1,075 Matching Annotations
  1. Sep 2025
  2. www.sciencedirect.com www.sciencedirect.com
    The kinesin motor Kif9 regulates centriolar satellite positioning during interphase
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    sciencedirect.com/science/article/pii/S0960982225011303
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of Clostridium novyi-NT in Patients with Advanced Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12434394/
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
  5. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
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    jbiomedsci.biomedcentral.com/articles/10.1186/s12929-025-01185-z
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    Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70255
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    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12457572/
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    Phosphatidylserine-positive extracellular vesicles for detecting multiple operable cancers
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    sciencedirect.com/science/article/pii/S2211124725010307
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    GALNT7 stratifies dMMR/MSI colorectal cancer into distinct molecular subsets associated with prognosis and PD-L1 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12412012/
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    Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
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    sciencedirect.com/science/article/pii/S1097276525007002
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    Chemotherapy modulation by a cancer-associated microbiota metabolite
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    sciencedirect.com/science/article/pii/S2405471225002303
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    Pan-carcinoma sialyl-Tn-targeting expands CAR therapy to solid tumors
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    sciencedirect.com/science/article/pii/S2666379125004239
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    A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875992/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA | The EMBO Journal
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402098/
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    DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396291/
  17. www.biorxiv.org www.biorxiv.org
    Sister chromatid separation determines the proliferative characteristics upon whole-genome duplication through homologous chromosome rearrangement
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    biorxiv.org/content/10.1101/2025.08.27.672736v1
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    Pharmacologic interrogation of USP28 cellular function in p53 signaling
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    sciencedirect.com/science/article/pii/S2451945625002326
  19. Aug 2025
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    Design of a selective peptide inhibitor targeting KDM5C demethylase activity
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    sciencedirect.com/science/article/pii/S096921262500303X
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    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  22. rupress.org rupress.org
    Identification of organelle-specific autophagy regulators from tandem CRISPR screens
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    rupress.org/jcb/article/224/10/e202405138/278221/Identification-of-organelle-specific-autophagy
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    Lifespan-Regulated CAR-Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202417677
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    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    sciencedirect.com/science/article/pii/S2211124725009593
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    A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
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    sciencedirect.com/science/article/pii/S1097276525006513
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    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    biorxiv.org/content/10.1101/2025.08.13.669992v1
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    Characterizing Compounds Targeting Colorectal Cancer Derived From Monastrol Using High-Through Screening of an Extensive Combinatorial Library
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    biorxiv.org/content/10.1101/2025.08.07.667829v1
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    Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains.
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    sciencedirect.com/science/article/pii/S0014299925008362
  29. 52.53.155.43 52.53.155.43
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    Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    Development and Preclinical Evaluation of CDH17-Specific ImmunoPET Imaging in Colorectal Cancers
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    pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00525
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-dependent mechanosensing by cells derived from human tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328224/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12292646/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
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    Combined MEK and PARP inhibition enhances radiation response in rectal cancer
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  37. www.cell.com www.cell.com
    Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system
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    cell.com/cell-systems/fulltext/S2405-4712(25)00184-X
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11802306/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314522/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12318036/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SDR42E1 modulates vitamin D absorption and cancer pathogenesis: insights from an in vitro model
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  44. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70137
  45. Jul 2025
  46. www.oaepublish.com www.oaepublish.com
    CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis
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    oaepublish.com/articles/cdr.2025.76
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    Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
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    sciencedirect.com/science/article/pii/S2211124725008617
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    14-3-3ɛ inhibits premature centriole disengagement by inhibiting the activity of Plk1 and Separase
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    pmc.ncbi.nlm.nih.gov/articles/PMC12301659/
  49. www.biorxiv.org www.biorxiv.org
    Mitotic slippage causes nuclear instability in polyploid cells
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    biorxiv.org/content/10.1101/2025.07.21.665898v1
  50. 52.53.155.43 52.53.155.43
    Forkhead box M1 mediates metabolic reprogramming in human colorectal cancer cells | American Journal of Physiology-Gastrointestinal and Liver Physiology
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  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12267056/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260813/
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    Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness
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    sciencedirect.com/science/article/pii/S221112472500720X
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
  55. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70075
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns
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    pmc.ncbi.nlm.nih.gov/articles/PMC12235874/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer
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    Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer
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    Physicochemical characterization and biological evaluation of amorphous solid dispersions of an anticancerous drug: Erlotinib HCl
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    nature.com/articles/s41598-025-07692-1
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    Protocol to detect m22G modification on single tRNA iso-decoders by immuno-northern blotting
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    sciencedirect.com/science/article/pii/S2666166725003302
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    Scalable screening of ternary-code DNA methylation dynamics associated with human traits
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    Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LCN2 promotes focal adhesion formation and invasion by stimulating c-Src activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12188317/
  64. www.biorxiv.org www.biorxiv.org
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  65. Jun 2025
  66. www.cell.com www.cell.com
    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    Targeting ceramide synthases for the development of new antifungals
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    sciencedirect.com/science/article/pii/S0969212625002138
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  71. www.nature.com www.nature.com
    PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
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    nature.com/articles/s41388-025-03468-z
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine
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    pmc.ncbi.nlm.nih.gov/articles/PMC12173229/
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    Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
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    sciencedirect.com/science/article/pii/S2451945625001734
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pleiotropic Effects of Metformin on the Chemotherapy Response of HPV‐Positive Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169209/
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    Enhancing anti-tumor immunity of natural killer cells through targeting IL-15R signaling
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    sciencedirect.com/science/article/pii/S153561082500220X
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127332/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11614700/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127799/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132575/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The solute carrier superfamily interactome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130317/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic mapping of the human solute carrier superfamily
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130231/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The genetic interaction map of the human solute carrier superfamily
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130552/
  83. www.sciencedirect.com www.sciencedirect.com
    Protocol to analyze tRNA and rRNA processing using biotin-labeled probes
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    sciencedirect.com/science/article/pii/S2666166725002722
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127464/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hypoxic HPV‐Positive Cancer Cells Are Particularly Sensitive to the Pro‐Senescent Effects of B‐MYB Repression Due to the Lack of Compensatory A‐MYB Induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12123558/
  86. May 2025
  87. www.sciencedirect.com www.sciencedirect.com
    Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity
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    sciencedirect.com/science/article/pii/S1931312825001830
  88. 52.53.155.43 52.53.155.43
    PDF-html.html
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    YTHDF1 differentiates the contributing roles of mTORC1 in aging
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    sciencedirect.com/science/article/pii/S1097276525004083
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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