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  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression
    1
    1. scibot 16 Jul 2024
      Jackson Laboratory)034848

      DOI: 10.1016/j.celrep.2024.114488

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    sciencedirect.com/science/article/pii/S2211124724008179
  3. Jun 2024
  4. link.springer.com link.springer.com
    Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice
    1
    1. scibot 30 Jun 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1186/s12974-024-03146-z

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    link.springer.com/article/10.1186/s12974-024-03146-z
  5. May 2024
  6. www.sciencedirect.com www.sciencedirect.com
    An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination
    1
    1. scibot 31 May 2024
      MMRRC_034848

      DOI: 10.1016/j.immuni.2024.05.005

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    sciencedirect.com/science/article/pii/S1074761324002589
  7. www.nature.com www.nature.com
    Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice
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    1. scibot 21 May 2024
      34848-JAX

      DOI: 10.1038/s41467-024-47996-w

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      RRID:MMRRC_034848-JAX DOI:10.1038/s41467-024-47996-w
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    nature.com/articles/s41467-024-47996-w
  8. Apr 2024
  9. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Peripheral HMGB1 is linked to O3 pathology of disease-associated astrocytes and amyloid
    1
    1. scibot 17 Apr 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1002/alz.13825

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    alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13825
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease
    1
    1. scibot 11 Apr 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.3389/fphar.2024.1365051

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    ncbi.nlm.nih.gov/pmc/articles/PMC10989684/
  11. www.biorxiv.org www.biorxiv.org
    Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in mice
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    1. scibot 02 Apr 2024
      034848

      DOI: 10.1101/2024.01.27.573841

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    biorxiv.org/content/10.1101/2024.01.27.573841v1
  12. www.nature.com www.nature.com
    New rabies viral resources for multi-scale neural circuit mapping
    1
    1. scibot 02 Apr 2024
      034848-JAX

      DOI: 10.1038/s41380-024-02451-6

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    nature.com/articles/s41380-024-02451-6
  13. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
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    1. scibot 02 Apr 2024
      034848-JAX, MMRRC

      DOI: 10.1002/alz.13753

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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13753
  14. Mar 2024
  15. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease
    1
    1. scibot 31 Mar 2024
      34848

      DOI: 10.1002/alz.13767

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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13767
  16. www.nature.com www.nature.com
    Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
    1
    1. scibot 31 Mar 2024
      34848-JAX

      DOI: 10.1038/s44161-024-00445-9

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    nature.com/articles/s44161-024-00445-9
  17. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage
    1
    1. scibot 31 Mar 2024
      34848

      DOI: 10.1002/alz.13783

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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13783
  18. www.sciencedirect.com www.sciencedirect.com
    The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s Disease
    1
    1. scibot 08 Mar 2024
      The Jackson LaboratoryCat# 34848-JAX

      DOI: 10.1016/j.isci.2024.109281

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      Curator: @abever99

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    sciencedirect.com/science/article/pii/S2589004224005029
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aβ*56 is a stable oligomer that impairs memory function in mice
    1
    1. scibot 06 Mar 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.isci.2024.109239

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    ncbi.nlm.nih.gov/pmc/articles/PMC10905009/
  20. Feb 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional connectivity favors aberrant visual network c-Fos expression accompanied by cortical synapse loss in amyloidosis
    1
    1. scibot 11 Feb 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1101/2023.01.05.522900

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    ncbi.nlm.nih.gov/pmc/articles/PMC9881957/
  22. link.springer.com link.springer.com
    Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway
    1
    1. scibot 07 Feb 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1007/s12035-024-03990-3

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    link.springer.com/article/10.1007/s12035-024-03990-3
  23. www.sciencedirect.com www.sciencedirect.com
    Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
    1
    1. scibot 06 Feb 2024
      MMRRC_034848

      DOI: 10.1016/j.immuni.2024.01.008

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    sciencedirect.com/science/article/pii/S1074761324000323
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
    1
    1. scibot 01 Feb 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.isci.2024.108800

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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  25. Jan 2024
  26. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Over-expression of N-acetylaspartate synthase exacerbates pathological energetic deficit and accelerates cognitive decline in the 5xFAD mouse
    1
    1. scibot 09 Jan 2024
      RRID:MMRRC_034848-JAX

      DOI: 10.1111/jnc.16044

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16044
  27. www.sciencedirect.com www.sciencedirect.com
    Current mouse models of Alzheimer’s disease for investigating therapeutic agents
    1
    1. scibot 03 Jan 2024
      034848

      DOI: 10.1016/B978-0-323-89833-1.00015-X

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    sciencedirect.com/science/article/pii/B978032389833100015X
  28. www.biorxiv.org www.biorxiv.org
    An inducible genetic tool for tracking and manipulating specific microglial states in development and disease
    1
    1. scibot 03 Jan 2024
      034848-JAX

      DOI: 10.1101/2023.12.01.569597

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    biorxiv.org/content/10.1101/2023.12.01.569597v1
  29. www.mdpi.com www.mdpi.com
    Long-Term Administration of Vespa velutina nigrithorax Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice
    1
    1. scibot 03 Jan 2024
      034848-JAX

      DOI: 10.3390/toxins15030203

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    mdpi.com/2072-6651/15/3/203
  30. www.sciencedirect.com www.sciencedirect.com
    The 5XFAD mouse model of Alzheimer’s disease displays age-dependent deficits in habituation to a novel environment
    1
    1. scibot 03 Jan 2024
      MMRRC:034848

      DOI: 10.1016/j.nbas.2023.100078

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      RRIDCUR:Unresolved RRID:MMRRC_034848-JAX
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    sciencedirect.com/science/article/pii/S2589958923000154
  31. www.sciencedirect.com www.sciencedirect.com
    Bezafibrate confers neuroprotection in the 5xFAD mouse model of Alzheimer's disease
    1
    1. scibot 02 Jan 2024
      MMRRC stock #34848

      DOI: 10.1016/j.bbadis.2023.166841

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    sciencedirect.com/science/article/pii/S0925443923002077
  32. www.biorxiv.org www.biorxiv.org
    Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain
    1
    1. scibot 02 Jan 2024
      MMRRC #34848-JAX

      DOI: 10.1101/2023.12.06.570499

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    biorxiv.org/content/10.1101/2023.12.06.570499v1
  33. www.mdpi.com www.mdpi.com
    Effect Sizes of Cognitive and Locomotive Behavior Tests in the 5XFAD-J Mouse Model of Alzheimer’s Disease
    1
    1. scibot 02 Jan 2024
      MMRRC Stock #34848

      DOI: 10.3390/ijms242015064

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    mdpi.com/1422-0067/24/20/15064
  34. www.sciencedirect.com www.sciencedirect.com
    Recent approaches in regenerative medicine in the fight against neurodegenerative disease
    1
    1. scibot 02 Jan 2024
      034848-JAX

      DOI: 10.1016/j.brainres.2023.148688

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    sciencedirect.com/science/article/pii/S0006899323004596
  35. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    1
    1. scibot 02 Jan 2024
      34,848, MMRRC

      DOI: 10.1186/s13024-023-00598-4

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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00598-4
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease
    1
    1. scibot 02 Jan 2024
      34848-JAX

      DOI: 10.1002/hipo.23586

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    onlinelibrary.wiley.com/doi/full/10.1002/hipo.23586
  37. link.springer.com link.springer.com
    Increased α-2,6 sialic acid on microglia in amyloid pathology is resistant to oseltamivir
    1
    1. scibot 02 Jan 2024
      MMRRC #034848-JAX

      DOI: 10.1007/s11357-023-00761-1

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    link.springer.com/article/10.1007/s11357-023-00761-1
  38. www.eneuro.org www.eneuro.org
    Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia
    1
    1. scibot 02 Jan 2024
      MMRRC #034848-JAX

      DOI: 10.1523/ENEURO.0422-23.2023

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    eneuro.org/content/10/11/ENEURO.0422-23.2023
  39. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Brain metabolic network covariance and aging in a mouse model of Alzheimer's disease
    1
    1. scibot 02 Jan 2024
      MMRRC stock #: 34848

      DOI: 10.1002/alz.13538

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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13538
  40. www.biorxiv.org www.biorxiv.org
    Levetiracetam Modulates Brain Metabolic Networks and Transcriptomic Signatures in the 5XFAD Mouse Model of Alzheimer’s disease
    1
    1. scibot 02 Jan 2024
      JAX MMRRC stock #:34848

      DOI: 10.1101/2023.11.10.566574

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    biorxiv.org/content/10.1101/2023.11.10.566574v2
  41. Nov 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease
    1
    1. scibot 10 Nov 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.celrep.2023.113392

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    sciencedirect.com/science/article/pii/S2211124723014043
  43. Sep 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease
    1
    1. scibot 07 Sep 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.immuni.2023.08.008

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    sciencedirect.com/science/article/pii/S1074761323003643
  45. Aug 2023
  46. 52.53.155.43 52.53.155.43
    PIIS2211124723009671-html.html
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    1. scibot 18 Aug 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.celrep.2023.112956

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  47. 52.53.155.43 52.53.155.43
    Distinct molecular profiles of skull bone marrow in health and neurological disorders
    2
    1. scibot 18 Aug 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.cell.2023.07.009

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      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.cell.2023.07.009

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    52.53.155.43/c928f1fc8df3e142d491a4d3444ce9d61a708916/PIIS0092867423007420-html.html
  48. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease
    1
    1. scibot 01 Aug 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1186/s13578-023-01085-5

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    cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01085-5
  49. Jul 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function
    1
    1. scibot 25 Jul 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.4103/1673-5374.371379

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    ncbi.nlm.nih.gov/pmc/articles/PMC10360091/
  51. www.sciencedirect.com www.sciencedirect.com
    Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
    1
    1. scibot 06 Jul 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.neuron.2023.06.002

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    sciencedirect.com/science/article/pii/S0896627323004373
  52. Jun 2023
  53. www.biorxiv.org www.biorxiv.org
    Genetic background influences the 5XFAD Alzheimer’s disease mouse model brain proteome
    1
    1. scibot 22 Jun 2023
      RRID:MMRC_034848-JAX

      DOI: 10.1101/2023.06.12.544646

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    biorxiv.org/content/10.1101/2023.06.12.544646v1
  54. May 2023
  55. www.mdpi.com www.mdpi.com
    New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs
    1
    1. scibot 06 May 2023
      MMRRC Strain #034848-JAX

      DOI: 10.3390/cells11162538

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  56. genomemedicine.biomedcentral.com genomemedicine.biomedcentral.com
    PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
    1
    1. scibot 06 May 2023
      Stock# 034848

      DOI: 10.1186/s13073-022-01022-0

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    genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01022-0
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice
    1
    1. scibot 05 May 2023
      MMRRC ID 034848

      DOI: 10.1111/cpr.13085

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    onlinelibrary.wiley.com/doi/full/10.1111/cpr.13085
  58. Apr 2023
  59. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study
    1
    1. scibot 29 Apr 2023
      MMRRC stock #: 34848

      DOI: 10.1002/trc2.12329

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  60. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease
    1
    1. scibot 29 Apr 2023
      034848-JAX

      DOI: 10.1002/alz.12849

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  61. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MAC2 is a long-lasting marker of peripheral cell infiltrates into the mouse CNS after bone marrow transplantation and coronavirus infection
    1
    1. scibot 29 Apr 2023
      34848

      DOI: 10.1002/glia.24144

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.24144
  62. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
    1
    1. scibot 29 Apr 2023
      JAX MMRRC Stock #034848

      DOI: 10.1002/alz.12577

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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12577
  63. Mar 2023
  64. journals.asm.org journals.asm.org
    Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer’s Disease
    1
    1. scibot 23 Mar 2023
      34848-JAX

      DOI: 10.1128/mbio.01794-22

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    journals.asm.org/doi/10.1128/mbio.01794-22
  65. www.biorxiv.org www.biorxiv.org
    Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease
    1
    1. scibot 23 Mar 2023
      MMRRC Stock# 034848

      DOI: 10.1101/2022.12.08.519685

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    biorxiv.org/content/10.1101/2022.12.08.519685v1
  66. www.biorxiv.org www.biorxiv.org
    Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s disease
    1
    1. scibot 23 Mar 2023
      Stock No: 34848-JAX

      DOI: 10.1101/2021.09.09.459627

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    biorxiv.org/content/10.1101/2021.09.09.459627v1
  67. www.biorxiv.org www.biorxiv.org
    Hypothalamic gene network dysfunction is associated with cognitive decline and body weight loss in Alzheimer’s disease mice
    1
    1. scibot 23 Mar 2023
      34848-JAX

      DOI: 10.1101/2022.04.08.487664

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    biorxiv.org/content/10.1101/2022.04.08.487664v1
  68. www.sciencedirect.com www.sciencedirect.com
    Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration
    1
    1. scibot 22 Mar 2023
      34848-JAX

      DOI: 10.1016/j.neuron.2022.07.023

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    sciencedirect.com/science/article/pii/S0896627322006687
  69. rupress.org rupress.org
    Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading
    1
    1. scibot 22 Mar 2023
      stock no. 34848

      DOI: 10.1084/jem.20220654

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    rupress.org/jem/article/220/1/e20220654/213537/Chronic-TREM2-activation-exacerbates-A-associated
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
    1
    1. scibot 22 Mar 2023
      MMRRC Stock No: 34848-JAX

      DOI: 10.3389/fnagi.2022.912709

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    ncbi.nlm.nih.gov/pmc/articles/PMC9260256/
  71. www.sciencedirect.com www.sciencedirect.com
    INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia
    1
    1. scibot 18 Mar 2023
      Stock# 034848

      DOI: 10.1016/j.nbd.2021.105303

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    sciencedirect.com/science/article/pii/S0969996121000528
  72. www.frontiersin.org www.frontiersin.org
    Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation
    1
    1. scibot 18 Mar 2023
      Stock 34848

      DOI: 10.3389/fimmu.2022.749336

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    frontiersin.org/articles/10.3389/fimmu.2022.749336/full
  73. www.biorxiv.org www.biorxiv.org
    Longitudinal analysis of the gut microbiome in the 5xfAD mouse model of Alzheimer’s disease
    1
    1. scibot 18 Mar 2023
      34848-JAX

      DOI: 10.1101/2022.03.02.482725

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    biorxiv.org/content/10.1101/2022.03.02.482725v1
  74. Jan 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Spatial proteomics in three-dimensional intact specimens
    1
    1. scibot 10 Jan 2023
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.cell.2022.11.021

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    sciencedirect.com/science/article/pii/S0092867422014659
  76. 52.53.155.43 52.53.155.43
    SSRN-id4168479-html.html
    1
    1. scibot 06 Jan 2023
      MMRRC_034848

      DOI: 10.2139/ssrn.4168479

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  77. Dec 2022
  78. www.tandfonline.com www.tandfonline.com
    Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
    1
    1. scibot 23 Dec 2022
      B6. Cg-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax

      DOI: 10.1080/19420862.2022.2107971

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    tandfonline.com/doi/full/10.1080/19420862.2022.2107971
  79. Nov 2022
  80. link.springer.com link.springer.com
    Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
    1
    1. scibot 12 Nov 2022
      RRID:MMRRC_034848-JAX

      DOI: 10.1007/s12035-022-03111-y

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  81. Aug 2022
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease
    1
    1. scibot 22 Aug 2022
      RRID:MMRRC_034848-JAX

      DOI: 10.3390/cells11152413

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    ncbi.nlm.nih.gov/pmc/articles/PMC9368483/
  83. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice
    1
    1. scibot 09 Aug 2022
      MMRRC ID #34848

      DOI: 10.1002/trc2.12317

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    alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12317
  84. Apr 2022
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD
    1
    1. scibot 16 Apr 2022
      MMRRC Stock 34848

      DOI: 10.3390/biology10090938

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    ncbi.nlm.nih.gov/pmc/articles/PMC8471964/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages
    1
    1. scibot 16 Apr 2022
      MMRRC stock no. 34848

      DOI: 10.3389/fnins.2021.681831

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    ncbi.nlm.nih.gov/pmc/articles/PMC8343228/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased tauopathy drives microglia-mediated clearance of beta-amyloid
    1
    1. scibot 14 Apr 2022
      stock# 034848-JAX

      DOI: 10.1186/s40478-016-0336-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC4918195/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Practical considerations for choosing a mouse model of Alzheimer’s disease
    1
    1. scibot 14 Apr 2022
      34,848-JAX

      DOI: 10.1186/s13024-017-0231-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC5741956/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in the molecular signature of the developing mouse hippocampus
    1
    1. scibot 14 Apr 2022
      MMRRC stock number 034848-JAX

      DOI: 10.1186/s12864-017-3608-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC5356301/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity
    1
    1. scibot 09 Apr 2022
      MMRRC stock #034848

      DOI: 10.1016/j.jbc.2021.100508

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    ncbi.nlm.nih.gov/pmc/articles/PMC8081927/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MicroRNA-485-3p Blocks Alzheimer’s Disease Progression
    1
    1. scibot 07 Apr 2022
      MMRRC#034848

      DOI: 10.3390/ijms222313136

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    ncbi.nlm.nih.gov/pmc/articles/PMC8658496/
  92. Nov 2021
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
    1
    1. scibot 29 Nov 2021
      34848-JAX

      DOI: 10.1186/s12974-021-02297-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC8605573/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
    1
    1. scibot 03 Nov 2021
      34848-JAX

      DOI: 10.1038/s41597-021-01054-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC8519958/
  95. Oct 2021
  96. www.sciencedirect.com www.sciencedirect.com
    Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice
    1
    1. scibot 27 Oct 2021
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.xpro.2021.100915

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    sciencedirect.com/science/article/pii/S2666166721006213
  97. Aug 2021
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
    1
    1. scibot 25 Aug 2021
      RRID:MMRRC_034848-JAX

      DOI: 10.1016/j.isci.2021.102942

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    ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study
    1
    1. scibot 13 Aug 2021
      MMRRC stock #: 34848

      DOI: 10.3389/fnagi.2021.713726

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    ncbi.nlm.nih.gov/pmc/articles/PMC8346252/
  100. Jul 2021
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic background modifies CNS‐mediated sensorimotor decline in the AD‐BXD mouse model of genetic diversity in Alzheimer's disease
    1
    1. scibot 31 Jul 2021
      MMRRC Stock No: 34848‐JAX

      DOI: 10.1111/gbb.12603

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    onlinelibrary.wiley.com/doi/full/10.1111/gbb.12603
  102. www.nature.com www.nature.com
    Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
    1
    1. scibot 31 Jul 2021
      MMRRC Stock 34848

      DOI: 10.1038/s41467-019-12242-1

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    nature.com/articles/s41467-019-12242-1
  103. content.iospress.com content.iospress.com
    5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer’s Disease
    1
    1. scibot 29 Jul 2021
      MMRRC stock number: 34848-JAX

      DOI: 10.3233/JAD-180678

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    content.iospress.com/articles/journal-of-alzheimers-disease/jad180678
  104. www.nature.com www.nature.com
    3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice
    1
    1. scibot 29 Jul 2021
      034848-JAX

      DOI: 10.1038/s42003-019-0599-8

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    nature.com/articles/s42003-019-0599-8
  105. www.osapublishing.org www.osapublishing.org
    Supervised learning to quantify amyloidosis in whole brains of an Alzheimer’s disease mouse model acquired with optical projection tomography
    1
    1. scibot 28 Jul 2021
      34848-JAX, MMRRC

      DOI: 10.1364/BOE.10.003041

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    osapublishing.org/boe/fulltext.cfm
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ultrasensitive Multiparameter Phenotyping of Rare Cells Using an Integrated Digital-Molecular-Counting Microfluidic Well Plate
    1
    1. scibot 06 Jul 2021
      MMRRC Stock no. 034848-JAX

      DOI: 10.1002/smll.202101743

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    onlinelibrary.wiley.com/doi/full/10.1002/smll.202101743
  107. www.sciencedirect.com www.sciencedirect.com
    Tetrandrine Ameliorated Alzheimer's Disease through Suppressing Microglial Inflammatory Activation and Neurotoxicity in the 5XFAD Mouse
    1
    1. scibot 06 Jul 2021
      34848-JAX

      DOI: 10.1016/j.phymed.2021.153627

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    sciencedirect.com/science/article/pii/S0944711321001707
  108. Jun 2021
  109. rupress.org rupress.org
    Activated microglia mitigate Aβ-associated tau seeding and spreading
    1
    1. scibot 16 Jun 2021
      MMRRC; stock no. 34848-JAX

      DOI: 10.1084/jem.20210542

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    rupress.org/jem/article/218/8/e20210542/212263/Activated-microglia-mitigate-A-associated-tau
  110. May 2021
  111. link.springer.com link.springer.com
    MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
    1
    1. scibot 26 May 2021
      RRID:MMRRC_034848-JAX

      DOI: 10.1186/s12868-021-00643-2

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    link.springer.com/article/10.1186/s12868-021-00643-2
  112. Mar 2021
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
    1
    1. scibot 04 Mar 2021
      RRID:MMRRC_034848-JAX

      DOI: 10.1038/s41598-021-84318-2

      Resource: (MMRRC Cat# 034848-JAX,RRID:MMRRC_034848-JAX)

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC7921657/
  114. Jan 2021
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
    1
    1. scibot 01 Jan 2021
      34848-JAX

      DOI: 10.1016/j.celrep.2020.108169

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    ncbi.nlm.nih.gov/pmc/articles/PMC7532726/
  116. Nov 2020
  117. onlinelibrary.wiley.com onlinelibrary.wiley.com
    CD11a expression distinguishes infiltrating myeloid cells from plaque‐associated microglia in Alzheimer's disease
    1
    1. scibot 17 Nov 2020
      MMRRC stock no. 034848, JAX

      DOI: 10.1002/glia.23575

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23575
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
    1
    1. scibot 17 Nov 2020
      MMRRC; 034848-JAX

      DOI: 10.1016/j.ebiom.2020.102919

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    ncbi.nlm.nih.gov/pmc/articles/PMC7399129/
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression
    1
    1. scibot 17 Nov 2020
      MMRRC; 034848-JAX

      DOI: 10.3390/antiox9070644

      Resource: (MMRRC Cat# 034848-JAX,RRID:MMRRC_034848-JAX)

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    ncbi.nlm.nih.gov/pmc/articles/PMC7402118/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease
    1
    1. scibot 17 Nov 2020
      MMRRC Stock 34848

      DOI: 10.3389/fnins.2020.00862

      Resource: (MMRRC Cat# 034848-JAX,RRID:MMRRC_034848-JAX)

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    ncbi.nlm.nih.gov/pmc/articles/PMC7438734/
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model
    1
    1. scibot 17 Nov 2020
      MMRRC Stock #034848

      DOI: 10.3389/fnagi.2020.00251

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    ncbi.nlm.nih.gov/pmc/articles/PMC7472639/
  122. Sep 2020
  123. link.springer.com link.springer.com
    Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer’s disease
    1
    1. scibot 12 Sep 2020
      RRID:MMRRC_034848-JAX

      DOI: 10.1186/s13195-020-00656-9

      Resource: (MMRRC Cat# 034848-JAX,RRID:MMRRC_034848-JAX)

      Curator: @Naa003

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    link.springer.com/article/10.1186/s13195-020-00656-9
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptome Analysis of Pineal Glands in the Mouse Model of Alzheimer’s Disease
    1
    1. scibot 04 Sep 2020
      34848

      DOI: 10.3389/fnmol.2019.00318

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    ncbi.nlm.nih.gov/pmc/articles/PMC6962250/
  125. www.sciencedirect.com www.sciencedirect.com
    Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology: Running title: BPSD in Alzheimer’s disease models
    1
    1. scibot 04 Sep 2020
      34848

      DOI: 10.1016/j.neubiorev.2020.02.012

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    sciencedirect.com/science/article/pii/S0149763419304695
  126. www.sciencedirect.com www.sciencedirect.com
    An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease
    1
    1. scibot 04 Sep 2020
      MMRRC, 034848-JAX

      DOI: 10.1016/j.jneumeth.2018.05.022

      Resource: (MMRRC Cat# 034848-JAX,RRID:MMRRC_034848-JAX)

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    sciencedirect.com/science/article/pii/S0165027018301602
  127. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice
    1
    1. scibot 04 Sep 2020
      MMRRC stock # 34848

      DOI: 10.1002/jnr.24578

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    onlinelibrary.wiley.com/doi/full/10.1002/jnr.24578
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Harnessing genetic complexity to enhance translatability of Alzheimer’s disease mouse models: a path towards experimental precision medicine
    1
    1. scibot 03 Sep 2020
      MMRRC Stock No: 34848-JAX

      DOI: 10.1016/j.neuron.2018.11.040

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    ncbi.nlm.nih.gov/pmc/articles/PMC6886697/
  129. rupress.org rupress.org
    Plaque-associated myeloid cells derive from resident microglia in an Alzheimer’s disease model
    1
    1. scibot 03 Sep 2020
      MMRRC 34848-JAX

      DOI: 10.1084/jem.20191374

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    rupress.org/jem/article/217/4/e20191374/133630/Plaque-associated-myeloid-cells-derive-from
  130. www.nature.com www.nature.com
    3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice
    1
    1. scibot 03 Sep 2020
      MMRRC) (Stock No. 034848-JA

      DOI: 10.1038/s42003-019-0599-8

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    nature.com/articles/s42003-019-0599-8.pdf
  131. May 2019
  132. www.karger.com www.karger.com
    Deletion of the Inflammasome Sensor Aim2 Mitigates Aβ Deposition and Microglial Activation but Increases Inflammatory Cytokine Expression in an Alzheimer Disease Mouse Model
    1
    1. scibot 02 May 2019
      034848

      Curator: @bandrow

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    karger.com/Article/FullText/477092
  133. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
    1
    1. scibot 02 May 2019
      MMRRC stock 34848

      Curator: @bandrow

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      RRID:MMRRC_034848-JAX

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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-018-0239-7
  134. www.osapublishing.org www.osapublishing.org
    Optical projection tomography for rapid whole mouse brain imaging
    1
    1. scibot 02 May 2019
      34848-JAX, MMRRC

      Curator: @bandrow

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      RRID:MMRRC_034848-JAX

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    osapublishing.org/boe/fulltext.cfm
  135. www.sciencedirect.com www.sciencedirect.com
    Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
    1
    1. scibot 02 May 2019
      MMRRC_034848

      Curator: @Jmenke

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      RRID:MMRRC_034848-JAX

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    sciencedirect.com/science/article/pii/S107476131830075X