1,333 Matching Annotations
  1. Dec 2022
  2. www.sciencedirect.com www.sciencedirect.com
    A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
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      DOI: 10.1016/j.jbc.2022.102806

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    sciencedirect.com/science/article/pii/S0021925822012492
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    Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal
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    sciencedirect.com/science/article/pii/S2211124722016321
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    sciencedirect.com/science/article/pii/S2211124722016424
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    Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning
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    sciencedirect.com/science/article/pii/S2211124722016497
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    SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX
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      DOI: 10.7554/eLife.82244

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    ncbi.nlm.nih.gov/pmc/articles/PMC9718523/
  7. Nov 2022
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    LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation
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    sciencedirect.com/science/article/pii/S2211124722015327
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    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
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    sciencedirect.com/science/article/pii/S2211124722015492
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    Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies
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    sciencedirect.com/science/article/pii/S2211124722015522
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    A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
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      DOI: 10.7554/eLife.80895

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    ncbi.nlm.nih.gov/pmc/articles/PMC9674349/
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    A novel function for the sperm adhesion protein IZUMO1 in cell–cell fusion
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    ncbi.nlm.nih.gov/pmc/articles/PMC9671554/
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    HBO1 catalyzes lysine benzoylation in mammalian cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9647509/
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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    sciencedirect.com/science/article/pii/S1097276522010541
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
    1
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      DOI: 10.1093/brain/awac325

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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac325/6694190
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    Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
    1
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    nature.com/articles/s41564-022-01264-z
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    ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation
    1
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    cell.com/molecular-cell/fulltext/S1097-2765(22)01017-6
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    Structural and functional basis of mammalian microRNA biogenesis by Dicer
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    sciencedirect.com/science/article/pii/S1097276522009674
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets
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      DOI: 10.1016/j.isci.2022.105351

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    Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
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    sciencedirect.com/science/article/pii/S2211124722014322
  21. Oct 2022
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    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    sciencedirect.com/science/article/pii/S1550413122004119
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    A surface-receptor-coupled G protein regulates plant immunity through nuclear protein kinases
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    sciencedirect.com/science/article/pii/S1931312822004681
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    Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy
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    sciencedirect.com/science/article/pii/S2211124722012955
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    Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation
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    sciencedirect.com/science/article/pii/S1097276522009078
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    Yeast Mediator facilitates transcription initiation at most promoters via a Tail-independent mechanism
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    sciencedirect.com/science/article/pii/S1097276522009054
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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    sciencedirect.com/science/article/pii/S221112472201275X
  28. www.nature.com www.nature.com
    Regulation of KDM5C stability and enhancer reprogramming in breast cancer
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      DOI: 10.1038/s41419-022-05296-5

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    nature.com/articles/s41419-022-05296-5
  29. Sep 2022
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules
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    ncbi.nlm.nih.gov/pmc/articles/PMC9508565/
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    Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
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    sciencedirect.com/science/article/pii/S2211124722011937
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    Heterologous reporter expression in the planarian Schmidtea mediterranea through somatic mRNA transfection
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      DOI: 10.1016/j.crmeth.2022.100298

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    sciencedirect.com/science/article/pii/S2667237522001801
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    Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers
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    Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages
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    sciencedirect.com/science/article/pii/S1534580722005950
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    Scalable CRISPR-Cas9 chemical genetic screens in non-transformed human cells
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    sciencedirect.com/science/article/pii/S266616672200555X
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    Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy
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    sciencedirect.com/science/article/pii/S2211124722011779
  37. Aug 2022
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    CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124722011172
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    Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions
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      DOI: 10.1371/journal.pbio.3001759

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    Tumor targeted 4-1BB agonist antibody-albumin fusions with high-affinity to FcRn induce anti-tumor immunity without toxicity
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    sciencedirect.com/science/article/pii/S2589004222012305
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    A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
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    sciencedirect.com/science/article/pii/S1097276522007560
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    Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
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    sciencedirect.com/science/article/pii/S1931312822003626
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    sciencedirect.com/science/article/pii/S2211124722010324
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    STK25 inhibits PKA signaling by phosphorylating PRKAR1A
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    sciencedirect.com/science/article/pii/S2211124722010208
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL
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      DOI: 10.1158/2159-8290.CD-21-1566

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357155/
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    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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    SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1
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    Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2
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    Evidence that HDAC7 acts as an epigenetic “reader” of AR acetylation through NCoR-HDAC3 dissociation
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    Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer
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    Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells
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    Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
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    Reciprocal regulation of phosphatidylcholine synthesis and H3K36 methylation programs metabolic adaptation
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    The CDC48 complex mediates ubiquitin-dependent degradation of intra-chloroplast proteins in plants
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    Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury
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    Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
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    Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia
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    Recycling of autophagosomal components from autolysosomes by the recycler complex
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    Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcaemia
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms
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    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
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    The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition
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    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
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    Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
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    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth
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    Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo
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    SARM1 IS A MULTI-FUNCTIONAL NAD(P)ASE WITH PROMINENT BASE EXCHANGE ACTIVITY, ALL REGULATED BY MULTIPLE PHYSIOLOGICALLY-RELEVANT NAD METABOLITES
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    SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
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    Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
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    The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
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    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    Targeting Pyruvate Kinase M2 phosphorylation reverses aggressive cancer phenotypes
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    Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease
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    PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways
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    Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors
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    Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub
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    Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors
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    Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain
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    Generation of 3X FLAG-tagged human embryonic stem cell (hESC) line to study WNT-induced β-catenin DNA interactions (HVRDe009-A-2)
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    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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