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  2. 54.241.53.176 54.241.53.176
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    Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
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    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
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    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
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    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
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    Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137021/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  9. 54.241.53.176 54.241.53.176
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    Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy
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    sciencedirect.com:5037/science/article/pii/S1550413125004759
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    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  12. Nov 2025
  13. 54.241.53.176 54.241.53.176
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    SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594208/
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    sciencedirect.com/science/article/pii/S1097276525008913
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    The Effects of Juglone on Cell Proliferation and Insulin-Like Growth Factor I Receptor/Phosphoinositide 3-Kinase/p85 (IGF-IR/PI3K/p85) Signaling Pathway in Pancreatic Cancer
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  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623807/
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    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
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    A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells
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  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells
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    Use of a Foamy‐Virus Vector System to Produce an ‘Off‐the‐Shelf’ Fcγ‐CR‐T Cell Product for the Treatment of Haematological and Solid Tumour Malignancies
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    OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis
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  26. Oct 2025
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    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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  34. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
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    Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
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  38. Sep 2025
  39. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
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    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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    Phosphatidylserine-positive extracellular vesicles for detecting multiple operable cancers
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    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
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    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
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    HuR-regulated extracellular vesicles promote endothelial cell remodeling in pancreatic cancer
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  49. Aug 2025
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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    Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
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    The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity
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  54. pubs.acs.org pubs.acs.org
    A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells
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    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    ‘Smart’ Polymer Sandwiches From Hydrogel Nanocoatings Attached to Stimuli-Responsive Grafted Brush Coatings: Changing the Cell Behavior
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
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  68. Jul 2025
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    A novel defined manganese metabolism‑related gene signature for predicting the prognosis of pancreatic ductal adenocarcinoma
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    The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12279627/
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    nature.com/articles/s41598-025-09411-2
  76. www.science.org www.science.org
    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    science.org/doi/10.1126/sciimmunol.adr1105
  77. www.science.org www.science.org
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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  80. Jun 2025
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    EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70066
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    Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12173530/
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    Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer
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    Cachexia-induced reprogramming of visceral organ metabolism by human pancreatic cancer xenografts
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    Metastatic breast cancer cells adapt to a soft environment with limited involvement of mechanotransduction
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  192. Mar 2024
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  198. Feb 2024
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  211. Jan 2024
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