292 Matching Annotations
  1. Mar 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aβ*56 is a stable oligomer that impairs memory function in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905009/
  3. Feb 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional connectivity favors aberrant visual network c-Fos expression accompanied by cortical synapse loss in amyloidosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9881957/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11339108/
  6. www.sciencedirect.com www.sciencedirect.com
    Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
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    sciencedirect.com/science/article/pii/S1074761324000323
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  8. Jan 2024
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Over-expression of N-acetylaspartate synthase exacerbates pathological energetic deficit and accelerates cognitive decline in the 5xFAD mouse
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16044
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    Current mouse models of Alzheimer’s disease for investigating therapeutic agents
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    sciencedirect.com/science/article/pii/B978032389833100015X
  11. www.biorxiv.org www.biorxiv.org
    An inducible genetic tool for tracking and manipulating specific microglial states in development and disease
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    biorxiv.org/content/10.1101/2023.12.01.569597v1
  12. www.mdpi.com www.mdpi.com
    Long-Term Administration of Vespa velutina nigrithorax Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice
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    mdpi.com/2072-6651/15/3/203
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    The 5XFAD mouse model of Alzheimer’s disease displays age-dependent deficits in habituation to a novel environment
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    sciencedirect.com/science/article/pii/S2589958923000154
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    Bezafibrate confers neuroprotection in the 5xFAD mouse model of Alzheimer's disease
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    sciencedirect.com/science/article/pii/S0925443923002077
  15. www.biorxiv.org www.biorxiv.org
    Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain
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    biorxiv.org/content/10.1101/2023.12.06.570499v1
  16. www.mdpi.com www.mdpi.com
    Effect Sizes of Cognitive and Locomotive Behavior Tests in the 5XFAD-J Mouse Model of Alzheimer’s Disease
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    mdpi.com/1422-0067/24/20/15064
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    Recent approaches in regenerative medicine in the fight against neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0006899323004596
  18. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00598-4
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease
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    onlinelibrary.wiley.com/doi/full/10.1002/hipo.23586
  20. link.springer.com link.springer.com
    Increased α-2,6 sialic acid on microglia in amyloid pathology is resistant to oseltamivir
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    link.springer.com/article/10.1007/s11357-023-00761-1
  21. www.eneuro.org www.eneuro.org
    Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia
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    eneuro.org/content/10/11/ENEURO.0422-23.2023
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Brain metabolic network covariance and aging in a mouse model of Alzheimer's disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC10984484/
  23. www.biorxiv.org www.biorxiv.org
    Levetiracetam Modulates Brain Metabolic Networks and Transcriptomic Signatures in the 5XFAD Mouse Model of Alzheimer’s disease
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    biorxiv.org/content/10.1101/2023.11.10.566574v2
  24. Nov 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S2211124723014043
  26. Sep 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S1074761323003643
  28. Aug 2023
  29. 52.53.155.43 52.53.155.43
    PIIS2211124723009671-html.html
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    52.53.155.43/0930b1a126a7ba8f04174ca993466b0fe3a7955f/PIIS2211124723009671-html.html
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct molecular profiles of skull bone marrow in health and neurological disorders
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    pmc.ncbi.nlm.nih.gov/articles/PMC10443631/
  31. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease
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    cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01085-5
  32. Jul 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function
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    ncbi.nlm.nih.gov/pmc/articles/PMC10360091/
  34. www.sciencedirect.com www.sciencedirect.com
    Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
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    sciencedirect.com/science/article/pii/S0896627323004373
  35. Jun 2023
  36. www.biorxiv.org www.biorxiv.org
    Genetic background influences the 5XFAD Alzheimer’s disease mouse model brain proteome
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    biorxiv.org/content/10.1101/2023.06.12.544646v1
  37. May 2023
  38. www.mdpi.com www.mdpi.com
    New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs
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    mdpi.com/2073-4409/11/16/2538/htm
  39. genomemedicine.biomedcentral.com genomemedicine.biomedcentral.com
    PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
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    genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01022-0
  40. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice
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    onlinelibrary.wiley.com/doi/full/10.1111/cpr.13085
  41. Apr 2023
  42. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study
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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12329
  43. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease
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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12849
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MAC2 is a long-lasting marker of peripheral cell infiltrates into the mouse CNS after bone marrow transplantation and coronavirus infection
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    onlinelibrary.wiley.com/doi/full/10.1002/glia.24144
  45. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12577
  46. Mar 2023
  47. journals.asm.org journals.asm.org
    Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer’s Disease
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    journals.asm.org/doi/10.1128/mbio.01794-22
  48. www.biorxiv.org www.biorxiv.org
    Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease
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    biorxiv.org/content/10.1101/2022.12.08.519685v1
  49. www.biorxiv.org www.biorxiv.org
    Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s disease
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    biorxiv.org/content/10.1101/2021.09.09.459627v1
  50. www.biorxiv.org www.biorxiv.org
    Hypothalamic gene network dysfunction is associated with cognitive decline and body weight loss in Alzheimer’s disease mice
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    biorxiv.org/content/10.1101/2022.04.08.487664v1
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC9547933/
  52. rupress.org rupress.org
    Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading
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    rupress.org/jem/article/220/1/e20220654/213537/Chronic-TREM2-activation-exacerbates-A-associated
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC9260256/
  54. www.sciencedirect.com www.sciencedirect.com
    INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia
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    sciencedirect.com/science/article/pii/S0969996121000528
  55. www.frontiersin.org www.frontiersin.org
    Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation
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    frontiersin.org/articles/10.3389/fimmu.2022.749336/full
  56. www.biorxiv.org www.biorxiv.org
    Longitudinal analysis of the gut microbiome in the 5xfAD mouse model of Alzheimer’s disease
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    biorxiv.org/content/10.1101/2022.03.02.482725v1
  57. Jan 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Spatial proteomics in three-dimensional intact specimens
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    sciencedirect.com/science/article/pii/S0092867422014659
  59. 52.53.155.43 52.53.155.43
    SSRN-id4168479-html.html
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    52.53.155.43/d01d75886eb8224e85413144472a36c3a6fa9512/SSRN-id4168479-html.html
  60. Dec 2022
  61. www.tandfonline.com www.tandfonline.com
    Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
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    tandfonline.com/doi/full/10.1080/19420862.2022.2107971
  62. Nov 2022
  63. link.springer.com link.springer.com
    Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
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    link.springer.com/article/10.1007/s12035-022-03111-y
  64. Aug 2022
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC9368483/
  66. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice
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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12317
  67. Apr 2022
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD
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    ncbi.nlm.nih.gov/pmc/articles/PMC8471964/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages
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    ncbi.nlm.nih.gov/pmc/articles/PMC8343228/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased tauopathy drives microglia-mediated clearance of beta-amyloid
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    ncbi.nlm.nih.gov/pmc/articles/PMC4918195/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Practical considerations for choosing a mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC5741956/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in the molecular signature of the developing mouse hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC5356301/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8081927/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MicroRNA-485-3p Blocks Alzheimer’s Disease Progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC8658496/
  75. Nov 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC8605573/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC8519958/
  78. Oct 2021
  79. www.sciencedirect.com www.sciencedirect.com
    Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice
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    sciencedirect.com/science/article/pii/S2666166721006213
  80. Aug 2021
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study
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    ncbi.nlm.nih.gov/pmc/articles/PMC8346252/
  83. Jul 2021
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic background modifies CNS‐mediated sensorimotor decline in the AD‐BXD mouse model of genetic diversity in Alzheimer's disease
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    onlinelibrary.wiley.com/doi/full/10.1111/gbb.12603
  85. www.nature.com www.nature.com
    Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
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    nature.com/articles/s41467-019-12242-1
  86. content.iospress.com content.iospress.com
    5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer’s Disease
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad180678
  87. www.nature.com www.nature.com
    3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice
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    nature.com/articles/s42003-019-0599-8
  88. www.osapublishing.org www.osapublishing.org
    Supervised learning to quantify amyloidosis in whole brains of an Alzheimer’s disease mouse model acquired with optical projection tomography
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    osapublishing.org/boe/fulltext.cfm
  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ultrasensitive Multiparameter Phenotyping of Rare Cells Using an Integrated Digital-Molecular-Counting Microfluidic Well Plate
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    onlinelibrary.wiley.com/doi/full/10.1002/smll.202101743
  90. www.sciencedirect.com www.sciencedirect.com
    Tetrandrine Ameliorated Alzheimer's Disease through Suppressing Microglial Inflammatory Activation and Neurotoxicity in the 5XFAD Mouse
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    sciencedirect.com/science/article/pii/S0944711321001707
  91. Jun 2021
  92. rupress.org rupress.org
    Activated microglia mitigate Aβ-associated tau seeding and spreading
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    rupress.org/jem/article/218/8/e20210542/212263/Activated-microglia-mitigate-A-associated-tau
  93. May 2021
  94. link.springer.com link.springer.com
    MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
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    link.springer.com/article/10.1186/s12868-021-00643-2
  95. Mar 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC7921657/
  97. Jan 2021
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7532726/
  99. Nov 2020
  100. onlinelibrary.wiley.com onlinelibrary.wiley.com
    CD11a expression distinguishes infiltrating myeloid cells from plaque‐associated microglia in Alzheimer's disease
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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23575
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
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    ncbi.nlm.nih.gov/pmc/articles/PMC7399129/
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7402118/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC7438734/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC7472639/
  105. Sep 2020
  106. link.springer.com link.springer.com
    Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer’s disease
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    link.springer.com/article/10.1186/s13195-020-00656-9
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptome Analysis of Pineal Glands in the Mouse Model of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC6962250/
  108. www.sciencedirect.com www.sciencedirect.com
    Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology: Running title: BPSD in Alzheimer’s disease models
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    sciencedirect.com/science/article/pii/S0149763419304695
  109. www.sciencedirect.com www.sciencedirect.com
    An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0165027018301602
  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice
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    onlinelibrary.wiley.com/doi/full/10.1002/jnr.24578
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Harnessing genetic complexity to enhance translatability of Alzheimer’s disease mouse models: a path towards experimental precision medicine
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    ncbi.nlm.nih.gov/pmc/articles/PMC6886697/
  112. rupress.org rupress.org
    Plaque-associated myeloid cells derive from resident microglia in an Alzheimer’s disease model
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    rupress.org/jem/article/217/4/e20191374/133630/Plaque-associated-myeloid-cells-derive-from
  113. www.nature.com www.nature.com
    3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice
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  114. May 2019
  115. www.karger.com www.karger.com
    Deletion of the Inflammasome Sensor Aim2 Mitigates Aβ Deposition and Microglial Activation but Increases Inflammatory Cytokine Expression in an Alzheimer Disease Mouse Model
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    karger.com/Article/FullText/477092
  116. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-018-0239-7
  117. www.osapublishing.org www.osapublishing.org
    Optical projection tomography for rapid whole mouse brain imaging
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  118. www.sciencedirect.com www.sciencedirect.com
    Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
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    sciencedirect.com/science/article/pii/S107476131830075X