509 Matching Annotations
  1. Apr 2025
  2. www.sciencedirect.com www.sciencedirect.com
    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962400/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
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    Unveiling transcriptional mechanisms of B7-H3 in breast cancer stem cells through proteomic approaches
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    sciencedirect.com/science/article/pii/S2589004225004791
  6. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  7. Mar 2025
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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    sciencedirect.com/science/article/pii/S107476132500072X
  9. Feb 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The IGF2BP1 oncogene is a druggable m6A-dependent enhancer of YAP1-driven gene expression in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850222/
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    SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer
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    sciencedirect.com/science/article/pii/S0304383525001508
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    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
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    Targeting Tumor-Associated Sialic Acids using Chimeric Switch Receptors based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells
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    aacrjournals.org/cancerimmunolres/article/12/10/1380/748721/Targeting-Tumor-Associated-Sialic-Acids-Using
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    Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC11783622/
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    1-s2.0-S2589004225002160-main-html.html
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  17. Jan 2025
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    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
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    mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
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    sciencedirect.com/science/article/pii/S2211124724015304
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    The design of the spheroids-based in vitro tumor model determines its biomimetic properties
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    Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense
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  23. Dec 2024
  24. www.cell.com www.cell.com
    Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine
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    MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11612619/
  28. Nov 2024
  29. www.sciencedirect.com www.sciencedirect.com
    Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
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    Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint
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  31. www.biorxiv.org www.biorxiv.org
    Biases in the Parsortix® system observed with pancreatic cancer cell lines
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    biorxiv.org/content/10.1101/2024.11.05.621344v1
  32. www.sciencedirect.com www.sciencedirect.com
    CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
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    A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
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    Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
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  35. Oct 2024
  36. www.sciencedirect.com www.sciencedirect.com
    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11448066/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443249/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual-hit strategy for therapeutic targeting of pancreatic cancer in patient-derived xenograft tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11019863/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11437985/
  41. Sep 2024
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered epitopes enhance macrophage-mediated anti-tumour immunity to low-immunogenic tumour mutations
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    onlinelibrary.wiley.com/doi/10.1111/imm.13854
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    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC11412720/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MicroRNA-26a-5p is a reliable biomarker in the adjuvant setting for pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407630/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11394991/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of oxidative- and endoplasmic-reticulum-stress dependent apoptosis in pancreatic cancer cell lines by DDOST knockdown
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369111/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  49. Aug 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11347226/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11326289/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11331593/
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    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124724009835
  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    In Vitro and In Vivo Effects of Melatonin-Containing Combinations in Human Pancreatic Ductal Adenocarcinoma
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    onlinelibrary.wiley.com/doi/10.1111/jpi.12997
  55. www.mdpi.com www.mdpi.com
    Characterization of Chemoresistance in Pancreatic Cancer: A Look at MDR-1 Polymorphisms and Expression in Cancer Cells and Patients
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  56. 52.53.155.43 52.53.155.43
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    52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html
  57. www.researchsquare.com www.researchsquare.com
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  58. www.embopress.org www.embopress.org
    Unexpected PD‐L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies
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    embopress.org/doi/full/10.15252/emmm.202012716
  59. Jul 2024
  60. 52.53.155.43 52.53.155.43
    Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway
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    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
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    sciencedirect.com/science/article/pii/S1535610824002174
  62. www.thelancet.com www.thelancet.com
    Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00254-8/abstract
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238362/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
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  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pantoprazole and riluzole target H+/K+-ATPases and pH-sensitive K+ channels in pancreatic cancer cells
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35076
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    The YY1-CPT1C signaling axis modulates the proliferation and metabolism of pancreatic tumor cells under hypoxia
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11190739/
  68. Jun 2024
  69. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles
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    onlinelibrary.wiley.com/doi/10.1002/cam4.7318
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer
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  71. May 2024
  72. www.biorxiv.org www.biorxiv.org
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    biorxiv.org/content/10.1101/2024.03.12.584316v1
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    sciencedirect.com/science/article/pii/S1097276524003939
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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  75. 52.53.155.43 52.53.155.43
    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    Ubiquitin-mediated regulation of APE2 protein abundance
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    sciencedirect.com/science/article/pii/S0021925824018386
  77. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Disrupting the interaction between a p53 gain-of-function mutant and the transcriptional co-activator PC4 reverses drug resistance in cancer cells
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14890
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    PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer
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  79. Apr 2024
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BUB1 Promotes Gemcitabine Resistance in Pancreatic Cancer Cells by Inhibiting Ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11048608/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11044319/
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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  83. jhoonline.biomedcentral.com jhoonline.biomedcentral.com
    Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
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    jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01538-5
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    QDPR deficiency drives immune suppression in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1550413124001190
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    Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis
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    sciencedirect.com/science/article/pii/S0925443924001728
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34960
  87. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13609
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Non-Viral DNA Delivery System Consisting of Multifunctional Chimaeric Peptide Fused with Zinc Finger Protein
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    ncbi.nlm.nih.gov/pmc/articles/PMC10981093/
  90. Mar 2024
  91. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    sciencedirect.com/science/article/pii/S2451945624000874
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    Hyperthermia improves gemcitabine sensitivity of pancreatic cancer cells by suppressing the EFNA4/β-catenin axis and activating dCK
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    sciencedirect.com/science/article/pii/S2405844024045195
  93. academic.oup.com academic.oup.com
    LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgae011/7608949
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924943/
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    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
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    sciencedirect.com/science/article/pii/S2666379124001058
  96. Feb 2024
  97. 52.53.155.43 52.53.155.43
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  98. aacrjournals.org aacrjournals.org
    Mitochondrial translocase TOMM22 is overexpressed in pancreatic cancer and promotes aggressive growth by modulating mitochondrial protein import and function
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  120. Dec 2023
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  124. Nov 2023
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  130. Oct 2023
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  134. Sep 2023
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  148. Jul 2023
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  152. Jun 2023
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  157. May 2023
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  164. Apr 2023
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  170. Jan 2023
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  174. Dec 2022
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  180. Nov 2022
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  186. Oct 2022
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  191. Sep 2022
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  197. Aug 2022
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  202. Jul 2022
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  207. Jun 2022
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  209. May 2022
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  213. Apr 2022
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  217. Mar 2022
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  226. Jan 2022
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  232. Dec 2021
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    Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells
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