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The HY5-NPR1 module governs light-dependent virulence of a plant bacterial pathogen

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Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia

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  DOI: 10.1038/s41375-025-02731-2
  
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Aug 2025
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1-s2.0-S2589004225017006-main-html.html

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Evolution of the SARS-CoV-2 spike protein in utilizing host transmembrane serine proteases

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StBPA1 attenuates surface receptor activation and finely regulates immune responses against bacterial and oomycete pathogens in potato

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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

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HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

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Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation

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Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

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Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system

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  DOI: 10.1016/j.cels.2025.101351
  
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2025.07.26.666918v1.full-html.html

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52.53.155.43/b861d752b12dd67d806a9ddbf467334dbc44c806/2025.07.26.666918v1.full-html.html
Jul 2025
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Interaction of IRS2 with PLK1 protects cells from mitotic stress

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  DOI: 10.1101/2025.07.17.665461
  
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A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I–III

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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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  DOI: 10.1126/sciadv.adu6354
  
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

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Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis

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Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

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  DOI: 10.7554/eLife.88588
  
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Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

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1-s2.0-S2589004225013203-main-html.html

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Comprehensive genetic profiling of sensorineural hearing loss using an integrative diagnostic approach

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Mechanical cues polarize ADIP protein complexes to control vertebrate morphogenesis and wound healing

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PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer

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Lipocalin-2 regulates astrocyte-oligodendrocyte interaction to drive post-stroke secondary demyelination

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Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

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1-s2.0-S258900422501226X-main-html.html

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Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

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CXCR4-LASP1-G9a-SNAIL axis drives NEPC transdifferentiation via induction of EMT and downregulation of REST

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Phenotypic landscape of an invasive fungal pathogen reveals its unique biology

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Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins

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  DOI: 10.1038/s42255-024-01162-0
  
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Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis

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Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development

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DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25

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  DOI: 10.1371/journal.pbio.3003203
  
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Histone deacetylation as a landmark for Sgo2 relocation from centromeres to subtelomeres during interphase

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  DOI: 10.1016/j.isci.2025.112717
  
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ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair

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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

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Generation of Hoxa11-3XFLAG and Hoxd11-3XFLAG alleles to investigate Hox11 genome-wide binding

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Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

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Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors

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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells

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Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs

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Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA

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Integrative characterization of MYC RNA-binding function

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HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma

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TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma

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Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice

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A natural gene on-off system confers field thermotolerance for grain quality and yield in rice

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APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

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Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2

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RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity

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Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth

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Herpes simplex virus 1 encodes a STING antagonist that can be therapeutically targeted

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Integrator loss leads to dsRNA formation that triggers the integrated stress response

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Antagonistic response regulators spatially regulate receptor methylation in the Pseudomonas aeruginosa Pil-Chp surface sensing system

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A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression

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A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors

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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

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Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis

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The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection

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Antagonistic roles for MITF and TFE3 in melanoma plasticity

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Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation

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Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways

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The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

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The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors

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Protocol to modulate SUMOylation of a specific protein in budding yeast using chemical genetic approaches

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Engineering mtDNA deletions by reconstituting end joining in human mitochondria

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p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

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Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control

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Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

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Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines

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YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks

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Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation

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Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance

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SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer

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PI3KC2β depletion rescues endosomal trafficking defects in Mtm1 knockout skeletal muscle cells

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Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons

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Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo

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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

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Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs

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Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase

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Cdk6’s functions are critically regulated by its unique C-terminus

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A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

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Mina53 catalyzes arginine demethylation of p53 to promote tumor growth

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The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway

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Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation

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TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells

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Structure of the Nipah virus polymerase complex

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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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can-23-2194-html.html

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Structure of the Nipah virus polymerase complex

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Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer

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Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma

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Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen

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Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

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can-23-2194-html.html

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Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3

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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

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DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance

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YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

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1-s2.0-S2589004224028141-main-html.html

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Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors

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Increased CSN5 expression enhances the sensitivity to lenalidomide in multiple myeloma cells

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SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro

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A function of TPL/TBL1-type corepressors is to nucleate the assembly of the preinitiation complex

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The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance

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Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

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Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

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OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

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Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

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The role of polo‐like kinases 2 in the proteasomal and lysosomal degradation of alpha‐synuclein in neurons

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EMF1 functions as a 3D chromatin modulator in Arabidopsis

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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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The Arabidopsis blue-light photoreceptor CRY2 is active in darkness to inhibit root growth

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Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

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Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection

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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies

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SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release

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Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins

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Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis

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Mass spectrometry identifies tau C-terminal phosphorylation cluster during neuronal hyperexcitation

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QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction

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Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor

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Highlights from MBoC Selection: Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage

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Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

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Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

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Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins

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Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions

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PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks

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The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment

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Determination of the Gene Regulatory Network of a Genome-Reduced Bacterium Highlights Alternative Regulation Independent of Transcription Factors

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Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway

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Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106

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RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells

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Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

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TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

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Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

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E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS

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Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration

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Rho-dependent transcriptional switches regulate the bacterial response to cold shock

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Defective CFTR modulates mechanosensitive channels TRPV4 and PIEZO1 and drives endothelial barrier failure

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RNA interacts with topoisomerase I to adjust DNA topology

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The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins

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The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex

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The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking

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Ubiquitination and degradation of plant helper NLR by the Ralstonia solanacearum effector RipV2 overcome tomato bacterial wilt resistance

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Oxidative stress reprograms the transcriptional coactivator Yki to suppress cell proliferation

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The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy

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The cullin Rtt101 promotes ubiquitin-dependent DNA−protein crosslink repair across the cell cycle

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Mrc1 regulates parental histone segregation and heterochromatin inheritance

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The fork protection complex promotes parental histone recycling and epigenetic memory

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Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency

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Jul 2024
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Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells

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Strategic targeting of Cas9 nickase induces large segmental duplications

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The molecular basis of tRNA selectivity by human pseudouridine synthase 3

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Genome-scale exon perturbation screens uncover exons critical for cell fitness

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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

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paul-chowdhuri-das-2024-tdp1-phosphorylation-by-cdk1-in-mitosis-promotes-mus81-dependent-repair-of-trapped-top1-dna-html.html

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TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes

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The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway

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Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

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Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis

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The antagonistic role of an E3 ligase pair in regulating plant NLR-mediated autoimmunity and fungal pathogen resistance

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The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation

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Characterising replisome disassembly in human cells

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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

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  DOI: 10.1016/j.molcel.2020.09.028
  
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Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium

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  DOI: 10.1038/s41422-020-0388-4
  
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The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit

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The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex

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  DOI: 10.1038/s44318-024-00164-8
  
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Phage detection by a bacterial NLR-related protein is mediated by DnaJ

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  DOI: 10.1101/2024.06.04.597415
  
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Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1

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  DOI: 10.1016/j.celrep.2024.114229
  
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Activity- and sleep-dependent regulation of tonic inhibition by Shisa7

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Electro-elution-based purification of covalent DNA–protein cross-links

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  DOI: 10.1038/s41596-024-01004-z
  
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Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells

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  DOI: 10.14814/phy2.16106
  
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EYA protein complex is required for Wntless retrograde trafficking from endosomes to Golgi

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  DOI: 10.1016/j.devcel.2024.05.021
  
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Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP

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The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress

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Transcriptional Synergy in Human Aortic Endothelial Cells is Vulnerable to Combination p300/CBP and BET Bromodomain Inhibition

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Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

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  DOI: 10.1186/s12943-024-02034-7
  
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Xbp1 targets canonical UPRER and non-canonical pathways in separate tissues to promote longevity

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  DOI: 10.1016/j.isci.2024.109962
  
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A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis

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  DOI: 10.1016/j.cell.2024.04.041
  
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PKCð regulates chromatin remodeling and DNA repair through SIRT6

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  DOI: 10.1158/1541-7786.MCR-23-0493
  
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Bilayer lipids modulate ligand binding to atypical chemokine receptor 3

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A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation

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  DOI: 10.1016/j.cub.2024.04.054
  
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2024.02.25.581951v1.full-html.html

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  DOI: 10.1038/nature12362
  
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Genetic compensation between ribosomal protein paralogs mediated by a cognate circular RNA

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  DOI: 10.1016/j.celrep.2024.114228
  
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Host-pathogen Coadaptation by running with PAR protein

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  DOI: 10.1101/2024.01.31.578330
  
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

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  DOI: 10.1016/j.xgen.2024.100550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099347/

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