448 Matching Annotations
  1. Last 7 days
  2. aacrjournals.org aacrjournals.org
    Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
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    aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Combination of a BCL-xL PROTAC and an mTOR Inhibitor Sensitizes Pancreatic Ductal Adenocarcinoma to KRASG12D Inhibitor Treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13025216/
  4. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
  7. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517184
  8. Mar 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011749/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Radiation-Enhanced CD24 Membrane Trafficking via GPI Anchoring Mediates Anti-Tumor Immune Evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012240/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003987/
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    Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification
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    sciencedirect.com/science/article/pii/S2451945626000711
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    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  14. www.biorxiv.org www.biorxiv.org
    L-Lactate reprograms tumor-associated macrophages to drive pancreatic cancer progression via BCL3 lactylation
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    biorxiv.org/content/10.64898/2026.03.06.710237v1
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
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    DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4
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    sciencedirect.com/science/article/pii/S0898656826000963
  17. Feb 2026
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
  19. www.science.org www.science.org
    KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors
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    science.org/doi/10.1126/sciadv.aea2511
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12922744/
  21. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
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    A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity
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    sciencedirect.com/science/article/pii/S266723752600007X
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    sciencedirect.com/science/article/pii/S0092867425015028
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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    sciencedirect.com/science/article/pii/S2211124726000343
  25. pubs.acs.org pubs.acs.org
    5′-NucA-SMCC-DM1 and 5′-NucA-SPDMV-DM1 are Potent Aptamer–Drug Conjugates against Pancreatic Cancer
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    pubs.acs.org/doi/full/10.1021/acsomega.5c11364
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING
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    pmc.ncbi.nlm.nih.gov/articles/PMC12868630/
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    USP20–RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake
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    sciencedirect.com/science/article/pii/S0304383526000625
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Supplemental_Material.pdf
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  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859874/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316562/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Estrogen Production in Pancreatic Cancer Shapes a Tumor Suppressive Stromal Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12862343/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859075/
  33. Jan 2026
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12846757/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12823056/
  37. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513020
  38. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  39. www.sciencedirect.com www.sciencedirect.com
    In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment
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    sciencedirect.com/science/article/pii/S2211124725015992
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833852/
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    Local mechanobiological disruption in solid tumor-driven vascular permeability: a competition between mechanical vs chemical stimuli
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    sciencedirect.com/science/article/pii/S1742706126000243
  42. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  43. Dec 2025
  44. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12717533/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrated Multiomics Unravels Hedgehog (HH) Signaling Characteristics in Pancreatic Cancer (PC) and DCBLD2 Regulates HH Signaling to Drive PC Progression
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    onlinelibrary.wiley.com/doi/full/10.1155/humu/4806397
  48. 54.241.53.176 54.241.53.176
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
  50. www.biorxiv.org www.biorxiv.org
    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
  51. www.nature.com www.nature.com
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137021/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  55. 54.241.53.176 54.241.53.176
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  56. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy
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    sciencedirect.com:5037/science/article/pii/S1550413125004759
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  58. Nov 2025
  59. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225025544-main-html.html
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  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594208/
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    sciencedirect.com/science/article/pii/S1097276525008913
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effects of Juglone on Cell Proliferation and Insulin-Like Growth Factor I Receptor/Phosphoinositide 3-Kinase/p85 (IGF-IR/PI3K/p85) Signaling Pathway in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12478651/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623807/
  64. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12605405/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
  67. www.sciencedirect.com www.sciencedirect.com
    Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells
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    sciencedirect.com/science/article/pii/S2666379125005191
  68. 54.241.53.176 54.241.53.176
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  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Use of a Foamy‐Virus Vector System to Produce an ‘Off‐the‐Shelf’ Fcγ‐CR‐T Cell Product for the Treatment of Haematological and Solid Tumour Malignancies
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    OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis
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    sciencedirect.com/science/article/pii/S0898656825006321
  71. 54.241.53.176 54.241.53.176
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  72. Oct 2025
  73. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
  74. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513552
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
  76. www.sciencedirect.com www.sciencedirect.com
    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124725012045
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    Super-adjuvant nanoparticles for platform cancer vaccination
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    sciencedirect.com/science/article/pii/S2666379125004884
  78. 54.241.53.176 54.241.53.176
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
  80. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  82. www.sciencedirect.com www.sciencedirect.com
    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
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    sciencedirect.com/science/article/pii/S221112472501143X
  83. www.sciencedirect.com www.sciencedirect.com
    Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
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    sciencedirect.com/science/article/pii/S1535610825003952
  84. Sep 2025
  85. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
  86. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12426058/
  88. 52.53.155.43 52.53.155.43
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    Phosphatidylserine-positive extracellular vesicles for detecting multiple operable cancers
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  189. Sep 2024
  190. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  191. www.sciencedirect.com www.sciencedirect.com
    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MicroRNA-26a-5p is a reliable biomarker in the adjuvant setting for pancreatic ductal adenocarcinoma
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer
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  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of oxidative- and endoplasmic-reticulum-stress dependent apoptosis in pancreatic cancer cell lines by DDOST knockdown
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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  197. Aug 2024
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer
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  201. www.sciencedirect.com www.sciencedirect.com
    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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  202. onlinelibrary.wiley.com onlinelibrary.wiley.com
    In Vitro and In Vivo Effects of Melatonin-Containing Combinations in Human Pancreatic Ductal Adenocarcinoma
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    Characterization of Chemoresistance in Pancreatic Cancer: A Look at MDR-1 Polymorphisms and Expression in Cancer Cells and Patients
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  205. www.researchsquare.com www.researchsquare.com
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    Unexpected PD‐L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies
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  207. Jul 2024
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    Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway
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  210. www.thelancet.com www.thelancet.com
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
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  213. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  216. Jun 2024
  217. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  219. May 2024
  220. www.biorxiv.org www.biorxiv.org
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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