
      Addgene_62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030350/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
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      RRID:Addgene_62988

      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus
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    1. scibot 23 Apr 2024
      62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC11021500/
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    Abnormal cell sorting and altered early neurogenesis in a human cortical organoid model of Protocadherin-19 clustering epilepsy
    1
    1. scibot 23 Apr 2024
      62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC11024992/
  7. www.embopress.org www.embopress.org
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
    2
    1. scibot 23 Apr 2024
      plasmid_62988

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      plasmid_62988

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    embopress.org/doi/10.1038/s44318-024-00065-w
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage
    1
    1. scibot 23 Apr 2024
      plasmid_62988

      DOI: 10.1093/nar/gkae004

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    ncbi.nlm.nih.gov/pmc/articles/PMC11024517/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders
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    1. scibot 23 Apr 2024
      plasmid_62988

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  10. Apr 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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    1. scibot 19 Apr 2024
      plasmid_62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC11021510/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal storage disease proteo/lipidomic profiling using nMOST links ferritinophagy with mitochondrial iron deficiencies in cells lacking NPC2
    1
    1. scibot 18 Apr 2024
      plasmid_62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC10996675/
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    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
    1
    1. scibot 15 Apr 2024
      62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945702/
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    FOXL2 interaction with different binding partners regulates the dynamics of ovarian development
    1
    1. scibot 15 Apr 2024
      62988

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  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4
    1
    1. scibot 15 Apr 2024
      plasmid_62988

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    An in vitro neurogenetics platform for precision disease modeling in the mouse
    1
    1. scibot 14 Apr 2024
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA LIP interacts with PARP-1 influencing the efficiency of base excision repair
    1
    1. scibot 14 Apr 2024
      pSpCas9(BB)-2A-Puro (PX459) V2.0

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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing
    1
    1. scibot 14 Apr 2024
      plasmid_62988

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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
    1
    1. scibot 14 Apr 2024
      Addgene_62988

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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage
    1
    1. scibot 13 Apr 2024
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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis
    1
    1. scibot 13 Apr 2024
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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70‐Derived Peptide: A Combined Computational and Experimental Study
    1
    1. scibot 13 Apr 2024
      62 988

      DOI: 10.1002/advs.202305998

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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions
    1
    1. scibot 13 Apr 2024
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  24. insight.jci.org insight.jci.org
    hsa-miRNA-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates
    1
    1. scibot 04 Apr 2024
      RRID:Addgene_62988

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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy
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    1. scibot 01 Apr 2024
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  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection
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    1. scibot 01 Apr 2024
      Plasmid_62988

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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn
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      plasmid_62

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  29. Mar 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protection of Chickens against H9N2 Avian Influenza Isolates with a Live Vector Vaccine Expressing Influenza Hemagglutinin Gene Derived from Y280 Avian Influenza Virus
    1
    1. scibot 31 Mar 2024
      pSpCas9(BB)-2A-Puro (PX459) V2.0

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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a Highly Efficient CRISPR/Cas9-Mediated Herpesvirus of Turkey-Based Vaccine against Novel Variant Infectious Bursal Disease Virus
    1
    1. scibot 31 Mar 2024
      pSpCas9(BB)-2A-Puro (PX459) V2.0

      DOI: 10.3390/vaccines12030226

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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DPY19L3 promotes vasculogenic mimicry by its C-mannosyltransferase activity
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    1. scibot 31 Mar 2024
      pSpCas9n(BB)-2A-Puro (PX459) V2.0

      DOI: 10.32604/or.2023.030304

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  33. www.futuremedicine.com www.futuremedicine.com
    Epigenetic disruption of histone deacetylase-2 accelerated apoptotic signaling and retarded malignancy in gastric cells
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    1. scibot 30 Mar 2024
      RRID:Addgene_62988

      DOI: 10.2217/epi-2023-0350

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    futuremedicine.com/doi/10.2217/epi-2023-0350
  34. www.sciencedirect.com www.sciencedirect.com
    Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis
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    1. scibot 27 Mar 2024
      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S1097276524001448
  35. link.springer.com link.springer.com
    CRISPR du-HITI an attractive approach to targeting Long Noncoding RNA HCP5 as inhibitory factor for proliferation of ovarian cancer cell
    1
    1. scibot 26 Mar 2024
      RRID:Addgene_62988

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity
    1
    1. scibot 22 Mar 2024
      plasmid_62988

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  37. www.sciencedirect.com www.sciencedirect.com
    De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
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    1. scibot 19 Mar 2024
      Addgene, Cat# 62988

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    sciencedirect.com/science/article/pii/S221112472400264X
  38. www.sciencedirect.com www.sciencedirect.com
    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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  39. www.nature.com www.nature.com
    On the genetic basis of tail-loss evolution in humans and apes
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2–p53 axis
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    1. scibot 17 Mar 2024
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
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    1. scibot 16 Mar 2024
      plasmid_62988

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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease
    1
    1. scibot 07 Mar 2024
      pSpCas9 (BB)-2A-Puro (PX459) V2.0

      DOI: 10.1097/HC9.0000000000000396

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    ncbi.nlm.nih.gov/pmc/articles/PMC10914241/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    1. scibot 06 Mar 2024
      RRID:Addgene_62988

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  44. www.sciencedirect.com www.sciencedirect.com
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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    1. scibot 05 Mar 2024
      Addgene# 62988

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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular transfection using rapid decrease in hydrostatic pressure
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Consequences of GMPPB deficiency for neuromuscular development and maintenance
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability
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  52. Feb 2024
  53. www.sciencedirect.com www.sciencedirect.com
    Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells
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      Addgene, 62,988

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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
    1
    1. scibot 29 Feb 2024
      pSpCas9(BB)-2A-Puro (PX459)

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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The methyltransferase N6AMT1 participates in the cell cycle by regulating cyclin E levels
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
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  57. www.sciencedirect.com www.sciencedirect.com
    The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
    2
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      RRID:Addgene_62988

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  58. 52.53.155.43 52.53.155.43
    HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins
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  59. 52.53.155.43 52.53.155.43
    can-23-1129-html.html
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  60. www.biorxiv.org www.biorxiv.org
    New submission 11/02/2024, 13:59:09
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  61. www.pnas.org www.pnas.org
    Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase
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  62. www.biorxiv.org www.biorxiv.org
    The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma
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  64. www.sciencedirect.com www.sciencedirect.com
    Persistence of backtracking by human RNA polymerase II
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  65. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell line derived from Becker muscular dystrophy patient with CRISPR/Cas9-mediated correction of DMD gene mutation
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular Targets and Lysine Selectivity of the HERC5 ISG15 Ligase
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  71. journals.plos.org journals.plos.org
    Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene
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  72. www.mdpi.com www.mdpi.com
    Biomarker RIPK3 Is Silenced by Hypermethylation in Melanoma and Epigenetic Editing Reestablishes Its Tumor Suppressor Function
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  73. Jan 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Strategies for single base gene editing in an immortalized human cell line by CRISPR/Cas9 technology
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells
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  77. www.sciencedirect.com www.sciencedirect.com
    Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase
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  78. www.sciencedirect.com www.sciencedirect.com
    Direct observation of a condensate effect on super-enhancer controlled gene bursting
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer
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  81. www.sciencedirect.com www.sciencedirect.com
    N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy
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  82. www.jneurosci.org www.jneurosci.org
    Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
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  83. Dec 2023
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response
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    onlinelibrary.wiley.com/doi/10.1111/cas.16044
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction
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  87. www.sciencedirect.com www.sciencedirect.com
    Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
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  88. www.sciencedirect.com www.sciencedirect.com
    Interactome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF524 directly interacts with telomeric DNA and supports telomere integrity
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    Heterozygous Knockout of ARID4B Using CRISPR/Cas9 Attenuates Some Aggressive Phenotypes in a Breast Cancer Cell Line
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    The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitotic bookmarking by SWI/SNF subunits
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  93. www.biorxiv.org www.biorxiv.org
    Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
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  97. 52.53.155.43 52.53.155.43
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for the saturation and multiplexing of genetic variants using CRISPR-Cas9
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  99. Nov 2023
  100. www.sciencedirect.com www.sciencedirect.com
    Generation of a CRISPR/Cas9-edited Plakoglobin (JUP)knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma
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    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
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  108. www.biorxiv.org www.biorxiv.org
    Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma
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  110. 52.53.155.43 52.53.155.43
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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  112. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
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  113. Sep 2023
  114. www.sciencedirect.com www.sciencedirect.com
    Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner
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  115. www.biorxiv.org www.biorxiv.org
    Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts
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  116. www.nature.com www.nature.com
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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  118. dx.doi.org dx.doi.org
    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
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    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
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  120. Aug 2023
  121. www.science.org www.science.org
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  123. www.nature.com www.nature.com
    Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
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  124. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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  125. www.biorxiv.org www.biorxiv.org
    Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma
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  127. 52.53.155.43 52.53.155.43
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma
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  129. Jul 2023
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP
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  131. www.mdpi.com www.mdpi.com
    Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability
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  132. www.embopress.org www.embopress.org
    An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates
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  134. Jun 2023
  135. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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  136. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
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  137. www.sciencedirect.com www.sciencedirect.com
    Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation
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  138. www.biorxiv.org www.biorxiv.org
    Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells
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  139. www.biorxiv.org www.biorxiv.org
    A furin-deficient HEK293 cell line suggests a role for furin trafficking in the intoxication pathway of recombinant immunotoxins based on Pseudomonas exotoxin A
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  140. May 2023
  141. www.nature.com www.nature.com
    Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction
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  142. 52.53.155.43 52.53.155.43
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  143. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
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  144. www.biorxiv.org www.biorxiv.org
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells
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  145. www.biorxiv.org www.biorxiv.org
    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
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    Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor
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  148. gut.bmj.com gut.bmj.com
    Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
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  151. www.biorxiv.org www.biorxiv.org
    Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly
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  152. Apr 2023
  153. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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  154. link.springer.com link.springer.com
    CRISPR/Cas9 System Mediated SIRT7 Gene Knockout Promotes Melanogenesis by MITF via MAPKS and BMP Activation in Melanoma Cells
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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  156. www.nature.com www.nature.com
    Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs
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  157. reader.elsevier.com reader.elsevier.com
    Phosphorylation barcodes direct biased chemokine signaling at CXCR3
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  158. 52.53.155.43 52.53.155.43
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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
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  160. Mar 2023
  161. rupress.org rupress.org
    cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities
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  162. www.embopress.org www.embopress.org
    Two Hippo signaling modules orchestrate liver size and tumorigenesis
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  163. www.sciencedirect.com www.sciencedirect.com
    Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
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  164. www.sciencedirect.com www.sciencedirect.com
    Generation of an induced pluripotent stem cell line carrying a biallelic deletion (SCTCi019-A) in GCDH using CRISPR/Cas9
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  165. www.sciencedirect.com www.sciencedirect.com
    Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway
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  166. www.cell.com www.cell.com
    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
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  167. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6A Methylation
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  168. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
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  169. www.biorxiv.org www.biorxiv.org
    Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  170. Feb 2023
  171. www.sciencedirect.com www.sciencedirect.com
    High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells
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  172. www.sciencedirect.com www.sciencedirect.com
    Generation of induced pluripotent stem cell line carrying frameshift variants in NPHP1 (UCSFi001-A-68) using CRISPR/Cas9
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  173. www.biorxiv.org www.biorxiv.org
    Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration
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  174. www.sciencedirect.com www.sciencedirect.com
    Generation of miR-15a/16-1 cluster-deficient human induced pluripotent stem cell line (DMBi001-A-2) using CRISPR/Cas9 gene editing
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  175. www.sciencedirect.com www.sciencedirect.com
    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
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  176. www.sciencedirect.com www.sciencedirect.com
    The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
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  177. www.sciencedirect.com www.sciencedirect.com
    Recycling of modified H2A-H2B provides short-term memory of chromatin states
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system
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    ncbi.nlm.nih.gov/pmc/articles/PMC9893511/
  179. elifesciences.org elifesciences.org
    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
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    1. scibot 02 Feb 2023
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      DOI: 10.7554/eLife.83077

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    elifesciences.org/articles/83077
  180. www.sciencedirect.com www.sciencedirect.com
    Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC) line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing
    1
    1. scibot 02 Feb 2023
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    sciencedirect.com/science/article/pii/S1873506123000247
  181. Jan 2023
  182. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
    2
    1. scibot 28 Jan 2023
      RRID: Addgene_62988

      DOI: 10.1016/j.celrep.2022.111897

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    sciencedirect.com/science/article/pii/S221112472201796X
  183. www.mdpi.com www.mdpi.com
    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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    1. scibot 04 Jan 2023
      RRID:Addgene_62988

      DOI: 10.3390/cancers15010241

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    mdpi.com/2072-6694/15/1/241
  184. Dec 2022
  185. link.springer.com link.springer.com
    Sushi domain-containing protein 4 binds to epithelial growth factor receptor and initiates autophagy in an EGFR phosphorylation independent manner
    1
    1. scibot 30 Dec 2022
      plasmid_62988

      DOI: 10.1186/s13046-022-02565-1

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    link.springer.com/article/10.1186/s13046-022-02565-1
  186. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    1. scibot 24 Dec 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.celrep.2022.111834

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    sciencedirect.com/science/article/pii/S2211124722017260
  187. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene
    1
    1. scibot 17 Dec 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.scr.2022.103004

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    sciencedirect.com/science/article/pii/S1873506122003531
  188. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system
    1
    1. scibot 08 Dec 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.scr.2022.103000

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    sciencedirect.com/science/article/pii/S187350612200349X
  189. Nov 2022
  190. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
    1
    1. scibot 29 Nov 2022
      plasmid_62988

      DOI: 10.1126/sciadv.abq6324

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    science.org/doi/10.1126/sciadv.abq6324
  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry
    1
    1. scibot 19 Nov 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2022.105481

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    ncbi.nlm.nih.gov/pmc/articles/PMC9668739/
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
    1
    1. scibot 18 Nov 2022
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      DOI: 10.7554/eLife.81606

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    ncbi.nlm.nih.gov/pmc/articles/PMC9651953/
  193. 52.53.155.43 52.53.155.43
    Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
    1
    1. scibot 03 Nov 2022
      RRID:Addgene_62988

      DOI: 10.21203/rs.3.rs-1913714/v1

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  194. 52.53.155.43 52.53.155.43
    Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
    2
    1. scibot 03 Nov 2022
      RRID:Addgene_62988

      DOI: 10.21203/rs.3.rs-1698453/v1

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  195. www.sciencedirect.com www.sciencedirect.com
    WNK kinases sense molecular crowding and rescue cell volume via phase separation
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    1. scibot 03 Nov 2022
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      DOI: 10.1016/j.cell.2022.09.042

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    sciencedirect.com/science/article/pii/S0092867422012612
  196. Oct 2022
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells
    1
    1. scibot 26 Oct 2022
      RRID:Addgene_62988

      DOI: 10.3390/ijms231911649

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    ncbi.nlm.nih.gov/pmc/articles/PMC9569948/
  198. www.nature.com www.nature.com
    Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
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    1. scibot 25 Oct 2022
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      DOI: 10.1038/s41380-022-01834-x

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    nature.com/articles/s41380-022-01834-x
  199. link.springer.com link.springer.com
    Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
    1
    1. scibot 19 Oct 2022
      RRID:Addgene_62988

      DOI: 10.1038/s41598-022-20970-6

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    link.springer.com/article/10.1038/s41598-022-20970-6
  200. Sep 2022
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
    1
    1. scibot 30 Sep 2022
      RRID:Addgene_62988

      DOI: 10.3389/fcell.2022.941493

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    ncbi.nlm.nih.gov/pmc/articles/PMC9510713/
  202. www.sciencedirect.com www.sciencedirect.com
    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
    2
    1. scibot 22 Sep 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.celrep.2022.111344

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      DOI: 10.1016/j.celrep.2022.111344

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    sciencedirect.com/science/article/pii/S221112472201172X
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALS-linked loss of Cyclin-F function affects HSP90
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    1. scibot 22 Sep 2022
      RRID:Addgene_62988

      DOI: 10.26508/lsa.202101359

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    ncbi.nlm.nih.gov/pmc/articles/PMC9481933/
  204. www.nature.com www.nature.com
    Quantitative analysis of CRISPR/Cas9-mediated provirus deletion in blue egg layer chicken PGCs by digital PCR
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    1. scibot 18 Sep 2022
      RRID:Addgene_62988

      DOI: 10.1038/s41598-022-19861-7

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    nature.com/articles/s41598-022-19861-7
  205. www.sciencedirect.com www.sciencedirect.com
    Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system
    1
    1. scibot 11 Sep 2022
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      DOI: 10.1016/j.xpro.2022.101660

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    sciencedirect.com/science/article/pii/S2666166722005408
  206. www.sciencedirect.com www.sciencedirect.com
    The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction
    1
    1. scibot 11 Sep 2022
      RRID:Addgene_62988

      DOI: 10.1016/j.chom.2022.08.008

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    sciencedirect.com/science/article/pii/S1931312822004073
  207. Aug 2022
  208. www.sciencedirect.com www.sciencedirect.com
    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
    1
    1. scibot 31 Aug 2022
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    sciencedirect.com/science/article/pii/S2211124722011160
  209. www.embopress.org www.embopress.org
    Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
    1
    1. scibot 23 Aug 2022
      Addgene_62988

      DOI: 10.15252/embj.2022110777

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    embopress.org/doi/10.15252/embj.2022110777
  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1
    1
    1. scibot 22 Aug 2022
      RRID:Addgene_62988

      DOI: 10.3390/molecules27154867

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    ncbi.nlm.nih.gov/pmc/articles/PMC9369648/
  211. www.sciencedirect.com www.sciencedirect.com
    APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
    2
    1. scibot 17 Aug 2022
      AddgeneCat#62988

      DOI: 10.1016/j.celrep.2022.111200

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      plasmid_62988

      DOI: 10.1016/j.celrep.2022.111200

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    sciencedirect.com/science/article/pii/S2211124722010178
  212. aacrjournals.org aacrjournals.org
    Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification
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    1. scibot 16 Aug 2022
      RRID:Addgene_62988

      DOI: 10.1158/0008-5472.CAN-22-0225

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    aacrjournals.org/cancerres/article/82/14/2576/706950/Proteomic-Mapping-and-Targeting-of-Mitotic