509 Matching Annotations
  1. Nov 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
    1
    1. scibot 15 Nov 2023
      Addgene_8454

      DOI: 10.1126/scisignal.adg0485

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    ncbi.nlm.nih.gov/pmc/articles/PMC10639087/
  3. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
    1
    1. scibot 10 Nov 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.immuni.2023.10.004

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    sciencedirect.com/science/article/pii/S1074761323004442
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species
    1
    1. scibot 09 Nov 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.celrep.2023.113151

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    ncbi.nlm.nih.gov/pmc/articles/PMC10627507/
  5. www.sciencedirect.com www.sciencedirect.com
    Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells
    1
    1. scibot 03 Nov 2023
      plasmid_8454

      DOI: 10.1016/j.cell.2023.10.001

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    sciencedirect.com/science/article/pii/S0092867423010838
  6. www.sciencedirect.com www.sciencedirect.com
    CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
    1
    1. scibot 02 Nov 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.drup.2023.101015

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    sciencedirect.com/science/article/pii/S1368764623000985
  7. Oct 2023
  8. link.springer.com link.springer.com
    A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens
    1
    1. scibot 31 Oct 2023
      RRID:Addgene_8454

      DOI: 10.1186/s12864-023-09754-y

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    link.springer.com/article/10.1186/s12864-023-09754-y
  9. www.sciencedirect.com www.sciencedirect.com
    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
    1
    1. scibot 28 Oct 2023
      Addgene_8454

      DOI: 10.1016/j.cmet.2023.09.012

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    sciencedirect.com/science/article/pii/S1550413123003686
  10. www.biorxiv.org www.biorxiv.org
    Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination
    1
    1. scibot 27 Oct 2023
      RRID:Addgene_8454

      DOI: 10.1101/2023.10.17.562812

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    biorxiv.org/content/10.1101/2023.10.17.562812v1
  11. www.biorxiv.org www.biorxiv.org
    Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus
    1
    1. scibot 27 Oct 2023
      RRID:Addgene_8454

      DOI: 10.1101/2023.10.20.563362

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    biorxiv.org/content/10.1101/2023.10.20.563362v1
  12. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  13. www.mdpi.com www.mdpi.com
    Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells
    1
    1. scibot 22 Oct 2023
      RRID:Addgene_8454

      DOI: 10.3390/ijms242015116

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    mdpi.com/1422-0067/24/20/15116
  14. www.sciencedirect.com www.sciencedirect.com
    Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
    1
    1. scibot 14 Oct 2023
      Addgene_8454

      DOI: 10.1016/j.cell.2023.08.041

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    sciencedirect.com/science/article/pii/S0092867423009753
  15. www.sciencedirect.com www.sciencedirect.com
    DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
    1
    1. scibot 13 Oct 2023
      Addgene_8454

      DOI: 10.1016/j.molcel.2023.09.023

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    sciencedirect.com/science/article/pii/S1097276523007505
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells
    1
    1. scibot 06 Oct 2023
      Addgene_8454

      DOI: 10.7554/eLife.88828

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    ncbi.nlm.nih.gov/pmc/articles/PMC10550287/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells
    1
    1. scibot 05 Oct 2023
      plasmid_8454

      DOI: 10.1101/2023.09.15.557984

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    ncbi.nlm.nih.gov/pmc/articles/PMC10516027/
  18. Sep 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing
    1
    1. scibot 23 Sep 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.xpro.2023.102165

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    ncbi.nlm.nih.gov/pmc/articles/PMC10510057/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The IFT81‐IFT74 complex acts as an unconventional RabL2 GTPase‐activating protein during intraflagellar transport
    1
    1. scibot 20 Sep 2023
      plasmid_8454

      DOI: 10.15252/embj.2022111807

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    ncbi.nlm.nih.gov/pmc/articles/PMC10505919/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes
    1
    1. scibot 20 Sep 2023
      Addgene_8454

      DOI: 10.15252/embj.2022112469

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    ncbi.nlm.nih.gov/pmc/articles/PMC10505912/
  22. dx.doi.org dx.doi.org
    Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
    1
    1. scibot 15 Sep 2023
      RRID:Addgene_8454

      DOI: 10.1158/0008-5472.CAN-22-3114

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    dx.doi.org/10.1158/0008-5472.CAN-22-3114
  23. link.springer.com link.springer.com
    Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
    1
    1. scibot 14 Sep 2023
      RRID:Addgene_8454

      DOI: 10.1007/s13402-023-00867-w

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    link.springer.com/article/10.1007/s13402-023-00867-w
  24. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
    1
    1. scibot 08 Sep 2023
      Addgene plasmid #8454

      DOI: 10.1016/j.devcel.2023.08.013

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      Curator: @olekpark

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    sciencedirect.com/science/article/pii/S1534580723004094
  25. Aug 2023
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
    1
    1. scibot 31 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1186/s12967-023-04448-1

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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC10463307/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens
    1
    1. scibot 31 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1101/2023.01.22.525086

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    ncbi.nlm.nih.gov/pmc/articles/PMC9882262/
  28. www.sciencedirect.com www.sciencedirect.com
    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
    1
    1. scibot 27 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.celrep.2023.113045

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    sciencedirect.com/science/article/pii/S2211124723010562
  29. www.science.org www.science.org
    Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
    1
    1. scibot 27 Aug 2023
      Addgene_8454

      DOI: 10.1126/scisignal.adg0485

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    science.org/doi/10.1126/scisignal.adg0485
  30. www.nature.com www.nature.com
    Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
    1
    1. scibot 24 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1038/s41467-023-40222-z

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    nature.com/articles/s41467-023-40222-z
  31. www.nature.com www.nature.com
    An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
    1
    1. scibot 24 Aug 2023
      Addgene_8454

      DOI: 10.1038/s41467-023-40688-x

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    nature.com/articles/s41467-023-40688-x
  32. www.sciencedirect.com www.sciencedirect.com
    IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
    1
    1. scibot 23 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.celrep.2023.112996

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    sciencedirect.com/science/article/pii/S2211124723010070
  33. www.embopress.org www.embopress.org
    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
    1
    1. scibot 23 Aug 2023
      RRID:Addgene_8454

      DOI: 10.15252/emmm.202217367

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    embopress.org/doi/10.15252/emmm.202217367
  34. 52.53.155.43 52.53.155.43
    SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine
    2
    1. scibot 17 Aug 2023
      Plasmid_8454

      DOI: 10.1016/j.celrep.2023.112940

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    2. scibot 16 Aug 2023
      Plasmid_8454

      DOI: 10.1016/j.celrep.2023.112940

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    52.53.155.43/746dceaaaecd8ad8008d9df523b985f7a77f181a/PIIS2211124723009518-html.html
  35. www.biorxiv.org www.biorxiv.org
    The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC reprogramming
    3
    1. scibot 12 Aug 2023
      plasmid #8454

      DOI: 10.1101/2023.07.31.551297

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      Curator: @olekpark

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    2. scibot 12 Aug 2023
      Addgene plasmid #8454

      DOI: 10.1101/2023.07.31.551297

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      Curator: @olekpark

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    3. scibot 12 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1101/2023.07.31.551297

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    biorxiv.org/content/10.1101/2023.07.31.551297v3
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
    1
    1. scibot 09 Aug 2023
      plasmid_8454

      DOI: 10.7554/eLife.80447

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    ncbi.nlm.nih.gov/pmc/articles/PMC10406432/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
    1
    1. scibot 03 Aug 2023
      RRID:Addgene_8454

      DOI: 10.1158/0008-5472.CAN-22-3173

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    ncbi.nlm.nih.gov/pmc/articles/PMC10391328/
  38. Jul 2023
  39. www.embopress.org www.embopress.org
    Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
    1
    1. scibot 29 Jul 2023
      RRID:Addgene_8454

      DOI: 10.15252/embr.202256279

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    embopress.org/doi/10.15252/embr.202256279
  40. 52.53.155.43 52.53.155.43
    Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal
    1
    1. scibot 15 Jul 2023
      8454

      DOI: 10.1101/2023.05.03.539283

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    52.53.155.43/8add9715cb6d409825df8305aa589d745e83436f/2023.05.03.539283.full-html.html
  41. www.biorxiv.org www.biorxiv.org
    Neuronal Activation of the Gαq Protein EGL-30/GNAQ Late in Life Rejuvenates Cognition Across Species
    1
    1. scibot 13 Jul 2023
      RRID:Addgene_8454

      DOI: 10.1101/2023.06.06.543909

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    biorxiv.org/content/10.1101/2023.06.06.543909v1
  42. 52.53.155.43 52.53.155.43
    can-22-3173-html.html
    1
    1. scibot 08 Jul 2023
      RRID:Addgene_8454

      DOI: 10.1158/0008-5472.can-22-3173

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    52.53.155.43/7a07162d3285902b20a1a359628fdd8826284ee8/can-22-3173-html.html
  43. Jun 2023
  44. 52.53.155.43 52.53.155.43
    can-22-3173-html.html
    1
    1. scibot 30 Jun 2023
      RRID:Addgene_8454

      DOI: 10.1158/0008-5472.CAN-22-3173

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    52.53.155.43/7a07162d3285902b20a1a359628fdd8826284ee8/can-22-3173-html.html
  45. www.sciencedirect.com www.sciencedirect.com
    LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy
    1
    1. scibot 23 Jun 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.devcel.2023.05.009

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    sciencedirect.com/science/article/pii/S1534580723002423
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
    1
    1. scibot 17 Jun 2023
      RRID:Addgene_8454

      DOI: 10.1016/j.molcel.2022.12.004

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
  47. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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    Coupled protein quality control during nonsense-mediated mRNA decay
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  49. May 2023
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    ATR protects centromere identity by promoting DAXX association with PML nuclear bodies
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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  53. journals.asm.org journals.asm.org
    Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
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  54. Apr 2023
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer
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  58. elifesciences.org elifesciences.org
    NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation
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    Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
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    The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
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  61. Mar 2023
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells
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    A central chaperone-like role for 14-3-3 proteins in human cells
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    Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease
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    IFNγ is a central node of cancer immune equilibrium
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies
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  68. Feb 2023
  69. www.sciencedirect.com www.sciencedirect.com
    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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  70. link.springer.com link.springer.com
    Baculovirus displaying SARS-CoV-2 spike RBD promotes neutralizing antibody production in a mouse model
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    Monitoring cell fate in 3D organotypic human squamous epithelial cultures
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combinatorial Treatment with Poly(ADP-ribose) Polymerase-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth Through Fos-Driven Changes in Gene Expression
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
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    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
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  75. Jan 2023
  76. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
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  77. www.science.org www.science.org
    Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases
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    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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    Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging
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    RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer
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    Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia
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    Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway
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  83. 52.53.155.43 52.53.155.43
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  84. www.pnas.org www.pnas.org
    Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs
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    T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens
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  87. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry
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    Functional partitioning of transcriptional regulators by patterned charge blocks
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    PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome
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  91. Dec 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
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  95. academic.oup.com academic.oup.com
    Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression
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  99. Nov 2022
  100. www.mdpi.com www.mdpi.com
    Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma
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  101. www.sciencedirect.com www.sciencedirect.com
    Autophagy promotes cell survival by maintaining NAD levels
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  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    HIV-induced bystander cell death in astrocytes requires cell-to-cell viral transmission
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    Genome-scale CRISPR screening in a single mouse liver
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  104. www.sciencedirect.com www.sciencedirect.com
    Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function
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    NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma
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  106. www.sciencedirect.com www.sciencedirect.com
    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
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  107. www.sciencedirect.com www.sciencedirect.com
    Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent in situ hybridization and a dual reporter system
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  108. Oct 2022
  109. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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  110. www.sciencedirect.com www.sciencedirect.com
    Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death
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  111. www.sciencedirect.com www.sciencedirect.com
    In vitro neurons learn and exhibit sentience when embodied in a simulated game-world
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration
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  113. Sep 2022
  114. www.sciencedirect.com www.sciencedirect.com
    The lncRNA ALPHA specifically targets chikungunya virus to control infection
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study
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  116. www.sciencedirect.com www.sciencedirect.com
    Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
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  119. Aug 2022
  120. www.sciencedirect.com www.sciencedirect.com
    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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  121. 52.53.155.43 52.53.155.43
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  122. 52.53.155.43 52.53.155.43
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  123. www.sciencedirect.com www.sciencedirect.com
    Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth
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  125. www.sciencedirect.com www.sciencedirect.com
    Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression
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    Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
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    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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    Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells
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    Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing
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  130. Jul 2022
  131. 52.53.155.43 52.53.155.43
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  132. www.sciencedirect.com www.sciencedirect.com
    Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors
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  133. Jun 2022
  134. 52.53.155.43 52.53.155.43
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  135. www.embopress.org www.embopress.org
    Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity
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  137. www.sciencedirect.com www.sciencedirect.com
    Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
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  138. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
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  139. www.sciencedirect.com www.sciencedirect.com
    Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression
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  140. May 2022
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
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      DOI: 10.7554/eLife.75594

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  142. www.sciencedirect.com www.sciencedirect.com
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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      DOI: 10.1016/j.cell.2022.04.019

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  143. www.sciencedirect.com www.sciencedirect.com
    Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
    1
    1. scibot 05 May 2022
      AddgeneCat#8454

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    sciencedirect.com/science/article/pii/S1550413122001310
  144. Apr 2022
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
    1
    1. scibot 27 Apr 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9099058/
  146. www.sciencedirect.com www.sciencedirect.com
    The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
    1
    1. scibot 22 Apr 2022
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    sciencedirect.com/science/article/pii/S1934590922001503
  147. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
    1
    1. scibot 21 Apr 2022
      RRID:Addgene_8454

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    sciencedirect.com/science/article/pii/S1534580722002295
  148. www.sciencedirect.com www.sciencedirect.com
    Functional elements of the cis-regulatory lincRNA-p21
    1
    1. scibot 20 Apr 2022
      RRID:Addgene_8454

      DOI: 10.1016/j.celrep.2022.110687

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  149. www.sciencedirect.com www.sciencedirect.com
    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
    1
    1. scibot 13 Apr 2022
      RRID:Addgene_8454

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    sciencedirect.com/science/article/pii/S1074761322001303
  150. Mar 2022
  151. www.sciencedirect.com www.sciencedirect.com
    Genome-wide analysis of haploinsufficiency in human embryonic stem cells
    1
    1. scibot 30 Mar 2022
      Addgene Cat# 8454

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    sciencedirect.com/science/article/pii/S2211124722003175
  152. www.sciencedirect.com www.sciencedirect.com
    Müller glia fused with adult stem cells undergo neural differentiation in human retinal models
    1
    1. scibot 13 Mar 2022
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    sciencedirect.com/science/article/pii/S2352396422000986
  153. elifesciences.org elifesciences.org
    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
    1
    1. scibot 11 Mar 2022
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      DOI: 10.7554/eLife.73150

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    elifesciences.org/articles/73150
  154. www.sciencedirect.com www.sciencedirect.com
    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
    1
    1. scibot 09 Mar 2022
      AddgeneCat#8454

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    sciencedirect.com/science/article/pii/S2211124722002066
  155. www.sciencedirect.com www.sciencedirect.com
    Glutamine-dependent signaling controls pluripotent stem cell fate
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    sciencedirect.com/science/article/pii/S1534580722000697
  156. www.sciencedirect.com www.sciencedirect.com
    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
    1
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    sciencedirect.com/science/article/pii/S1097276522001186
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells
    1
    1. scibot 04 Mar 2022
      RRID:Addgene_8454

      DOI: 10.3390/pharmaceutics14020329

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    ncbi.nlm.nih.gov/pmc/articles/PMC8880011/
  158. elifesciences.org elifesciences.org
    Pathway-specific effects of ADSL deficiency on neurodevelopment
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    1. scibot 04 Mar 2022
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      DOI: 10.7554/eLife.70518

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    elifesciences.org/articles/70518
  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure
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    1. scibot 03 Mar 2022
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  160. www.sciencedirect.com www.sciencedirect.com
    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
    2
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    sciencedirect.com/science/article/pii/S1534580722000703
  161. Feb 2022
  162. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TBK1-METTL3 axis facilitates antiviral immunity
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    1. scibot 16 Feb 2022
      AddGeneCat#8454

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    pubmed.ncbi.nlm.nih.gov/35172162/
  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons
    1
    1. scibot 16 Feb 2022
      RRID:Addgene_8454

      DOI: 10.3389/fnana.2021.757017

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    ncbi.nlm.nih.gov/pmc/articles/PMC8841415/
  164. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4
    4
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.chembiol.2022.01.007

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    sciencedirect.com/science/article/pii/S2451945622000496
  165. www.sciencedirect.com www.sciencedirect.com
    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
    2
    1. scibot 11 Feb 2022
      Plasmid_8454

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    sciencedirect.com/science/article/pii/S2589004222000803
  166. www.sciencedirect.com www.sciencedirect.com
    Development of human alveolar epithelial cell models to study distal lung biology and disease
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      RRID:Addgene_8454

      DOI: 10.1016/j.isci.2022.103780

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    sciencedirect.com/science/article/pii/S2589004222000505
  167. www.sciencedirect.com www.sciencedirect.com
    Upregulation of CD14 in mesenchymal stromal cells accelerates lipopolysaccharide-induced response and enhances antibacterial properties
    1
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      RRID:Addgene_8454

      DOI: 10.1016/j.isci.2022.103759

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    sciencedirect.com/science/article/pii/S2589004222000293
  168. Jan 2022
  169. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
    1
    1. scibot 28 Jan 2022
      plasmid_8454

      DOI: 10.1016/j.cell.2021.12.046

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    sciencedirect.com/science/article/pii/S0092867421015786
  170. www.sciencedirect.com www.sciencedirect.com
    Isolation and characterization of the immune cell fraction from murine brain tumor microenvironment
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    1. scibot 21 Jan 2022
      RRID:Addgene_8454

      DOI: 10.1016/j.xpro.2021.101106

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    sciencedirect.com/science/article/pii/S2666166721008121
  171. www.sciencedirect.com www.sciencedirect.com
    Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release
    1
    1. scibot 19 Jan 2022
      AddgeneCatalog # 8454

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    sciencedirect.com/science/article/pii/S2211124721017678
  172. www.nature.com www.nature.com
    Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins
    1
    1. scibot 15 Jan 2022
      RRID:Addgene_8454

      DOI: 10.1038/s42003-021-02953-x

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    nature.com/articles/s42003-021-02953-x
  173. www.sciencedirect.com www.sciencedirect.com
    Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
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    sciencedirect.com/science/article/pii/S0092867421014847
  174. link.springer.com link.springer.com
    Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy
    1
    1. scibot 11 Jan 2022
      RRID:Addgene_8454

      DOI: 10.1186/s13046-021-02231-y

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  175. www.sciencedirect.com www.sciencedirect.com
    Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
    1
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    sciencedirect.com/science/article/pii/S2589004221016205
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer
    1
    1. scibot 05 Jan 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8292166/
  177. link.springer.com link.springer.com
    Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma
    1
    1. scibot 04 Jan 2022
      RRID:Addgene_8454

      DOI: 10.1186/s13046-021-02208-x

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    link.springer.com/article/10.1186/s13046-021-02208-x
  178. Dec 2021
  179. www.sciencedirect.com www.sciencedirect.com
    WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues
    1
    1. scibot 17 Dec 2021
      RRID:Addgene_8454

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    sciencedirect.com/science/article/pii/S1534580721009497
  180. www.sciencedirect.com www.sciencedirect.com
    Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1
    1
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      Plasmid_8454

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    sciencedirect.com/science/article/pii/S2211124721015989
  181. www.sciencedirect.com www.sciencedirect.com
    Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
    1
    1. scibot 07 Dec 2021
      RRID:Addgene_8454

      DOI: 10.1016/j.jbc.2021.101459

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    sciencedirect.com/science/article/pii/S0021925821012680
  182. link.springer.com link.springer.com
    Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning
    1
    1. scibot 02 Dec 2021
      RRID:Addgene_8454

      DOI: 10.1007/s12035-021-02651-z

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    link.springer.com/article/10.1007/s12035-021-02651-z
  183. Nov 2021
  184. elifesciences.org elifesciences.org
    Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells
    1
    1. scibot 24 Nov 2021
      RRID:Addgene_8454

      DOI: 10.7554/eLife.65109

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    elifesciences.org/articles/65109
  185. www.sciencedirect.com www.sciencedirect.com
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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  186. www.nature.com www.nature.com
    Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
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    1. scibot 21 Nov 2021
      RRID:Addgene_8454

      DOI: 10.1038/s41467-021-26823-6

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    nature.com/articles/s41467-021-26823-6
  187. www.sciencedirect.com www.sciencedirect.com
    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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    1. scibot 12 Nov 2021
      RRID:Addgene_8454

      DOI: 10.1016/j.immuni.2021.10.011

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    sciencedirect.com/science/article/pii/S1074761321004489
  188. www.sciencedirect.com www.sciencedirect.com
    TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
    1
    1. scibot 10 Nov 2021
      plasmid_8454

      DOI: 10.1016/j.celrep.2021.109979

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    sciencedirect.com/science/article/pii/S2211124721014583
  189. www.sciencedirect.com www.sciencedirect.com
    Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action
    1
    1. scibot 03 Nov 2021
      Addgene, Cat# 8454

      DOI: 10.1016/j.celrep.2021.109918

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    sciencedirect.com/science/article/pii/S2211124721013917
  190. Oct 2021
  191. www.sciencedirect.com www.sciencedirect.com
    GEM-IL: A highly responsive fluorescent lactate indicator
    1
    1. scibot 22 Oct 2021
      8454

      DOI: 10.1016/j.crmeth.2021.100092

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    sciencedirect.com/science/article/pii/S2667237521001478
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system
    1
    1. scibot 02 Oct 2021
      RRID:Addgene_8454

      DOI: 10.1038/s41598-021-98657-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC8478948/
  193. Sep 2021
  194. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells
    1
    1. scibot 30 Sep 2021
      RRID:Addgene_8454

      DOI: 10.1111/gtc.12893

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    onlinelibrary.wiley.com/doi/10.1111/gtc.12893
  195. www.sciencedirect.com www.sciencedirect.com
    Lrp1 is a host entry factor for Rift Valley fever virus
    1
    1. scibot 24 Sep 2021
      RRID:Addgene_8454

      DOI: 10.1016/j.cell.2021.09.001

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    sciencedirect.com/science/article/pii/S0092867421010485
  196. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
    1
    1. scibot 23 Sep 2021
      Addgene_8454

      DOI: 10.1016/j.molcel.2021.08.034

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    sciencedirect.com/science/article/pii/S1097276521007140
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
    1
    1. scibot 04 Sep 2021
      RRID:Addgene_8454

      DOI: 10.1038/s41467-021-25187-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC8355319/
  198. www.sciencedirect.com www.sciencedirect.com
    Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome
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    1. scibot 02 Sep 2021
      Addgene: 8454

      DOI: 10.1016/j.celrep.2021.109597

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    sciencedirect.com/science/article/pii/S2211124721010354
  199. Aug 2021
  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
    1
    1. scibot 16 Aug 2021
      RRID:Addgene_8454

      DOI: 10.1091/mbc.E20-06-0382

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    ncbi.nlm.nih.gov/pmc/articles/PMC8351540/
  201. www.embopress.org www.embopress.org
    The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder
    1
    1. scibot 15 Aug 2021
      RRID:Addgene_8454

      DOI: 10.15252/embr.202051991

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    embopress.org/doi/abs/10.15252/embr.202051991
  202. www.sciencedirect.com www.sciencedirect.com
    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength
    1
    1. scibot 15 Aug 2021
      Addgene_8454

      DOI: 10.1016/j.celrep.2021.109467

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    sciencedirect.com/science/article/pii/S2211124721008901
  203. www.sciencedirect.com www.sciencedirect.com
    RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal
    1
    1. scibot 14 Aug 2021
      Addgene_8454

      DOI: 10.1016/j.celrep.2021.109451

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    sciencedirect.com/science/article/pii/S2211124721008688
  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Positive Role of c-Myc in Regulating Androgen Receptor and its Splice Variants in Prostate Cancer
    1
    1. scibot 14 Aug 2021
      plasmid_8454

      DOI: 10.1038/s41388-019-0768-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC6586509/
  205. www.sciencedirect.com www.sciencedirect.com
    Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2
    1
    1. scibot 11 Aug 2021
      Addgene Cat. #8454

      DOI: 10.1016/j.celrep.2021.109512

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    sciencedirect.com/science/article/pii/S2211124721009426
  206. www.sciencedirect.com www.sciencedirect.com
    UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
    1
    1. scibot 10 Aug 2021
      Plasmid_8454

      DOI: 10.1016/j.cell.2018.11.024

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    sciencedirect.com/science/article/pii/S0092867418315162
  207. www.sciencedirect.com www.sciencedirect.com
    The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base
    1
    1. scibot 09 Aug 2021
      plasmid_8454

      DOI: 10.1016/j.devcel.2017.05.016

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    sciencedirect.com/science/article/pii/S1534580717304240
  208. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 07 Aug 2021
      Addgene_8454

      DOI: 10.1016/j.chembiol.2018.10.026

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    sciencedirect.com/science/article/pii/S2451945618303866
  209. www.nature.com www.nature.com
    Untitled document
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    1. scibot 06 Aug 2021
      RRID:Addgene_8454

      DOI: 10.1038/s41598-018-37940-6

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    nature.com/articles/s41598-018-37940-6
  210. www.sciencedirect.com www.sciencedirect.com
    Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
    1
    1. scibot 06 Aug 2021
      Addgene_8454

      DOI: 10.1016/j.cell.2017.06.031

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    sciencedirect.com/science/article/pii/S0092867417307158
  211. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 04 Aug 2021
      Addgene_8454

      DOI: 10.1016/j.cell.2018.11.038

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    sciencedirect.com/science/article/pii/S0092867418315630
  212. Jul 2021
  213. www.sciencedirect.com www.sciencedirect.com
    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
    1
    1. scibot 31 Jul 2021
      Plasmid No. 8454

      DOI: 10.1016/j.cell.2021.07.005

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    sciencedirect.com/science/article/pii/S009286742100831X
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 31 Jul 2021
      RRID:Addgene_8454

      DOI: 10.1038/s41598-018-37940-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC6362041/
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 31 Jul 2021
      plasmid_8454

      DOI: 10.7554/eLife.41351

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    ncbi.nlm.nih.gov/pmc/articles/PMC6351101/
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity
    1
    1. scibot 30 Jul 2021
      RRID:Addgene_8454

      DOI: 10.7554/eLife.50036

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    ncbi.nlm.nih.gov/pmc/articles/PMC6897534/
  217. www.sciencedirect.com www.sciencedirect.com
    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
    1
    1. scibot 30 Jul 2021
      Addgene_8454

      DOI: 10.1016/j.molcel.2018.06.041

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      Curator: @Jmenke

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      RRIDCUR:Validated RRID:Addgene_8454
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    sciencedirect.com/science/article/pii/S1097276518305161
  218. www.sciencedirect.com www.sciencedirect.com
    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
    1
    1. scibot 29 Jul 2021
      Addgene: Cat#8454

      DOI: 10.1016/j.ccell.2019.10.004

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    sciencedirect.com/science/article/pii/S1535610819304787
  219. www.sciencedirect.com www.sciencedirect.com
    Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor
    1
    1. scibot 29 Jul 2021
      RRID: Addgene_8454

      DOI: 10.1016/j.celrep.2019.10.012

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    sciencedirect.com/science/article/pii/S2211124719313129